Early life nutrition and neural plasticity
Open accessAbstract
The human brain undergoes a remarkable transformation during fetal life and the first postnatal years from a relatively undifferentiated but pluripotent organ to a highly specified and organized one. The outcome of this developmental maturation is highly dependent on a sequence of environmental exposures that can have either positive or negative influences on the ultimate plasticity of the adult brain. Many environmental exposures are beyond the control of the individual, but nutrition is not. An ever-increasing amount of research demonstrates not only that nutrition shapes the brain and affects its function during development but also that several nutrients early in life have profound and long-lasting effects on the brain. Nutrients have been shown to alter opening and closing of critical and sensitive periods of particular brain regions. This paper discusses the roles that various nutrients play in shaping the developing brain, concentrating specifically on recently explicated biological mechanisms by which particularly salient nutrients influence childhood and adult neural plasticity.
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Malnutrition has a substantial impact on brain function, neuroplasticity, and stress regulation.
“A key example is malnutrition, which has a substantial impact on brain function, neuroplasticity and stress regulation87.”
From Resilience and brain health in global populations (2025) · cites this paper as [87]
Section IV says early nutrient deficits can cause acute or chronic brain dysfunction and affect later neural plasticity. Section III discusses altered stress-response regulation as an effect of early-life stress and maternal care, not malnutrition. The cited paper therefore supports the brain-function and neuroplasticity parts, but not the attributed effect on stress regulation; its focus is also early-life nutrition rather than malnutrition at any age. (LLM, conf=0.88)
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- Authors
- Georgieff, M. K., Brunette, K. E., & Tran, P. V.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Georgieff, Michael K.
- Venue
- Development and Psychopathology
- Publisher
- Cambridge University Press (CUP)
- Published
- 2015-05
- Volume
- 27
- Issue
- 2
- Pages
- 411-423
- ISSN
- 0954-5794 (ISSN-L)
- 1469-2198
- PMC
- PMC4443711
- OpenAlex
- W1952322632
- Cited by
- 177
- References
- 99
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 22 · 2023: 15 · 2022: 24 · 2021: 16 · 2020: 12 · 2019: 18 · 2018: 20 · 2017: 15 · 2016: 13 · 2015: 1
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Development and Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM008471)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD054490, R01HD029421, R01 HD29421-18)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- early life nutrition, neuroplasticity, brain development, critical period, sensitive period, nutrients, childhood, adult brain, environmental influences on brain development
- MeSH terms
- Adult, Brain, Child, Humans, Neuronal Plasticity, Nutritional Status
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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