Insulin modulation of luteinizing hormone secretion in normal female volunteers and lean polycystic ovary syndrome patients
Open accessAbstract
Background/Aims: Endocrine features of polycystic ovary syndrome (PCOS) include altered ovarian steroidogenesis, hyperinsulinemia and abnormal luteinizing hormone (LH) secretion. This study was undertaken to further evaluate the role of insulin to modulate LH secretion in lean PCOS patients with normal insulin sensitivity and normal volunteers. Methods: The study was performed in five nonobese patients diagnosed with PCOS on the basis of amenorrhea and a polycystic morphology at ovarian ultrasound, and 5 normal controls in early to mid-follicular phase and matched for weight and age. All subjects were phenotyped, and then admitted for 12 h of frequent (q 10’) blood sampling on two separate occasions, once for a baseline study and the other time for a hyperinsulinemic and euglycemic clamp study. LH was measured in samples obtained throughout each admission in order to perform LH pulse analysis. Results: Baseline LH secretion in PCOS subjects was significantly different from controls: they had higher LH levels, higher LH/FSH ratios as well as a faster LH pulse frequency than normal women. Insulin administration did not affect the pattern of LH secretion of PCOS patients, whereas it significantly increased the LH pulse frequency while decreasing the LH interpulse intervals in the controls. Conclusions: These data confirm that an abnormal pattern of LH secretion characteristic of PCOS can be observed in lean patients, and appears independent of peripheral insulin levels. Furthermore, our results in lean controls provide the first direct evidence that peripheral insulin can modulate the activity of hypothalamic gonadotropin-releasing hormone (GnRH) neurons in the human.
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Studies have suggested that insulin acts on the hypothalamic-pituitary-gonadal axis at the level of the hypothalamus to directly or indirectly modulate GnRH secretion (possibly via kisspeptin), as well as at the level of the pituitary gonadotrope.
“Studies have suggested that insulin acts on the hypothalamic-pituitary-gonadal axis at the level of the hypothalamus to directly or indirectly modulate GnRH secretion (possibly via kisspeptin), as well as at the level of the pituitary gonadotrope.105”
From Pubertal development and regulation (2016) · cites this paper as [105]
Cites
(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050 · see citing works
Durnin, J. V. G. A., & Womersley, J. (1974) · British Journal Of Nutrition · doi:10.1079/bjn19740060 · Cited by 6,343 · see citing works
Franks, S. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509283331307 · Cited by 2,463 · see citing works
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235 · see citing works
Amenorrhea associated with bilateral polycystic ovaries
Stein, I. F., & Leventhal, M. L. (1935) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(15)30642-6 · Cited by 2,121 · see citing works
Ehrmann, D. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041536 · Cited by 1,884 · see citing works
Legro, R. S. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.1.165 · Cited by 1,743 · see citing works
Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection
Veldhuis, J. D., & Johnson, M. L. (1986) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1986.250.4.e486 · Cited by 855 · see citing works
Barbieri, R. L., Makris, A., Randall, R. W., Daniels, G. H., Kistner, R. W., & Ryan, K. J. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-62-5-904 · Cited by 629 · see citing works
Nestler, J. E., Jakubowicz, D. J., Falcon de Vargas, A., Brik, C., Quintero, N., & Medina, F. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4886 · Cited by 617 · see citing works
Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome.
Rebar, R. W., Judd, H. L., Yen, S. S. C., Rakoff, J. S., Vandenberg, G., & Naftolin, F. N. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108400 · Cited by 615 · see citing works
Nelson, V. L., Legro, R. S., Strauss, J. F., & McAllister, J. M. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.6.0311 · Cited by 556 · see citing works
Taylor, A. E., McCourt, B. J., Martin, K. A., Anderson, E. J., Adams, J. M., Schoenfeld, D., & Hall, J. E. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.7.4105 · Cited by 502 · see citing works
Morales, A. J., Laughlin, G. A., Bützow, T. L., Maheshwari, H., Baumann, G., & Yen, S. S. C. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.8.8768842 · Cited by 453 · see citing works
Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries
Gilling‐Smith, C., Willis, D., Beard, R. W., & Franks, S. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.4.7962289 · Cited by 436 · see citing works
Waldstreicher, J., Santoro, N. F., Hall, J. E., Filicori, M., & Crowley, W. F. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-1-165 · Cited by 400 · see citing works
Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome
Gilling‐Smith, C., Story, H., Rogers, V., & Franks, S. (1997) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1997.2321049.x · Cited by 301 · cited 1× · see citing works
“PCOS women have an abnormal ovarian steroid response to gonadotropin stimulation [”
BackgroundThe origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndrome
Blank, S. K., McCartney, C. R., & Marshall, J. C. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml017 · Cited by 301 · see citing works
Burcelin, R., Thorens, B., Glauser, M., Gaillard, R. C., & Pralong, F. P. (2003) · Endocrinology · doi:10.1210/en.2003-0457 · Cited by 173 · see citing works
Self-citationControl of GnRH neuronal activity by metabolic factors: The role of leptin and insulin
Gamba, M., & Pralong, F. P. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.04.023 · Cited by 135 · see citing works
Self-citationSalvi, R., Castillo, E., Voirol, M., Glauser, M., Rey, J.-P., Gaillard, R., Vollenweider, P., & Pralong, F. (2006) · Endocrinology · doi:10.1210/en.2005-0728 · Cited by 122 · see citing works
Self-citationIbáñez, L., Hall, J. E., Potau, N., Carrascosa, A., Prat, N., & Taylor, A. E. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.11.8923867 · Cited by 85 · see citing works
Patel, K., Coffler, M. S., Dahan, M. H., Yoo, R. Y., Lawson, M. A., Malcom, P. J., & Chang, R. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030816 · Cited by 60 · see citing works
Mehta, R. V., Patel, K. S., Coffler, M. S., Dahan, M. H., Yoo, R. Y., Archer, J. S., Malcom, P. J., & Chang, R. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1040 · Cited by 47 · see citing works
Three protocols for measuring subcutaneous fat thickness on the upper extremities
Weiss, L. W., & Clark, F. C. (1987) · European Journal of Applied Physiology · doi:10.1007/bf00640647 · Cited by 21 · see citing works
Evans, W. S., Taylor, A. E., Boyd, D. G., Johnson, M. L., Matt, D. W., Jimenez, Y., & Nestler, J. E. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.11.109 · Cited by 7 · see citing works
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Abreu, A. P., & Kaiser, U. B. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00418-0 · Cited by 611 · see citing works
Ibáñez, L., Oberfield, S. E., Witchel, S., Auchus, R. J., Chang, R. J., Codner, E., Dabadghao, P., Darendeliler, F., Elbarbary, N. S., Gambineri, A., et al. (2017) · Hormone Research in Paediatrics · doi:10.1159/000479371 · Cited by 463 · see citing works
Sex differences in obesity and the regulation of energy homeostasis
Lovejoy, J. C., Sainsbury, A., & the Stock Conference 2008 Working Group (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2008.00529.x · Cited by 422 · see citing works
Cassar, S., Misso, M. L., Hopkins, W. G., Shaw, C. S., Teede, H. J., & Stepto, N. K. (2016) · Human Reproduction · doi:10.1093/humrep/dew243 · Cited by 415 · see citing works
The relationship between gut and adipose hormones, and reproduction
Comninos, A. N., Jayasena, C. N., & Dhillo, W. S. (2013) · Human Reproduction Update · doi:10.1093/humupd/dmt033 · Cited by 167 · see citing works
Manfredi-Lozano, M., Roa, J., & Tena-Sempere, M. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.07.008 · Cited by 162 · see citing works
Childhood obesity and central precocious puberty
Shi, L., Jiang, Z., & Zhang, L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1056871 · Cited by 146 · see citing works
Acupuncture for ovulation induction in polycystic ovary syndrome: a randomized controlled trial
Johansson, J., Redman, L. M., Veldhuis, P. P., Sazonova, A., Labrie, F., Holm, G., Johannsson, G., & Stener‐Victorin, E. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00039.2013 · Cited by 131 · see citing works
Androgens and polycystic ovary syndrome
Nisenblat, V., & Norman, R. J. (2009) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32832afd4d · Cited by 125 · see citing works
Qiu, X., Dowling, A. R., Marino, J. S., Faulkner, L. D., Bryant, B., Brüning, J. C., Elias, C. F., & Hill, J. W. (2013) · Endocrinology · doi:10.1210/en.2012-2056 · Cited by 112 · see citing works
Obesity induced by high-fat diet promotes insulin resistance in the ovary
Akamine, E. H., Marçal, A. C., Camporez, J. P., Hoshida, M. S., Caperuto, L. C., Bevilacqua, E. M. A. F., & Carvalho, C. R. D. O. (2010) · Journal of Endocrinology · doi:10.1677/joe-09-0461 · Cited by 111 · see citing works
Molecular & genetic factors contributing to insulin resistance in polycystic ovary syndrome.
Mukherjee, S., & Maitra, A. (2010) · PubMed · Cited by 92 · see citing works
Development of Obesity and Polycystic Ovary Syndrome in Adolescents
Vilmann, L. S., Thisted, E., Baker, J. L., & Holm, J. (2012) · Hormone Research in Paediatrics · doi:10.1159/000345310 · Cited by 84 · see citing works
Wolfe, A., Divall, S., & Wu, S. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.05.007 · Cited by 83 · see citing works
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Eng, P. C., Phylactou, M., Qayum, A., Woods, C., Lee, H., Aziz, S., Moore, B., Miras, A. D., Comninos, A. N., Tan, T., et al. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad027 · Cited by 79 · see citing works
Weight management interventions in women with and without PCOS: a systematic review
Kataoka, J., Tassone, E., Misso, M., Joham, A., Stener-Victorin, E., Teede, H., & Moran, L. (2017) · Nutrients · doi:10.3390/nu9090996 · Cited by 58 · see citing works
Treatments targeting neuroendocrine dysfunction in polycystic ovary syndrome (PCOS)
Garg, A., Patel, B., Abbara, A., & Dhillo, W. S. (2022) · Clinical Endocrinology · doi:10.1111/cen.14704 · Cited by 61 · see citing works
Witchel, S. F., & Tena‐Sempere, M. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.05.024 · Cited by 51 · see citing works
Evans, M. C., Rizwan, M., Mayer, C., Boehm, U., & Anderson, G. M. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12166 · Cited by 51 · see citing works
Ablating astrocyte insulin receptors leads to delayed puberty and hypogonadism in mice
Manaserh, I. H., Chikkamenahalli, L. L., Ravi, S., Dube, P. R., Park, J. J., & Hill, J. W. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000189 · Cited by 49 · see citing works
Regulation of gonadotropin-releasing hormone neurons by glucose
Roland, A. V., & Moenter, S. M. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.07.001 · Cited by 45 · see citing works
Control of Germline Stem Cell Lineages by Diet and Physiology
Laws, K. M., & Drummond‐Barbosa, D. (2017) · Results and problems in cell differentiation · doi:10.1007/978-3-319-44820-6_3 · Cited by 43 · see citing works
Yellapragada, V., Liu, X., Lund, C., Känsäkoski, J., Pulli, K., Vuoristo, S., Lundin, K., Tuuri, T., Varjosalo, M. T., & Raivio, T. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00048 · Cited by 42 · see citing works
Pournaderi, P. S., Yaghmaei, P., Khodaei, H., Noormohammadi, Z., & Hejazi, S. H. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.01.057 · Cited by 41 · see citing works
Rani, R., Hajam, Y. A., Kumar, R., Bhat, R. A., Rai, S., & Rather, M. A. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100161 · Cited by 43 · see citing works
Neuroendocrine mechanisms in athletes
Misra, M. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-59602-4.00025-3 · Cited by 38 · see citing works
Bungum, L. J., Franssohn, F., Bungum, M., Humaidan, P., & Giwercman, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068223 · Cited by 35 · see citing works
Pirotta, S., Joham, A., Grieger, J. A., Tay, C. T., Bahri-Khomami, M., Lujan, M., Lim, S. S., & Moran, L. J. (2020) · Seminars in Reproductive Medicine · doi:10.1055/s-0041-1726866 · Cited by 29 · see citing works
Parker, V. J., Solano, M. E., Arck, P., & Douglas, A. J. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.164 · Cited by 28 · see citing works
Cernea, M., Phillips, R., Padmanabhan, V., Coolen, L. M., & Lehman, M. N. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13373 · Cited by 28 · see citing works
Barrett, E. S., Thune, I., Lipson, S., Furberg, A., & Ellison, P. T. (2012) · Human Reproduction · doi:10.1093/humrep/des429 · Cited by 28 · see citing works
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Chen, X., Huang, L., Tan, H. Y., Li, H., Wan, Y., Cowley, M. A., Veldhuis, J. D., & Chen, C. (2016) · Reproduction · doi:10.1530/rep-16-0341 · Cited by 26 · see citing works
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Torshizi, F. F., Chamani, M., Khodaei, H. R., Sadeghi, A. A., Hejazi, S. H., & Heravi, R. M. (2020) · PubMed Central · doi:10.22038/ijbms.2019.36004.8586 · Cited by 21 · see citing works
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Pesant, M.-H., Dwyer, A. A., Marques-Vidal, P. M., Schneiter, P., Giusti, V., Tappy, L., & Pralong, F. P. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.030189 · Cited by 7 · see citing works
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Bianchini, M., Chiefari, A., Lauretta, R., Mormando, M., Puliani, G., & Appetecchia, M. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780192864642.003.0014
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- Authors
- Moret, M., Stettler, R., Rodieux, F., Gaillard, R. C., Waeber, G., Wirthner, D., Giusti, V., Tappy, L., & Pralong, F. P.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- University of Lausanne (CH)
- Centre for Medically Assisted Procreation (CH)
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2008-10-02
- Volume
- 89
- Issue
- 2
- Pages
- 131-139
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W1992916596
- Semantic Scholar
- 38a4059fe5d6cb3bdb1bc579208177c475a084ed
- Cited by
- 72
- References
- 26
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 6 · 2016: 6 · 2015: 2 · 2014: 5 · 2013: 9 · 2012: 4
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- Locations
- Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- polycystic ovary syndrome, luteinizing hormone secretion, insulin, LH pulse frequency, LH/FSH ratio, GnRH neurons, hyperinsulinemic-euglycemic clamp
- MeSH terms
- Adult, Female, Humans, Hypothalamus, Insulin, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Polycystic Ovary Syndrome, Thinness, Glucose Clamp Technique
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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