Insulin and NPY pathways and the control of GnRH function and puberty onset

Pralong, François P.

doi:10.1016/j.mce.2010.01.037

Cited by 78Hypothalamic control of reproductive hormonesRegulation of Appetite and ObesityGrowth Hormone and Insulin-like Growth Factors

Insulin and NPY pathways and the control of GnRH function and puberty onset

Pralong, François P.·2010·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2010.01.037

Open this paper in CoChat — free account

Abstract

Energy balance exerts a critical influence on reproductive function. Leptin and insulin are among the metabolic factors signaling the nutritional status of an individual to the hypothalamus, and their role in the overall modulation of the activity of GnRH neurons is increasingly recognized. As such, they participate to a more generalized phenomenon: the signaling of peripheral metabolic changes to the central nervous system. The physiological importance that the interactions occurring between peripheral metabolic factors and the central nervous system bear for the control of food intake is increasingly recognized. The central mechanisms implicated are the focus of attention of very many research groups worldwide. We review here the experimental data that suggest that similar mechanisms are at play for the metabolic control of the neuroendocrine reproductive function. It is appearing that metabolic signals are integrated at the levels of first-order neurons equipped with the proper receptors, ant that these neurons send their signals towards hypothalamic GnRH neurons which constitute the integrative element of this network.

Integrity signals

Registry

Crossref · 10.1016/j.mce.2010.01.037

Cites

74 of 74 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Another systemic hormone with a major role in the regulation of reproduction is the pancreatic hormone insulin.
“Another systemic hormone with a major role in the regulation of reproduction is the pancreatic hormone insulin (figure 3).104”
From Pubertal development and regulation (2016) · cites this paper as [104]

Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works
Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243 · see citing works
Role of leptin in the neuroendocrine response to fasting
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117 · see citing works
Congenital leptin deficiency is associated with severe early-onset obesity in humans
Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936 · see citing works
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235 · see citing works
The role of neuropeptide Y in the antiobesity action of the obese gene product
Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., et al. (1995) · Nature · doi:10.1038/377530a0 · Cited by 1,498 · see citing works
Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
Chehab, F. F., Lim, M. E., & Lu, R. (1996) · Nature Genetics · doi:10.1038/ng0396-318 · Cited by 1,476 · see citing works
Menstrual cycles: fatness as a determinant of minimum weight for height necessary for their maintenance or onset
Frisch, R. E., & McArthur, J. W. (1974) · Science · doi:10.1126/science.185.4155.949 · Cited by 1,412 · see citing works
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15693 · Cited by 1,359 · see citing works
Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
Woods, S. C., Lotter, E. C., McKay, L. D., & Porte, D. (1979) · Nature · doi:10.1038/282503a0 · Cited by 1,114 · see citing works
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215693 · Cited by 1,105 · see citing works
Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
Schwartz, M. W., Peskind, E., Raskind, M., Boyko, E. J., & Porte, D. (1996) · Nature Medicine · doi:10.1038/nm0596-589 · Cited by 1,014 · see citing works
Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area
Elias, C. F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R. S., Bjorbæk, C., Flier, J. S., Saper, C. B., & Elmquist, J. K. (1999) · Neuron · doi:10.1016/s0896-6273(01)80035-0 · Cited by 924 · see citing works
A receptor subtype involved in neuropeptide-Y-induced food intake
Gerald, C., Walker, M. W., Criscione, L., Gustafson, E. L., Batzl‐Hartmann, C., Smith, K. E., Vaysse, P. J. ‐., Durkin, M. M., Laz, T. M., Linemeyer, D. L., et al. (1996) · Nature · doi:10.1038/382168a0 · Cited by 891 · see citing works
Leptin accelerates the onset of puberty in normal female mice.
Ahima, R. S., Dushay, J. R., Flier, S. N., Prabakaran, D., & Flier, J. S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119172 · Cited by 755 · see citing works
Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food.
Kalra, S. P., Dubé, M., Sahu, A., Phelps, C. P., & Kalra, P. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10931 · Cited by 665 · see citing works
Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
Spanswick, D., Smith, M. A., Groppi, V. E., Logan, S. D., & Ashford, M. L. J. (1997) · Nature · doi:10.1038/37379 · Cited by 628 · see citing works
KiSS‐1 Neurones Are Direct Targets for Leptin in the ob/ob Mouse
Smith, J. T., Acohido, B. V., Clifton, D. K., & Steiner, R. A. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01417.x · Cited by 559 · see citing works
Inhibition of hypothalamic neuropeptide Y gene expression by insulin.
Schwartz, M. W., Sipols, A. J., Marks, J. L., Sanacora, G., White, J. D., Scheurink, A., Kahn, S. E., Baskin, D. G., Woods, S. C., & Figlewicz, D. P. (1992) · Endocrinology · doi:10.1210/endo.130.6.1597158 · Cited by 555 · see citing works
Leptin Is a Metabolic Gate for the Onset of Puberty in the Female Rat
Cheung, C. C., Thornton, J. E., Kuijper, J. L., Weigle, D. S., Clifton, D. K., & Steiner, R. A. (1997) · Endocrinology · doi:10.1210/endo.138.2.5054 · Cited by 534 · see citing works
Leptin's Actions on the Reproductive Axis: Perspectives and Mechanisms
Cunningham, M. J., Clifton, D. K., & Steiner, R. A. (1999) · Biology of Reproduction · doi:10.1095/biolreprod60.2.216 · Cited by 531 · see citing works
Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain.
Baura, G. D., Foster, D. M., Porte, D., Kahn, S. E., Bergman, R. N., Cobelli, C., & Schwartz, M. W. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116773 · Cited by 489 · see citing works
Leptin Treatment Rescues the Sterility of Genetically Obese ob/ob Males*
Mounzih, K., Lu, R., & Chehab, F. F. (1997) · Endocrinology · doi:10.1210/en.138.3.1190 · Cited by 482 · see citing works
Insulin Activation of Phosphatidylinositol 3-Kinase in the Hypothalamic Arcuate Nucleus
Niswender, K. D., Morrison, C. D., Clegg, D. J., Olson, R., Baskin, D. G., Myers, M. G., Seeley, R. J., & Schwartz, M. W. (2003) · Diabetes · doi:10.2337/diabetes.52.2.227 · Cited by 476 · see citing works
SOCS-3 Inhibits Insulin Signaling and Is Up-regulated in Response to Tumor Necrosis Factor-α in the Adipose Tissue of Obese Mice
Emanuelli, B., Peraldi, P., Filloux, C., Carine Chavey, A., Freidinger, K., Hilton, D. J., Hotamışlıgil, G. S., & OBBERGHEN, E. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104602200 · Cited by 449 · see citing works
Body weight and food intake as initiating factors for puberty in the rat
Kennedy, G. C., & Mitra, J. (1963) · The Journal of Physiology · doi:10.1113/jphysiol.1963.sp007112 · Cited by 443 · see citing works
Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus.
Baskin, D. G., Breininger, J. F., & Schwartz, M. W. (1999) · Diabetes · doi:10.2337/diabetes.48.4.828 · Cited by 351 · see citing works
Insulin-like growth factor I of peripheral origin acts centrally to accelerate the initiation of female puberty
Hiney, J. K., Srivastava, V. K., Nyberg, C. L., Ojeda, S. R., & Dees, W. L. (1996) · Endocrinology · doi:10.1210/endo.137.9.8756538 · Cited by 304 · see citing works
Neuropeptide Y: the universal soldier
Pedrazzini, T., Pralong, F. P., & Grouzmann, E. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s000180300029 · Cited by 286 · see citing works
Self-citation
Norepinephrine-like effects of neuropeptide Y on LH release in the rat
Kalra, S. P., & Crowley, W. R. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90187-5 · Cited by 271 · see citing works
Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis
Niswender, K. D., Baskin, D. G., & Schwartz, M. W. (2004) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2004.07.009 · Cited by 262 · see citing works
Physiological Perspectives on Leptin as a Regulator of Reproduction: Role in Timing Puberty1
Foster, D. L., & Nagatani, S. (1999) · Biology of Reproduction · doi:10.1095/biolreprod60.2.205 · Cited by 229 · see citing works
Gonadotropin-Releasing Hormone: Role of Pulsatile Secretion in the Regulation of Reproduction
Flier, J. S., Underhill, L. H., Marshall, J. C., & Kelch, R. P. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612043152306 · Cited by 212 · see citing works
Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats
Catzeflis, C., Pierroz, D. D., Rohner‐Jeanrenaud, F., Rivier, J., Sizonenko, P. C., & Aubert, M. L. (1993) · Endocrinology · doi:10.1210/endo.132.1.8380374 · Cited by 206 · see citing works
Food-Restricted, Prepubertal, Female Rats: Rapid Recovery of Luteinizing Hormone Pulsing with Excess Food, and Full Recovery of Pubertal Development with Gonadotropin-Releasing Hormone*
Bronson, F. H. (1986) · Endocrinology · doi:10.1210/endo-118-6-2483 · Cited by 205 · see citing works
Regulation of gonadotropin subunit gene transcription
Burger, L. L., Haisenleder, D. J., Dalkin, A. C., & Marshall, J. C. (2004) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01600 · Cited by 195 · see citing works
Morphological Evidence for Direct Interaction between Arcuate Nucleus Neuropeptide Y (NPY) Neurons and Gonadotropin-Releasing Hormone Neurons and the Possible Involvement of NPY Y1 Receptors1
Li, C., Chen, P., & Smith, M. S. (1999) · Endocrinology · doi:10.1210/endo.140.11.7093 · Cited by 187 · see citing works
Inhibition of Food Intake by Neuropeptide Y Y5 Receptor Antisense Oligodeoxynucleotides
Schaffhauser, A. O., Stricker‐Krongrad, A., Brunner, L., Cumin, F., Gerald, C., Whitebread, S., Criscione, L., & Hofbauer, K. G. (1997) · Diabetes · doi:10.2337/diab.46.11.1792 · Cited by 185 · see citing works
Multiple Receptors for the Pancreatic Polypeptide (PP-Fold) Family: Physiological Implications
Gehlert, D. R. (1998) · Experimental Biology and Medicine · doi:10.3181/00379727-218-44263 · Cited by 181 · see citing works
Gonadotropin-Releasing Hormone Secretion from Hypothalamic Neurons: Stimulation by Insulin and Potentiation by Leptin
Burcelin, R., Thorens, B., Glauser, M., Gaillard, R. C., & Pralong, F. P. (2003) · Endocrinology · doi:10.1210/en.2003-0457 · Cited by 173 · see citing works
Self-citation
Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in intact adult male rats
Pierroz, D. D., Catzeflis, C., Aebi, A., Rivier, J. E., & Aubert, M. L. (1996) · Endocrinology · doi:10.1210/endo.137.1.8536627 · Cited by 172 · see citing works
KiSS-1/kisspeptins and the metabolic control of reproduction: Physiologic roles and putative physiopathological implications
Castellano, J. M., Roa, J., Luque, R. M., Diéguez, C., Aguilar, E., Pinilla, L., & Tena‐Sempere, M. (2008) · Peptides · doi:10.1016/j.peptides.2008.06.007 · Cited by 166 · see citing works
Availability of Metabolic Fuels Controls Estrous Cyclicity of Syrian Hamsters
Schneider, J. E., & Wade, G. N. (1989) · Science · doi:10.1126/science.2734610 · Cited by 161 · see citing works
Neuropeptide Y: A hypothalamic brake restraining the onset of puberty in primates
Majdoubi, M. E., Sahu, A., Ramaswamy, S., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090099697 · Cited by 151 · see citing works
Control of GnRH neuronal activity by metabolic factors: The role of leptin and insulin
Gamba, M., & Pralong, F. P. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.04.023 · Cited by 135 · see citing works
Self-citation
Bimodal Effects of Neuropeptide Y on Hypothalamic Release of Gonadotropin-Releasing Hormone in Conscious Rabbits
Khorram, O., Pau, K. ‐. F., & Spies, H. G. (2008) · Neuroendocrinology · doi:10.1159/000124743 · Cited by 130 · see citing works
A longitudinal hormonal profile of the genetically obese mouse.
Garthwaite, T., Martinson, D., Tseng, L.-F., Hagen, T. C., & Menahan, L. A. (1980) · Endocrinology · doi:10.1210/endo-107-3-671 · Cited by 129 · see citing works
Third-Ventricular Infusion of Neuropeptide Y Suppresses Luteinizing Hormone Secretion in Ovariectomized Rhesus Macaques*
Kaynard, A. H., Pau, K. ‐. F., Hess, D. L., & Spies, H. G. (1990) · Endocrinology · doi:10.1210/endo-127-5-2437 · Cited by 123 · see citing works
Gonadotropin-releasing hormone-expressing neurons immortalized conditionally are activated by insulin: implication of the mitogen-activated protein kinase pathway.
Salvi, R., Castillo, E., Voirol, M., Glauser, M., Rey, J.-P., Gaillard, R., Vollenweider, P., & Pralong, F. (2006) · Endocrinology · doi:10.1210/en.2005-0728 · Cited by 122 · see citing works
Self-citation
Increased Hypothalamic Neuropeptide Y Concentrations in Diabetic Rat
Williams, G., Steel, J. H., Cardoso, H., Ghatei, M. A., Lee, Y. C., Gill, J. S., Burrin, J. M., Polak, J. M., & Bloom, S. R. (1988) · Diabetes · doi:10.2337/diab.37.6.763 · Cited by 121 · see citing works
Effects of chronic intrahypothalamic infusion of insulin on food intake and diurnal meal patterning in the rat.
McGowan, M. K., Andrews, K. M., Kelly, J., & Grossman, S. P. (1990) · Behavioral Neuroscience · doi:10.1037/0735-7044.104.2.373 · Cited by 109 · see citing works
Metabolic control of sexual function and growth: Role of neuropeptide Y and leptin
Aubert, M. L., Pierroz, D. D., Gruaz, N. M., et al. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00058-6 · Cited by 106 · see citing works
Evidence That the Inhibition of Luteinizing Hormone Secretion Exerted by Central Administration of Neuropeptide Y (NPY) in the Rat Is Predominantly Mediated by the NPY-Y5 Receptor Subtype1
Raposinho, P., Broqua, P., Pierroz, D. D., Hayward, A., Dumont, Y., Quirion, R., Junien, J., & Aubert, M. L. (1999) · Endocrinology · doi:10.1210/endo.140.9.6985 · Cited by 104 · see citing works
Neuropeptide-Y Suppresses Pulsatile Secretion of Luteinizing Hormone in Ovariectomized Rats: Possible Site of Action*
McDonald, J. K., Lumpkin, M. D., & DePaolo, L. V. (1989) · Endocrinology · doi:10.1210/endo-125-1-186 · Cited by 97 · see citing works
Central Inhibition of Gonadotropin-Releasing Hormone Secretion in the Growth-Restricted Hypogonadotropic Female Sheep1
I’Anson, H., Manning, J. M., Herbosa, C. G., Pelt, J., Friedman, C. R., Wood, R. I., Bucholtz, D. C., & Foster, D. L. (2000) · Endocrinology · doi:10.1210/endo.141.2.7308 · Cited by 93 · see citing works
The neuropeptide Y Y1 receptor regulates leptin‐mediated control of energy homeostasis and reproductive functions
Pralong, F. P., Gonzales, C., Voirol, M., Palmiter, R. D., Brunner, H. R., Gaillard, R. C., Seydoux, J., & Pedrazzini, T. (2002) · The FASEB Journal · doi:10.1096/fj.01-0754fje · Cited by 92 · see citing works
Self-citation
Involvement of the Y-1 receptor subtype in the regulation of luteinizing hormone secretion by neuropeptide Y in rats
Kalra, S. P., Fuentes, M., Fournier, A., Parker, S. L., & Crowley, W. R. (1992) · Endocrinology · doi:10.1210/endo.130.6.1317781 · Cited by 92 · see citing works
Chronic Administration of Neuropeptide Y into the Lateral Ventricle Starting at 30 Days of Life Delays Sexual Maturation in the Female Rat
Pierroz, D. D., Gruaz, N. M., d’Allèves, V., et al. (2008) · Neuroendocrinology · doi:10.1159/000126851 · Cited by 85 · see citing works
Food restriction and reproductive development: male and female mice and male rats
Hamilton, G. D., & Bronson, F. H. (1986) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1986.250.3.r370 · Cited by 76 · see citing works
Insulin modulation of luteinizing hormone secretion in normal female volunteers and lean polycystic ovary syndrome patients
Moret, M., Stettler, R., Rodieux, F., Gaillard, R. C., Waeber, G., Wirthner, D., Giusti, V., Tappy, L., & Pralong, F. P. (2009) · Neuroendocrinology · doi:10.1159/000160911 · Cited by 72 · see citing works
Self-citation
Insulin-Like Growth Factor-I Effects on Gonadotropin-Releasing Hormone Biosynthesis in GT1-7 Cells
Longo, K. M., Sun, Y., & Gore, A. C. (1998) · Endocrinology · doi:10.1210/endo.139.3.5852 · Cited by 66 · see citing works
Increased hypothalamic neuropeptide Y concentrations in diabetic rat
Williams, G. H., Steel, J. H., Cardoso, H., et al. (1988) · Diabetes · doi:10.2337/diabetes.37.6.763 · Cited by 60 · see citing works
Effects of cytokines on gonadotropin-releasing hormone (GnRH) gene expression in primary hypothalamic neurons and in GnRH neurons immortalized conditionally.
Igaz, P., Salvi, R., Rey, J.-P., Glauser, M., Pralong, F., & Gaillard, R. (2006) · Endocrinology · doi:10.1210/en.2005-0729 · Cited by 59 · see citing works
Self-citation
Inhibition of food intake by neuropeptide Y Y5 receptor antisense oligodeoxynucleotides
Schaffhauser, A. O., Stricker‐Krongrad, A., Brunner, L., et al. (1997) · Diabetes · doi:10.2337/diabetes.46.11.1792 · Cited by 58 · see citing works
Morphological Evidence for Direct Interaction between Arcuate Nucleus Neuropeptide Y (NPY) Neurons and Gonadotropin-Releasing Hormone Neurons and the Possible Involvement of NPY Y1 Receptors
Li, C. (1999) · Endocrinology · doi:10.1210/en.140.11.5382 · Cited by 54 · see citing works
Staying Slim with Insulin in Mind
Schwartz, M. W. (2000) · Science · doi:10.1126/science.289.5487.2066 · Cited by 53 · see citing works
Differential Effects of Pancreatic Polypeptide on Luteinizing Hormone Release in Female Rats
Kalra, S. P., & Crowley, W. R. (2008) · Neuroendocrinology · doi:10.1159/000123941 · Cited by 53 · see citing works
The neuropeptide Y Y1 receptor mediates NPY‐induced inhibition of the gonadotrope axis under poor metabolic conditions
Gonzales, C., Voirol, M., Giacomini, M., Gaillard, R. C., Pedrazzini, T., & Pralong, F. P. (2003) · The FASEB Journal · doi:10.1096/fj.03-0189fje · Cited by 52 · see citing works
Self-citation
Remembrance: the discovery of the hypothalamic gonadotropin-releasing hormone pulse generator and of its physiological significance
Knobil, E. (1992) · Endocrinology · doi:10.1210/endo.131.3.1505445 · Cited by 50 · see citing works
Effects of glucose and related substrates on the recovery of the electrical activity of gonadotropin-releasing hormone pulse generator which is decreased by insulin-induced hypoglycemia in the estrogen-primed ovariectomized rat
He, D., Funabashi, T., Sano, A., Uemura, T., MINAGUCHI, H., & Kimura, F. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01358-4 · Cited by 49 · see citing works
Acceleration of pubertal development following central blockade of the Y1 subtype of neuropeptide Y receptors
Pralong, F. P., Voirol, M., Giacomini, M., Gaillard, R. C., & Grouzmann, E. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00130-0 · Cited by 39 · see citing works
Self-citation
Central Inhibition of Gonadotropin-Releasing Hormone Secretion in the Growth-Restricted Hypogonadotropic Female Sheep
I'Anson, H. (2000) · Endocrinology · doi:10.1210/en.141.2.520 · Cited by 38 · see citing works
Evidence That the Inhibition of Luteinizing Hormone Secretion Exerted by Central Administration of Neuropeptide Y (NPY) in the Rat Is Predominantly Mediated by the NPY-Y5 Receptor Subtype
Raposinho, P. (1999) · Endocrinology · doi:10.1210/en.140.9.4046 · Cited by 35 · see citing works
Egr-1 binds the GnRH promoter to mediate the increase in gene expression by insulin
DiVall, S. A., Radovick, S., & Wolfe, A. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.02.007 · Cited by 32 · see citing works

Flagged first, then by citations

Sorted by citations

Pubertal development and regulation
Abreu, A. P., & Kaiser, U. B. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00418-0 · Cited by 611 · see citing works
Sex differences in the physiology of eating
Asarian, L., & Geary, N. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00446.2012 · Cited by 513 · see citing works
Direct Regulation of GnRH Neuron Excitability by Arcuate Nucleus POMC and NPY Neuron Neuropeptides in Female Mice
Roa, J., & Herbison, A. E. (2012) · Endocrinology · doi:10.1210/en.2012-1470 · Cited by 192 · see citing works
Female reproduction and type 1 diabetes: From mechanisms to clinical findings
Codner, E., Merino, P. M., & Tena-Sempere, M. (2012) · Human Reproduction Update · doi:10.1093/humupd/dms024 · Cited by 182 · see citing works
Connecting metabolism and reproduction: roles of central energy sensors and key molecular mediators
Roa, J., & Tena-Sempere, M. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.09.027 · Cited by 136 · see citing works
Puberty as a life history transition
Ellison, P. T., Reiches, M. W., Shattuck-Faegre, H., Breakey, A., Konecna, M., Urlacher, S., & Wobber, V. (2012) · Annals of Human Biology · doi:10.3109/03014460.2012.693199 · Cited by 73 · see citing works
Metabolic Regulation of Kisspeptin
Castellano, J. M., & Tena-Sempere, M. (2013) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4614-6199-9_17 · Cited by 42 · see citing works
Hypothalamic Regulation of Anterior Pituitary Function
Ben-Shlomo, A., & Melmed, S. (2017) · The Pituitary · doi:10.1016/b978-0-12-804169-7.00002-7 · Cited by 11 · see citing works

흰쥐의 발정주기동안 난소내 Leptin 및 Leptin 수용체 발현의 주기적 변화에 관한 연구
김명신, 양현원, 권혁찬, et al. (2002) · 발생과 생식
흰쥐 난소내 Leption 및 Leption 수용체의 발현
김명신, 양현원, 권혁찬, et al. (1998) · 발생과 생식
Expression of Obesity Hormone Leptin in Human Colorectal Cancer
Jin-chun, Cong, C., Xianwei, et al. (2009) · Acta Scientiarum Naturalium Universitatis Sunyatseni
Leptin이 생쥐 배아의 체외 발달에 미치는 영향
조영록, Joo, J. K., 김휘곤, et al. (2009) · Obstetrics & Gynecology Science
Pleiotropic cellular effects of leptin
Considine, R. V., & Caro, J. F. (1999) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-199904000-00013 · Cited by 25 · see citing works

Authors: Pralong, F. P.
Affiliations: Centre Hospitalier Universitaire Vaudois (CH)
Corresponding author: Pralong, François P.
ORCID: Pralong, François P.
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2010-08
Volume: 324
Issue: 1-2
Pages: 82-86
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/j.mce.2010.01.037
OpenAlex: W2067251390
Cited by: 78
References: 74
Citations by year: 2026: 2 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 9 · 2016: 9 · 2015: 5 · 2014: 8 · 2013: 7 · 2012: 6
FWCI: 0.81
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords: insulin, neuropeptide Y, GnRH neurons, puberty onset, energy balance, leptin, hypothalamus, metabolic signaling, food intake regulation
MeSH terms: Animals, Humans, Insulin, Gonadotropin-Releasing Hormone, Neuropeptide Y, Puberty, Sexual Maturation, Signal Transduction, Leptin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Insulin and NPY pathways and the control of GnRH function and puberty onset

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks