Choline: Clinical Nutrigenetic/Nutrigenomic Approaches for Identification of Functions and Dietary Requirements
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Choline is an essential nutrient, so eliminating it entirely from the diet is ill advised and could cause deficiency.
“However, it is important to note that choline is an essential nutrient; therefore, its total elimination from the diet is ill advised, and could result in development of a deficiency state35.”
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Flagged first, then by citations
Research works printed but not linked: 7
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Cited by
Sorted by citations
Tang, W. H. W., Wang, Z., Kennedy, D. J., Wu, Y., Buffa, J. A., Agatisa-Boyle, B., Li, X. S., Levison, B. S., & Hazen, S. L. (2015) · Circulation Research · doi:10.1161/circresaha.116.305360 · Cited by 1,223 · see citing works
“However, it is important to note that choline is an essential nutrient; therefore, its total elimination from the diet is ill advised and could result in development of a deficiency state.(35) Collectively, the present data indicate a dietary-induced, intestinal microbiota-dependent mechanism may contribute to both pr…”
BackgroundEarly life nutrition and neural plasticity
Georgieff, M. K., Brunette, K. E., & Tran, P. V. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000061 · Cited by 177 · see citing works
“However, the most intriguing role from a neural plasticity/critical period perspective is that it can act as a methyl donor for epigenetic modification of chromatin (Zeisel, 2010).”
BackgroundIron assessment to protect the developing brain
Georgieff, M. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.155846 · Cited by 153 · see citing works
“Examples that have shown epigenetic effects include protein-energy restriction (10) and deficiencies of long-chain PUFAs (11), folate (12), choline (13), and iron (14).”
BackgroundDietary Intake and Plasma Levels of Choline and Betaine in Children with Autism Spectrum Disorders
Hamlin, J. C., Pauly, M., Melnyk, S., Pavliv, O., Starrett, W., Crook, T. A., & James, S. J. (2013) · Autism Research and Treatment · doi:10.1155/2013/578429 · Cited by 46 · see citing works
“Research studies have shown that insufficient dietary folate increases requirement for choline and betaine-derived methyl groups and conversely, choline and betaine deficiency increases the requirement for folate-derived methyl groups [17].”
BackgroundAlldred, M. J., Chao, H. M., Lee, S. H., Beilin, J., Powers, B. E., Petkova, E., Strupp, B. J., & Ginsberg, S. D. (2018) · Hippocampus · doi:10.1002/hipo.22832 · Cited by 35 · see citing works
“In addition, choline is a key substrate of the phosphatidylethanolamineN-methyltransferase (PEMT) pathway, which generates phosphatidylcholine species, crucial elements in neuronal and non-neuronal lipid membranes (Lindblom & Oradd, 2009; Wang, Megill, Wong, Kirkwood, & Lee, 2016; Zeisel, 2010; Zeisel & Niculescu, 200…”
BackgroundAlldred, M. J., Pidikiti, H., Heguy, A., Roussos, P., & Ginsberg, S. D. (2023) · The FASEB Journal · doi:10.1096/fj.202202111rr · Cited by 24 · see citing works
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- Authors
- Zeisel, S. H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Zeisel, Steven H.
- ORCID
- Zeisel, Steven H.
- Venue
- Journal of Nutrigenetics and Nutrigenomics
- Publisher
- S. Karger AG
- Published
- 2010
- Volume
- 3
- Issue
- 4-6
- Pages
- 209-219
- ISSN
- 1661-6499 (ISSN-L)
- 1661-6758
- OpenAlex
- W4231247103
- Cited by
- 9
- References
- 64
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2021: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Lifestyle Genomics (publishedVersion)
- Funders
- National Institutes of Health (DK56350, AG-09525)
- National Institute on Aging (P01AG009525, AG 09525)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK055865, DK-55865, DK56350, P30DK056350)
- National Institute of Environmental Health Sciences (P30ES010126)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- choline, nutrigenomics, nutrigenetics, nutrient requirements, gene-diet interaction, choline metabolism, functional genomics
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