Beneficial Effects of Probiotic Bifidobacterium and Galacto-Oligosaccharide in Patients with Ulcerative Colitis: A Randomized Controlled Study
Abstract
Background/Aim: In previous studies, we described the beneficial effects of bifidobacteria-fermented milk in patients with ulcerative colitis (UC). Here, we examined the effects of a live Bifidobacterium breve strain Yakult, a probiotic contained in bifidobacteria-fermented milk, and galacto-oligosaccharide (GOS) as synbiotics in UC patients. Methods: Forty-one patients with mild to moderate UC were assigned to two groups; one group was treated with the synbiotics and the other was not (control). The treatment group ingested 1 g of the probiotic powder (109 CFU/g) three times a day, and 5.5 g of GOS once a day for one year. At the start and the end of this study, colonoscopic index and the amount of myeloperoxidase in a lavage solution were used as disease activity indices. Bacterial counts in the feces at the start and the end of this study were also examined. Results: After a one-year treatment with the synbiotics, the clinical status of the UC patients as assessed by colonoscopy, significantly improved. Furthermore, the amount of myeloperoxidase in the lavage also decreased in these patients after the synbiotic treatment. The synbiotics significantly reduced the fecal counts of Bacteroidaceae and fecal pH. Conclusion: Administration of live B. breve strain Yakult and GOS can improve the clinical condition of patients with UC. These results encouraged us to perform a large-scale randomized, placebo-controlled trial.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The two B. breve strains included in Table 2 were tested together with other bacteria or with prebiotics such as galacto-oligosaccharides.
“the two strains of B. breve included in the table were tested together with some of these bacteria [139,141] , or even with prebiotics such as galacto-oligosaccharides [140]”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [140]
Cites
AFRC, R. F. (1989) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1989.tb05105.x · Cited by 4,831 · see citing works
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413 · see citing works
Kruis, W., Frič, P., Pokrotnieks, J., Lukáš, M., Fixa, B., Kaščák, M., Kamm, M. A., Weismueller, J., Beglinger, C., Stolte, M., et al. (2004) · Gut · doi:10.1136/gut.2003.037747 · Cited by 1,285 · see citing works
Furrie, E., Macfarlane, S., Kennedy, A., Cummings, J. H., Walsh, S. V., O’Neil, D. A., & Macfarlane, G. T. (2005) · Gut · doi:10.1136/gut.2004.044834 · Cited by 766 · see citing works
VSL#3 Probiotic-Mixture Induces Remission in Patients with Active Ulcerative Colitis
Bibiloni, R., Fedorak, R. N., Tannock, G. W., Madsen, K. L., Gionchetti, P., Campieri, M., Simone, C. D., & Sartor, R. B. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41794.x · Cited by 743 · see citing works
Kato, K., Mizuno, S., Umesaki, Y., Ishii, Y., Sugitani, M., Imaoka, A., Otsuka, M., Hasunuma, O., Kurihara, R., Iwasaki, A., et al. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02268.x · Cited by 397 · see citing works
Self-citationA pilot trial of Saccharomyces boulardii in ulcerative colitis
Guslandi, M., Giollo, P., & Testoni, P. A. (2003) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200306000-00017 · Cited by 383 · see citing works
G Protein-Coupled Receptor 43 Is Essential for Neutrophil Recruitment during Intestinal Inflammation
Sina, C., Gavrilova, O., Förster, M., Till, A., Derer, S., Hildebrand, F., Rabe, B., Chalaris, A., Scheller, J., Rehmann, A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900063 · Cited by 377 · see citing works
Randomized Controlled Trial of the Effect of Bifidobacteria-Fermented Milk on Ulcerative Colitis
Ishikawa, H., Akedo, I., Umesaki, Y., Tanaka, R., Imaoka, A., & Otani, T. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719276 · Cited by 369 · see citing works
Self-citationEarly administration of Bifidobacterium breve to preterm infants: randomised controlled trial
Kitajima, H., Sumida, Y., Tanaka, R., Yuki, N., Takayama, H., & Fujimura, M. (1997) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.76.2.f101 · Cited by 315 · see citing works
Self-citationTHE VALUE OF RECTAL BIOPSY IN THE DIAGNOSIS OF ULCERATIVE COLITIS1
Matts, S. G. F. (1961) · QJM · doi:10.1093/oxfordjournals.qjmed.a066953 · Cited by 311 · see citing works
Imaoka, A., Shima, T., Kato, K., Mizuno, S., Uehara, T., Matsumoto, S., Setoyama, H., Hara, T., & Umesaki, Y. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.2511 · Cited by 179 · see citing works
Self-citationWatanabe, T., Nishio, H., Tanigawa, T., Yamagami, H., Okazaki, H., Watanabe, K., Tominaga, K., Fujiwara, Y., Oshitani, N., Asahara, T., et al. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90553.2008 · Cited by 160 · see citing works
Colitis in transgenic and knockout animals as models of human inflammatory bowel disease
Bhan, A. K., Mizoguthi, E., Smith, R. N., & Mizoguchi, A. (1999) · Immunological Reviews · doi:10.1111/j.1600-065x.1999.tb01316.x · Cited by 151 · see citing works
Matsuda, H., Fujiyama, Y., Andoh, A., Ushijima, T., Kajinami, T., & Bamba, T. (2000) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2000.02045.x · Cited by 133 · see citing works
Carlson, M., Raab, Y., Sevéus, L., Xu, S., Hällgren, R., & Venge, P. (2002) · Gut · doi:10.1136/gut.50.4.501 · Cited by 129 · see citing works
Improved medium for selective isolation and enumeration of Bifidobacterium
Tanaka, R., & Mutai, M. (1980) · Applied and Environmental Microbiology · doi:10.1128/aem.40.5.866-869.1980 · Cited by 108 · see citing works
Self-citationSetoyama, H., Imaoka, A., Ishikawa, H., & Umesaki, Y. (2003) · Microbes and Infection · doi:10.1016/s1286-4579(02)00080-1 · Cited by 106 · see citing works
Self-citationTsuda, Y., Yoshimatsu, Y., Aoki, H., Nakamura, K., Irie, M., Fukuda, K., Hosoe, N., Takada, N., Shirai, K., & Suzuki, Y. (2007) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520701396091 · Cited by 73 · see citing works
Immune Networks in Animal Models of Inflammatory Bowel Disease
Mizoguchi, A., Mizoguchi, E., & Bhan, A. K. (2003) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200307000-00005 · Cited by 72 · see citing works
Matsumoto, S., Watanabe, N., Imaoka, A., & Okabe, Y. (2001) · Digestion · doi:10.1159/000048846 · Cited by 72 · see citing works
Self-citationEnhancement of experimental ulcerative colitis by immunization with Bacteroides vulgatus
Onderdonk, A. B., Cisneros, R. L., & Bronson, R. T. (1983) · Infection and Immunity · doi:10.1128/iai.42.2.783-788.1983 · Cited by 55 · see citing works
Comparison of Bacteroides vulgatus strains in the enhancement of experimental ulcerative colitis
Onderdonk, A. B., Bronson, R. T., & Cisneros, R. L. (1987) · Infection and Immunity · doi:10.1128/iai.55.3.835-836.1987 · Cited by 45 · see citing works
Helphingstine, C. J., Hentges, D. J., Campbell, B. J., Butt, J. H., & Barrett, J. T. (1979) · Journal of Clinical Microbiology · doi:10.1128/jcm.9.3.373-378.1979 · Cited by 19 · see citing works
[Assessment of probiotics according to the international organizations (FAO/WHO)].
Tm, L., & Vs, P. (2006) · PubMed · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Bifidobacteria and Their Role as Members of the Human Gut Microbiota
O’Callaghan, A. A., & van Sinderen, D. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00925 · Cited by 1,108 · see citing works
Actinobacteria: A relevant minority for the maintenance of gut homeostasis
Binda, C., Lopetuso, L. R., Rizzatti, G., Gibiino, G., Cennamo, V., & Gasbarrini, A. (2018) · Digestive and Liver Disease · doi:10.1016/j.dld.2018.02.012 · Cited by 814 · see citing works
Khan, I., Ullah, N., Zha, L., Bai, Y., Khan, A., Zhao, T., Che, T., & Zhang, C. (2019) · Pathogens · doi:10.3390/pathogens8030126 · Cited by 771 · see citing works
ESPEN guideline: Clinical nutrition in inflammatory bowel disease
Forbes, A., Escher, J., Hébuterne, X., Kłęk, S., Krznaric, Z., Schneider, S., Shamir, R., Stardelova, K., Wierdsma, N., Wiskin, A. E., et al. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2016.12.027 · Cited by 625 · see citing works
RetractedIntestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis
Tojo, R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i41.15163 · Cited by 533 · see citing works
Bifidobacteria and Their Health-Promoting Effects
Hidalgo-Cantabrana, C., Delgado, S., Ruiz, L., Ruas-Madiedo, P., Sánchez, B., & Margolles, A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0010-2016 · Cited by 490 · see citing works
Sáez‐Lara, M. J., Gómez‐Llorente, C., Plaza‐Díaz, J., & Gil, Á. (2015) · BioMed Research International · doi:10.1155/2015/505878 · Cited by 390 · see citing works
Probiotics, prebiotics and amelioration of diseases
Tsai, Y.-L., Lin, T.-L., Chang, C.-J., Wu, T.-R., Lai, W.-F., Lu, C.-C., & Lai, H.-C. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-018-0493-6 · Cited by 388 · see citing works
ESPEN guideline on Clinical Nutrition in inflammatory bowel disease
Bischoff, S. C., Bager, P., Escher, J. C., Forbes, A., Hébuterne, X., Hvas, C. L., Joly, F., Kłęk, S., Krznarić, Ž., Ockenga, J., et al. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2022.12.004 · Cited by 399 · see citing works
Ganji‐Arjenaki, M., & Rafieian‐Kopaei, M. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25911 · Cited by 314 · see citing works
ESPEN practical guideline: Clinical Nutrition in inflammatory bowel disease
Bischoff, S. C., Escher, J., Hébuterne, X., Kłęk, S., Krznaric, Z., Schneider, S., Shamir, R., Stardelova, K., Wierdsma, N., Wiskin, A. E., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2019.11.002 · Cited by 351 · see citing works
Jakubczyk, D., Leszczyńska, K., & Górska, S. (2020) · Nutrients · doi:10.3390/nu12071973 · Cited by 314 · see citing works
Dupont, A. W., Richards, Jelinek, K. A., Krill, J. T., Rahimi, E. F., & Ghouri, Y. A. (2014) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s27530 · Cited by 303 · see citing works
New Approaches for Bacteriotherapy: Prebiotics, New-Generation Probiotics, and Synbiotics
Patel, R., & DuPont, H. L. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ177 · Cited by 272 · see citing works
Prebiotics, Probiotics, Synbiotics, Paraprobiotics and Postbiotic Compounds in IBD
Martyniak, A., Medyńska-Przęczek, A., Wędrychowicz, A., Skoczeń, S., & Tomasik, P. (2021) · Biomolecules · doi:10.3390/biom11121903 · Cited by 249 · see citing works
The intestinal microbiota and its role in human health and disease
Kataoka, K. (2016) · The Journal of Medical Investigation · doi:10.2152/jmi.63.27 · Cited by 214 · see citing works
Beyond Heat Stress: Intestinal Integrity Disruption and Mechanism-Based Intervention Strategies
Lian, P., Braber, S., Garssen, J., Wichers, H. J., Folkerts, G., Fink‐Gremmels, J., & Varasteh, S. (2020) · Nutrients · doi:10.3390/nu12030734 · Cited by 202 · see citing works
Zhang, X.-F., Guan, X.-X., Tang, Y.-J., Sun, J.-F., Wang, X.-K., Wang, W.-D., & Fan, J.-M. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02503-5 · Cited by 193 · see citing works
Probiotics for maintenance of remission in ulcerative colitis
Iheozor‐Ejiofor, Z., Kaur, L., Gordon, M. A., Baines, P. A., Sinopoulou, V., & Akobeng, A. K. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007443.pub3 · Cited by 193 · see citing works
Miele, E., Shamir, R., Aloi, M., Assa, A., Braegger, C., Bronsky, J., de Ridder, L., Escher, J. C., Hojsak, I., Kolaček, S., et al. (2018) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001896 · Cited by 191 · see citing works
Zhao, Y., & Jiang, Q. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa104 · Cited by 191 · see citing works
Microbial-Based and Microbial-Targeted Therapies for Inflammatory Bowel Diseases
Oka, A., & Sartor, R. B. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06090-z · Cited by 185 · see citing works
The involvement of gut microbiota in inflammatory bowel disease pathogenesis: Potential for therapy
Cammarota, G., Ianiro, G., Cianci, R., Bibbò, S., Gasbarrini, A., & Currò, D. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.006 · Cited by 180 · see citing works
Intestinal microbiota, probiotics and prebiotics in inflammatory bowel disease
Orel, R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i33.11505 · Cited by 177 · see citing works
Malnutrition and Gut Microbiota in Children
Iddrisu, I., Monteagudo-Mera, A., Poveda, C. G., Pyle, S., Shahzad, M. A., Andrews, S. C., & Walton, G. (2021) · Nutrients · doi:10.3390/nu13082727 · Cited by 170 · see citing works
Ponziani, F. R., Zocco, M. A., D’Aversa, F., Pompili, M., & Gasbarrini, A. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i25.4491 · Cited by 173 · see citing works
Celiberto, L. S., Graef, F. A., Healey, G. R., Bosman, E. S., Jacobson, K., Sly, L. M., & Vallance, B. A. (2018) · Immunology · doi:10.1111/imm.12939 · Cited by 167 · see citing works
Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders
Currò, D., Ianiro, G., Pecere, S., Bibbò, S., & Cammarota, G. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13632 · Cited by 160 · see citing works
Gut Microbiota in Colorectal Cancer: Biological Role and Therapeutic Opportunities
Pandey, H., Tang, D. W. T., Wong, S. H., & Lal, D. (2023) · Cancers · doi:10.3390/cancers15030866 · Cited by 165 · see citing works
Fiber in the Treatment and Maintenance of Inflammatory Bowel Disease
Wedlake, L. J., Slack, N., Andreyev, J. N., & Whelan, K. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000437984.92565.31 · Cited by 160 · see citing works
Akbari, P., Braber, S., Alizadeh, A., Verheijden, K. A. T., Schoterman, M. H. C., Kraneveld, A. D., Garssen, J., & Fink‐Gremmels, J. (2015) · Journal of Nutrition · doi:10.3945/jn.114.209486 · Cited by 147 · see citing works
Yoshimatsu, Y., Yamada, A., Furukawa, R., Sono, K., Osamura, A., Nakamura, K., Aoki, H., Tsuda, Y., Hosoe, N., Takada, N., et al. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i19.5985 · Cited by 137 · see citing works
Exploring the role of the microbiota member Bifidobacterium in modulating immune-linked diseases
O’Neill, I. J., Schofield, Z., & Hall, L. J. (2017) · Emerging Topics in Life Sciences · doi:10.1042/etls20170058 · Cited by 129 · see citing works
Cionci, N. B., Baffoni, L., Gaggìa, F., & Gioia, D. D. (2018) · Nutrients · doi:10.3390/nu10111723 · Cited by 130 · see citing works
Efficacy of Bifidobacterium breve fermented milk in maintaining remission of ulcerative colitis
Matsuoka, K., Uemura, Y., Kanai, T., Kunisaki, R., Suzuki, Y., Yokoyama, K., Yoshimura, N., & Hibi, T. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-4946-2 · Cited by 128 · see citing works
Probiotics and prebiotics in ulcerative colitis
Derikx, L. A. A. P., Dieleman, L. A., & Hoentjen, F. (2016) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2016.02.005 · Cited by 124 · see citing works
Probiotics for inflammatory bowel diseases: a promising adjuvant treatment
Coqueiro, A. Y., Raizel, R., Bonvini, A., Tirapegui, J., & Rogero, M. M. (2018) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2018.1477123 · Cited by 114 · see citing works
Astó, E., Méndez, I., Audivert, S., Farrán-Codina, A., & Espadaler, J. (2019) · Nutrients · doi:10.3390/nu11020293 · Cited by 109 · see citing works
The emerging role of the gut microbiota and its application in inflammatory bowel disease
Xiu, W., Peng, J., Cai, P., Xia, Y., Yi, C., Shang, A., Akanyibah, F. A., & Mao, F. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117302 · Cited by 105 · see citing works
Biological activity of galacto-oligosaccharides: A review
Mei, Z., Yuan, J., & Li, D. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.993052 · Cited by 100 · see citing works
The administration of probiotics and synbiotics in immune compromised adults: is it safe?
van den Nieuwboer, M., Brummer, R. J., Guarner, F., Morelli, L., Cabana, M. D., & Claassen, E. (2014) · Beneficial Microbes · doi:10.3920/bm2014.0079 · Cited by 99 · see citing works
Perioperative dietary therapy in inflammatory bowel disease.
Adamina, M., Gerasimidis, K., Sigall-Boneh, R., Zmora, O., van Overstraeten, A. D. B., Campmans-Kuijpers, M., Ellul, P., Katsanos, K., Kotze, P., Noor, N., et al. (2019) · Journal of Crohn's & Colitis · doi:10.1093/ecco-jcc/jjz160 · Cited by 86 · see citing works
The Effect of Probiotics and Gut Microbiota on Th17 Cells
Tanabe, S. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2013.839665 · Cited by 99 · see citing works
Potential role of nutraceutical compounds in inflammatory bowel disease
Larussa, T., Imeneo, M., & Luzza, F. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i14.2483 · Cited by 88 · see citing works
Synbiotics for Improved Human Health: Recent Developments, Challenges, and Opportunities
Krumbeck, J. A., Walter, J., & Hutkins, R. W. (2018) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030117-012757 · Cited by 84 · see citing works
Dore, M. P., Bibbò, S., Fresi, G., Bassotti, G., & Pes, G. M. (2019) · Nutrients · doi:10.3390/nu11122913 · Cited by 83 · see citing works
Gut microbiota in pathophysiology, diagnosis, and therapeutics of inflammatory bowel disease
Pandey, H., Jain, D., Tang, D. W. T., Wong, S. H., & Lal, D. (2023) · Intestinal Research · doi:10.5217/ir.2023.00080 · Cited by 88 · see citing works
Microbiota in Inflammatory Bowel Disease Pathogenesis and Therapy
Serban, D. E. (2015) · Nutrition in Clinical Practice · doi:10.1177/0884533615606898 · Cited by 77 · see citing works
Probiotics in the Management of Ulcerative Colitis
Chibbar, R., & Dieleman, L. A. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000368 · Cited by 74 · see citing works
Soldavini, J., & Kaunitz, J. D. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-013-2744-4 · Cited by 73 · see citing works
Modulating Composition and Metabolic Activity of the Gut Microbiota in IBD Patients
Matijašić, M., Meštrović, T., Perić, M., Paljetak, H. Č., Panek, M., Bender, D. V., Kelečić, D. L., Krznarić, Ž., & Verbanac, D. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040578 · Cited by 71 · see citing works
Commensal Obligate Anaerobic Bacteria and Health: Production, Storage, and Delivery Strategies
Andrade, J. C., Almeida, D., Domingos, M., Seabra, C. L., Machado, D., Freitas, A. C., & Gomes, A. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00550 · Cited by 77 · see citing works
Keulers, L., Dehghani, A., Knippels, L. M. J., Garssen, J., Papadopoulos, N. G., Folkerts, G., Braber, S., & van Bergenhenegouwen, J. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119066 · Cited by 72 · see citing works
Lomer, M. C. E., Wilson, B., & Wall, C. L. (2022) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.13054 · Cited by 70 · see citing works
ALTUN, H. K., Yıldız, E. A., & Akın, M. (2019) · The Turkish Journal of Gastroenterology · doi:10.5152/tjg.2019.18356 · Cited by 70 · see citing works
Gut microbiota and colorectal cancer
Yamamoto, M., & Matsumoto, S. (2016) · Genes and Environment · doi:10.1186/s41021-016-0038-8 · Cited by 68 · see citing works
Self-citationMicrobial-Derived Tryptophan Catabolites, Kidney Disease and Gut Inflammation
Madella, A. M., van Bergenhenegouwen, J., Garssen, J., Masereeuw, R., & Overbeek, S. A. (2022) · Toxins · doi:10.3390/toxins14090645 · Cited by 66 · see citing works
Targeted Approaches for In Situ Gut Microbiome Manipulation
Lee, H. L., Shen, H., Hwang, I. Y., Ling, H., Yew, W. S., Lee, Y. S., & Chang, M. W. (2018) · Genes · doi:10.3390/genes9070351 · Cited by 68 · see citing works
Jadhav, A., Jagtap, S., Vyavahare, S., Sharbidre, A., & Kunchiraman, B. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1268041 · Cited by 58 · see citing works
Highlighting the Relevance of Gut Microbiota Manipulation in Inflammatory Bowel Disease
Pavel, F. M., Vesa, C. M., Gheorghe, G., Diaconu, C. C., Stoicescu, M., Munteanu, M. A., Babeş, E. E., Ţiţ, D. M., Toma, M. M., & BUNGAU, S. G. (2021) · Diagnostics · doi:10.3390/diagnostics11061090 · Cited by 64 · see citing works
Clinical Evidence for the Microbiome in Inflammatory Diseases
Slingerland, A. E., Schwabkey, Z. I., Wiesnoski, D. H., & Jenq, R. R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00400 · Cited by 64 · see citing works
Pourrajab, B., Fatahi, S., Sohouli, M. H., Găman, M.-A., & Shidfar, F. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1821166 · Cited by 82 · see citing works
Adaptation of bifidobacteria to the gastrointestinal tract and functional consequences
Sánchez, B., Ruíz, L., Gueimonde, M., Ruas‐Madiedo, P., & Margollés, A. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.11.004 · Cited by 64 · see citing works
Li, Q., Zheng, T., Ding, H., Chen, J., Li, B., Zhang, Q., Yang, S., Zhang, S., & Guan, W. (2023) · Antioxidants · doi:10.3390/antiox12071342 · Cited by 60 · see citing works
Huang, C., Hao, W., Wang, X., Zhou, R., & Lin, Q. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1211271 · Cited by 59 · see citing works
Ashique, S., Mishra, N., Garg, A., Sibuh, B. Z., Taneja, P., Rai, G., Djearamane, S., Wong, L. S., Al‐Dayan, N., Roychoudhury, S., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1126579 · Cited by 58 · see citing works
Ulcerative colitis as a polymicrobial infection characterized by sustained broken mucus barrier
Chen, S.-J., Liu, X., Liu, J.-P., Xi-yan, Y., & Lu, F. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i28.9468 · Cited by 58 · see citing works
Selvamani, S., Mehta, V. K., Enshasy, H. A. E., Thevarajoo, S., Adawi, H. E., Zeini, I. M., Pham, K. T., Varzakas, T. H., & Abomoelak, B. (2022) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2022.02.044 · Cited by 56 · see citing works
Wilson, B., Eyice, Ö., Koumoutsos, I., Lomer, M. C. E., Irving, P. M., Lindsay, J. O., & Whelan, K. (2021) · Nutrients · doi:10.3390/nu13103598 · Cited by 52 · see citing works
Enteric microbiota leads to new therapeutic strategies for ulcerative colitis
Chen, W.-X. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i42.15657 · Cited by 51 · see citing works
An introduction of the role of probiotics in human infections and autoimmune diseases
Sales‐Campos, H., Soares, S. D. C., & Oliveira, C. J. F. (2019) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2019.1621261 · Cited by 50 · see citing works
Cheng, Y., Jin, U.-H., Davidson, L. A., Chapkin, R. S., Jayaraman, A., Tamamis, P., Orr, A., Allred, C., Denison, M. S., Soshilov, A., et al. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfw230 · Cited by 48 · see citing works
Vakadaris, G., Stefanis, C., Giorgi, E., Brouvalis, M., Voidarou, C. C., Kourkoutas, Y., Tsigalou, C., & Bezirtzoglou, E. (2023) · Biomedicines · doi:10.3390/biomedicines11020494 · Cited by 48 · see citing works
Gut Microbiome as a Target of Intervention in Inflammatory Bowel Disease Pathogenesis and Therapy
Hetta, . F., Ramadan, Y. N., Alharbi, A. A., Alsharif, S. M., Alkindy, T. T., Alkhamali, A., Albalawi, A. S., & El‐Amin, H. (2024) · Immuno · doi:10.3390/immuno4040026 · Cited by 50 · see citing works
Microbe-metabolite-host axis, two-way action in the pathogenesis and treatment of human autoimmunity
Meng, X. L., Zhou, H., Shen, H., Lufumpa, E., Li, X., Guo, B., & Li, B. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.03.006 · Cited by 45 · see citing works
Prebiotics and synbiotics in ulcerative colitis
Laurell, A., & Sjöberg, K. (2016) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2016.1263680 · Cited by 44 · see citing works
Hu, Y., Ye, Z., Wu, M., She, Y., Li, L., Xu, Y.-J., Qin, K., Hu, Z., Yang, M., Lu, F., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.766126 · Cited by 44 · see citing works
Lunken, G., Tsai, K., Schick, A., Lisko, D. J., Cook, L. E., Vallance, B. A., & Jacobson, K. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.06.011 · Cited by 42 · see citing works
Probiotics for inflammatory bowel disease: Is there sufficient evidence?
Ma, Y., Yang, D., Huang, J., Liu, K., Liu, H., Wu, H., & Bao, C. (2024) · Open Life Sciences · doi:10.1515/biol-2022-0821 · Cited by 42 · see citing works
Sivamaruthi, B. S. (2018) · Asian Pacific Journal of Tropical Biomedicine · doi:10.4103/2221-1691.228000 · Cited by 42 · see citing works
Hong, D., Kim, H. K., Yang, W., Yoon, C., Kim, M., Yang, C., & Yoon, S. (2024) · Communications Biology · doi:10.1038/s42003-024-06409-w · Cited by 39 · see citing works
Liu, Y., Li, Y., Yu, X., Yu, L., Tian, F., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2020) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2003.03041 · Cited by 39 · see citing works
Prebiotics and Inflammatory Bowel Disease
Rasmussen, H. E., & Hamaker, B. R. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2017.08.004 · Cited by 38 · see citing works
Therapeutic applications of probiotics in ulcerative colitis: An updated review
Dhillon, P., & Singh, K. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100194 · Cited by 37 · see citing works
Petrova, P. M., & Petrov, K. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811413-1.00007-3 · Cited by 36 · see citing works
Li, Y., Liu, M., Zhou, J., Hou, B., Su, X.-H., Liu, Z., Yuan, J., & Li, M. (2019) · Beneficial Microbes · doi:10.3920/bm2018.0122 · Cited by 32 · see citing works
Kangwan, N., Kongkarnka, S., Boonkerd, N., Unban, K., Shetty, K., & Khanongnuch, C. (2022) · Nutrients · doi:10.3390/nu14010227 · Cited by 32 · see citing works
Bifidobacteria and Their Health-Promoting Effects
Hidalgo-Cantabrana, C., Delgado, S., Ruíz, L., Ruas‐Madiedo, P., Sánchez, B., & Margollés, A. (2018) · ASM Press eBooks · doi:10.1128/9781555819705.ch3 · Cited by 31 · see citing works
Lê, A., Mantel, M., Marchix, J., Bodinier, M., Jan, G., & Rolli‐Derkinderen, M. (2022) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00002.2022 · Cited by 30 · see citing works
Mangiferin attenuates DSS colitis in mice: Molecular docking and in vivo approach
Somani, S. J., Zambad, S. P., & Modi, K. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.04.033 · Cited by 30 · see citing works
Synbiotics improve clinical indicators of ulcerative colitis: systematic review with meta-analysis
Rufino, M. N., da Costa, A. L., Jorge, E. N., Paiano, V. F., Camparoto, M. L., Keller, R., & Bremer‐Neto, H. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuab017 · Cited by 30 · see citing works
Kitagaki, H. (2021) · Journal of Fungi · doi:10.3390/jof7040243 · Cited by 29 · see citing works
Probiotic actions on diseases: implications for therapeutic treatments
Chiu, Y., Lin, S.-L., Tsai, J., & Lin, M. (2014) · Food & Function · doi:10.1039/c3fo60600g · Cited by 28 · see citing works
Tian, S., Paudel, D., Hao, F., Neupane, R., Castro, R., Patterson, A. D., Tiwari, A. K., Prabhu, K. S., & Singh, V. (2023) · Cancer Reports · doi:10.1002/cnr2.1863 · Cited by 28 · see citing works
Bifidobacteria in Fermented Dairy Foods: A Health Beneficial Outlook
Jena, R., & Choudhury, P. K. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10189-w · Cited by 36 · see citing works
Barnes, D. M., & Yeh, A. M. (2015) · Nutrition in Clinical Practice · doi:10.1177/0884533615610081 · Cited by 27 · see citing works
First and second generation probiotic therapeutics for Inflammatory Bowel Disease
Sireswar, S., Ghosh, I., & Dey, G. (2019) · PharmaNutrition · doi:10.1016/j.phanu.2019.100159 · Cited by 26 · see citing works
Synergy between oligosaccharides and probiotics: From metabolic properties to beneficial effects
Han, D., Żulewska, J., Xiong, K., & Yang, Z. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2139218 · Cited by 27 · see citing works
Akiyama, T., Kimura, K., & Hatano, H. (2014) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2014.987204 · Cited by 27 · see citing works
Probiotics and Their Metabolites Ameliorate Inflammatory Bowel Disease: A Critical Review
Liang, Y., Liu, M., Pu, J., Zhu, Z., Gao, Z., Zhou, Q., Gu, Q., & Li, P. (2020) · Infectious Microbes & Diseases · doi:10.1097/im9.0000000000000046 · Cited by 25 · see citing works
- Authors
- Ishikawa, H., Matsumoto, S., Ohashi, Y., Imaoka, A., Setoyama, H., Umesaki, Y., Tanaka, R., & Otani, T.
- Affiliations
- Kyoto Prefectural University of Medicine (JP)
- Yakult Central Institute (JP)
- Osaka International Cancer Institute (JP)
- Venue
- Digestion
- Publisher
- S. Karger AG
- Published
- 2011
- Volume
- 84
- Issue
- 2
- Pages
- 128-133
- ISSN
- 0012-2823 (ISSN-L)
- 1421-9867
- OpenAlex
- W2050226660
- Cited by
- 197
- References
- 25
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 19 · 2023: 16 · 2022: 14 · 2021: 21 · 2020: 19 · 2019: 15 · 2018: 14 · 2017: 17 · 2016: 11 · 2015: 11 · 2014: 14 · 2013: 4 · 2012: 7
- FWCI
- 12.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Digestion (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- ulcerative colitis, Bifidobacterium breve, Yakult, galactooligosaccharides, synbiotics, probiotics, myeloperoxidase, fecal pH, disease activity, colonoscopy
- MeSH terms
- Adult, Bifidobacterium, Colitis, Ulcerative, Colonoscopy, Feces, Female, Humans, Male, Middle Aged, Peroxidase, Oligosaccharides, Severity of Illness Index, Probiotics, Prebiotics, Synbiotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
