Cited by 84Bipolar Disorder and TreatmentNeurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

A Preliminary Study of Dopamine Transporter Binding in Bipolar and Unipolar Depressed Patients and Healthy Controls

Amsterdam, Jay D., Newberg, Andrew B.·2007·Neuropsychobiology

Abstract

Objective: We examined striatal dopamine transporter (DAT) binding in bipolar and unipolar depressed patients and compared these values to those obtained from healthy control subjects using the selective DAT radioligand [99m Tc]TRODAT-1 and single photon emission computed tomography imaging. We hypothesized that DAT levels might be higher in bipolar versus unipolar patients. Methods: [99m Tc]TRODAT-1 scans were acquired from 5 bipolar and 10 unipolar patients and from 46 healthy controls. Distribution volume ratio (DVR) of [99m Tc]TRODAT-1 binding affinity was calculated for regions of interest in the striatum. Results: Bipolar patients had greater DVR values compared to controls in the right posterior putamen (p = 0.001) and in the left caudate region (p = 0.007). Bipolar patients had modestly lower DAT binding in all brain regions examined, and a significantly lower DVR in the right caudate region compared to unipolar patients (p = 0.05). Conclusion: These data suggest that striatal DAT density may be increased in bipolar and unipolar depressed patients compared to controls, and that bipolar and unipolar depressed patients may have a different pattern of striatal DAT binding.

Integrity signals

Registry

Crossref · 10.1159/000106476

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Amsterdam, J. D., & Newberg, A. B.
Affiliations
University of Pennsylvania (US)
Venue
Neuropsychobiology
Publisher
S. Karger AG
Published
2007
Volume
55
Issue
3-4
Pages
167-170
ISSN
  • 0302-282X (ISSN-L)
  • 1423-0224
OpenAlex
W2071810323
Cited by
84
References
21
Citations by year
2026: 3 · 2025: 1 · 2023: 1 · 2022: 3 · 2021: 23 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 7 · 2013: 2 · 2012: 11
FWCI
2.41
Type
journal article
Language
en
Open access
closed
Locations
  • Neuropsychobiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (2r01ns018509-18, 5r01da009469-03)
  • National Institute on Aging (AG17524, R01AG017524)
  • National Institute of Mental Health (MH-070753, R34MH070753)
  • National Institute on Drug Abuse (DA 09469)
  • National Institute of Neurological Disorders and Stroke (NS 18509)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
dopamine transporter, striatum, bipolar disorder, major depressive disorder, SPECT imaging, distribution volume ratio, caudate nucleus, putamen, dopamine transporter density
MeSH terms
Adult, Depression, Female, Humans, Functional Laterality, Male, Putamen, Tropanes, Organotechnetium Compounds, Tomography, Emission-Computed, Single-Photon, Radiopharmaceuticals, Dopamine Plasma Membrane Transport Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review