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Clinical Criteria for the Diagnosis of Parkinson’s Disease
Open accessAbstract
The diagnosis of Parkinson’s disease (PD) follows the UK Brain Bank Criteria, which demands bradykinesia and one additional symptom, i.e. rigidity, resting tremor or postural instability. The latter is not a useful sign for the early diagnosis of PD, because it does not appear before Hoehn and Yahr stage 3. Early symptoms of PD which precede the onset of motor symptoms are hyposmia, REM sleep behavioral disorder, constipation, and depression. In addition, an increasing number of patients whose PD is related to a genetic defect are being described. Thus, genetic testing may eventually develop into a tool to identify at-risk patients. The clinical diagnosis of PD can be supported by levodopa or apomorphine tests. Imaging studies such as cranial CT or MRI are helpful to distinguish idiopathic PD from atypical or secondary PD. SPECT and PET methods are valuable to distinguish PD tremor from essential tremor if this is clinically not possible. Using all of these methods, we may soon be able to make a premotor diagnosis of PD, which will raise the question whether early treatment is possible and ethically and clinically advisable.
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“Occasionally, the tremor involves the legs and other tremor types may occur (Reichmann 2010).”
From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Reichmann 2010
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Cites
Parkinsonism: onset, progression, and mortality
Hoehn, M. M., & Yahr, M. D. (1967) · Neurology · doi:10.1212/wnl.17.5.427 · Cited by 12,107
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777
Hughes, A. J., Daniel, S. E., Kilford, L., & Lees, A. J. (1992) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.3.181 · Cited by 10,378
Epidemiology of Parkinson's disease
de Lau, L. M., & Breteler, M. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70471-9 · Cited by 4,110
A systematic review of prevalence studies of dementia in Parkinson's disease
Aarsland, D., ZACCAI, J. H., & Brayne, C. (2005) · Movement Disorders · doi:10.1002/mds.20527 · Cited by 1,714
Braak, H., de Vos, R. A. I., Bohl, J., & Del Tredici, K. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.11.012 · Cited by 1,354
A systematic review of prevalence studies of depression in Parkinson's disease
Reijnders, J. S. A. M., Ehrt, U., Weber, W. E. J., Aarsland, D., & Leentjens, A. F. G. (2008) · Movement Disorders · doi:10.1002/mds.21803 · Cited by 1,239
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease
Gerhard, A., Pavese, N., Hotton, G., Turkheimer, F., Es, M., Hammers, A., Eggert, K., Oertel, W., Banati, R. B., & Brooks, D. J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.08.002 · Cited by 1,200
Schenck, C. H., Bundlie, S. R., & Mahowald, M. W. (1996) · Neurology · doi:10.1212/wnl.46.2.388 · Cited by 1,083
Iranzo, Á., Molinuevo, J. L., Santamaría, J., Serradell, M., Martı́, M. J., Valldeoriola, F., & Tolosa, E. S. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70476-8 · Cited by 976
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Sorted by citations
Items 101–146 of 146
Özkan, T., Ateş, Y., Erkoç, A., Karadağ, Y. S., & Ünlüer, N. Ö. (2024) · Journal of Basic and Clinical Health Sciences · doi:10.30621/jbachs.1518833 · Cited by 2
Aghakhani, N., Arzoo, A., Dorflinger, B. G., Athari, S. Z., & Mohaddes, G. (2025) · Brain Disorders · doi:10.1016/j.dscb.2025.100297 · Cited by 2
AI-powered speech analysis for early prediction of Parkinson's disease:
Chauhan, R., Sharma, U., & Singh, D. (2026) · Digital Health · doi:10.1177/20552076261432053 · Cited by 2
“Prodromal signs are subtle and often overlooked, 7,8 while conventional diagnostic tools like neurological exams, imaging, and patient history exist, they lack sensitivity at the earliest stages.”
Unnithan, D., Sartaj, A., Iqubal, M., Ali, J., & Baboota, S. (2024) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2024.2331214
“…dyskinesia, progressive disease trajectory, and persistent asymmetry predominantly affecting the side of initial onset the presence collectively signal the presence of PD. Taking into consideration the above-mentioned criteria, a physician will come to a clinical diagnosis of PD [21,22].”
BackgroundAhangar, A. A., Saadat, P., Hajian‐Tilaki, K., & Kiapasha, G. (2018) · Archives of Neuroscience · doi:10.5812/archneurosci.61085 · Cited by 2
“Inclusion criteria were having a diagnosis of PD in accordance with common criteria and four cardinal features based on UK Brain Bank Criteria (20), patient’s consent, the possibility of taking blood samples to measure serum vitamin D levels, and access to patients and their information during the study.”
MethodAllen, J. E., & Miles, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-28852-5_12 · Cited by 2
Dépression et maladie de Parkinson
Spampinato, U., & Tison, F. (2012) · Encyclopédie médico-chirurgicale. Neurologie · doi:10.1016/s0246-0378(12)35611-x · Cited by 2
Liu, Z., Lemus, J., Smirnova, I. V., & Liu, W. (2023) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2023.00049 · Cited by 1
Bonini, L. D. S., dos Santos, A. P., Vitor, J. D. S., Brasolotto, A. G., Antonetti, A. E. D. S., & Silvério, K. C. A. (2024) · Journal of Voice · doi:10.1016/j.jvoice.2024.03.031 · Cited by 1
Cavallieri, F., Fraternali, A., Arnone, A., Campanini, I., Marti, A., Gessani, A., Fioravanti, V., Molinari, M. A., Rauso, G. D., Antonelli, F., et al. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14121150 · Cited by 1
“A previous diagnosis of PD was made in accordance with the UK Brain Bank criteria [14].”
Eker, S., Karaküçük, Y., Gümüş, H., TEKNECİ, S., & Acar, U. (2025) · Journal of Research in Medical Sciences · doi:10.4103/jrms.jrms_250_24 · Cited by 1
“[27,28] The diagnosis was confirmed by an experienced neurologist (H. G.).”
Early Detection of Parkinson's Disease Using a Multimodal Machine Learning Model
Sundaresan, A., & Veeramani, K. (2026) · International Conference on Advances in Electrical, Computing, Communication and Sustainable Technologies (ICAECT) · doi:10.1109/icaect68478.2026.11426081 · Cited by 1
“Traditional PD diagnosis relies predominantly on clinical assessments performed by neurologists such as MDS - UPDRS(Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale) [2].”
Nocturnal manifestations of Parkinson’s disease and atypical Parkinsonism
Reichmann, H., & Bhidayasiri, R. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1186-2 · Cited by 1
“REM sleep behaviour disorder (RBD) is associated with hyposmia, constipation and depression as among the most frequent and important pre-motor symptoms in PD (Bhidayasiri and Reichmann 2013; Reichmann 2010).”
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Hidasi, E. (2010) · University of Debrecen Electronic Archive (University of Debrecen) · Cited by 1
Parkinsonism and D-512, dopamine D2/3 receptor agonist; A review of literature
Waleed, M. S. (2020) · International Journal of Clinical Case Reports and Reviews · doi:10.31579/2690-4861/077 · Cited by 1
“Microganthia and hypophonia are also associated with PD [36-38].”
BackgroundEnhancing FoG Detection with Wavelet Transforms Using Random Forest and Neural Networks
Ayeesha Banu, W., & Shilpa, N. (2024) · IEEE International Conference for Women in Computing (InCoWoCo) · doi:10.1109/incowoco64194.2024.10863094 · Cited by 1
Aarsland, D., Cummings, J. L., Weintraub, D., & Chaudhuri, К. R. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139856669.002 · Cited by 1
Late or early treatment in Parkinson's disease?
Jost, W. H. (2013) · Basal Ganglia · doi:10.1016/j.baga.2013.02.001
Depressione e malattia di Parkinson
Spampinato, U., & Tison, F. (2013) · EMC - Neurologia · doi:10.1016/s1634-7072(12)63928-2
Management of psychotic symptoms in Parkinson’s disease
Friedman, J. H. (2012) · Clinical Practice · doi:10.2217/cpr.11.85
Singh, G. (2016) · KU ScholarWorks (The University of Kansas)
Patients with Parkinsonism and Sleep Problems
Berry, R. B., & Wagner, M. H. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-7051-9.00109-1
Sleep and Neurologic Disorders
Berry, R. B. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0326-9.00031-2
Effect of exercise therapy in multi disiciplainary approach of parkinson disorder: A short review
Sheebakauser, M., Vandanapu, S., Irani, A., Kodurupaka, P., Bhartiya, M., & Devi, V. S. (2020) · IP Indian Journal of Neurosciences · doi:10.18231/j.ijn.2020.052
Sambyal, S., Karhail, S., & Monga, S. (2021) · PARIPEX-INDIAN JOURNAL OF RESEARCH · doi:10.36106/paripex/1201684
Does Motor Freezing Affect Gait and Balance Functions in Parkinson's Patients?
Usta, A., Balkan, A. F., Salcı, Y., Topuz, S., Çakmaklı, G. Y., Aksoy, S., Armutlu, K., & Elibol, B. (2021) · Hacettepe Üniversitesi Sağlık Bilimleri Fakültesi Dergisi · doi:10.21020/husbfd.932935
Parkinsons Disease: Recent Advancement and Future Aspects
Indrakshi, T., Aparna, A., Krishna, H., Aashul, N., & Rajawat, J. S. (2022) · International Journal for Research in Applied Science and Engineering Technology · doi:10.22214/ijraset.2022.47171
Impairement of functional ability in patients with Parkinson’s disease, a qualitative study
Mathew, M. M., & Suresh, J. (2022) · doi:10.56984/8zg20ak5q
Walters, K. R., Armstrong, M., Gardner, B., Ambler, G., Hunter, R. M., Maydon, B., Davies, N., Atkinson, C., Brown, R. G., Rookes, T., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3067426/v1
Rookes, T., Armstrong, M., Walters, K. R., Read, J., Chesterman, E., Davies, N., Pigott, J., Nimmons, D., Ambler, G., Adeleke, M., et al. (2025) · Parkinson s Disease · doi:10.1155/padi/2804226
“• Community-dwelling adults (i.e., 18 years and above) • A confrmed diagnosis of PD (defned using UK Brain Bank Criteria [24]), including those with dementia diagnosed at least 1 year after their PD diagnosis.”
Li, H., Wei, M., Zhu, X., Yang, X., Tong, Q., & Han, Q. (2025) · Brain and Behavior · doi:10.1002/brb3.70806
Walters, K. R., Armstrong, M., Gardner, B., Ambler, G., Hunter, R. M., Maydon, B., Davies, N., Atkinson, C., Brown, R. G., Rookes, T., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26650005
Walters, K. R., Armstrong, M., Gardner, B., Ambler, G., Hunter, R. M., Maydon, B., Davies, N., Atkinson, C., Brown, R. G., Rookes, T., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24751370
Walters, K. R., Armstrong, M., Gardner, B., Ambler, G., Hunter, R. M., Maydon, B., Davies, N., Atkinson, C., Brown, R. G., Rookes, T., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24751647
Walters, K. R., Armstrong, M., Gardner, B., Ambler, G., Hunter, R. M., Maydon, B., Davies, N., Atkinson, C., Brown, R. G., Rookes, T., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26650002
Gubinelli, F. (2019) · theses.fr (ABES) · doi:10.70675/b37261d3zcc7bz45bezb526z9e35982e09bb
Eyeblink conditioning is preserved in Parkinson’s disease with tremor
Batzianouli, E. T., Schoenfeldt-Reichmann, E. T., Geiser, E., Herrmann, F., & Benninger, D. H. (2026) · Clinical Neurophysiology · doi:10.1016/j.clinph.2026.2111891
黄, 佳. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.1641718
Smith, D., & Schoonbee, J. (2026) · Springer eBooks · doi:10.1007/978-3-031-90919-1_11-1
Exploratory multi‑omics analysis for candidate biomarker identification in Parkinson’s disease
Liu, T., Cao, S., Liang, H., & Wei, J. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.05.035
Stephenson, D. T., Concha‐Marambio, L., Lanz, T. A., Merchant, K., Brockmann, K., King, N. M. P., Carrillo, L., Pedata, A., Kocherla, H., & Hutten, S. J. (2026) · Journal of Parkinson s Disease · doi:10.1177/1877718x261463936 · Cited by 1
“15 DLB can present with parkinsonism but is characterized by visual hallucinations and cognitive decline leading to dementia.”
Dai, P., Zhao, J., Xue, C., Xu, K., Liang, Y., Zhang, Z., Huang, Y., Shuai, J., Chen, X., Nie, S., et al. (2026) · Advanced Science · doi:10.1002/advs.77842
“The primary pathological feature of PD is the progressive loss of dopaminergic neurons in the substantia nigra pars compacta, which leads to a marked decrease in dopamine levels in the brain and consequently gives rise to characteristic symptoms of PD, like bradykinesia and tremor [ 2, 3 ].”
The Role of Mediterranean, MIND, and Ketogenic Diets in the Management of Parkinson’s Disease
Şahin, İ. N., & Yıldıran, H. (2026) · Current Nutrition Reports · doi:10.1007/s13668-026-00813-w
“…effects of diet and nutritional factors on the onset and progression of PD. Research examining the effects of diet on neurodegenerative diseases suggests that dietary habits may influence pathophysiological mechanisms such as oxi - dative stress, inflammation, and mitochondrial dysfunction [9].”
Role of ER Stress in Dysfunction of the Nervous System
Kanekura, K., Lu, S., Lipson, K. L., & Urano, F. (2012) · Springer eBooks · doi:10.1007/978-94-007-4351-9_13
Metadata
- Authors
- Reichmann, H.
- Affiliations
- University Hospital Carl Gustav Carus (DE)
- Corresponding author
- Reichmann, Heinz
- ORCID
- Reichmann, Heinz
- Venue
- Neurodegenerative Diseases
- Publisher
- S. Karger AG
- Published
- 2010
- Volume
- 7
- Issue
- 5
- Pages
- 284-290
- ISSN
- 1660-2854 (ISSN-L)
- 1660-2862
- OpenAlex
- W2080778120
- Cited by
- 145
- References
- 60
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 18 · 2023: 7 · 2022: 11 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 9 · 2017: 11 · 2016: 12 · 2015: 9 · 2014: 7 · 2013: 10 · 2012: 7
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurodegenerative Diseases (publishedVersion)
- PubMed (publishedVersion)
- Qucosa (Saxon State and University Library Dresden) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Parkinson's disease, diagnosis, bradykinesia, postural instability, REM sleep behavior disorder, hyposmia, constipation, depression, genetic testing, apomorphine test, SPECT, PET, essential tremor, atypical Parkinson's disease
- MeSH terms
- Diagnostic Imaging, Humans, Movement, Parkinson Disease, Point-of-Care Systems, Clinical Laboratory Techniques, Early Diagnosis
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