The primate cortico-cerebellar system: anatomy and function

Ramnani, Narender

doi:10.1038/nrn1953

Cited by 1,011Motor Control and AdaptationVestibular and auditory disordersMemory and Neural Mechanisms

The primate cortico-cerebellar system: anatomy and function

Ramnani, Narender·2006·Nature Reviews Neuroscience

DOI 10.1038/nrn1953

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Abstract

Evidence has been accumulating that the primate cerebellum contributes not only to motor control, but also to higher 'cognitive' function. However, there is no consensus about how the cerebellum processes such information. The answer to this puzzle can be found in the nature of cerebellar connections to areas of the cerebral cortex (particularly the prefrontal cortex) and in the uniformity of its intrinsic cellular organization, which implies uniformity in information processing regardless of the area of origin in the cerebral cortex. With this in mind, the relatively well-developed models of how the cerebellum processes information from the motor cortex might be extended to explain how it could also process information from the prefrontal cortex.

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Such quantitative changes are likely warranted by increases in the absolute numbers of neurons in relevant cortical areas and in the cerebellar circuits that interact with them.
“Such quantitative changes are likely to be warranted by increases in the absolute (rather than relative) numbers of neurons in relevant cortical areas and, coordinately, in the cerebellar circuits that interact with them (Ramnani, 2006).”
From The human brain in numbers: a linearly scaled-up primate brain (2009) · cites this paper as Ramnani, 2006

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“The cerebellum, while mainly known for its functions in motor control, has also been implicated in higher cognitive functions including the regulation of affect and cognition (Ramnani, 2006; Stoodley and Schmahmann, 2010).”
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Authors: Ramnani, N.
Affiliations: Royal Holloway University of London (GB)
Corresponding author: Ramnani, Narender
ORCID: Ramnani, Narender
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2006-07
Volume: 7
Issue: 7
Pages: 511-522
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn1953
OpenAlex: W2001821181
Cited by: 1,011
References: 12
Citations by year: 2026: 34 · 2025: 45 · 2024: 32 · 2023: 43 · 2022: 54 · 2021: 79 · 2020: 55 · 2019: 71 · 2018: 48 · 2017: 63 · 2016: 57 · 2015: 47 · 2014: 69 · 2013: 56 · 2012: 56
FWCI: 3.39
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: cerebellum, prefrontal cortex, cerebellar cognitive function, motor control, motor cortex
MeSH terms: Animals, Cerebellum, Cerebral Cortex, Humans, Nerve Net, Neural Pathways

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The primate cortico-cerebellar system: anatomy and function

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