Structural correlates of apathy in Alzheimer's disease
Abstract
BACKGROUND: Apathy is the most common noncognitive symptom in Alzheimer's disease (AD). The structural correlates of apathy in AD have not yet been described. METHODS: We analyzed magnetic resonance imaging data of 35 AD patients with and without apathy. RESULTS: There was a significant linear association between apathy severity and cortical gray matter atrophy in the bilateral anterior cingulate [Brodmann area (BA) 24; r = 0.39-0.42, p = 0.01] and left medial frontal cortex (BA 8 and 9; r = 0.4, p < 0.02). Left mean cingulate cortical thinning predicted the presence/absence of apathy at the trend level of significance. CONCLUSION: Our study demonstrates a strong association between apathy and the integrity of medial frontal regions in AD.
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Apathy in Alzheimer's disease is associated with volume loss in anterior cingulate cortex, including reduced gray matter volume and cortical thinning.
“Structural imaging studies report volume loss in ACC, including reduced gray matter volume (Apostolova et al., 2007; Bruen et al., 2008; Stanton et al., 2013) and cortical thinning (Tunnard et al., 2011).”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Apostolova et al., 2007
Apathy in Alzheimer's disease is associated with volume loss and/or cortical thinning in frontal cortex.
“There are also links between apathy and volume loss and/or cortical thinning in frontal cortex (Apostolova et al., 2007; Bruen et al., 2008; Stanton et al., 2013; Tunnard et al., 2011), though there is no strict concordance on the specific regions of frontal cortex which include medial, lateral, and orbital regions.”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Apostolova et al., 2007
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- Authors
- Apostolova, L. G., Akopyan, G. G., Partiali, N., Steiner, C. A., Dutton, R. A., Hayashi, K. M., Dinov, I. D., Toga, A. W., Cummings, J. L., & Thompson, P. M.
- Affiliations
- University of California, Los Angeles (US)
- ORCID
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2007
- Volume
- 24
- Issue
- 2
- Pages
- 91-97
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W2165677325
- Cited by
- 190
- References
- 28
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 5 · 2023: 9 · 2022: 7 · 2021: 13 · 2020: 10 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 12 · 2015: 15 · 2014: 12 · 2013: 14 · 2012: 12
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P50AG016570, K23 AG036803)
- National Institute of Mental Health (R01MH071940)
- National Institute of Neurological Disorders and Stroke (NS 049194)
- National Institute of Biomedical Imaging and Bioengineering (EB 01651)
- U.S. National Library of Medicine (LM 05639, R01LM005639)
- National Center for Research Resources (P41RR013642, R21RR019771, U54RR021813, RR019771)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 050735, R01HD050735)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Keywords
- apathy, Alzheimer's disease, gray matter atrophy, anterior cingulate cortex, medial frontal cortex, cortical thinning, non-cognitive symptoms, brain structure
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Cerebral Cortex, Dominance, Cerebral, Female, Frontal Lobe, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Motivation, Reference Values, Statistics as Topic, Imaging, Three-Dimensional
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