The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The HPV-16 E5 Protein Inhibits TRAIL- and FasL-Mediated Apoptosis in Human Keratinocyte Raft Cultures
Abstract
By using raft cultures of the polyclonal HaCaT cell lines stably transfected either with E5 (HaCaT/E5) or the empty vector (HaCaT/pMSG) as reference, we investigated the effect of the human papillomavirus type 16 (HPV-16) E5 protein on apoptosis. In comparison to conventional monolayer cultures this model system allows analysis of apoptosis under more tissue-like conditions by mimicking the stratified organization of a normal surface epithelium. Apoptosis was triggered either by FasL or TRAIL. Execution of the death program was checked at early and late stages by monitoring procaspase-3 cleavage and DNA fragmentation, respectively. Rafts of E5-expressing keratinocytes were completely protected from apoptosis and showed a background of apoptotic cells as low as the untreated cultures. In contrast, the HaCaT/pMSG cultures revealed a dramatic increase in apoptotic cells upon ligand treatment throughout the epithelial compartment. We conclude that the presence of the HPV-16 E5 protein in our tissue-like model prevents FasL- or TRAIL-mediated apoptosis.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“the expression of HPV-16 E5 prevents FasL- or TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis by downregulating the expression of Fas receptors and abrogating the recruitment of the Fas-associated protein with death domain (FADD) to form the death-induced signalling complex (DISC) in raft cultures of HaCaT cells stably expressing HPV-16 E5 [197]”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [197]
Citations
Cites
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.
Boukamp, P., Petrussevska, R. T., Breitkreutz, D., Hornung, J., Markham, A., & Fusenig, N. E. (1988) · The Journal of cell biology · doi:10.1083/jcb.106.3.761 · Cited by 4,170
Identification and characterization of a new member of the TNF family that induces apoptosis
Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C.-P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90057-8 · Cited by 2,900
Research works printed but not linked: 26
- 10.1046/j.1365-2613.2001.00177.x · DOI
- 10.1006/viro.1998.9262 · DOI
- 10.1006/viro.1996.0475 · DOI · Paper page
- 10.1016/0046-8177(92)90232-R · DOI
- 10.1038/sj.onc.1204010 · DOI
- 10.1006/excr.1998.4024 · DOI · Paper page
- 10.1023/A:1008112207824 · DOI · Paper page
- 10.1006/viro.1994.1456 · DOI · Paper page
- 10.1038/sj.onc.1205147 · DOI
- 10.1128/JVI.76.1.220-231.2002 · DOI · Paper page
- 10.1146/annurev.cellbio.15.1.269 · DOI
- 10.1038/35037710 · DOI · Paper page
- 10.1006/excr.2000.4840 · DOI
- 10.1128/MCB.21.24.8247-8254.2001 · DOI
- 10.1074/jbc.274.3.1541 · DOI
- 10.1006/excr.2000.4834 · DOI
- 10.1046/j.0022-202x.2001.01380.x · DOI
- 10.1146/annurev.biochem.69.1.217 · DOI
- 10.1046/j.1525-1438.2000.010005417.x · DOI
- 10.1128/JVI.76.23.12162-12172.2002 · DOI
- 10.1007/s004410000231 · DOI
- 10.1111/1523-1747.ep12472288 · DOI
- 10.1111/1523-1747.ep12476930 · DOI
- 10.1006/taap.2001.9202 · DOI
- 10.1054/bjoc.2000.1118 · DOI
- 10.1016/0092-8674(90)90409-8 · DOI · Paper page
Cited by
Basukala, O., & Banks, L. (2021) · Viruses · doi:10.3390/v13101892 · Cited by 137
Metadata
- Authors
- Kabsch, K., Mossadegh, N., Kohl, A., Komposch, G., Schenkel, J., Alonso, A., & Tomakidi, P.
- Venue
- Intervirology
- Publisher
- S. Karger AG
- Published
- 2004
- Volume
- 47
- Issue
- 1
- Pages
- 48-56
- ISSN
- 0300-5526
- 1423-0100
- Cited by
- 58
- References
- 2
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
