Cited by 393Glycosylation and Glycoproteins ResearchAllergic Rhinitis and SensitizationFood Allergy and Anaphylaxis Research

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

The Role of Protein Glycosylation in Allergy

Altmann, Friedrich·2007·International Archives of Allergy and Immunology

DOI 10.1159/000096114

Open this paper in CoChat — free account

Abstract

The asparagine-linked carbohydrate moieties of plant and insect glycoproteins are the most abundant environmental immune determinants. They are the structural basis of what is known as cross-reactive carbohydrate determinants (CCDs). Despite some structural variation, the two main motifs are the xylose and the core-3-linked fucose, which form the essential part of two independent epitopes. Plants contain both epitopes, insect glycoproteins only fucose. These epitopes and other fucosylated determinants are also found in helminth parasites where they exert remarkable immunomodulatory effects. About 20% or more of allergic patients generate specific anti-glycan IgE, which is often accompanied by IgG. Even though antibody-binding glycoproteins are widespread in pollens, foods and insect venoms, CCDs do not appear to cause clinical symptoms in most, if not all patients. When IgE binding is solely due to CCDs, a glycoprotein allergen thus can be rated as clinical irrelevant allergen. Low binding affinity between IgE and plant N-glycans now drops out as a plausible explanation for the benign nature of CCDs. This rather may result from blocking antibodies induced by an incidental ‘immune therapy’ (‘glyco-specific immune therapy’) exerted by everyday contact with plant materials, e.g. fruits or vegetables. The need to detect and suppress anti-CCD IgE without interference from peptide epitopes can be best met by artificial glycoprotein allergens. Hydroxyproline-linked arabinose (single β-arabinofuranosyl residues) has been identified as a new IgE-binding carbohydrate epitope in the major mugwort allergen. However, currently the occurrence of this O-glycan determinant appears to be rather restricted.

Integrity signals

Registry

Crossref · 10.1159/000096114

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Specific IgE to cross-reactive carbohydrate determinants strongly affect the in vitro diagnosis of allergic diseases
Mari, A., Iacovacci, P., Afferni, C., Barletta, B., Tinghino, R., Di Felice, G., & Pini, C. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70171-5 · Cited by 217
Lacto- N -fucopentaose III Found on Schitosoma mansoni Egg Antigens Functions as Adjuvant for Proteins by Inducing Th2-Type Response
Okano, M., Satoskar, A. R., Nishizaki, K., & Harn, D. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.1.442 · Cited by 210
LacdiNAc-glycans constitute a parasite pattern for galectin-3-mediated immune recognition
van den Berg, T. K., Honing, H., Franke, N., van Remoortere, A., Schiphorst, W. E. C. M., Liu, F.-T., Deelder, A. M., Cummings, R. D., Hokke, C. H., & van Die, I. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1902 · Cited by 170

Show all 0 references

Research works printed but not linked: 106

10.1016%2F0091-6749%2881%2990133-0 · DOI
10.1016%2FS0091-6749%2897%2970245-8 · DOI
10.1097%2F00130832-200406000-00017 · DOI
10.1111%2Fj.1365-2222.2004.01837.x · DOI
10.1111%2Fj.1365-2222.2005.02217.x · DOI
10.1111%2Fj.1398-9995.1995.tb01202.x · DOI
10.1111%2Fj.1365-2222.2005.02294.x · DOI
10.1067%2Fmai.2001.116430 · DOI
10.1159%2F000067591 · DOI
10.1067%2Fmai.2003.1683 · DOI
10.1046%2Fj.1398-9995.2003.00407.x · DOI · Paper page
10.1067%2Fmai.2002.126380 · DOI
10.1007%2FBF01108609 · DOI
10.1093%2Fglycob%2F8.7.651 · DOI
10.1093%2Fglycob%2F11.4.261 · DOI · Paper page
10.1023%2FA%3A1006012005654 · DOI
10.1074%2Fjbc.M410407200 · DOI
10.1111%2Fj.1398-9995.1987.tb00364.x · DOI
10.1159%2F000236534 · DOI
10.2174%2F1389201003378843 · DOI
10.1016%2FS0959-440X%2802%2900367-6 · DOI
10.1016%2FS0300-9084%2801%2901297-4 · DOI
10.1055%2Fs-2003-44721 · DOI
10.1023%2FA%3A1006960401562 · DOI
10.1271%2Fbbb.69.137 · DOI
10.1271%2Fbbb.69.1700 · DOI
10.1016%2FS0008-6215%2800%2990610-4 · DOI
10.1111%2Fj.1432-1033.1987.tb13517.x · DOI
10.1515%2FBC.2004.044 · DOI
10.1046%2Fj.1432-1033.2003.03503.x · DOI
10.1074%2Fjbc.275.15.11451 · DOI
10.1006%2Fabio.2000.4737 · DOI
10.1042%2FBJ20041062 · DOI
10.1111%2Fj.1742-4658.2005.05000.x · DOI
10.1074%2Fjbc.271.43.26653 · DOI
10.1111%2Fj.1365-2222.2004.01897.x · DOI
10.1007%2FBF00731872 · DOI
10.1111%2Fj.1432-1033.1993.tb17870.x · DOI
10.1093%2Fglycob%2F4.2.105 · DOI
10.1111%2Fj.1742-4658.2005.04841.x · DOI
10.1093%2Fglycob%2F11.2.149 · DOI
10.1093%2Fglycob%2F7.5.653 · DOI
10.1016%2FS0014-5793%2899%2901508-2 · DOI
10.1074%2Fjbc.271.48.30561 · DOI
10.1111%2Fj.1432-1033.1995.tb20809.x · DOI
10.1111%2Fj.1432-1033.2004.04045.x · DOI
10.1111%2Fj.1432-1033.1997.00195.x · DOI
10.1016%2FS0014-5793%2899%2901489-1 · DOI
10.1111%2Fj.1365-3024.2005.00781.x · DOI
10.1016%2Fj.ijpara.2004.04.009 · DOI
10.1016%2Fj.bmc.2005.02.009 · DOI
10.1111%2Fj.1742-4658.2005.05068.x · DOI
10.1017%2FS0031182004006390 · DOI
10.1074%2Fjbc.M505985200 · DOI
10.1111%2Fj.0105-2896.2004.00187.x · DOI
10.1128%2FIAI.72.1.398-407.2004 · DOI
10.1002%2Feji.200323717 · DOI · Paper page
10.1016%2FS0198-8859%2899%2900136-6 · DOI
10.1126%2Fscience.296.5567.490 · DOI
10.1007%2FBF01049085 · DOI
10.1016%2F0300-9084%2888%2990285-4 · DOI
10.1006%2Fabio.1993.1088 · DOI
10.1016%2FS0091-6749%2896%2970130-6 · DOI
10.1093%2Fglycob%2Fcwh058 · DOI
10.1021%2Fbi00025a027 · DOI
10.1111%2Fj.1432-1033.1990.tb15553.x · DOI
10.1093%2Fglycob%2Fcwj071 · DOI
10.1093%2Fglycob%2Fcwg024 · DOI
10.1111%2Fj.1398-9995.1998.tb03934.x · DOI
10.1046%2Fj.1365-2222.2001.01019.x · DOI
10.1007%2FBF00393072 · DOI
10.1093%2Fglycob%2Fcwg025 · DOI · Paper page
10.1016%2Fj.micron.2003.10.033 · DOI
10.1046%2Fj.1365-2222.1999.00590.x · DOI
10.1016%2FS0091-6749%2899%2970538-5 · DOI
10.1023%2FA%3A1014860030380 · DOI · Paper page
10.1067%2Fmai.2001.120013 · DOI
10.1046%2Fj.1365-2222.2002.01516.x · DOI
10.1111%2Fj.1365-2222.2005.02371.x · DOI
10.1159%2F000024404 · DOI
10.1159%2F000090384 · DOI
10.1159%2F000065180 · DOI
10.1016%2Fj.jaci.2004.11.020 · DOI
10.1034%2Fj.1398-9995.2002.23686.x · DOI
10.1034%2Fj.1398-9995.2002.13423.x · DOI
10.1046%2Fj.1365-2222.2002.01530.x · DOI
10.1111%2Fj.1365-2222.2004.1948.x · DOI
10.1111%2Fj.1398-9995.1998.tb03813.x · DOI
10.1067%2Fmai.2000.108711 · DOI
10.1067%2Fmai.2003.173 · DOI
10.1046%2Fj.1432-1327.1998.2520118.x · DOI
10.1159%2F000066770 · DOI
10.1006%2Fabio.1999.4277 · DOI
10.1159%2F000073260 · DOI
10.1172%2FJCI25575 · DOI
10.1016%2Fj.jaci.2004.03.024 · DOI
10.1159%2F000236835 · DOI
10.1159%2F000091169 · DOI
10.1159%2F000023996 · DOI
10.1515%2FCCLM.2006.024 · DOI
10.1111%2Fj.1365-2222.2006.2492.x · DOI
10.1016%2Fj.ymeth.2003.08.018 · DOI
10.1515%2FCCLM.2005.226 · DOI
10.1067%2Fmai.2003.1495 · DOI
10.1002%2Feji.1830250235 · DOI
10.1016%2Fj.jim.2006.01.001 · DOI

Sorted by citations

EAACI Molecular Allergology User's Guide
Matricardi, P. M., Kleine‐Tebbe, J., Hoffmann, H. J., Valenta, R., Hilger, C., Hofmaier, S., Aalberse, R. C., Agache, I., Asero, R., Ballmer‐Weber, B., et al. (2016) · Pediatric Allergy and Immunology · doi:10.1111/pai.12563 · Cited by 932
“, nasal, or conjunctival) challenge with the biologic source can prove the genuine protein epitopes IgE recognition (37).”
Background
Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-α-1,3-galactose
Commins, S., Satinover, S., Hosen, J., Mozena, J., Borish, L., Lewis, B. D., Woodfolk, J., & Platts-Mills, T. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.10.052 · Cited by 688
Scientific Opinion on the assessment of allergenicity of GM plants and microorganisms and derived food and feed
Panel), E. P. O. G. M. O. (. (2010) · EFSA Journal · doi:10.2903/j.efsa.2010.1700 · Cited by 611
Generation of glyco‐engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human‐like N‐glycan structure
Strasser, R., Stadlmann, J., Schähs, M., Stiegler, G. M., Quendler, H., Mach, L., Glössl, J., Weterings, K., Pabst, M., & Steinkellner, H. (2008) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2008.00330.x · Cited by 528
EAACI Molecular Allergology User's Guide 2.0
Dramburg, S., Hilger, C., Santos, A. F., Vecillas, L. D. L., Aalberse, R. C., Acevedo, N., Aglas, L., Altmann, F., Arruda, L. K., Asero, R., et al. (2023) · Pediatric Allergy and Immunology · doi:10.1111/pai.13854 · Cited by 342
Self-citation
Thirty years of baculovirus–insect cell protein expression: from dark horse to mainstream technology
van Oers, M. M., Pijlman, G. P., & Vlak, J. M. (2014) · Journal of General Virology · doi:10.1099/vir.0.067108-0 · Cited by 362
Metabonomic, transcriptomic, and genomic variation of a population cohort
Inouye, M., Kettunen, J., Soininen, P., Silander, K., Ripatti, S., Kumpula, L. S., Hämäläinen, E., Jousilahti, P., Kangas, A. J., Männistö, S., et al. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.93 · Cited by 250
“Glycoproteins are known to have potentially allergenic effects”
Background
Food Allergies: The Basics
Valenta, R., Hochwallner, H., Linhart, B., & Pahr, S. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.02.006 · Cited by 336
Panallergens and their impact on the allergic patient
Hauser, M., Roulias, A., Ferreira, F., & Egger, M. (2010) · Allergy, Asthma & Clinical Immunology · doi:10.1186/1710-1492-6-1 · Cited by 284
“Compiled evidence suggests that CCDs do not cause clinical symptoms in most, if not all, allergic individuals [72].”
Preclinical and Clinical Development of Plant-Made Virus-Like Particle Vaccine against Avian H5N1 Influenza
Landry, N., Ward, B., Trépanier, S., Montomoli, E., Dargis, M., Lapini, G., & Vézina, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015559 · Cited by 279
Common food allergens and their IgE-binding epitopes.
Matsuo, H., Yokooji, T., & Taogoshi, T. (2015) · Allergology International · doi:10.1016/j.alit.2015.06.009 · Cited by 235
Position paper of the EAACI: food allergy due to immunological cross‐reactions with common inhalant allergens
Werfel, T., Asero, R., Ballmer-Weber, B., Beyer, K., Enrique, E., Knulst, A., Mari, A., Muraro, A., Ollert, M., Poulsen, L., et al. (2015) · Allergy. European Journal of Allergy and Clinical Immunology · doi:10.1111/all.12666 · Cited by 224
“They can be identified by testing specific IgE to bromelain or its glycan structure, MUXF, coupled to a protein backbone, for example BSA (9).”
Background
Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes
Barrett, N. A., Rahman, O. M., Fernandez, J., Parsons, M. W., Xing, W., Austen, K. F., & Kanaoka, Y. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20100793 · Cited by 196
“Thus, N-linked core -fucosylated and/or -xylosylated complex mannose glycans found widely in plants, insects, and helminths and -1,3/1,6-glucans found in fungi appear to be nonmammalian molecular patterns important in triggering Th2 immunity (Altmann, 2007; Wills-Karp et al., 2010).”
Background
Mold Allergens in Respiratory Allergy: From Structure to Therapy
Twaroch, T., Curin, M., Valenta, R., & Swoboda, I. (2015) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2015.7.3.205 · Cited by 210
“In case of plant carbohydrates, structures that are crucial for IgE antibody binding have been determined: asparagine-linked xylose and fucose residues are mainly responsible for structural similarities which cause cross-reactivity.(84,85) In contrast to plant carbohydrates, mold proteins are highly mannosylated, indi…”
Background
Allergenicity assessment of genetically modified crops—what makes sense?
Goodman, R., Vieths, S., Sampson, H., Hill, D., Ebisawa, M., Taylor, S., & van Ree, R. (2008) · Nature Biotechnology · doi:10.1038/nbt1343 · Cited by 210
“Otherwise, carbohydrate-binding sera would lead to designating most glycoproteins as an allergenic risk, although it is widely accepted that the glycans are unlikely to cause clinical food allerg”
Fungi: the neglected allergenic sources
Crameri, R., Garbani, M., Rhyner, C., & Huitema, C. (2014) · Allergy · doi:10.1111/all.12325 · Cited by 207
Stepping stones in DNA sequencing
Stranneheim, H., & Lundeberg, J. (2012) · Biotechnology Journal · doi:10.1002/biot.201200153 · Cited by 83
“The contribution of the N-glycan epitopes to allergic reactions has been discussed intensively (recent reviewed in [31, 32]).”
Background
The production of biopharmaceuticals in plant systems
Karg, S. R., & Kallio, P. T. (2009) · Biotechnology Advances · doi:10.1016/j.biotechadv.2009.07.002 · Cited by 137
Allergens and their role in the allergic immune response
Platts‐Mills, T. A. E., & Woodfolk, J. A. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01021.x · Cited by 142
“there are also IgE antibodies directed against oligosaccharides on plant proteins (41, 42).”
Background
Inactivation of the β(1,2)-xylosyltransferase and the α(1,3)-fucosyltransferase genes in Nicotiana tabacum BY-2 Cells by a Multiplex CRISPR/Cas9 Strategy Results in Glycoproteins without Plant-Specific Glycans
Mercx, S., Smargiasso, N., Chaumont, F., Pauw, E. D., Boutry, M., & Navarre, C. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.00403 · Cited by 137
“While the immunogenicity of these residues has been demonstrated in different studies (Wilson et al., 1998; van Ree et al., 2000; Altmann, 2007; Bosch et al., 2013), others did not observe any adverse immune response of the injected recombinant protein such as the plant-produced taliglucerase and the influenza virus-l…”
Background
Are allergic multimorbidities and IgE polysensitization associated with the persistence or re‐occurrence of foetal type 2 signalling? The M e DALL hypothesis
Bousquet, J. J., Anto, J. M., Wickman, M. C., Keil, T. O. P., Valenta, R., Haahtela, T., Carlsen, K.-H., van Hage, M., Akdiş, C. A., Bachert, C., et al. (2015) · Allergy · doi:10.1111/all.12637 · Cited by 125
“An allergen microarray containing 103 allergen molecules has detected a high prevalence of asymptomatic IgE sensitizations to tropical pollen-derived cross-reactive carbohydrate determinants (59, 60).”
Background
IgE antibodies to alpha‐gal in the general adult population: relationship with tick bites, atopy, and cat ownership
González-Quintela, A., Laursen, A. S. D., Vidal, C., Skaaby, T., Gudé, F., & Linneberg, A. (2014) · Clinical and Experimental Allergy · doi:10.1111/cea.12326 · Cited by 126
Vicilin allergens of peanut and tree nuts (walnut, hazelnut and cashew nut) share structurally related IgE-binding epitopes.
Barre, A., Sordet, C., Culerrier, R., Rancé, F., Didier, A., & Rougé, P. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2007.09.014 · Cited by 119
Evaluation by double‐blind placebo‐controlled oral challenge of the clinical relevance of IgE antibodies against plant glycans
Mari, A., Heer, P., Scala, E., Giani, M., Pirrotta, L., Zuidmeer, L., Bethell, D., & van Ree, R. (2008) · Allergy. European Journal of Allergy and Clinical Immunology · doi:10.1111/j.1398-9995.2008.01703.x · Cited by 117
“Are they an allergenic risk? Since their discovery, there has been a debate on the clinical relevance of IgE antibodies against plant glycans (5, 6).”
BackgroundInfluential
Predictive values of alpha‐gal IgE levels and alpha‐gal IgE: Total IgE ratio and oral food challenge‐proven meat allergy in a population with a high prevalence of reported red meat allergy
Mabelane, T., Basera, W., Botha, M., Thomas, H., Ramjith, J., & Levin, M. (2018) · Pediatric Allergy and Immunology · doi:10.1111/pai.12969 · Cited by 114
Recombinant allergen-based IgE testing to distinguish bee and wasp allergy.
Mittermann, I., Zidarn, M., Šilar, M., Marković-Housley, Z., Aberer, W., Korošec, P., Košnik, M., & Valenta, R. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.03.017 · Cited by 113
Affinity of IgE and IgG against cross-reactive carbohydrate determinants on plant and insect glycoproteins.
Jin, C., Hantusch, B., Hemmer, W., Stadlmann, J., & Altmann, F. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.07.047 · Cited by 113
Self-citation
A plant-derived human monoclonal antibody induces an anti-carbohydrate immune response in rabbits
Jin, C., Altmann, F., Strasser, R., Mach, L., Schähs, M., Kunert, R., Rademacher, T., Glössl, J., & Steinkellner, H. (2007) · Glycobiology · doi:10.1093/glycob/cwm137 · Cited by 119
Self-citation
Human antibody response to N-glycans present on plant-made influenza virus-like particle (VLP) vaccines.
Ward, B., Landry, N., Trépanier, S., Mercier, G., Dargis, M., Couture, M., D'Aoust, M.-A., & Vézina, L. (2014) · Vaccine · doi:10.1016/j.vaccine.2014.08.079 · Cited by 98
Molecular Aspects of Allergens and Allergy
Valenta, R., Karaulov, A. V., Niederberger, V., Gattinger, P., van Hage, M., Flicker, S., Linhart, B., Campana, R., Focke‐Tejkl, M., Curin, M., et al. (2018) · Advances in immunology · doi:10.1016/bs.ai.2018.03.002 · Cited by 135
Controlled glycosylation of plant-produced recombinant proteins.
Strasser, R., Altmann, F., & Steinkellner, H. (2014) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.06.008 · Cited by 96
Self-citation
Functional Interaction of Common Allergens and a C-type Lectin Receptor, Dendritic Cell-specific ICAM3-grabbing Non-integrin (DC-SIGN), on Human Dendritic Cells*
Hsu, S.-C., Chen, C.-H., Tsai, S.-H., Kawasaki, H., Hung, C.-H., Chu, Y.-T., Chang, H.-W., Zhou, Y.-F., Fu, J.-R., Plunkett, B., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.058370 · Cited by 95
Component‐resolved diagnosis with commercially available D. pteronyssinus Der p 1, Der p 2 and Der p 10: relevant markers for house dust mite allergy
Bronnert, M., Mancini, J., Birnbaum, J., Agabriel, C., Liabeuf, V., Porri, F., Cleach, I., Fabre, A., Deneux, I., Grandné, V., et al. (2012) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2012.04035.x · Cited by 94
Cross‐reactivity among fungal allergens: a clinically relevant phenomenon?
Crameri, R., Zeller, S., Glaser, A. G., Vilhelmsson, M., & Rhyner, C. (2009) · Mycoses · doi:10.1111/j.1439-0507.2008.01644.x · Cited by 94
The carbohydrate galactose-α-1,3-galactose is a major IgE-binding epitope on cat IgA
Grönlund, H., Adédoyin, J., Commins, S., Platts-Mills, T., & van Hage, M. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.03.011 · Cited by 92
Characterization of peach thaumatin‐like proteins and their identification as major peach allergens
Palacín, A., Tordesillas, L., Gamboa, P., Sánchez-Monge, R., Cuesta-Herranz, J., Sanz, M. L., Barber, D., Salcedo, G., & Díaz-Perales, A. (2010) · Clinical and Experimental Allergy · doi:10.1111/j.1365-2222.2010.03578.x · Cited by 91
Food Allergen Epitope Mapping.
Liu, C., & Sathe, S. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b01967 · Cited by 90
Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity
Amoah, A., Obeng, B., Larbi, I. A., Versteeg, S., Aryeetey, Y., Akkerdaas, J., Zuidmeer, L., Lidholm, J., Fernández-Rivas, M., Hartgers, F., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.023 · Cited by 90
“CCDs have negligible in vivo biological activity as well as clinical relevance [37-39].”
Background
Post-translational modification of plant-made foreign proteins; glycosylation and beyond.
Webster, D., & Thomas, M. (2012) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.07.015 · Cited by 88
Inhibition of IgE binding to cross-reactive carbohydrate determinants enhances diagnostic selectivity
Holzweber, F., Svehla, E., Fellner, W., Dalik, T., Stubler, S., Hemmer, W., & Altmann, F. (2013) · Allergy. European Journal of Allergy and Clinical Immunology · doi:10.1111/all.12229 · Cited by 87
“The structural basis of CCDs is complex-type Asn-linked oligosaccharides on glycoproteins (3, 4).”
BackgroundSelf-citation
Reassessing the role of hyaluronidase in yellow jacket venom allergy.
Jin, C., Focke, M., Léonard, R., Jarisch, R., Altmann, F., & Hemmer, W. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.08.037 · Cited by 87
Self-citation
The potential of papain and alcalase enzymes and process optimizations to reduce allergenic gliadins in wheat flour.
Li, Y., Yu, J.-M., Goktepe, I., & Ahmedna, M. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2015.10.089 · Cited by 84
Role and Mechanism of Galactose-Alpha-1,3-Galactose in the Elicitation of Delayed Anaphylactic Reactions to Red Meat
Hilger, C., Fischer, J., Wölbing, F., & Biedermann, T. (2019) · Current Allergy and Asthma Reports · doi:10.1007/s11882-019-0835-9 · Cited by 83
The Glycosylation Pattern of Common Allergens: The Recognition and Uptake of Der p 1 by Epithelial and Dendritic Cells Is Carbohydrate Dependent
Al-Ghouleh, A., Johal, R., Sharquie, I. K., Emara, M., Harrington, H., Shakib, F., & Ghaemmaghami, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033929 · Cited by 83
“Can f 1, the dog allergen Canis familiaris, is also not fucosylated as it is from a mammalian source [34,35], but it is mannosylated and appears to contain sialic acid too (Table 1).”
BackgroundInfluential
Allergenicity of Carbohydrates and Their Role in Anaphylactic Events
Commins, S., & Platts-Mills, T. (2010) · Current Allergy and Asthma Reports · doi:10.1007/s11882-009-0079-1 · Cited by 82
“The presence of IgE antibodies to carbohydrate antigens was first identified from in vitro experiments looking at crossreactivity between different plant-derived antigens [1, 2, 13].”
Background
The Molecular Basis of Peanut Allergy
Mueller, G., Maleki, S., & Pedersen, L. (2014) · Current Allergy and Asthma Reports · doi:10.1007/s11882-014-0429-5 · Cited by 81
Inconsistent Results of Diagnostic Tools Hamper the Differentiation between Bee and Vespid Venom Allergy
Sturm, G., Jin, C., Kranzelbinder, B., Hemmer, W., Sturm, E., Griesbacher, A., Heinemann, A., Vollmann, J., Altmann, F., Crailsheim, K., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020842 · Cited by 80
“There are several hypotheses why sIgE to CCDs are not relevant, one of them is that patients are constantly exposed to these carbohydrate structures and therefore produce blocking IgG4 antibodies, comparable with the effect of immunotherapy [4].”
BackgroundSelf-citation
The additional values of microarray allergen assay in the management of polysensitized patients with respiratory allergy
Passalacqua, G., Melioli, G., Bonifazi, F., Bonini, S., Maggi, E., Senna, G., Triggiani, M., Nettis, E., Rossi, R. E., Vacca, A., et al. (2013) · Allergy · doi:10.1111/all.12194 · Cited by 73
“In addition, extractive preparations may contain cross-reactive components (5), which are highly conserved across widely different allergen sources (6, 7).”
Background
Activity, Splice Variants, Conserved Peptide Motifs, and Phylogeny of Two New α1,3-Fucosyltransferase Families (FUT10 and FUT11)*
Mollicone, R., Moore, S., Bovin, N., Garcia-Rosasco, M., Candelier, J., Martínez-Duncker, I., & Oriol, R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809312200 · Cited by 79
Review/N-glycans: The making of a varied toolbox
Lannoo, N., & Damme, E. J. M. V. (2015) · Plant Science · doi:10.1016/j.plantsci.2015.06.023 · Cited by 79
A Molecular Diagnostic Algorithm to Guide Pollen Immunotherapy in Southern Europe: Towards Component-Resolved Management of Allergic Diseases
Douladiris, N., Savvatianos, S., Roumpedaki, I., Skevaki, C. L., Mitsias, D. I., & Papadopoulos, N. G. (2013) · International Archives of Allergy and Immunology · doi:10.1159/000353113 · Cited by 80
Galactose-α-1,3-galactose-specific IgE is associated with anaphylaxis but not asthma.
Commins, S., Kelly, L. A., Rönmark, E., James, H., Pochan, S., Peters, E., Lundbäck, B., Nganga, L., Cooper, P., Hoskins, J., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201111-2017oc · Cited by 77
“The blunted skin test response using this mammalian oligosaccharide is consistent with responses to skin testing in patients with IgE antibodies to plant oligosaccharides (34, 35).”
Background
Sweet and sour: the impact of sugars on disease.
Alavi, A., & Axford, J. (2008) · Rheumatology · doi:10.1093/rheumatology/ken081 · Cited by 76
Egg proteins as allergens and the effects of the food matrix and processing
Benedé, S., López‐Expósito, I., Molina, E., & López‐Fandiño, R. (2014) · Food & Function · doi:10.1039/c4fo01104j · Cited by 83
The IgE repertoire in children and adolescents resolved at component level: A cross‐sectional study
Melioli, G., Marcomini, L., Agazzi, A., Bazurro, G., Tosca, M., Rossi, G. A., Minale, P., Rossi, R. E., Reggiardo, G., Canonica, G. W., et al. (2011) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2011.01228.x · Cited by 69
“These differences could be explained, at least in part, by the large molecular structure of animal-derived components (ranging from 60 to 100 kDa for allergens included in ISAC) in comparison with the small molecular weight (ranging from 15 to 32 kDa) of plant-inhalant components which, frequently, are glycosylated (1…”
Background
Using glyco-engineering to produce therapeutic proteins
Dicker, M., & Strasser, R. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.1069271 · Cited by 73
“Plants typically generate rather simple biantennary complex N-glycans with attached b1,2-xylose and core a1,3-fucose residues (Figure 2F) that are not found on N-glycans in mammals and therefore represent potentially immunogenic residues [55].”
Background
Clinical View on the Importance of Dendritic Cells in Asthma
Gaurav, R., & Agrawal, D. (2013) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2013.837260 · Cited by 70
Glycans and glycan-specific IgE in clinical and molecular allergology: Sensitization, diagnostics, and clinical symptoms.
Homann, A., Schramm, G., & Jappe, U. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.04.019 · Cited by 68
“If there was additional species-specific IgE present, there would 10 have been no complete inhibition.(13,21) As recombinant allergens are used in 11 commercial diagnostic assays, it is very important to consider the differing 12 glycosylation pattern of these recombinantly produced allergens.”
Background
Helminth glycomics - glycan repertoires and host-parasite interactions.
Hokke, C., & van Diepen, A. (2017) · Molecular and biochemical parasitology (Print) · doi:10.1016/j.molbiopara.2016.12.001 · Cited by 67
Precision medicine allergy immunoassay methods for assessing immunoglobulin E sensitization to aeroallergen molecules
Popescu, F.-D., & Vieru, M. (2018) · World Journal of Methodology · doi:10.5662/wjm.v8.i3.17 · Cited by 67
Comparative Glycomics Analysis of Influenza Hemagglutinin (H5N1) Produced in Vaccine Relevant Cell Platforms
An, Y.-M., Rininger, J., Jarvis, D., Jing, X., Ye, Z., Aumiller, J. J., Eichelberger, M., & Cipollo, J. (2013) · Journal of Proteome Research · doi:10.1021/pr400329k · Cited by 66
Carbohydrate epitopes currently recognized as targets for IgE antibodies
Platts‐Mills, T. A. E., Hilger, C., Jappe, U., van Hage, M., Gadermaier, G., Spillner, E., Lidholm, J., Keshavarz, B., Aalberse, R. C., van Ree, R., et al. (2021) · Allergy · doi:10.1111/all.14802 · Cited by 76
“Beta(1,2)xylose and alpha(1,3)fucose residues have a strong contribution in IgE binding to plant glycoallergens.”
Background
Proteomics for exploiting diversity of lupin seed storage proteins and their use as nutraceuticals for health and welfare.
Cabello-Hurtado, F., Keller, J., Ley, J., Sanchez-Lucas, R., Jorrín-Novo, J., & Aïnouche, A. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2016.03.026 · Cited by 62
“These CCDs could contribute to the allergenicity of glycoproteins, but the degree of their contribution and their clinical relevance are controversial issues [109].”
Background
Assessment of component-resolved in vitro diagnosis of celeriac allergy.
Bauermeister, K., Ballmer-Weber, B., Bublin, M., Fritsche, P., Hanschmann, K., Hoffmann-Sommergruber, K., Lidholm, J., Oberhuber, C., Randow, S., Holzhauser, T., et al. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.07.033 · Cited by 61
Going over Fungal Allergy: Alternaria alternata and Its Allergens
Abel-Fernández, E., Martínez, M. J., Galán, T., & Pineda, F. (2023) · Journal of Fungi · doi:10.3390/jof9050582 · Cited by 66
“Indeed, they seem to be responsible for false positive results during the quantification of IgE antibodies in the serum of the patients [81,82].”
Background
Synthesis and microarray-assisted binding studies of core xylose and fucose containing N-glycans.
Brzezicka, K., Echeverria, B., Serna, S., van Diepen, A., Hokke, C., & Reichardt, N. (2015) · ACS Chemical Biology · doi:10.1021/cb501023u · Cited by 60
The performance of a component‐based allergen microarray for the diagnosis of kiwifruit allergy
Bublin, M., Dennstedt, S., Buchegger, M., Ciardiello, M., Bernardi, M. L., Tuppo, L., Harwanegg, C., Hafner, C., Ebner, C., Ballmer-Weber, B., et al. (2011) · Clinical and Experimental Allergy · doi:10.1111/j.1365-2222.2010.03619.x · Cited by 60
Characterising microbial protein test substances and establishing their equivalence with plant-produced proteins for use in risk assessments of transgenic crops
Raybould, A., Kilby, P., & Graser, G. (2012) · Transgenic research · doi:10.1007/s11248-012-9658-3 · Cited by 59
“However, increasing knowledge of plant glycosylation has recently led to the conclusion that carbohydrate moieties are probably insignificant as clinically important allergen determinants (Altmann 2007).”
Background
The role of lectins in allergic sensitization and allergic disease.
Salazar, F., Sewell, H., Shakib, F., & Ghaemmaghami, A. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.02.001 · Cited by 58
Determinants of Food Allergy
Masilamani, M., Commins, S. P., & Shreffler, W. G. (2012) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2011.12.003 · Cited by 67
Monitoring honeybee venom immunotherapy in children with the basophil activation test
Žitnik, S., Vesel, T., Avčin, T., Šilar, M., Košnik, M., & Korošec, P. (2012) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2011.01233.x · Cited by 57
“Double-positivity can be a result of the presence and serological recognition of cross-reactive carbohydrate epitopes, which lack allergenic activity and hence may give rise to false positive in vitro diagnostic results (19).”
Background
Glycoprotein production in moss bioreactors
Decker, E. L., & Reski, R. (2011) · Plant Cell Reports · doi:10.1007/s00299-011-1152-5 · Cited by 57
Ao38, a new cell line from eggs of the black witch moth, Ascalapha odorata (Lepidoptera: Noctuidae), is permissive for AcMNPV infection and produces high levels of recombinant proteins
Hashimoto, Y., Zhang, S., & Blissard, G. (2010) · BMC Biotechnology · doi:10.1186/1472-6750-10-50 · Cited by 57
Sensitization profiles to purified plant food allergens among pediatric patients with allergy to banana
Palacín, A., Quirce, S., Sánchez-Monge, R., Bobolea, I., Díaz-Perales, A., Martín-Muñoz, F., Pascual, C., & Salcedo, G. (2011) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2010.01125.x · Cited by 56
“Gluc, recently designated as Mus a 5 by the IUIS Allergen Nomenclature Sub-Committee, harbored cross-reactive carbohydrate determinants (CCDs) (35).”
Background
Latex-allergic patients sensitized to the major allergen hevein and hevein-like domains of class I chitinases show no increased frequency of latex-associated plant food allergy
Radauer, C., Adhami, F., Fürtler, I., Wagner, S., Allwardt, D., Scala, E., Ebner, C., Hafner, C., Hemmer, W., Mari, A., et al. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2010.10.019 · Cited by 56
“Most patients with CCD sensitization display allergic symptoms towards a limited range of sources despite the ubiquitous reactivity of their IgE (Altmann, 2007).”
Background
Glycoproteomic profile in wine: a 'sweet' molecular renaissance.
Palmisano, G., Antonacci, D., & Larsen, M. (2010) · Journal of Proteome Research · doi:10.1021/pr100298j · Cited by 56
Mapping the interactions between a major pollen allergen and human IgE antibodies.
Razzera, G., Gadermaier, G., de Paula, V. S., Almeida, M., Egger, M., Jahn-Schmid, B., Almeida, F. C., Ferreira, F., & Valente, A. (2010) · Structure · doi:10.1016/j.str.2010.05.012 · Cited by 55
“Moreover, their involvement in IgE cross-reactivity (Altmann, 2007) seems to be very limited due to restricted distribution of hydroxyproline-linked b-arabinoses within plant proteins.”
Background
Real-Life Study for the Diagnosis of House Dust Mite Allergy - The Value of Recombinant Allergen-Based IgE Serology
Becker, S., Schlederer, T., Kramer, M., Haack, M., Vrtala, S., Resch, Y., Lupinek, C., Valenta, R., & Gröger, M. (2016) · International Archives of Allergy and Immunology · doi:10.1159/000447694 · Cited by 54
Single recombinant and purified major allergens and peptides How they are made and how they change allergy diagnosis and treatment
Curin, M., Garib, V., & Valenta, R. (2017) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2016.11.022 · Cited by 52
Targeted Glycoproteomic Analysis Reveals That Kappa-5 is a Major, Uniquely Glycosylated Component of Schistosoma mansoni Egg Antigens*
Meevissen, M. H. J., Balog, C., Koeleman, C., Doenhoff, M., Schramm, G., Haas, H., Deelder, A., Wuhrer, M., & Hokke, C. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.005710 · Cited by 52
“Notably, asparagine-linked glycans belong to the most abundant environmental immune determinants and form the basis of the so-called cross-reactive carbohydrate determinants (46).”
Background
Safety assessment of biotechnology products for potential risk of food allergy: implications of new research.
Selgrade, M., Bowman, C., Ladics, G., Privalle, L., & Laessig, S. A. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp075 · Cited by 52
“Generally, IgE binding to carbohydrate domains is irrelevant to clinical allergy, unless there are multiple carbohydrates on the potentially allergenic protein (Altmann, 2007).”
Background
Production of recombinant human granulocyte macrophage‐colony stimulating factor in rice cell suspension culture with a human‐like N‐glycan structure
Shin, Y., Chong, Y.-J., Yang, M., & Kwon, T. (2011) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2011.00636.x · Cited by 52
“…proteins requires modification of their N-glycosylation patterns because the plant-specific core a-1,3-fucose, b-1,2-xylose and Lewis a epitope of their complex-type N-glycans are potentially immunogenic or allergenic to humans (Chargelegue et al., 2000; Bardor et al., 2003b; Altmann, 2007).”
Influential
New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis
Střı́ž, I., Golebski, K., Strizova, Z. O., Loukides, S., Bakakos, P., Hanania, N. A., Jeseňák, M., & Diamant, Z. (2023) · Clinical Science · doi:10.1042/cs20190281 · Cited by 75
Mechanisms of Allergen-Antibody Interaction of Cockroach Allergen Bla g 2 with Monoclonal Antibodies That Inhibit IgE Antibody Binding
Glesner, J., Wünschmann, S., Li, M., Gustchina, A., Wlodawer, A., Himly, M., Chapman, M., & Pomés, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022223 · Cited by 50
“Cross-reactive carbohydrate determinants (CCD) from plants and insects are N-glycans recognized by IgE, with minimal or no clinical significance [35–37].”
Background
Immunogenicity of glycans on biotherapeutic drugs produced in plant expression systems—The taliglucerase alfa story
Rup, B., Alon, S., Amit-Cohen, B.-C., Almon, E. B., Chertkoff, R., Tekoah, Y., & Rudd, P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186211 · Cited by 48
“However, further studies have indicated that anti-cross-reactive carbohydrate determinant antibodies do not bind equally to all glycans with α (1,3) fucose and/or β (1,2) xylose, indicating that other features of the glycan structure or protein play a critical role in the binding [7].”
Innate immunostimulatory properties of allergens and their relevance to food allergy
Ruiter, B., & Shreffler, W. G. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-012-0334-8 · Cited by 47
“The finding that glycan-specific antibodies are common from human clinical contexts as well as in murine models suggests that glycans enhance immunogenicity [13, 14].”
Cross‐reactive carbohydrate determinants strongly affect the results of the basophil activation test in hymenoptera‐venom allergy
Mertens, M., Amler, S., Moerschbacher, B., & Brehler, R. (2010) · Clinical and Experimental Allergy · doi:10.1111/j.1365-2222.2010.03535.x · Cited by 47
Genetic engineering approaches to improve posttranslational modification of biopharmaceuticals in different production platforms
Amann, T., Schmieder, V., Faustrup Kildegaard, H., Borth, N., & Andersen, M. R. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.27101 · Cited by 46
“Plants contain β-hexosaminidases, which give rise to N-glycan structures with terminal mannoses (Altmann, 2006; Choi, et al., 2012) and thus are far from their human counterparts.”
Identification of abundant proteins and potential allergens in Culicoides nubeculosus salivary glands.
Wilson, A., Heesom, K., Mawby, W., Mellor, P., & Russell, C. L. (2008) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2007.10.011 · Cited by 46
Sensitization to cross‐reactive carbohydrate determinants in relation to alcohol consumption
González-Quintela, A., Garrido, M., Gude, F., Campos, J., Linneberg, A., Lojo, S., & Vidal, C. (2007) · Clinical and Experimental Allergy · doi:10.1111/j.1365-2222.2007.02863.x · Cited by 46
Demonstration of in vivo stability and lack of immunogenicity of a polyethyleneglycol-conjugated recombinant CHO-derived butyrylcholinesterase bioscavenger using a homologous macaque model.
Rosenberg, Y., Saxena, A., Sun, W., Jiang, X., Chilukuri, N., Luo, C., Doctor, B. P., & Lee, K. D. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.02.042 · Cited by 45
Component-resolved allergy diagnosis by microarray: potential, pitfalls, and prospects.
Knop, K. J. D., Bridts, C., Verweij, M., Hagendorens, M., Clerck, L. D. D., Stevens, W., & Ebo, D. (2010) · Advances in Clinical Chemistry · doi:10.1016/s0065-2423(10)50005-2 · Cited by 45
“Sera containing antiprofilin and anti-CCD sIgE antibodies display a very broad spectrum of cross-reactivity involving pollen, latex, fruit, vegetables, and venoms extending beyond clinical relevance, as these antibodies rarely give rise to clinically relevant allergy [6–12].”
Background
The red meat allergy syndrome in Sweden
Apostolović, D., Tran, T. A. T., Starkhammar, M., Sánchez-Vidaurre, S., Hamsten, C., & van Hage, M. (2016) · Allergo Journal International · doi:10.1007/s40629-016-0098-0 · Cited by 44
“e current estimate is that 15–30 % of allergic patients generate speci c anti-carbohydrate IgE antibodies [34], but this IgE response has very little clinical relevance [35].”
Background
The production of human glucocerebrosidase in glyco‐engineered N icotiana benthamiana plants
Limkul, J., Iizuka, S., Sato, Y., Misaki, R., Ohashi, T., Ohashi, T., & Fujiyama, K. (2016) · Plant Biotechnology Journal · doi:10.1111/pbi.12529 · Cited by 45
“N-glycosylation processes in the endoplasmic reticulum (ER) of plants are similar to those in humans, but the modification processes in the Golgi complex differ between plants and humans, with the former leading to the formation of plantspecific sugars that may induce immune responses in humans (Altmann, 2007; Bosch e…”
Background
Allergen microarray detects high prevalence of asymptomatic IgE sensitizations to tropical pollen-derived carbohydrates
Cabauatan, C., Lupinek, C., Scheiblhofer, S., Weiss, R., Focke-Tejkl, M., Bhalla, P., Singh, M. B., Knight, P., van Hage, M., Ramos, J. D., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.10.004 · Cited by 44
Multiple grass mixes as opposed to single grasses for allergen immunotherapy in allergic rhinitis
Gangl, K., Niederberger, V., & Valenta, R. (2013) · Clinical and Experimental Allergy · doi:10.1111/cea.12128 · Cited by 44
Ascaris lumbricoides: An Overview of Therapeutic Targets
Hagel, I., & Giusti, T. (2010) · Infectious Disorders - Drug Targets · doi:10.2174/187152610793180876 · Cited by 53
“Immunological cross reactivity between different carbohydrate epitopes of different species of plants and invertebrates have been also reported [201] suggesting that these IgE stimulating glycans may represent a fundamental class of ligands widely distributed in nature.”
Background
The Changing Fate of a Secretory Glycoprotein in Developing Maize Endosperm1[C][W]
Arcalís, E., Stadlmann, J., Marcel, S., Drakakaki, G., Winter, V., Rodríguez, J., Fischer, R., Altmann, F., & Stoger, E. (2010) · Plant Physiology · doi:10.1104/pp.109.152363 · Cited by 44
“This localization is in agreement with the main N-glycan structure attached to phytase at this stage (MMXF), which is typically found on vacuolar glycoproteins (Lerouge et al., 1998).”
BackgroundInfluentialSelf-citation
Effect of Food Thermal Processing on Allergenicity Proteins in Bombay Locust (Patanga Succincta)
Phiriyangkul, P., Srinroch, C., Srisomsap, C., Chokchaichamnankit, D., & Punyarit, P. (2015) · doi:10.18178/ijfe.1.1.23-28 · Cited by 44
“Moreover, Altmann (2006) [27] has review about structural of insect glycoprotein that discovery of core 1, 3 fucose in insect glycoproteins, it became apparent that this widely distributed residue is involved in cross-reactions between plant and insect glycoproteins.”
Background
Biochemical composition of haemagglutinin-based influenza virus-like particle vaccine produced by transient expression in tobacco plants.
Mauff, F. L., Mercier, G., Chan, P., Burel, C., Vaudry, D., Bardor, M., Vézina, L., Couture, M., Lerouge, P., & Landry, N. (2015) · Plant Biotechnology Journal · doi:10.1111/pbi.12301 · Cited by 43
“, 2003) and could be involved in allergic reactions (Altmann, 2007).”
Background

Authors: Altmann, F.
Affiliations: BOKU University (AT)
Corresponding author: Altmann, Friedrich
ORCID: Altmann, Friedrich
Venue: International Archives of Allergy and Immunology
Publisher: S. Karger AG
Published: 2006-10-09
Volume: 142
Issue: 2
Pages: 99-115
ISSN: 1018-2438 (ISSN-L)
1423-0097
DOI: 10.1159/000096114
OpenAlex: W1976454430
Cited by: 393
References: 0
Citations by year: 2026: 11 · 2025: 10 · 2024: 10 · 2023: 10 · 2022: 5 · 2021: 17 · 2020: 20 · 2019: 17 · 2018: 16 · 2017: 23 · 2016: 21 · 2015: 31 · 2014: 25 · 2013: 33 · 2012: 25
FWCI: 1.27
Type: journal article
Language: en
Open access: closed
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: International Archives of Allergy and Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Keywords: protein glycosylation, allergy, cross-reactive carbohydrate determinants, N-glycans, helminth immunomodulation, pollen allergens, insect venom, food allergens
MeSH terms: Allergens, Animals, Carbohydrate Conformation, Carbohydrates, Glycoproteins, Glycosylation, Humans, Hypersensitivity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Role of Protein Glycosylation in Allergy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks