A Preliminary Study of Dopamine Transporter Binding in Bipolar and Unipolar Depressed Patients and Healthy Controls
Abstract
Objective: We examined striatal dopamine transporter (DAT) binding in bipolar and unipolar depressed patients and compared these values to those obtained from healthy control subjects using the selective DAT radioligand [99m Tc]TRODAT-1 and single photon emission computed tomography imaging. We hypothesized that DAT levels might be higher in bipolar versus unipolar patients. Methods: [99m Tc]TRODAT-1 scans were acquired from 5 bipolar and 10 unipolar patients and from 46 healthy controls. Distribution volume ratio (DVR) of [99m Tc]TRODAT-1 binding affinity was calculated for regions of interest in the striatum. Results: Bipolar patients had greater DVR values compared to controls in the right posterior putamen (p = 0.001) and in the left caudate region (p = 0.007). Bipolar patients had modestly lower DAT binding in all brain regions examined, and a significantly lower DVR in the right caudate region compared to unipolar patients (p = 0.05). Conclusion: These data suggest that striatal DAT density may be increased in bipolar and unipolar depressed patients compared to controls, and that bipolar and unipolar depressed patients may have a different pattern of striatal DAT binding.
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Amsterdam and Newberg reported higher striatal DAT binding in the right posterior putamen and left caudate in a small number of patients with bipolar disorder.
“Amsterdam and Newberg [283] reported higher striatal DAT binding in the right posterior putamen and left caudate in a small number of patients with bipolar disorder”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [283]
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Huang, M., Zhu, J., Tu, P., Chan, Y. E., Mao, W., & Su, T. (2026) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2026.105137
- Authors
- Amsterdam, J. D., & Newberg, A. B.
- Affiliations
- University of Pennsylvania (US)
- ORCID
- Newberg, Andrew B.
- Venue
- Neuropsychobiology
- Publisher
- S. Karger AG
- Published
- 2007
- Volume
- 55
- Issue
- 3-4
- Pages
- 167-170
- ISSN
- 0302-282X (ISSN-L)
- 1423-0224
- OpenAlex
- W2071810323
- Cited by
- 84
- References
- 21
- Citations by year
- 2026: 3 · 2025: 1 · 2023: 1 · 2022: 3 · 2021: 23 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 7 · 2013: 2 · 2012: 11
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2r01ns018509-18, 5r01da009469-03)
- National Institute on Aging (AG17524, R01AG017524)
- National Institute of Mental Health (MH-070753, R34MH070753)
- National Institute on Drug Abuse (DA 09469)
- National Institute of Neurological Disorders and Stroke (NS 18509)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- dopamine transporter, striatum, bipolar disorder, major depressive disorder, SPECT imaging, distribution volume ratio, caudate nucleus, putamen, dopamine transporter density
- MeSH terms
- Adult, Depression, Female, Humans, Functional Laterality, Male, Putamen, Tropanes, Organotechnetium Compounds, Tomography, Emission-Computed, Single-Photon, Radiopharmaceuticals, Dopamine Plasma Membrane Transport Proteins
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