Neuropsychiatric correlates of cerebrospinal fluid biomarkers in Alzheimer's disease
Abstract
BACKGROUND: The aim of this study was to explore the relationship between cerebrospinal fluid biomarkers and neuropsychiatric symptoms in people with Alzheimer's disease. Psychosis, agitation, apathy and depression were assessed using standardised measures in 32 patients with mild Alzheimer's disease. METHODS: The levels of the 42-amino-acid form of beta-amyloid (A beta(1-42)), tau and p-tau (phosphorylated at threonine 181) were quantified using the conventional enzyme-linked immunosorbent assay method. RESULTS: Our result shows that apathy is significantly correlated with tau and p-tau but not with A beta(1-42). There were no significant correlations between indices of psychosis/agitation,or depression and cerebrospinal fluid A beta(1-42), tau or p-tau concentrations. CONCLUSION: Our finding suggests that apathy is associated with the level of neurofibrillary tangles in people with mild Alzheimer's disease. In contrast, the overall levels of neurofibrillary tangles or amyloid plaques do not seem to be associated with depression or psychosis, indicating that other brain changes contribute to these symptoms.
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Apathy severity in Alzheimer's disease is associated with higher levels of cerebrospinal fluid tau and phospho-tau but not cerebrospinal fluid Aβ1-42.
“Apathy severity was associated with higher levels of CSF tau and phospho-tau but not CSF Aβ1–42.”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Skogseth et al., 2008
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Neuropsychiatric symptoms in Alzheimer’s disease
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Depression in Alzheimer's disease : biomarkers and treatment
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Depressive symptoms are not associated with predementia CSF amyloid pathology
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Apathy and Affective Symptoms Associated with Elevated Alzheimer’s Disease BiomarkersPreprint
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The Assessment and Management of Apathy in Neurocognitive Disorders
Pérez-Palmer, N., Camacho, D. F., Forrest, L., & Conroy, M. (2026) · Advances in Psychiatry and Behavioral Health · doi:10.1016/j.ypsc.2026.05.005
- Authors
- Skogseth, R., Mulugeta, E., Ballard, C., Rongve, A., Nore, S., Alves, G., & Aarsland, D.
- Affiliations
- University of Bergen (NO)
- King's College London (GB)
- Fonna Hospital Trust (NO)
- Haraldsplass Diakonale Sykehus (NO)
- Stavanger University Hospital (NO)
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2008
- Volume
- 25
- Issue
- 6
- Pages
- 559-563
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W1972343395
- Cited by
- 71
- References
- 29
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 7 · 2018: 4 · 2017: 1 · 2016: 7 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- Alzheimer's disease, cerebrospinal fluid biomarkers, neuropsychiatric symptoms, apathy, psychosis, agitation, depression, tau protein, phosphorylated tau, amyloid-beta 42, neurofibrillary tangles, amyloid plaques, mild Alzheimer's disease
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Depression, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Peptide Fragments, Psychotic Disorders, Severity of Illness Index, Biomarkers, Amyloid beta-Peptides, tau Proteins
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