Cited by 384Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationFetal and Pediatric Neurological Disorders

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Role of Intermediate Progenitor Cells in Cerebral Cortex Development

Pontious, Adria, Kowalczyk, Tom, Englund, Chris, Hevner, Robert F.·2008·Developmental Neuroscience

DOI 10.1159/000109848

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Abstract

Intermediate progenitor cells (IPCs) are a type of neurogenic transient amplifying cells in the developing cerebral cortex. IPCs divide symmetrically at basal (abventricular) positions in the neuroepithelium to produce pairs of new neurons or, in amplifying divisions, pairs of new IPCs. In contrast, radial unit progenitors (neuroepithelial cells and radial glia) divide at the apical (ventricular) surface and produce only single neurons or single IPCs by asymmetric division, or self-amplify by symmetric division. Histologically, IPCs are most prominent during the middle and late stages of neurogenesis, when they accumulate in the subventricular zone, a progenitor compartment linked to the genesis of upper neocortical layers (II–IV). Nevertheless, IPCs are present throughout cortical neurogenesis and produce neurons for all layers. In mice, changes in the abundance of IPCs caused by mutations of Pax6, Ngn2, Id4 and other genes are associated with parallel changes in cortical thickness but not surface area. In gyrencephalic brains, IPCs may play broader roles in determining not only laminar thickness, but also cortical surface area and gyral patterns. We propose that regulation of IPC genesis and amplification across developmental stages and regional subdivisions modulates laminar neurogenesis and contributes to the cytoarchitectonic differentiation of cortical areas.

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Authors: Pontious, A., Kowalczyk, T., Englund, C., & Hevner, R. F.
Affiliations: University of Washington (US)
ORCID: Hevner, Robert F.
Venue: Developmental Neuroscience
Publisher: S. Karger AG
Published: 2007-12-13
Volume: 30
Issue: 1-3
Pages: 24-32
ISSN: 0378-5866 (ISSN-L)
1421-9859
DOI: 10.1159/000109848
OpenAlex: W2012470399
Cited by: 378
References: 73
Citations by year: 2026: 3 · 2025: 5 · 2024: 18 · 2023: 13 · 2022: 15 · 2021: 18 · 2020: 22 · 2019: 22 · 2018: 18 · 2017: 19 · 2016: 20 · 2015: 22 · 2014: 30 · 2013: 31 · 2012: 28
FWCI: 2.07
Type: journal article
Language: en
Open access: closed
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Developmental Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Keywords: intermediate progenitor cells, cortical development, cortical neurogenesis, subventricular zone, radial glia, neuroepithelial cells, cortical lamination, cortical thickness, cortical surface area, Pax6, Ngn2, Id4, cytoarchitecture, gyrencephaly
MeSH terms: Animals, Cell Differentiation, Cerebral Cortex, Humans, Nerve Growth Factors, Nervous System Malformations, Neural Pathways, Neurons, Stem Cells, Signal Transduction, Gene Expression Regulation, Developmental, Mice

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Role of Intermediate Progenitor Cells in Cerebral Cortex Development

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