Synbiotics for Improved Human Health: Recent Developments, Challenges, and Opportunities
Open accessAbstract
Research on combining pro- and prebiotics as synbiotics to enhance human and animal health has accelerated in the past 10 years, including many clinical trials that have assessed a diverse range of synbiotic formulations. In this review, we summarize these studies as well as the commercial applications of synbiotics that are available. In particular, we critically assess the claimed health benefits of synbiotic applications and the ecological and therapeutic factors to consider when designing synbiotics and discuss the implications of these concepts for future research in this field.
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Autochthonous bacterial strains could metabolize the administered prebiotics starting an antagonistic relationship against probiotics for the same fiber utilization.
“moreover, it is clearly established that autochthonous bacterial strains could metabolize the administered prebiotics starting an antagonistic relationship against probiotics for the same fiber utilization [23].”
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- Authors
- Krumbeck, J. A., Walter, J., & Hutkins, R. W.
- Affiliations
- University of Nebraska–Lincoln (US)
- University of Alberta (CA)
- Venue
- Annual Review of Food Science and Technology
- Publisher
- Annual Reviews
- Published
- 2018-03-25
- Volume
- 9
- Issue
- 1
- Pages
- 451-479
- ISSN
- 1941-1421 (ISSN-L)
- 1941-1413
- OpenAlex
- W2619400681
- Cited by
- 84
- References
- 170
- Citations by year
- 2026: 12 · 2025: 10 · 2024: 16 · 2023: 9 · 2022: 11 · 2021: 6 · 2020: 8 · 2019: 8 · 2018: 4
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- Locations
- Annual Review of Food Science and Technology (publishedVersion)
- PubMed (publishedVersion)
- Lincoln (University of Nebraska) (submittedVersion)
- Funders
- U.S. Department of Agriculture
- European Food Safety Authority
- European Commission
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- synbiotics, probiotics, prebiotics, gut microbiota, human health, animal health, clinical trials, health claims
- MeSH terms
- Gastrointestinal Microbiome, Clinical Trials as Topic, Humans, Synbiotics
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