Apathy is associated with increased amyloid burden in mild cognitive impairment
Open accessAbstract
Apathy is the most common neuropsychiatric symptom in mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia. The authors sought to determine whether apathy is associated with cortical amyloid burden, as measured by Pittsburgh Compound B (PiB) positron emission tomography (PET), and regional hypometabolism, measured by 18F-fluorodeoxyglocuse (FDG) PET in MCI. The authors found a significant association between increased apathy (lower Apathy Evaluation Scale score) and greater cortical PiB retention independent of age, but no significant association between apathy and regional FDG metabolism. These results suggest that increased apathy is associated with greater amyloid burden but not regional hypometabolism in MCI.
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Apathy in Alzheimer's disease is associated with damage to anterior cingulate cortex, as evidenced by decreased structural integrity or perfusion of anterior cingulate cortex, and with increased amyloid burden globally, especially in anterior cingulate cortex.
“First and foremost, apathy in AD is associated with damage to the ACC as evidenced by decreased structural integrity or perfusion of the ACC, as well as with increased amyloid burden globally (Marshall et al., 2013) especially in ACC.”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Marshall et al., 2013
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Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits?
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- Authors
- Marshall, G. A., Donovan, N. J., Lorius, N., Gidicsin, C. M., Maye, J., Pepin, L. C., Becker, J. A., Amariglio, R. E., Rentz, D. M., Sperling, R. A., & Johnson, K. A.
- Affiliations
- Brigham and Women's Hospital (US)
- ORCID
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 2013-10
- Volume
- 25
- Issue
- 4
- Pages
- 302-307
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- PMC
- PMC3957217
- OpenAlex
- W2050725763
- Cited by
- 73
- References
- 44
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 9 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 4
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Pfizer
- U.S. Public Health Service (P01AGO36694)
- Pfizer Pharmaceuticals
- National Institute on Aging (K24AG035007, R01AG027435, P50AG005134, K23AG033634, P01AG036694, P30AG062421)
- Division of Materials Research
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- apathy, mild cognitive impairment, amyloid burden, Pittsburgh compound B PET, FDG-PET, neuropsychiatric symptoms, Alzheimer's disease, cortical amyloid deposition
- MeSH terms
- Aged, Aged, 80 and over, Amyloid, Aniline Compounds, Cerebral Cortex, Female, Humans, Male, Middle Aged, Thiazoles, Radiopharmaceuticals, Fluorodeoxyglucose F18, Positron-Emission Tomography, Apathy, Functional Neuroimaging, Cognitive Dysfunction
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