Insular hypoperfusion correlates with the severity of delusions in individuals with Alzheimer's disease
Abstract
BACKGROUND: The aim of this study was to identify the brain regions associated with the severity of delusions in individuals with Alzheimer's disease (AD) using single-photon emission computed tomography. METHODS: Thirty-five AD patients participated in this study. Multiple regression analysis was performed to identify a linear correlation between the delusion subscale score of the Neuropsychiatric Inventory (NPI) and regional cerebral blood flow (rCBF) in AD patients with delusions (n = 14). In addition, rCBF in patients with (n = 14) and without delusions (n = 21) was compared using a 2-sample t test. RESULTS: The delusion subscale score of the NPI was negatively correlated with rCBF in the right anterior insula (uncorrected p < 0.01 at the voxel level and corrected p < 0.05 at the cluster level). Compared to patients without delusions, however, rCBF in the right anterior insula was not significantly decreased in patients with delusions. CONCLUSION: We suggest that right anterior insular dysfunction may exacerbate delusions, although it is not responsible for the onset of delusions.
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Delusions in Alzheimer's disease are associated with decreased perfusion in right anterior insula and decreased gray matter volume in left insula.
“Delusions were also associated with decreased perfusion in right anterior insula (Matsuoka et al., 2010) and decreased GM volume in left insula (Nakaaki et al., 2013).”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Matsuoka et al., 2010
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568 · see citing works
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657 · see citing works
Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia
Lieberman, J. A., Stroup, T. S., McEvoy, J. P., Swartz, M. S., Rosenheck, R. A., Perkins, D. O., Keefe, R. S. E., Davis, S. M., Davis, C. E., Lebowitz, B. D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051688 · Cited by 5,892 · see citing works
Effectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer's Disease
Schneider, L. S., Tariot, P. N., Dagerman, K. S., Davis, S. M., Hsiao, J. K., Ismail, M. S., Lebowitz, B. D., Lyketsos, C. G., Ryan, J. M., Stroup, T. S., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061240 · Cited by 1,206 · see citing works
Insula of the old world monkey. III: Efferent cortical output and comments on function
Mesulam, M. ‐., & Mufson, E. J. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902120104 · Cited by 1,013 · see citing works
The primate cortico-cerebellar system: anatomy and function
Ramnani, N. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1953 · Cited by 1,011 · see citing works
Psychiatric symptoms and nursing home placement of patients with Alzheimer's disease
(1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.8.1049 · Cited by 744 · see citing works
Overview of depression and psychosis in Alzheimer's disease
Wragg, R. E., & Jeste, D. V. (1989) · American Journal of Psychiatry · doi:10.1176/ajp.146.5.577 · Cited by 683 · see citing works
The role of the cerebellum in schizophrenia
Andreasen, N. C., & Pierson, R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.01.003 · Cited by 669 · see citing works
Ballard, C., Hanney, M. L., Theodoulou, M., Douglas, S., McShane, R., Kossakowski, K., Gill, R., Juszczak, E., Yu, L.-M., & Jacoby, R. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70295-3 · Cited by 567 · see citing works
Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease
Bruen, P. D., McGeown, W. J., Shanks, M. F., & Venneri, A. (2008) · Brain · doi:10.1093/brain/awn151 · Cited by 374 · see citing works
Kales, H. C., Valenstein, M., Kim, H. M., McCarthy, J. F., Ganoczy, D., Cunningham, F., & Blow, F. C. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06101710 · Cited by 258 · see citing works
Minoshima, S., Frey, K. A., Foster, N. L., & Kuhl, D. E. (1995) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199507000-00006 · Cited by 252 · cited 1× · see citing works
“Moreover, the regional metabolic rate in the cerebellum can be decreased through the mechanism of diaschisis even in mild AD [”
BackgroundMatsumoto, N., Ikeda, M., Fukuhara, R., Shinagawa, S., Ishikawa, T., Mori, T., Toyota, Y., Matsumoto, T., Adachi, H., Hirono, N., et al. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000099472 · Cited by 217 · see citing works
Crespo‐Facorro, B. (2000) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00028-1 · Cited by 189 · see citing works
Cerebral correlates of psychotic symptoms in Alzheimer's disease
Mega, M. S. (2000) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.2.167 · Cited by 189 · see citing works
Delusional Thoughts and Regional Frontal/Temporal Cortex Metabolism in Alzheimer’s Disease
Sultzer, D. L., Brown, C. V., Mandelkern, M. A., Mahler, M. E., Mendez, M. F., Chen, S. T., & Cummings, J. L. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.2.341 · Cited by 176 · see citing works
Alzheimer's disease: amyloid plaques in the cerebellum
Braak, H., Braak, E., Böhl, J., & Lang, W. (1989) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(89)90197-4 · Cited by 157 · see citing works
Reduction of cerebellar glucose metabolism in advanced Alzheimer's disease.
Ishii, K., Sasaki, M., Kitagaki, H., Yamaji, S., Sakamoto, S., Matsuda, K. M., & Mori, E. (1997) · PubMed · Cited by 151 · see citing works
YAMAGUCHI, H., Hirai, S., Morimatsu, M., Shoji, M., & Nakazato, Y. (1989) · Acta Neuropathologica · doi:10.1007/bf00687584 · Cited by 140 · see citing works
SPECT findings on psychosis in Alzheimer's disease
Kotrla, K. J., Chacko, R. C., Harper, R. G., Jhingran, S. G., & Doody, R. S. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.10.1470 · Cited by 125 · see citing works
Delusions in Alzheimer's Disease: Spet Evidence of Right Hemispheric Dysfunction
Staff, R. T., Shanks, M. F., Macintosh, L., et al. (1999) · Cortex · doi:10.1016/s0010-9452(08)70818-9 · Cited by 85 · see citing works
Relationship between Delusions and Regional Cerebral Blood Flow in Alzheimer’s Disease
Nakano, S., Yamashita, F., Matsuda, H., Kodama, C., & Yamada, T. (2005) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000089215 · Cited by 69 · see citing works
Royall, D. R., Gao, J., & Kellogg, D. L. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2005.10.036 · Cited by 62 · see citing works
Alteration of rCBF in Alzheimer's disease patients with delusions of theft
Fukuhara, R., Ikeda, M., Nebu, A., Kikuchi, T., Maki, N., Hokoishi, K., Shigenobu, K., Komori, K., & Tanabe, H. (2001) · Neuroreport · doi:10.1097/00001756-200108080-00037 · Cited by 51 · see citing works
Crossed cerebellar and uncrossed basal ganglia and thalarnic diaschisis in Alzheimer's disease
Akiyama, H., Harrop, R., McGeer, P. L., et al. (1989) · Neurology · doi:10.1212/wnl.39.4.541 · Cited by 45 · see citing works
Psychosis of Alzheimer's disease: Gender differences in regional perfusion
Moran, E. K., Becker, J. A., Satlin, A., Lyoo, I. K., Fischman, A. J., & Johnson, K. A. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.02.024 · Cited by 31 · see citing works
The Psychotic Phenomenon in Probable Alzheimer's Disease
López, O. L., Smith, G. S., Becker, J. T., MELTZER, C. C., & DeKosky, S. T. (2001) · Journal of Neuropsychiatry · doi:10.1176/jnp.13.1.50 · Cited by 6 · see citing works
Asymmetric Insular Function Predicts Positional Blood Pressure in Nondemented Elderly
Royall, D. R., Gao, J. H., Zhao, X., et al. (2009) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.21.2.173 · Cited by 5 · see citing works
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Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits?
Rosenberg, P. B., Nowrangi, M. A., & Lyketsos, C. G. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.05.005 · Cited by 302 · see citing works
Moon, Y., Moon, W.-J., Kim, H., & Han, S.-H. (2014) · European Neurology · doi:10.1159/000356343 · Cited by 56 · see citing works
- Authors
- Matsuoka, T., Narumoto, J., Shibata, K., Okamura, A., Nakamura, K., Okuyama, C., Nishimura, T., & Fukui, K.
- Affiliations
- Kyoto Prefectural University of Medicine (JP)
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2010
- Volume
- 29
- Issue
- 4
- Pages
- 287-293
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W2081489960
- Cited by
- 32
- References
- 31
- Citations by year
- 2024: 4 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2015: 2 · 2014: 6 · 2013: 8 · 2012: 4
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- Alzheimer's disease, delusions, anterior insula, regional cerebral blood flow, neuropsychiatric symptoms, Neuropsychiatric Inventory
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, Cerebrovascular Circulation, Delusions, Female, Humans, Ischemia, Male, Regression Analysis, Severity of Illness Index, Tomography, Emission-Computed, Single-Photon
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