Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease
Open accessAbstract
Alzheimer's disease research has largely concentrated on the study of cognitive decline, but the associated behavioural and neuropsychiatric symptoms are of equal importance in the clinical profile of the disease. There is emerging evidence that regional differences in brain atrophy may align with variant disease presentations. The objective of this study was to identify the regions of decreased grey matter (GM) volume which were associated with specific neuropsychiatric behaviours in patients with mild Alzheimer's disease. Voxel-based morphometry was used to correlate GM derived from T(1)-weighted MRI images of 31 patients with mild Alzheimer's disease and specific neuropsychiatric symptoms and behaviours measured by the Neuropsychiatric Inventory. Delusions were associated with decreased GM density in the left frontal lobe, in the right frontoparietal cortex and in the left claustrum. Apathy was associated with GM density loss in the anterior cingulate and frontal cortex bilaterally, the head of the left caudate nucleus and in bilateral putamen. Agitation was associated with decreased GM values in the left insula, and in anterior cingulate cortex bilaterally. Neuropsychiatric symptoms of Alzheimer's disease seem to associate with neurodegeneration of specific neural networks supporting personal memory, reality monitoring, processing of reward, interoceptive sensations and subjective emotional experience. The study of neurodegenerative disorders such as Alzheimer's disease using voxel-based morphometry and other imaging modalities may further the understanding of the neural structures that mediate the genesis of abnormal behaviours.
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Apathy in Alzheimer's disease is associated with volume loss in anterior cingulate cortex, including reduced gray matter volume and cortical thinning.
“Structural imaging studies report volume loss in ACC, including reduced gray matter volume (Apostolova et al., 2007; Bruen et al., 2008; Stanton et al., 2013) and cortical thinning (Tunnard et al., 2011).”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Bruen et al., 2008
Apathy in Alzheimer's disease is associated with volume loss and/or cortical thinning in frontal cortex.
“There are also links between apathy and volume loss and/or cortical thinning in frontal cortex (Apostolova et al., 2007; Bruen et al., 2008; Stanton et al., 2013; Tunnard et al., 2011), though there is no strict concordance on the specific regions of frontal cortex which include medial, lateral, and orbital regions.”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Bruen et al., 2008
Agitation in Alzheimer's disease is associated with deficits in structure and function of frontal cortex, anterior cingulate cortex, posterior cingulate cortex, amygdala, and hippocampus.
“Agitation in AD appears to be associated with deficits in structure and function of frontal cortex, anterior cingulate cortex, posterior cingulate cortex, amygdala, and hippocampus, and may be associated with mechanisms underlying misinterpretation of threats and affective regulation.”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Bruen et al., 2008
Agitation in Alzheimer's disease is associated with volume loss in frontal cortex, anterior cingulate cortex, posterior cingulate cortex, insula, amygdala, and hippocampus.
“Agitation was consistently associated with volume loss in several specific brain areas including frontal cortex (Hu et al., 2015; Trzepacz et al., 2013b), anterior cingulate cortex (ACC) (Bruen et al., 2008; Trzepacz et al., 2013b), posterior cingulate cortex (PCC) (Hu et al., 2015; Trzepacz et al., 2013b), insula (Bruen et al., 2008; Hu et al., 2015; Trzepacz et al., 2013b), amygdala (Trzepacz et”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Bruen et al., 2008
Delusions in Alzheimer's disease are associated with decreased gray matter volume, perfusion or metabolism in frontal cortex and anterior cingulate cortex.
“Delusions were associated with decreased gray matter (GM) volume, perfusion or metabolism in frontal cortex and ACC (Bruen et al., 2008; Koppel et al., 2014; Mega et al., 2000; Nakaaki et al., 2013; Rafii et al., 2011; Sultzer et al., 2003; Whitehead et al., 2012).”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Bruen et al., 2008
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Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Journal of Clinical Psychiatry
(2018) · Journal of Clinical Psychiatry · doi:10.5505/kpd · Cited by 13,703 · see citing works
The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568 · see citing works
Román, G. C., Tatemichi, T. K., Erkinjuntti, T., Cummings, J. L., Masdeu, J. C., Garcia, J. H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., et al. (1993) · Neurology · doi:10.1212/wnl.43.2.250 · Cited by 4,921 · see citing works
McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., et al. (1996) · Neurology · doi:10.1212/wnl.47.5.1113 · Cited by 3,960 · see citing works
Contributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377 · see citing works
. Cerebral blood flow in dementia.
Hachinski, V. C., Iliff, L. D., Zilhka, E., Du Boulay, G. H., McAllister, V. L., Marshall, J., Russell, R. W. R., & Symon, L. (1975) · Archives of Neurology · doi:10.1001/archneur.1975.00490510088009 · Cited by 3,186 · see citing works
The somatic marker hypothesis and the possible functions of the prefrontal cortex
Damasio, A. R. (1996) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1996.0125 · Cited by 2,847 · cited 1× · see citing works
“The insula also has a role in body representation, subjective emotional experience, the integration of sensory information and the processing of convergent information to make sensory experience emotionally salient (Damasio, 1996).”
BackgroundAmerican Journal of Neuroradiology
(2020) · American Journal of Neuroradiology · doi:10.3174/ajnr · Cited by 2,468 · see citing works
Lyketsos, C. G., Lopez, O., Jones, B., Fitzpatrick, A. L., Breitner, J., & DeKosky, S. (2002) · JAMA · doi:10.1001/jama.288.12.1475 · Cited by 2,049 · see citing works
Neuroimaging studies of working memory:
Wager, T. D., & Smith, E. E. (2003) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.3.4.255 · Cited by 1,889 · see citing works
Meditation experience is associated with increased cortical thickness
Lazar, S. W., Kerr, C. E., Wasserman, R. H., Gray, J. R., Greve, D. N., Treadway, M. T., McGarvey, M., Quinn, B. T., Dusek, J. A., Benson, H., et al. (2005) · NeuroReport · doi:10.1097/01.wnr.0000186598.66243.19 · Cited by 1,698 · see citing works
The functional neuroanatomy of emotion and affective style
Davidson, R. J., & Irwin, W. (1999) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(98)01265-0 · Cited by 1,684 · see citing works
Principles of Behavioral and Cognitive Neurology
(2000) · doi:10.1093/oso/9780195134759.001.0001 · Cited by 1,448 · see citing works
Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups.
(1994) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.4.416 · Cited by 1,331 · see citing works
Apathy and the Functional Anatomy of the Prefrontal Cortex–Basal Ganglia Circuits
Levy, R., & Dubois, B. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhj043 · Cited by 1,285 · see citing works
The spectrum of behavioral changes in Alzheimer's disease
Mega, M., Cummings, J., Fiorello, T., & Gornbein, J. (1996) · Neurology · doi:10.1212/wnl.46.1.130 · Cited by 1,124 · see citing works
Patient and Caregiver Characteristics and Nursing Home Placement in Patients With Dementia
Yaffe, K. (2002) · JAMA · doi:10.1001/jama.287.16.2090 · Cited by 903 · see citing works
Allman, J. M., Hakeem, A. Y., Erwin, J. M., Nimchinsky, E. A., & Hof, P. R. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03476.x · Cited by 903 · see citing works
What is the function of the claustrum?
Crick, F. C., & Koch, C. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1661 · Cited by 742 · see citing works
Frontal-subcortical circuitry and behavior
Bonelli, R. M., & Cummings, J. L. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.2/rbonelli · Cited by 613 · see citing works
Neuroanatomical correlates of behavioural disorders in dementia
Rosen, H. J., Allison, S. C., Schauer, G. F., Gorno-Tempini, M. L., Weiner, M. W., & Miller, B. L. (2005) · Brain · doi:10.1093/brain/awh628 · Cited by 497 · see citing works
Brain atrophy rates predict subsequent clinical conversion in normal elderly and amnestic MCI
Jack, C. R., Shiung, M. M., Weigand, S. D., O’Brien, P. C., Gunter, J. L., Boeve, B. F., Knopman, D. S., Smith, G. E., Ivnik, R. J., Tangalos, E. G., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000180958.22678.91 · Cited by 492 · see citing works
Predictors of progression from mild cognitive impairment to Alzheimer disease
Palmer, K., Berger, A., Monastero, R., Winblad, B. G., Bäckman, L., & Fratiglioni, L. (2007) · Neurology · doi:10.1212/01.wnl.0000260968.92345.3f · Cited by 436 · see citing works
Neurobehavioral changes associated with caudate lesions
Mendez, M. F., Adams, N. L., & Lewandowski, K. S. (1989) · Neurology · doi:10.1212/wnl.39.3.349 · Cited by 404 · see citing works
Delusions and Hallucinations Are Associated With Worse Outcome in Alzheimer Disease
Scarmeas, N., Brandt, J., Albert, M., Hadjigeorgiou, G. M., Papadimitriou, A., Dubois, B., Sarazin, M., Devanand, D. P., Honig, L. S., Marder, K. S., et al. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.1601 · Cited by 350 · see citing works
Tekin, S., Mega, M. S., Masterman, D. M., Chow, T. W., Garakian, J., Vinters, H. V., & Cummings, J. L. (2001) · Annals of Neurology · doi:10.1002/ana.72 · Cited by 278 · see citing works
Nocturnal Hypermotor Seizures, Suggesting Frontal Lobe Epilepsy, Can Originate in the Insula
Ryvlin, P., Minotti, L., Demarquay, G., Hirsch, É., Arzimanoglou, A. A., Hoffman, D., Guénot, M., Picard, F., Rheims, S., & Kahane, P. (2006) · Epilepsia · doi:10.1111/j.1528-1167.2006.00510.x · Cited by 243 · see citing works
Cerebral blood flow correlates of apathy in Alzheimer disease.
Craig, A. H., Cummings, J. L., Fairbanks, L. A., Itti, L., Miller, B. L., Li, J., & Mena, I. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550110056012 · Cited by 227 · see citing works
Tekin, S., Mega, M. S., Masterman, D. M., Chow, T. E., Garakian, J., Vinters, H. V., & Cummings, J. L. (2001) · Annals of Neurology · doi:10.1002/ana.72.abs · Cited by 226 · see citing works
Positron emission tomography metabolic correlates of apathy in Alzheimer disease.
Marshall, G., Monserratt, L., Harwood, D., Mandelkern, M., Cummings, J., & Sultzer, D. (2007) · Archives of Neurology · doi:10.1001/archneur.64.7.1015 · Cited by 209 · see citing works
Structural correlates of apathy in Alzheimer's disease
Apostolova, L. G., Akopyan, G. G., Partiali, N., Steiner, C. A., Dutton, R. A., Hayashi, K. M., Dinov, I. D., Toga, A. W., Cummings, J. L., & Thompson, P. M. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000103914 · Cited by 190 · see citing works
Cerebral correlates of psychotic symptoms in Alzheimer's disease
Mega, M. S. (2000) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.2.167 · Cited by 189 · see citing works
Migneco, O., Benoit, M., Koulibaly, P., Dygaĭ, I., Bertogliati, C., Desvignes, P., Robert, P., Malandain, G., Bussière, F., & Darcourt, J. (2001) · NeuroImage · doi:10.1006/nimg.2000.0741 · Cited by 187 · see citing works
The organization of the connections between the cortex and the claustrum in the monkey
Pearson, R. C. A., Brodal, P., Gatter, K. C., & Powell, T. P. S. (1982) · Brain Research · doi:10.1016/0006-8993(82)90883-6 · Cited by 184 · see citing works
Delusional Thoughts and Regional Frontal/Temporal Cortex Metabolism in Alzheimer’s Disease
Sultzer, D. L., Brown, C. V., Mandelkern, M. A., Mahler, M. E., Mendez, M. F., Chen, S. T., & Cummings, J. L. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.2.341 · Cited by 176 · see citing works
Neuropathologic Correlates of Apathy in Alzheimer’s Disease
Marshall, G. A., Fairbanks, L. A., Tekin, S., Vinters, H. V., & Cummings, J. L. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000090674 · Cited by 147 · see citing works
Shiino, A., Watanabe, T., Maeda, K., Kotani, E., Akiguchi, I., & Matsuda, M. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.06.010 · Cited by 147 · see citing works
Executive Dysfunction in Alzheimer's Disease
Chen, S. T., Sultzer, D. L., Hinkin, C. H., Mahler, M. E., & Cummings, J. L. (1998) · Journal of Neuropsychiatry · doi:10.1176/jnp.10.4.426 · Cited by 137 · see citing works
A SPECT study of apathy in Alzheimer's disease
Lanctôt, K. L., Moosa, S., Herrmann, N., Leibovitch, F. S., Rothenburg, L., Cotter, A., & Black, S. E. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000103633 · Cited by 126 · see citing works
Ryu, S.-H. (2005) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.13.11.976 · Cited by 109 · see citing works
Dissociating neuro-cognitive component processes: voxel-based correlational methodology
TYLER, L. K., Marslen‐Wilson, W. D., & Stamatakis, E. A. (2004) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2004.07.020 · Cited by 105 · see citing works
Förstl, H., Burns, A. S., Jacoby, R., et al. (1991) · PubMed · Cited by 104 · see citing works
Psychotic symptoms in Alzheimer disease: evidence for a distinct phenotype
Sweet, R. A., Nimgaonkar, V. L., Devlin, B., & Jeste, D. V. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001262 · Cited by 103 · see citing works
The anatomical bases of semantic retrieval deficits in early Alzheimer's disease
Venneri, A., McGeown, W. J., Hietanen, H., Guerrini, C., Ellis, A. W., & Shanks, M. F. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.08.026 · Cited by 90 · see citing works
Self-citationDelusions in Alzheimer's Disease: Spet Evidence of Right Hemispheric Dysfunction
Staff, R. T., Shanks, M. F., Macintosh, L., et al. (1999) · Cortex · doi:10.1016/s0010-9452(08)70818-9 · Cited by 85 · see citing works
Self-citationImaging attentional and attributional bias: an fMRI approach to the paranoid delusion
Blackwood, N., Howard, R. J., Ffytche, D. H., Simmons, A., Bentall, R. P., & Murray, R. M. (2000) · Psychological Medicine · doi:10.1017/s0033291799002421 · Cited by 75 · see citing works
The neuropsychiatry of Alzheimer's disease and other dementias
Cummings, J. L. (2003) · Medical Entomology and Zoology · Cited by 74 · see citing works
Perez-Madriñan, G., Cook, S. E., Saxton, J. A., Miyahara, S., López, O. L., Kaufer, D., Aizenstein, H. J., DeKosky, S. T., & Sweet, R. A. (2004) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200409000-00003 · Cited by 65 · see citing works
Aging, dementia, and brain atrophy: a longitudinal computed tomographic study.
Gado, M. H., Hughes, C. P., Danziger, W. L., & Chi, D. (1983) · PubMed Central · Cited by 63 · see citing works
Avoid falling into the depths of the insular trap
Ryvlin, P. (2006) · Epileptic Disorders · doi:10.1684/j.1950-6945.2006.tb00208.x · Cited by 62 · see citing works
Multiple Fregoli Delusions after Traumatic Brain Injury
Feinberg, T. E., Eaton, L. A., Roane, D. M., et al. (1999) · Cortex · doi:10.1016/s0010-9452(08)70806-2 · Cited by 62 · see citing works
Habib, M. C., & Poncet, M. (1988) · PubMed · Cited by 54 · see citing works
Provoked confabulations in Alzheimer's disease
Cooper, J. M., Shanks, M. F., & Venneri, A. (2006) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.03.029 · Cited by 43 · see citing works
Self-citationPerez-Madriñan, G. (2004) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.12.5.449 · Cited by 40 · see citing works
[Disorders of voluntary motor activity and lesions of caudate nuclei].
Trillet, M., Croisile, B., Tourniaire, D., et al. (1990) · PubMed · Cited by 29 · see citing works
Confabulations in Episodic Memory Are Associated With Delusions in Alzheimer’s Disease
Lee, E., Meguro, K., Hashimoto, R., Meguro, M., Ishii, H., Yamaguchi, S., & Mori, E. (2007) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988706292760 · Cited by 28 · see citing works
The emergence of delusional companions in Alzheimer's disease: An unusual misidentification syndrome
Shanks, M. F., & Venneri, A. (2002) · Cognitive Neuropsychiatry · doi:10.1080/13546800244000021 · Cited by 27 · see citing works
Self-citationAbe, N., Ishii, H., Fujii, T., et al. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.06.003 · Cited by 19 · see citing works
Thinking through delusions in Alzheimer's disease
Shanks, M. F., & Venneri, A. (2004) · The British Journal of Psychiatry · doi:10.1192/bjp.184.3.193 · Cited by 15 · see citing works
Self-citationNeurobehavioral changes following caudate infarct: a case report with literature review.
Wang, P. Y. (1991) · PubMed · Cited by 9 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Brun A, Englund B, Gustafson L, Passant V, Mann DMA, Neary D, et al. Clinical and neuropathological criteria for frontotemporal dementia. J Neurol Neurosurg Psychiatry 1994; 57: 416-8.
Cited by
Sorted by citations
Behavioral and psychological symptoms of dementia
Cerejeira, J., Lagarto, L., & Mukaetova-Ladinska, E. B. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00073 · Cited by 1,425 · see citing works
The road to restoring neural circuits for the treatment of Alzheimer's disease
Canter, R. G., Penney, J., & Tsai, L.-H. (2016) · Nature · doi:10.1038/nature20412 · Cited by 565 · see citing works
Ossenkoppele, R., Pijnenburg, Y. A. L., Perry, D. C., Cohn-Sheehy, B. I., Scheltens, N. M. E., Vogel, J. W., Kramer, J. H., van der Vlies, A. E., Joie, R. L., Rosen, H. J., et al. (2015) · Brain · doi:10.1093/brain/awv191 · Cited by 548 · see citing works
The anatomy of apathy: a neurocognitive framework for amotivated behaviour
Le Heron, C., Apps., M. A. J., & Husain, M. (2018) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.07.003 · Cited by 380 · see citing works
Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits?
Rosenberg, P. B., Nowrangi, M. A., & Lyketsos, C. G. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.05.005 · Cited by 302 · see citing works
Episodic retrieval and the cortical binding of relational activity
Shimamura, A. P. (2011) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-011-0031-4 · Cited by 205 · see citing works
Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders
Penzes, P., Buonanno, A., Passafaro, M., Sala, C., & Sweet, R. A. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12261 · Cited by 125 · see citing works
Apathy correlates with prefrontal amyloid deposition in Alzheimer's disease
Mori, T., Shimada, H., Shinotoh, H., Hirano, S., Eguchi, Y., Yamada, M., Fukuhara, R., Tanimukai, S., Zhang, M.-R., Kuwabara, S., et al. (2014) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-306110 · Cited by 122 · see citing works
Donovan, N. J., Wadsworth, L. P., Lorius, N., Locascio, J. J., Rentz, D. M., Johnson, K. A., Sperling, R. A., & Marshall, G. A. (2014) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.03.006 · Cited by 106 · see citing works
Kos, C., van Tol, M.-J., Marsman, J.-B. C., Knegtering, H., & Aleman, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.012 · Cited by 101 · see citing works
Stanton, B. R., Leigh, P. N., Howard, R. J., Barker, G. J., & Brown, R. G. (2013) · Journal of Neurology · doi:10.1007/s00415-013-6989-9 · Cited by 92 · see citing works
Microstructural alteration of the anterior cingulum is associated with apathy in Alzheimer disease
Kim, J. W., Lee, D. Y., Choo, I. H., Seo, E. H., Kim, S. G., Park, S. Y., & Woo, J. I. (2011) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31820dcc73 · Cited by 79 · see citing works
Hahn, C., Lim, H.-K., Won, W. Y., Ahn, K. J., Jung, W.-S., & Lee, C. U. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053493 · Cited by 76 · see citing works
Structural MRI correlates of apathy symptoms in older persons without dementia: AGES-Reykjavik Study
Grool, A. M., Geerlings, M. I., Sigurdsson, S., Eiriksdottir, G., Jonsson, P. V., Garcia, M. E., Siggeirsdottir, K., Harris, T. B., Sigmundsson, T., Gudnason, V., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000378 · Cited by 73 · see citing works
Zahodne, L. B., Gongvatana, A., Cohen, R. A., Ott, B. R., & Tremont, G. (2013) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.01.043 · Cited by 72 · see citing works
Guercio, B. J., Donovan, N. J., Ward, A., Schultz, A., Lorius, N., Amariglio, R. E., Rentz, D. M., Johnson, K. A., Sperling, R. A., & Marshall, G. A. (2015) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.13060141 · Cited by 61 · see citing works
Relationship between apathy and diffusion tensor imaging metrics of the brain in Alzheimer's disease
Ota, M., Sato, N., Nakata, Y., Arima, K., & Uno, M. (2012) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2779 · Cited by 58 · see citing works
Moon, Y., Moon, W.-J., Kim, H., & Han, S.-H. (2014) · European Neurology · doi:10.1159/000356343 · Cited by 56 · see citing works
Willette, A. A., Bendlin, B. B., McLaren, D. G., Canu, E., Kastman, E. K., Kosmatka, K. J., Xu, G., Field, A. S., Alexander, A. L., Colman, R. J., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.03.015 · Cited by 55 · see citing works
Kamat, R., Brown, G. G., Bolden, K., Fennema-Notestein, C., Archibald, S., Marcotte, T. D., Letendre, S. L., Ellis, R. J., Woods, S. P., Grant, I., et al. (2014) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2014.950636 · Cited by 47 · see citing works
Iaccarino, L., Sala, A., Caminiti, S. P., Presotto, L., Perani, D., & Initiative, F. T. A. D. N. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-190954 · Cited by 40 · see citing works
Jones, S. A., De Marco, M., Manca, R., Bell, S. M., Blackburn, D. J., Wilkinson, I. D., Soininen, H., & Venneri, A. (2019) · Cortex · doi:10.1016/j.cortex.2019.04.008 · Cited by 37 · see citing works
Matsuoka, T., Narumoto, J., Shibata, K., Okamura, A., Nakamura, K., Okuyama, C., Nishimura, T., & Fukui, K. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000295115 · Cited by 32 · see citing works
Beta-amyloid short- and long-term synaptic entanglement
Lanni, C., Fagiani, F., Racchi, M., Preda, S., Pascale, A., Grilli, M., Allegri, N., & Govoni, S. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2018.11.018 · Cited by 29 · see citing works
Lee, J. S., Kim, J. H., & Lee, S.-K. (2020) · Psychiatry Investigation · doi:10.30773/pi.2020.0009 · Cited by 25 · see citing works
Plasma biomarkers are associated with agitation and regional brain atrophy in Alzheimer’s disease
Hsu, J.-L., Lee, W.-J., Liao, Y.-C., Lirng, J.-F., Wang, S.-J., & Fuh, J.-L. (2017) · Scientific Reports · doi:10.1038/s41598-017-05390-1 · Cited by 18 · see citing works
A review of neuroimaging-based data-driven approach for Alzheimer’s disease heterogeneity analysis
Liu, L., Sun, S., Kang, W., Wu, S., & Lin, L. (2024) · Reviews in the Neurosciences · doi:10.1515/revneuro-2023-0033 · Cited by 16 · see citing works
- Authors
- Bruen, P. D., McGeown, W. J., Shanks, M. F., & Venneri, A.
- Affiliations
- University of Parma (IT)
- University of Modena and Reggio Emilia (IT)
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-08-21
- Volume
- 131
- Issue
- 9
- Pages
- 2455-2463
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2039731390
- Cited by
- 374
- References
- 61
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 20 · 2023: 19 · 2022: 23 · 2021: 18 · 2020: 26 · 2019: 22 · 2018: 17 · 2017: 24 · 2016: 22 · 2015: 29 · 2014: 24 · 2013: 37 · 2012: 16
- FWCI
- 12.38
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Funders
- European Commission
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- Alzheimer's disease, neuropsychiatric symptoms, delusions, apathy, agitation, gray matter atrophy, regional brain atrophy, Neuropsychiatric Inventory, left frontal lobe, anterior cingulate cortex, claustrum, insula, caudate nucleus, putamen, mild Alzheimer's disease, behavioural symptoms
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Brain, Brain Mapping, Delusions, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Psychomotor Agitation, Lethargy
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