Apathy is associated with lower inferior temporal cortical thickness in mild cognitive impairment and normal elderly individuals
Open accessAbstract
Apathy is a common neuropsychiatric symptom in Alzheimer's disease dementia and amnestic mild cognitive impairment and is associated with cortical atrophy in Alzheimer's disease dementia. This study investigated possible correlations between apathy and cortical atrophy in 47 individuals with mild cognitive impairment and 19 clinically normal elderly. Backward elimination multivariate linear regression was used to evaluate the cross-sectional relationship between scores on the Apathy Evaluation Scale and thickness of several cortical regions and covariates. Lower inferior temporal cortical thickness was predictive of greater apathy. Greater anterior cingulate cortical thickness was also predictive of greater apathy, suggesting an underlying reactive process.
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Apathy in Alzheimer's disease is associated with decreased inferior temporal cortical thickness.
“Two studies note an association of apathy with decreased inferior temporal cortical (ITC) thickness (Donovan et al., 2014; Guercio et al., 2015).”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Guercio et al., 2015
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Apathy co-occurs with subjective cognitive decline among community-dwelling older adults
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Clinical and neurovisualization characteristics of apathetic depression
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Mild Behavioral Impairment and Cortical Thinning: Biomarkers of Early Neurodegeneration.
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Neuropsychiatric Aspects of Alzheimer Dementia
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Global Hypoactivity and Apathy
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Investigating the structural neuroimaging signature of apathy in Parkinson's disease
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Apathy in Mild Behavioural Impairment: Associations with Cortical Thickness and Grey Matter VolumePreprint
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Impact of neuropsychiatric symptoms on limbic structures in age-related cognitive declinePreprint
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- Authors
- Guercio, B. J., Donovan, N. J., Ward, A., Schultz, A., Lorius, N., Amariglio, R. E., Rentz, D. M., Johnson, K. A., Sperling, R. A., & Marshall, G. A.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Marshall, Gad A.
- ORCID
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 2015-01
- Volume
- 27
- Issue
- 1
- Pages
- e22-e27
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- PMC
- PMC4342844
- OpenAlex
- W2099148018
- Cited by
- 61
- References
- 47
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 2 · 2023: 8 · 2022: 8 · 2021: 8 · 2020: 3 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 4
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (P01AGO36694)
- National Institute on Aging (K24AG035007, R01AG027435, R01AG037497, P50AG005134, K23AG033634, P01AG036694, P30AG062421)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- apathy, inferior temporal cortex, cortical thickness, cortical atrophy, mild cognitive impairment, anterior cingulate cortex, Apathy Evaluation Scale, Alzheimer's dementia, neuropsychiatric symptoms
- MeSH terms
- Acoustic Stimulation, Aged, Aged, 80 and over, Aging, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Psychiatric Status Rating Scales, Temporal Lobe, Verbal Learning, Linear Models, Apathy, Cognitive Dysfunction
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