The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Role of Intermediate Progenitor Cells in Cerebral Cortex Development
Abstract
Intermediate progenitor cells (IPCs) are a type of neurogenic transient amplifying cells in the developing cerebral cortex. IPCs divide symmetrically at basal (abventricular) positions in the neuroepithelium to produce pairs of new neurons or, in amplifying divisions, pairs of new IPCs. In contrast, radial unit progenitors (neuroepithelial cells and radial glia) divide at the apical (ventricular) surface and produce only single neurons or single IPCs by asymmetric division, or self-amplify by symmetric division. Histologically, IPCs are most prominent during the middle and late stages of neurogenesis, when they accumulate in the subventricular zone, a progenitor compartment linked to the genesis of upper neocortical layers (II–IV). Nevertheless, IPCs are present throughout cortical neurogenesis and produce neurons for all layers. In mice, changes in the abundance of IPCs caused by mutations of Pax6, Ngn2, Id4 and other genes are associated with parallel changes in cortical thickness but not surface area. In gyrencephalic brains, IPCs may play broader roles in determining not only laminar thickness, but also cortical surface area and gyral patterns. We propose that regulation of IPC genesis and amplification across developmental stages and regional subdivisions modulates laminar neurogenesis and contributes to the cytoarchitectonic differentiation of cortical areas.
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“Cortical surface area and thickness are controlled by the mechanisms involved in RGC and IPC proliferation and differentiation decisions [99, 100].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [99]
Citations
Cites
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“Both the ULH and the IPH contrast with the radial unit hypothesis (RUH) [”
BackgroundNoctor, S. C., Martínez-Cerdeño, V., Ivic, L., & Kriegstein, A. R. (2004) · Nature Neuroscience · doi:10.1038/nn1172 · Cited by 2,229
The cell biology of neurogenesis
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Neurons derived from radial glial cells establish radial units in neocortex
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A tension-based theory of morphogenesis and compact wiring in the central nervous system
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Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9
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The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475
“…et al. 2001; Smart et al. 2002; Nieto et al. 2004; Noctor et al. 2004, 2007; Zimmer et al. 2004; Zecevic et al. 2005; Martínez-Cerdeño et al. 2006; Pontious et al. 2008). nIPCs, which frequently have multipolar processes, do not appear to contact the ventricle or pial surface, but they do display…”
BackgroundDistinct Genetic Influences on Cortical Surface Area and Cortical Thickness
Panizzon, M. S., Fennema-Notestine, C., Eyler, L. T., Jernigan, T. L., Prom-Wormley, E., Neale, M., Jacobson, K., Lyons, M. J., Grant, M. D., Franz, C. E., et al. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp026 · Cited by 1,304
“…of the radial unit hypothesis, referred to as the radial amplification hypothesis, highlights the contribution of intermediate progenitor cells to neurogenesis and how their manipulation within animal models results in changes to cortical thickness but not surface area (Pontious et al. 2008).”
for the ENIGMA Bipolar Disorder Working Group, Hibar, D. P., Westlye, L. T., Doan, N. T., Jahanshad, N., Cheung, J. T. P., Ching, C. R. K., Versace, A., Bilderbeck, A. C., Uhlmann, A., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.73 · Cited by 798
“18,19,47 It is therefore possible that the neurobiological mechanisms associated with BD reduce neuron numbers but do not affect overall size of the cortex or cortical columnar organization.”
Lange, C., Huttner, W. B., & Calegari, F. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.05.026 · Cited by 565
Neuroimaging in autism spectrum disorder: brain structure and function across the lifespan
Ecker, C., Bookheimer, S. Y., & Murphy, D. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00050-2 · Cited by 574
Metadata
- Authors
- Pontious, A., Kowalczyk, T., Englund, C., & Hevner, R. F.
- Affiliations
- University of Washington (US)
- ORCID
- Hevner, Robert F.
- Venue
- Developmental Neuroscience
- Publisher
- S. Karger AG
- Published
- 2007-12-13
- Volume
- 30
- Issue
- 1-3
- Pages
- 24-32
- ISSN
- 0378-5866 (ISSN-L)
- 1421-9859
- OpenAlex
- W2012470399
- Cited by
- 378
- References
- 73
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 18 · 2023: 13 · 2022: 15 · 2021: 18 · 2020: 22 · 2019: 22 · 2018: 18 · 2017: 19 · 2016: 20 · 2015: 22 · 2014: 30 · 2013: 31 · 2012: 28
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- intermediate progenitor cells, cortical development, cortical neurogenesis, subventricular zone, radial glia, neuroepithelial cells, cortical lamination, cortical thickness, cortical surface area, Pax6, Ngn2, Id4, cytoarchitecture, gyrencephaly
- MeSH terms
- Animals, Cell Differentiation, Cerebral Cortex, Humans, Nerve Growth Factors, Nervous System Malformations, Neural Pathways, Neurons, Stem Cells, Signal Transduction, Gene Expression Regulation, Developmental, Mice
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