Cited by 182Menstrual Health and DisordersHypothalamic control of reproductive hormonesNeuroscience and Neuropharmacology Research

Patients with Premenstrual Syndrome Have a Different Sensitivity to a Neuroactive Steroid during the Menstrual Cycle Compared to Control Subjects

Sundström, Inger, Andersson, Agneta, Nyberg, Sigrid, Ashbrook, Donald, Purdy, Robert H., Bäckström, Torbjörn·1998·Neuroendocrinology

Abstract

We have evaluated the functional sensitivity to a neuroactive steroid in 12 women with and 12 women without premenstrual syndrome (PMS) at two stages of the menstrual cycle, by comparing the effects of three increasing doses of intravenous pregnanolone (3α-hydroxy-5β-pregnan-20-one) on saccadic eye velocity (SEV) and self-rated sedation. Control subjects in the follicular and luteal phase showed a significant reduction in SEV after pregnanolone injections compared to vehicle. In PMS patients, pregnanolone injections induced a significant dose-related decrease in SEV compared to vehicle only in the follicular phase, not in the luteal phase. After pregnanolone injections, sedation scores increased significantly from vehicle among control subjects in the luteal phase but not among PMS patients in either cycle phase. High-severity PMS patients responded with less decrease in SEV and less increase in sedation scores following pregnanolone injections compared to low-severity patients. Control subjects increased their SEV response to pregnanolone in the luteal phase compared to the follicular phase, whereas PMS patients did not. These findings are compatible with a decreased GABA A-receptor sensitivity in brain areas controlling saccadic eye movements among PMS patients in the late luteal phase.

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Crossref · 10.1159/000054307

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Authors
Sundström, I., Andersson, A., Nyberg, S., Ashbrook, D., Purdy, R. H., & Bäckström, T.
Affiliations
  • Umeå University (SE)
  • University Hospital of Umeå (SE)
  • University of California San Diego (US)
Venue
Neuroendocrinology
Publisher
S. Karger AG
Published
1998
Volume
67
Issue
2
Pages
126-138
ISSN
  • 0028-3835 (ISSN-L)
  • 1423-0194
OpenAlex
W2012453718
Cited by
182
References
46
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 4 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 6 · 2014: 6 · 2013: 7 · 2012: 7
FWCI
12.59
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Vetenskapsrådet
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
premenstrual syndrome, pregnanolone, neurosteroids, sedation, menstrual cycle, luteal phase, follicular phase, dose-response relationship
MeSH terms
Adult, Affect, Behavior, Female, Follicular Phase, Humans, Hypnotics and Sedatives, Luteal Phase, Menstrual Cycle, Pregnanolone, Premenstrual Syndrome, Saccades

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