Probiotics, prebiotics and amelioration of diseases
Open accessAbstract
Dysbiosis of gut microbiota is closely related to occurrence of many important chronic inflammations-related diseases. So far the traditionally prescribed prebiotics and probiotics do not show significant impact on amelioration of these diseases in general. Thus the development of next generation prebiotics and probiotics designed to target specific diseases is urgently needed. In this review, we first make a brief introduction on current understandings of normal gut microbiota, microbiome, and their roles in homeostasis of mucosal immunity and gut integrity. Then, under the situation of microbiota dysbiosis, development of chronic inflammations in the intestine occurs, leading to leaky gut situation and systematic chronic inflammation in the host. These subsequently resulted in development of many important diseases such as obesity, type 2 diabetes mellitus, liver inflammations, and other diseases such as colorectal cancer (CRC), obesity-induced chronic kidney disease (CKD), the compromised lung immunity, and some on brain/neuro disorders. The strategy used to optimally implant the effective prebiotics, probiotics and the derived postbiotics for amelioration of the diseases is presented. While the effectiveness of these agents seems promising, additional studies are needed to establish recommendations for most clinical settings.
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Psychobiotics impact the hypothalamic-pituitary-adrenal (HPA) axis, reducing stress hormone levels and promoting mental well-being.
“Psychobiotics impact the hypothalamic–pituitary–adrenal (HPA) axis, reducing stress hormone levels and promoting mental well-being.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [42]
The Introduction section on mechanisms of probiotics and prebiotics administration says some strains modulate neurological and brain-behavior effects and have endocrine-modulation effects. It does not identify psychobiotics or say that they act on the HPA axis, reduce stress hormones, or promote mental well-being. (LLM, conf=0.82)
Experimental — accuracy not yet measuredThrough the synthesis of neurotransmitters like serotonin, gamma-aminobutyric acid, and dopamine, psychobiotics contribute to mood regulation and stress response, potentially alleviating depressive and anxious feelings.
“Through the synthesis of neurotransmitters like serotonin, gamma-aminobutyric acid, and dopamine, psychobiotics contribute to mood regulation and stress response, potentially alleviating depressive and anxious feelings.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [42]
The Introduction’s “Mechanisms of probiotics and prebiotics administration” section says that some strains can modulate neurological and behavioral effects. It does not say that psychobiotics synthesize serotonin, gamma-aminobutyric acid, or dopamine, or connect that proposed mechanism to mood, stress, depression, and anxiety. Searches for those terms found no supporting passage in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measuredPsychobiotics, encompassing probiotics, prebiotics, and postbiotics, have been shown to modulate the gut microbiota, stimulate the development of beneficial bacteria, and alleviate conditions linked to gut dysbiosis, such as depression and anxiety.
“Supported by a body of studies (19, 32, 41–43), psychobiotics have been shown to modulate the gut microbiota, stimulate the development of beneficial bacteria, and alleviate conditions linked to gut dysbiosis, such as depression and anxiety.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [42]
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Experimental — accuracy not yet measuredPsychobiotics may enhance synaptic plasticity, neurotrophic factor production, and maintain the blood-brain barrier's integrity, positively impacting learning, memory retention, and brain health.
“Psychobiotics may enhance synaptic plasticity, neurotrophic factor production, and maintain the blood–brain barrier’s integrity, positively impacting learning, memory retention, and brain health.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [42]
The Introduction’s “Mechanisms of probiotics and prebiotics administration” section says that some strains can modulate neurological and brain-behavior effects. It does not address synaptic plasticity, neurotrophic factors, blood–brain barrier integrity, or improvements in learning and memory; its discussion of barrier integrity concerns the intestine. No page number is available in our copy. (LLM, conf=0.83)
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Cites
Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc11-s062 · Cited by 14,019 · see citing works
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726 · see citing works
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592 · see citing works
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762 · see citing works
Diagnosis and classification of diabetes mellitus
American Diabetes Association (2014) · Diabetes Care · doi:10.2337/dc14-s081 · Cited by 5,974 · see citing works
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579 · see citing works
Role of the microbiota in immunity and inflammation.
Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385 · see citing works
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works
Proteobacteria: Microbial signature of dysbiosis in gut microbiota
Shin, N.-R., Whon, T. W., & Bae, J.-W. (2015) · Trends in Biotechnology · doi:10.1016/j.tibtech.2015.06.011 · Cited by 3,954 · see citing works
Gut microbiota, metabolites and host immunity
Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409 · see citing works
Role of the normal gut microbiota
Jandhyala, S. M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i29.8787 · Cited by 3,001 · see citing works
Human nutrition, the gut microbiome and the immune system
Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588 · see citing works
Succession of microbial consortia in the developing infant gut microbiome
Koenig, J. E., Spor, A., Scalfone, N., Fricker, A. D., Stombaugh, J., Knight, R., Angenent, L. T., & Ley, R. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000081107 · Cited by 2,540 · see citing works
Effects of probiotics, prebiotics, and synbiotics on human health
Markowiak, P., & Śliżewska, K. (2017) · Nutrients · doi:10.3390/nu9091021 · Cited by 2,401 · see citing works
Fiber and prebiotics: Mechanisms and health benefits
Slavin, J. (2013) · Nutrients · doi:10.3390/nu5041417 · Cited by 2,340 · see citing works
Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health
Ríos-Covián, D., Ruas‐Madiedo, P., Margollés, A., Gueimonde, M., Reyes‐Gavilán, C. G. D. L., & Salazar, N. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00185 · Cited by 2,215 · see citing works
Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans
Sender, R., Fuchs, S., & Milo, R. (2016) · Cell · doi:10.1016/j.cell.2016.01.013 · Cited by 2,050 · see citing works
Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians
Biagi, E., Nylund, L., Candela, M., Ostan, R., Bucci, L., Pini, E., Nikkïla, J., Monti, D., Satokari, R., Franceschi, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010667 · Cited by 1,483 · see citing works
Impact of the gut microbiota on inflammation, obesity, and metabolic disease
Boulangé, C. L., Neves, A. L., Chilloux, J., Nicholson, J. K., & Dumas, M.-E. (2016) · Genome Medicine · doi:10.1186/s13073-016-0303-2 · Cited by 1,438 · see citing works
The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy
Gopalakrishnan, V., Helmink, B. A., Spencer, C. N., Reuben, A., & Wargo, J. A. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.015 · Cited by 1,392 · see citing works
Probiotics, prebiotics and synbiotics- a review
Pandey, K. R., Naik, S. R., & Vakil, B. V. (2015) · Journal of Food Science and Technology · doi:10.1007/s13197-015-1921-1 · Cited by 1,350 · see citing works
Regulation of immune cell function by short‐chain fatty acids
Corrêa‐Oliveira, R., Fachi, J. L., Vieira, A., Sato, F. T., & Vinolo, M. A. R. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.17 · Cited by 1,346 · see citing works
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans
Vatanen, T., Kostic, A. D., d’Hennezel, E., Siljander, H., Franzosa, E. A., Yassour, M., Kolde, R., Vlamakis, H., Arthur, T. D., Hämäläinen, A.-M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.007 · Cited by 1,289 · see citing works
Pluznick, J. L., Protzko, R. J., Gevorgyan, H., Peterlin, Z., Sipos, A., Han, J., Brunet, I., Wan, L.-X., Rey, F., Wang, T., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215927110 · Cited by 1,191 · see citing works
Hemarajata, P., & Versalovic, J. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x12459294 · Cited by 1,083 · see citing works
Microorganisms with Claimed Probiotic Properties: An Overview of Recent Literature
Fijan, S. (2014) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph110504745 · Cited by 1,059 · see citing works
Doron, S., & Snydman, D. R. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ085 · Cited by 942 · see citing works
Effects of gut microbes on nutrient absorption and energy regulation
Krajmalnik‐Brown, R., Ilhan, Z., Kang, D., & DiBaise, J. K. (2012) · Nutrition in Clinical Practice · doi:10.1177/0884533611436116 · Cited by 852 · see citing works
Probiotic use in clinical practice: what are the risks?
Boyle, R. J., Robins-Browne, R. M., & Tang, M. L. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1256 · Cited by 776 · see citing works
Furrie, E., Macfarlane, S., Kennedy, A., Cummings, J. H., Walsh, S. V., O’Neil, D. A., & Macfarlane, G. T. (2005) · Gut · doi:10.1136/gut.2004.044834 · Cited by 766 · see citing works
Causes and Timing of Death in Extremely Premature Infants from 2000 through 2011
Patel, R. M., Kandefer, S. C., Walsh, M. C., Bell, E. F., Carlo, W. A., Laptook, A. R., Sánchez, P. J., Shankaran, S., Meurs, K. P. V., Ball, M. B., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1403489 · Cited by 716 · see citing works
An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice
Fei, N., & Zhao, L.-P. (2012) · The ISME Journal · doi:10.1038/ismej.2012.153 · Cited by 713 · see citing works
Pammi, M., Cope, J., Tarr, P. I., Warner, B. B., Morrow, A. L., Mai, V., Gregory, K. E., Kroll, J. S., McMurtry, V., Ferris, M. J., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0248-8 · Cited by 708 · see citing works
Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis
Sivaprakasam, S., Prasad, P. D., & Singh, N. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.007 · Cited by 573 · see citing works
Aachary, A. A., & Prapulla, S. G. (2010) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2010.00135.x · Cited by 557 · see citing works
Gut microbiota and metabolic syndrome
Festi, D., Schiumerini, R., Eusebi, L. H., Marasco, G., Taddia, M., & Colecchia, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i43.16079 · Cited by 534 · see citing works
Towards a better understanding of Lactobacillus rhamnosus GG - host interactions
Segers, M. E., & Lebeer, S. (2014) · Microbial Cell Factories · doi:10.1186/1475-2859-13-s1-s7 · Cited by 508 · see citing works
Probiotics, their health benefits and applications for developing healthier foods: a review
Nagpal, R., Kumar, A., Kumar, M., Behare, P. V., Jain, S., & Yadav, H. (2012) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2012.02593.x · Cited by 496 · see citing works
A Bioinformatician's Guide to Metagenomics
Kunin, V., Copeland, A., Lapidus, A. L., Mavromatis, K., & Hugenholtz, P. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00009-08 · Cited by 492 · see citing works
Warner, B. B., Deych, E., Zhou, Y., Hall-Moore, C. M., Weinstock, G. M., Sodergren, E. J., Shaikh, N., Hoffmann, J. A., Linneman, L. A., Hamvas, A., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00081-7 · Cited by 475 · see citing works
The gut microbiota and its relationship to diet and obesity
Clarke, S. F., Murphy, E. F., Nilaweera, K. N., Ross, R. P., Shanahan, F., O’Toole, P. W., & Cotter, P. D. (2012) · Gut Microbes · doi:10.4161/gmic.20168 · Cited by 458 · see citing works
Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut
Underwood, M. A., German, J. B., Lebrilla, C. B., & Mills, D. A. (2015) · Pediatric Research · doi:10.1038/pr.2014.156 · Cited by 439 · see citing works
Oulas, A., Pavloudi, C., Polymenakou, P., Pavlopoulos, G. A., Papanikolaou, N., Kotoulas, G., Arvanitidis, C., & Iliopoulos, L. (2015) · Bioinformatics and Biology Insights · doi:10.4137/bbi.s12462 · Cited by 423 · see citing works
Discovering probiotic microorganisms: in vitro, in vivo, genetic and omics approaches
Papadimitriou, K., Ζουμποπούλου, Γ., Foligné, B., Alexandraki, V., Κάζου, Μ., Pot, B., & Tsakalidou, E. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00058 · Cited by 388 · see citing works
Bourlioux, P., Koletzko, B. V., Guarner, F., & Braesco, V. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.4.675 · Cited by 348 · see citing works
Regulation of Bacterial Pathogenesis by Intestinal Short-Chain Fatty Acids
Sun, Y., & O’Riordan, M. X. (2013) · Advances in applied microbiology · doi:10.1016/b978-0-12-407672-3.00003-4 · Cited by 338 · see citing works
Altered gut microbial energy and metabolism in children with non-alcoholic fatty liver disease
Michail, S., Lin, M., Frey, M. R., Fanter, R., Paliy, O., Hilbush, B., & Reo, N. V. (2015) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiu002 · Cited by 336 · see citing works
Sáez‐Lara, M. J., Robles-Sánchez, C., Ruiz‐Ojeda, F. J., Plaza‐Díaz, J., & Gil, Á. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060928 · Cited by 331 · see citing works
Senok, A. C., Ismaeel, A. Y., & Botta, G. A. (2005) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2005.01228.x · Cited by 329 · see citing works
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans
Vatanen, T., Kostic, A. D., d’Hennezel, E., Siljander, H., Franzosa, E. A., Yassour, M., Kolde, R., Vlamakis, H., Arthur, T. D., Hämäläinen, A.-M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.056 · Cited by 298 · see citing works
Composition Diversity and Abundance of Gut Microbiome in Prediabetes and Type 2 Diabetes
Shah, V. O., Lambeth, S. M., Carson, T., Lowe, J. R., Ramaraj, T., Leff, J. W., Luo, L., & Bell, C. J. (2015) · Journal of Diabetes and Obesity · doi:10.15436/2376-0949.15.031 · Cited by 286 · see citing works
Proteobacteria-specific IgA regulates maturation of the intestinal microbiota
Mirpuri, J., Raetz, M. M., Sturge, C. R., Wilhelm, C. L., Benson, A., Savani, R. C., Hooper, L. V., & Yarovinsky, F. (2013) · Gut Microbes · doi:10.4161/gmic.26489 · Cited by 279 · see citing works
Fecal Microbiota Transplantation: Indications, Methods, Evidence, and Future Directions
Borody, T. J., Paramsothy, S., & Agrawal, G. (2013) · Current Gastroenterology Reports · doi:10.1007/s11894-013-0337-1 · Cited by 275 · see citing works
Effects of obesity on depression: A role for inflammation and the gut microbiota
Schachter, J., Martel, J., Lin, C.-S., Chang, C., Wu, T.-R., Lu, C., Ko, Y., Lai, H., Ojcius, D. M., & Young, J. D. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.08.026 · Cited by 252 · see citing works
Self-citationNon-alcoholic fatty liver and the gut microbiota
Bashiardes, S., Shapiro, H., Rozin, S., Shibolet, O., & Elinav, E. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.003 · Cited by 241 · see citing works
Diet-driven microbiota dysbiosis is associated with vagal remodeling and obesity
Sen, T., Cawthon, C. R., Ihde, B. T., Hajnal, A., DiLorenzo, P. M., de La Serre, C. B., & Czaja, K. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.02.027 · Cited by 239 · see citing works
A Clinician's Primer on the Role of the Microbiome in Human Health and Disease
Khanna, S., & Tosh, P. K. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.10.011 · Cited by 231 · see citing works
Therapeutic Use of Prebiotics, Probiotics, and Postbiotics to Prevent Necrotizing Enterocolitis
Patel, R. M., & Denning, P. W. (2013) · Clinics in Perinatology · doi:10.1016/j.clp.2012.12.002 · Cited by 218 · see citing works
Amar, J., Lange, C., Payros, G., Garret, C., Chabo, C., Lantieri, O., Courtney, M., Marre, M., Charles, M.-A. A., Balkau, B., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054461 · Cited by 218 · see citing works
Fecal microbiota transplantation in relapsing Clostridium difficile infection
Rohlke, F., & Stollman, N. (2012) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x12453637 · Cited by 214 · see citing works
Probiotics: what are they? What are their effects on gut physiology?
Fioramonti, J., Théodorou, V., & Bueno, L. P. (2003) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/s1521-6918(03)00075-1 · Cited by 212 · see citing works
The role of the gut microbiota in metabolic health
Janssen, A. W. F., & Kersten, S. (2015) · The FASEB Journal · doi:10.1096/fj.14-269514 · Cited by 199 · see citing works
Ishikawa, H., Matsumoto, S., Ohashi, Y., Imaoka, A., Setoyama, H., Umesaki, Y., Tanaka, R., & Otani, T. (2011) · Digestion · doi:10.1159/000322977 · Cited by 197 · see citing works
Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanisms and Therapy
Ma, J., Zhou, Q., & Li, H. (2017) · Nutrients · doi:10.3390/nu9101124 · Cited by 197 · see citing works
Bacteria in the Intestine, Helpful Residents or Enemies from Within?
Canny, G., & McCormick, B. A. (2008) · Infection and Immunity · doi:10.1128/iai.00187-08 · Cited by 189 · see citing works
Butyrate and glucose metabolism by colonocytes in experimental colitis in mice
Ahmad, M. S., Krishnan, S., Ramakrishna, B., Mathan, M. M., Pulimood, A. B., & Murthy, S. N. (2000) · Gut · doi:10.1136/gut.46.4.493 · Cited by 186 · see citing works
Intestinal Microbial Ecology and Environmental Factors Affecting Necrotizing Enterocolitis
Torrazza, R. J. M., Ukhanova, M., Wang, X., Sharma, R. R., Hudak, M. L., Neu, J., & Mai, V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083304 · Cited by 184 · see citing works
Epidemiological Interpretation of Studies Examining the Effect of Antibiotic Usage on Resistance
Schechner, V., Temkin, E., Harbarth, S., Carmeli, Y., & Schwaber, M. J. (2013) · Clinical Microbiology Reviews · doi:10.1128/cmr.00001-13 · Cited by 179 · see citing works
Hsieh, T.-H., Kuo, C.-W., Hsieh, K.-H., Shieh, M.-J., Peng, C.-W., Chen, Y.-C., Chang, Y.-L., Huang, Y.-Z., Chen, C.-C., Chang, P.-K., et al. (2020) · Brain Sciences · doi:10.3390/brainsci10040206 · Cited by 174 · see citing works
Probiotics and necrotizing enterocolitis
Patel, R. M., & Underwood, M. A. (2017) · Seminars in Pediatric Surgery · doi:10.1053/j.sempedsurg.2017.11.008 · Cited by 170 · see citing works
Trosvik, P., & de Muinck, E. J. (2015) · Microbiome · doi:10.1186/s40168-015-0107-4 · Cited by 168 · see citing works
C. Vaughn, A., M. Cooper, E., M. DiLorenzo, P., J. O’Loughlin, L., E. Konkel, M., H. Peters, J., Hajnal, A., Sen, T., Hye Lee, S., B. de La Serre, C., et al. (2017) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2017-033 · Cited by 166 · see citing works
Can probiotics benefit children with autism spectrum disorders?
Navarro, F., Liu, Y., & Rhoads, J. M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i46.10093 · Cited by 154 · see citing works
Selvanantham, T., Lin, Q., Guo, C. X., Surendra, A., Fiévé, S., Escalante, N. K., Guttman, D. S., Streutker, C., Robertson, S. J., Philpott, D. J., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1601410 · Cited by 121 · see citing works
Johanesen, P., Mackin, K. E., Hutton, M. L., Awad, M. M., Larcombe, S., Amy, J., & Lyras, D. (2015) · Genes · doi:10.3390/genes6041347 · Cited by 112 · see citing works
EPIDEMIOLOGY OF COLORECTAL CANCER
Janout, V., & Kollárová, H. (2001) · Biomedical Papers · doi:10.5507/bp.2001.001 · Cited by 111 · see citing works
Understanding gastrointestinal perfusion in critical care: so near, and yet so far.
Ackland, G. L., Grocott, M. P. W., & Mythen, M. G. (2000) · Critical Care · doi:10.1186/cc709 · Cited by 102 · see citing works
The Biosynthesis of Lipooligosaccharide from Bacteroides thetaiotaomicron
Jacobson, A. N., Choudhury, B., & Fischbach, M. A. (2018) · mBio · doi:10.1128/mbio.02289-17 · Cited by 87 · see citing works
The Promising Role of Probiotics in Managing the Altered Gut in Autism Spectrum Disorders
Abdellatif, B., McVeigh, C., Bendriss, G., & Châari, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114159 · Cited by 84 · see citing works
The potential impact of gut on your health: Current status and future challenges
Sirisinha, S. (2016) · Asian Pacific Journal of Allergy and Immunology · doi:10.12932/ap0803 · Cited by 83 · see citing works
Probiotics in Inflammatory Bowel Diseases and Associated Conditions
Mack, D. R. (2011) · Nutrients · doi:10.3390/nu3020245 · Cited by 78 · see citing works
Anti-tumor activities of probiotics in cervical cancer
Jahanshahi, M., Dana, P. M., Badehnoosh, B., Asemi, Z., Hallajzadeh, J., Mansournia, M. A., Yousefi, B., Moazzami, B., & Chaichian, S. (2020) · Journal of Ovarian Research · doi:10.1186/s13048-020-00668-x · Cited by 73 · see citing works
Mitra, S., Förster‐Fromme, K., Damms-Machado, A., Scheurenbrand, T., Biskup, S., Huson, D. H., & Bischoff, S. C. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-s5-s16 · Cited by 70 · see citing works
The Impact of Nutrition and Intestinal Microbiome on Elderly Depression—A Systematic Review
Klímová, B., Novotný, M., & Vališ, M. (2020) · Nutrients · doi:10.3390/nu12030710 · Cited by 59 · see citing works
Gut Virome and Inflammatory Bowel Disease
Lopetuso, L. R., Ianiro, G., Scaldaferri, F., Cammarota, G., & Gasbarrini, A. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000807 · Cited by 57 · see citing works
Xie, C., Li, J., Wang, K., Li, Q., & Chen, D. (2015) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2015.03.001 · Cited by 49 · see citing works
The Intestinal Microbiota in Inflammatory Bowel Diseases
Sartor, R. B. (2014) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000360674 · Cited by 39 · see citing works
Lombardi, F., Palumbo, P., Mattei, A., Augello, F. R., Cifone, M. G., Giuliani, M., & Cinque, B. (2019) · Biomolecules · doi:10.3390/biom9120756 · Cited by 32 · see citing works
Oxidized LDL and abdominal obesity: a key to understanding the metabolic syndrome1,2
Knopp, R. H., & Paramsothy, P. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.1.1 · Cited by 28 · see citing works
Rees, C. M., Hall, N. J., Fleming, P., & Eaton, S. D. (2017) · BMJ Paediatrics Open · doi:10.1136/bmjpo-2017-000066 · Cited by 24 · see citing works
Introduction: What we do and do not know regarding redox processes of thiols in signaling pathways
Poole, L. B., & Schöneich, C. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.02.005 · Cited by 23 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [38]Hill C Expert consensus document. The international scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic Nat Rev Gastroenterol Hepatol 2014 11 8 506 514 24912386
Cited by
Sorted by citations
Prebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications
Davani-Davari, D., Negahdaripour, M., Karimzadeh, I., Seifan, M., Mohkam, M., Masoumi, S. J., Berenjian, A., & Ghasemi, Y. (2019) · Foods · doi:10.3390/foods8030092 · Cited by 1,773 · see citing works
The Intestinal Microbiota and Colorectal Cancer
Cheng, Y., Ling, Z., & Li, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.615056 · Cited by 588 · see citing works
Modulation of Gut Microbiota and Immune System by Probiotics, Pre-biotics, and Post-biotics
Liu, Y., Wang, J., & Wu, C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.634897 · Cited by 393 · see citing works
Lai, H., Lin, T., Chen, T.-W., Kuo, Y.-L., Chang, C., Wu, T.-R., Shu, C.-C., Tsai, Y.-H., Swift, S., & Lu, C. (2021) · Gut · doi:10.1136/gutjnl-2020-322599 · Cited by 333 · see citing works
Self-citationThe mutual interplay of gut microbiota, diet and human disease
Illiano, P., Brambilla, R., & Parolini, C. (2020) · FEBS Journal · doi:10.1111/febs.15217 · Cited by 331 · see citing works
Abouelela, M. E., & Helmy, Y. A. (2024) · Microorganisms · doi:10.3390/microorganisms12030430 · Cited by 259 · see citing works
Food as medicine: targeting the uraemic phenotype in chronic kidney disease
Mafra, D., Borges, N. A., Lindholm, B., Shiels, P. G., Evenepoel, P., & Stenvinkel, P. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-020-00345-8 · Cited by 238 · see citing works
The Role of Prebiotics in Modulating Gut Microbiota: Implications for Human Health
Yoo, S., Jung, S., Kwak, K., & Kim, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094834 · Cited by 231 · see citing works
Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony
Zhou, P., Chen, C., Patil, S., & Dong, S. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1355542 · Cited by 193 · see citing works
Lactiplantibacillus plantarum–Nomad and Ideal Probiotic
Fidanza, M., Panigrahi, P., & Kollmann, T. R. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.712236 · Cited by 186 · see citing works
Leaky Gut and the Ingredients That Help Treat It: A Review
Alemán, R. S., Moncada, M. L., & Aryana, K. J. (2023) · Molecules · doi:10.3390/molecules28020619 · Cited by 185 · see citing works
Hsieh, T.-H., Kuo, C.-W., Hsieh, K.-H., Shieh, M.-J., Peng, C.-W., Chen, Y.-C., Chang, Y.-L., Huang, Y.-Z., Chen, C.-C., Chang, P.-K., et al. (2020) · Brain Sciences · doi:10.3390/brainsci10040206 · Cited by 174 · see citing works
Role of gut microbiota in identification of novel TCM-derived active metabolites
Lin, T., Lu, C., Lai, W.-F., Wu, T., Lu, J., Chen, Y.-M., Tzeng, C., Liu, H., Wei, H., & Lai, H. (2020) · Protein & Cell · doi:10.1007/s13238-020-00784-w · Cited by 175 · see citing works
Self-citationMa, J., Lyu, Y., Liu, X., Jia, X., Cui, F., Wu, X., Deng, S., & Yue, C. (2022) · Microbial Cell Factories · doi:10.1186/s12934-022-01799-0 · Cited by 153 · see citing works
Ojo, O., Feng, Q.-Q., Ojo, O. O., & Wang, X.-H. (2020) · Nutrients · doi:10.3390/nu12113239 · Cited by 134 · see citing works
Ortega, M. A., Álvarez-Mon, M. Á., Montero, C. G., Fraile‐Μartinez, O., Monserrat, J., Martinez-Rozas, L., Rodríguez–Jiménez, R., Álvarez‐Mon, M., & Lahera, G. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01964-w · Cited by 129 · see citing works
Targeting gut microbiota for precision medicine: Focusing on the efficacy and toxicity of drugs
Feng, W., Liu, J., Ao, H., Yue, S., & Peng, C. Y. (2020) · Theranostics · doi:10.7150/thno.47289 · Cited by 127 · see citing works
Commercial probiotic products in public health: current status and potential limitations
Liang, D., Wu, F. L., Zhou, D., Tan, B., & Chen, T. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2169858 · Cited by 124 · see citing works
Xing, C., Zhang, J., Zhao, H., & He, B. (2022) · International Journal of Women's Health · doi:10.2147/ijwh.s344542 · Cited by 118 · see citing works
Pivari, F., Mingione, A., Piazzini, G., Ceccarani, C., Ottaviano, E., Brasacchio, C., Dei, M., Vischi, M., Cozzolino, M. G., Fogagnolo, P., et al. (2022) · Nutrients · doi:10.3390/nu14010231 · Cited by 115 · see citing works
da Silva, T. F., Glória, R. D. A., Americo, M. F., Freitas, A. D. S., de Jesus, L. C. L., Barroso, F. A. L., Laguna, J. G., Coelho-Rocha, N. D., Tavares, L. M., le Loir, Y., et al. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10247-x · Cited by 117 · see citing works
Kumari, M., Singh, P., Nataraj, B. H., Kokkiligadda, A., Naithani, H., Ali, S. A., Behare, P. V., & Nagpal, R. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110716 · Cited by 107 · see citing works
Can Gut Microbiota Affect Dry Eye Syndrome?
Moon, J., Yoon, C. H., Choi, S. H., & Kim, M. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228443 · Cited by 98 · see citing works
Tsai, W.-H., Chou, C.-H., Chiang, Y.-J., Lin, C.-G., & Lee, C.-H. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.51545 · Cited by 98 · see citing works
The central role of the gut microbiota in the pathophysiology and management of type 2 diabetes
Baars, D. P., Fondevila, M. F., Meijnikman, A. S., & Nieuwdorp, M. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.07.017 · Cited by 102 · see citing works
Intestinal permeability disturbances: causes, diseases and therapy
Macura, B., Kiecka, A., & Szczepanik, M. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01496-9 · Cited by 99 · see citing works
Investiture of next generation probiotics on amelioration of diseases – Strains do matter
Lin, T., Shu, C.-C., Lai, W.-F., Tzeng, C., Lai, H., & Lu, C. (2019) · Medicine in Microecology · doi:10.1016/j.medmic.2019.100002 · Cited by 93 · see citing works
Self-citationConte, L., & Toraldo, D. M. (2020) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753466620937170 · Cited by 93 · see citing works
Gut and obesity/metabolic disease: Focus on microbiota metabolites
Lin, K., Zhu, L., & Li, Y. (2022) · MedComm · doi:10.1002/mco2.171 · Cited by 95 · see citing works
Liu, Y., Gao, Y., Ma, F., Sun, M., Mu, G., & Tuo, Y. (2020) · Food & Function · doi:10.1039/d0fo00439a · Cited by 90 · see citing works
Ojo, O., Ojo, O., Zand, N., & Wang, X. (2021) · Nutrients · doi:10.3390/nu13061805 · Cited by 97 · see citing works
The Promising Role of Probiotics in Managing the Altered Gut in Autism Spectrum Disorders
Abdellatif, B., McVeigh, C., Bendriss, G., & Châari, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114159 · Cited by 84 · see citing works
Gut-muscle crosstalk. A perspective on influence of microbes on muscle function
Chew, W., Lim, Y. P., Lim, W. S., Chambers, E. S., Frost, G. S., Wong, S. H., & Ali, Y. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2022.1065365 · Cited by 82 · see citing works
Gut microbiota: A new target of traditional Chinese medicine for insomnia
Feng, W., Yang, Z., Liu, Y., Chen, R., Song, Z., Pan, G., Zhang, Y., Guo, Z., Ding, X., Chen, L., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114344 · Cited by 85 · see citing works
Gut Microbiota: the Emerging Link to Lung Homeostasis and Disease
Zhou, A., Lei, Y., Tang, L., Hu, S., Yang, M., Wu, L., Yang, S., & Tang, B. (2020) · Journal of Bacteriology · doi:10.1128/jb.00454-20 · Cited by 78 · see citing works
Holdemanella biformis improves glucose tolerance and regulates GLP‐1 signaling in obese mice
Romaní‐Pérez, M., López‐Almela, I., Bullich‐Vilarrubias, C., Rueda‐Ruzafa, L., del Pulgar, E. M. G., Benítez‐Páez, A., Liebisch, G., Lamas, J. A., & Sanz, Y. (2021) · The FASEB Journal · doi:10.1096/fj.202100126r · Cited by 77 · see citing works
Li, Z. H. (2024) · Gut · doi:10.1136/gutjnl-2024-331880 · Cited by 76 · see citing works
Anti-tumor activities of probiotics in cervical cancer
Jahanshahi, M., Dana, P. M., Badehnoosh, B., Asemi, Z., Hallajzadeh, J., Mansournia, M. A., Yousefi, B., Moazzami, B., & Chaichian, S. (2020) · Journal of Ovarian Research · doi:10.1186/s13048-020-00668-x · Cited by 73 · see citing works
Castro-López, C., García, H. S., Guadalupe Martínez-Ávila, G. C., González-Córdova, A. F., Vallejo-Cordoba, B., & Hernández-Mendoza, A. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.12.017 · Cited by 72 · see citing works
Advances in the study of IL-17 in neurological diseases and mental disorders
Lu, Y., Zhang, P., Xu, F., Zheng, Y., & Zhao, H. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1284304 · Cited by 71 · see citing works
Preventing Colorectal Cancer through Prebiotics
Mahdavi, M., Laforest‐Lapointe, I., & Massé, É. (2021) · Microorganisms · doi:10.3390/microorganisms9061325 · Cited by 71 · see citing works
Gut Microbiome in Retina Health: The Crucial Role of the Gut-Retina Axis
Scuderi, G., Troiani, E., & Minnella, A. M. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.726792 · Cited by 70 · see citing works
Li, L., Xiong, Q., Zhao, J., Lin, X., He, S., Wu, N., Yao, Y., Liang, W., Zuo, X., & Ying, C. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz337 · Cited by 70 · see citing works
Microbiome and Cognitive Impairment: Can Any Diets Influence Learning Processes in a Positive Way?
Novotný, M., Klímová, B., & Vališ, M. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00170 · Cited by 68 · see citing works
Chen, Y., Zhang, L., Hong, G., Huang, C., Qian, W., Bai, T., Song, J., Song, Y., & Hou, X. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117089 · Cited by 65 · see citing works
Tate, W. P., Walker, M., Peppercorn, K., Blair, A., & Edgar, C. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065124 · Cited by 60 · see citing works
Ma, Y., Hu, C., Yan, W., Jiang, H., & Liu, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.591408 · Cited by 61 · see citing works
The Impact of Nutrition and Intestinal Microbiome on Elderly Depression—A Systematic Review
Klímová, B., Novotný, M., & Vališ, M. (2020) · Nutrients · doi:10.3390/nu12030710 · Cited by 59 · see citing works
Probiotic bacteria and plant-based matrices: An association with improved health-promoting features
Bellis, P. D., Sisto, A., & Lavermicocca, P. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104821 · Cited by 58 · see citing works
Wang, X., Hu, J., Liu, L., Zhang, Y., Dang, K., Cheng, L., Zhang, J., Xu, X., & Li, Y. (2023) · Nutrients · doi:10.3390/nu15143148 · Cited by 58 · see citing works
Gut Microbiota and Neuroplasticity
Murciano-Brea, J., García-Montes, M. E., Geuna, S., & Herrera‐Rincon, C. (2021) · Cells · doi:10.3390/cells10082084 · Cited by 59 · see citing works
Lopes, S. A., Roque‐Borda, C. A., Duarte, J. L., Filippo, L. D. D., Cardoso, V. M. B., Pavan, F. R., Chorilli, M., & Meneguin, A. B. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15112600 · Cited by 57 · see citing works
Bengoa, A. A., Dardis, C., Gagliarini, N., Garrote, G. L., & Abraham, A. G. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.583254 · Cited by 55 · see citing works
Wallimann, A., Magrath, W. J., Pugliese, B. R., Stocker, N., Westermann, P., Heider, A., Gehweiler, D., Zeiter, S., Claesson, M. J., Richards, R. G., et al. (2021) · Mediators of Inflammation · doi:10.1155/2021/8817421 · Cited by 55 · see citing works
Rahmati, H., Momenabadi, S., Vafaei, A. A., Bandegi, A. R., Mazaheri, Z., & Vakili, A. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-04949-7 · Cited by 55 · see citing works
The effect of natural plant-based homogenates as additives on the quality of yogurt: A review
Fan, X., Li, X., Du, L., Li, J., Xu, J., Shi, Z., Li, C., Tu, M., Zeng, X., Wu, Z. F., et al. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.101953 · Cited by 52 · see citing works
The chemistry of gut microbiome in health and diseases
Lau, A., Tan, L. T., Mutalib, N. A., Wong, S. H., Letchumanan, V., & Lee, L. (2021) · Progress In Microbes & Molecular Biology · doi:10.36877/pmmb.a0000175 · Cited by 52 · see citing works
Dietary interventions for better management of osteoporosis: An overview
Guo, D., Zhao, M., Xu, W., He, H., Li, B., & Hou, T. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1944975 · Cited by 51 · see citing works
The effects and benefits of arabinoxylans on human gut microbiota – A narrative review
Schupfer, E., Pak, S. C., Wang, S., Micalos, P. S., Jeffries, T. C., Ooi, S. L., Golombick, T., Harris, G., & El-Omar, E. M. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101267 · Cited by 53 · see citing works
Sathikulpakdee, S., Kanokrungsee, S., Vitheejongjaroen, P., Kamanamool, N., Udompataikul, M., & Taweechotipatr, M. (2022) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.14971 · Cited by 51 · see citing works
Border Control: The Role of the Microbiome in Regulating Epithelial Barrier Function
Schreiber, F., Balas, I., Robinson, M. J., & Bakdash, G. (2024) · Cells · doi:10.3390/cells13060477 · Cited by 54 · see citing works
Chikkerur, J., Samanta, A. K., Kolte, A. P., Dhali, A., & Roy, S. (2019) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-019-03215-7 · Cited by 51 · see citing works
The role of functional oligosaccharides as prebiotics in ulcerative colitis
Liu, N., Wang, H., Yang, Z., Zhao, K., Li, S., & He, N. (2022) · Food & Function · doi:10.1039/d2fo00546h · Cited by 51 · see citing works
Fentie, E. G., Lim, K., Jeong, M., & Shin, J. (2024) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13424 · Cited by 50 · see citing works
Ding, L.-N., Ding, W.-Y., Ning, J., Wang, Y., Yan, Y., & Wang, Z.-B. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.770861 · Cited by 49 · see citing works
Ursodeoxycholic acid: a promising therapeutic target for inflammatory bowel diseases?
Keely, S. J., Steer, C. J., & Lajczak, N. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00163.2019 · Cited by 49 · see citing works
Sajdel, E. M. (2021) · BioMed Research International · doi:10.1155/2021/7880448 · Cited by 49 · see citing works
Heat-Killed Lactobacilli Preparations Promote Healing in the Experimental Cutaneous Wounds
Tsai, W.-H., Chou, C., Huang, T.-Y., Wang, H., Chien, P., Chang, W., & Lee, H. (2021) · Cells · doi:10.3390/cells10113264 · Cited by 49 · see citing works
Andrade, A. C., Marinho, J. F. U., de Souza, A. C., Tavares, T. D. S., Dias, D. R., Schwan, R. F., Nunes, C. A., & Bastos, S. C. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109595 · Cited by 51 · see citing works
A Brief Overview on Probiotics: The Health Friendly Microbes
Mishra, S., & Acharya, S. (2021) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/2285 · Cited by 46 · see citing works
Chen, L., Shi, J., Ma, X., Shi, D., & Qu, H. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab149 · Cited by 48 · see citing works
Stachyose modulates gut microbiota and alleviates DSS-induced ulcerative colitis in mice
Wang, C., Bai, J., Wang, B., Yu, L., Tian, F., Zhao, J., Zhang, H., Suo, H., Chen, W., & Zhai, Q. (2023) · Food Science and Human Wellness · doi:10.1016/j.fshw.2023.03.041 · Cited by 48 · see citing works
Prebióticos, probióticos y trasplante de microbiota fecal en el autismo: una revisión sistemática
Martínez‐González, A. E., & Andreo‐Martínez, P. (2020) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.rpsm.2020.06.002 · Cited by 46 · see citing works
Role of gut microbiota‐derived metabolites on vascular calcification in CKD
Yin, L., Li, X.-X., Ghosh, S., Xie, C., Chen, J., & Huang, H. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16230 · Cited by 46 · see citing works
Antimicrobial Activity of Probiotic Bacteria Isolated from Plants: A Review
Sharma, A., & Lee, H. (2025) · Foods · doi:10.3390/foods14030495 · Cited by 45 · see citing works
Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time?
Ren, J., Li, H., Zeng, G., Pang, B., Wang, Q., & Wei, J.-P. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1178596 · Cited by 44 · see citing works
Prospecting prebiotics, innovative evaluation methods, and their health applications: a review
Khangwal, I., & Shukla, P. (2019) · 3 Biotech · doi:10.1007/s13205-019-1716-6 · Cited by 45 · see citing works
The Pivotal Role of the Gut Microbiome in Colorectal Cancer
Siddiqui, R., Boghossian, A., Alharbi, A. M., Alfahemi, H. H., & Khan, N. A. (2022) · Biology · doi:10.3390/biology11111642 · Cited by 43 · see citing works
Cheng, X., Zhang, Y., Li, Y., Wu, Q., Wu, J., Park, S., Guo, C., & Lu, J. (2022) · BMC Microbiology · doi:10.1186/s12866-022-02686-9 · Cited by 43 · see citing works
Tao, P., Ji, J., Wang, Q., Cui, M., Cao, M., & Xu, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1080456 · Cited by 45 · see citing works
Crosstalk between immune cells and bone cells or chondrocytes
Deng, Z., Zhang, Q., Zhao, Z., Yong-shen, L., Chen, X., Lin, Z., Deng, Z., Liu, J., Duan, L., Wang, D., et al. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108179 · Cited by 43 · see citing works
Charoensiddhi, S., Chanput, W. P., & Sae‐tan, S. (2022) · Nutrients · doi:10.3390/nu14112275 · Cited by 42 · see citing works
Relationship between Diet, Microbiota, and Healthy Aging
Sanchez-Morate, E., Gimeno-Mallench, L., Stromsnes, K., Sanz‐Ros, J., Román-Domínguez, A., Parejo-Pedrajas, S., Inglés, M., González, G. O., Gambini, J., & Mas‐Bargues, C. (2020) · Biomedicines · doi:10.3390/biomedicines8080287 · Cited by 39 · see citing works
The Role and Mechanism of Probiotics Supplementation in Blood Glucose Regulation: A Review
Shen, X., Ma, C., Yang, Y., Liu, X., Wang, B., Wang, Y., Zhang, G., Bian, X., & Zhang, N. (2024) · Foods · doi:10.3390/foods13172719 · Cited by 40 · see citing works
Butyrate as a potential therapeutic agent for neurodegenerative disorders
Chakraborty, P., Gamage, H. K. A. H., & Laird, A. S. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105745 · Cited by 41 · see citing works
Exploring Therapeutic Advances: A Comprehensive Review of Intestinal Microbiota Modulators
Pires, L., Gonzaléz‐Paramás, A. M., Heleno, S. A., & Calhelha, R. C. (2024) · Antibiotics · doi:10.3390/antibiotics13080720 · Cited by 43 · see citing works
Benefits of using probiotics as adjuvants in anticancer therapy (Review)
Vivarelli, S., Falzone, L., Basile, M. S., Nicolosi, D., Genovese, C., Libra, M., & Salmeri, M. (2019) · World Academy of Sciences Journal · doi:10.3892/wasj.2019.13 · Cited by 39 · see citing works
Probiotics treatment for Parkinson disease: a systematic review and meta-analysis of clinical trials
Hong, C., Chen, J., & Huang, T. (2022) · Aging · doi:10.18632/aging.204266 · Cited by 38 · see citing works
Cabała, S., Ozgo, M., & Herosimczyk, A. (2024) · Metabolites · doi:10.3390/metabo14010078 · Cited by 38 · see citing works
Oral microbiome and serological analyses on association of Alzheimer's disease and periodontitis
Fu, K., Chiu, M., Wara‐aswapati, N., Yang, C., Chang, L., Guo, Y. L., Ni, Y., & Chen, Y. (2022) · Oral Diseases · doi:10.1111/odi.14348 · Cited by 38 · see citing works
Probiotics: functional food ingredients with the potential to reduce hypertension
Chen, Z., Liang, W., Liang, J., Dou, J., Guo, F., Zhang, D., Xu, Z., & Wang, T. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1220877 · Cited by 37 · see citing works
Vu, V., Muthuramalingam, K., Singh, V., Hyun, C. L., Kim, Y., Unno, T., & Cho, M. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02668-z · Cited by 37 · see citing works
Huang, Y., Lu, Y., Liu, X., Wu, W.-T., Li, W., Lai, S.-Q., Aadil, R. M., Rajoka, M. S. R., Wang, L., & Zeng, X. (2023) · Food Reviews International · doi:10.1080/87559129.2023.2202406 · Cited by 37 · see citing works
Respiratory diseases and the gut microbiota: an updated review
Xin, Y., Yu, X., Wang, Y., Guo, X., Wang, C., & Wang, F. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1629005 · Cited by 38 · see citing works
Haidmayer, A., Bösch, P., Lackner, A., D’Orazio, M., Fessler, J., & Stradner, M. H. (2020) · Nutrients · doi:10.3390/nu12082337 · Cited by 36 · see citing works
Chavan, A. R., Singh, A. K., Gupta, R. K., Nakhate, S. P., Poddar, B. J., Gujar, V. V., Purohit, H. J., & Khardenavis, A. A. (2023) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2022.2152627 · Cited by 35 · see citing works
Dietary legumes, intestinal microbiota, inflammation and colorectal cancer
Aranda‐Olmedo, I., & Rubio, L. A. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103707 · Cited by 35 · see citing works
Ivashkin, V. T., Maev, I. V., Abdulganieva, D. I., Alekseenko, S. A., Gorelov, A. V., Zakharova, I. N., Zolnikova, O. Y., Ivashkina, N. Y., Korochanskaya, N. V., Mammayev, S. N., et al. (2021) · Russian Journal of Gastroenterology, Hepatology, Coloproctology · doi:10.22416/1382-4376-2021-31-2-65-91 · Cited by 35 · see citing works
A Perspective on the Role of Microbiome for Colorectal Cancer Treatment
Kalasabail, S., Engelman, J., Zhang, L. Y., El-Omar, E. M., & Yim, H. C. H. (2021) · Cancers · doi:10.3390/cancers13184623 · Cited by 35 · see citing works
Oh, J. K., Vasquez, R., Kim, S. H., Lee, J. H., Kim, E. J., Hong, S., & Kang, D. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104869 · Cited by 34 · see citing works
- Authors
- Tsai, Y.-L., Lin, T.-L., Chang, C.-J., Wu, T.-R., Lai, W.-F., Lu, C.-C., & Lai, H.-C.
- Affiliations
- Chang Gung University (TW)
- Institute of Biomedical Sciences, Academia Sinica (TW)
- Fu Jen Catholic University (TW)
- Chang Gung University of Science and Technology (TW)
- Corresponding author
- Lu, Chia-Chen
- Lai, Hsin-Chih
- Venue
- Journal of Biomedical Science
- Published
- 2019-01-04
- Volume
- 26
- Issue
- 1
- Pages
- 3-3
- ISSN
- 1021-7770 (ISSN-L)
- 1423-0127
- PMC
- PMC6320572
- OpenAlex
- W2913324394
- Cited by
- 388
- References
- 94
- Citations by year
- 2026: 17 · 2025: 41 · 2024: 70 · 2023: 63 · 2022: 68 · 2021: 61 · 2020: 43 · 2019: 23 · 2018: 1 · 2012: 1
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Journal of Biomedical Science (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Chang Gung Memorial Hospital (CORPD1F0013, CMRPD1F0123)
- Ministry of Science and Technology, Taiwan (107-2321-B-182-002, MOST 107-3017-F-182-001)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- probiotics, prebiotics, postbiotics, gut dysbiosis, chronic inflammation, mucosal immunity, intestinal barrier integrity, leaky gut, obesity, type 2 diabetes, liver inflammation, colorectal cancer, lung immunity, neurodegenerative diseases
- MeSH terms
- Gastrointestinal Microbiome, Humans, Inflammation, Inflammatory Bowel Diseases, Probiotics, Prebiotics, Dysbiosis
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