Cited by 149Fatty Acid Research and HealthNutritional Studies and DietDiet and metabolism studies

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index; none of the 29 sources its claims cite is checked for support yet.

Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis

Schwingshackl, L., Strasser, B., Hoffmann, G.·2011·Annals of Nutrition and Metabolism

DOI 10.1159/000331214

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Abstract

Background/Aims: In 2008, the American Diabetes Association recommended low-carbohydrate or low-fat diets for weight management in patients with established type 2 diabetes (T2D), while the amount of monounsaturated fatty acids (MUFA) was not specified. This systematic review focused on the effects of diets high in MUFA versus diets low in MUFA on important risk factors of T2D (i.e. plasma glucose, insulin, homeostasis model assessment of insulin resistance and glycosylated haemoglobin, HbA1c). Methods: Nine randomized controlled intervention trials with a total of 1,547 participants and a running time of at least 6 months, comparing diets high versus low in MUFA among adults with abnormal glucose metabolism (T2D, impaired glucose tolerance and insulin resistant), being overweight or obese, have been included in the meta-analysis. We performed a random effects meta-analysis to determine the weighted mean differences with 95% confidence intervals using the software package Review Manager 5.0.25 of the Cochrane Collaboration. Results: Significant differences in HbA1c were found (weighted mean difference –0.21%, 95% CI –0.40 to –0.02; p = 0.03), favouring the high MUFA groups. In contrast, fasting plasma glucose, fasting plasma insulin as well as the homeostasis model assessment of insulin resistance were not affected by the amounts of MUFA in the dietary protocols. Conclusions: In summary, this systematic review found that high MUFA diets appear to be effective in reducing HbA1c, and therefore, should be recommended in the dietary regimes of T2D.

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Written from the paper’s full text.

TL;DR

This systematic review and meta-analysis of 9 long-term RCTs in people with abnormal glucose metabolism found that high-MUFA diets (≥12% of total energy) significantly lowered HbA1c compared with low-MUFA diets. Fasting plasma glucose, fasting insulin, and HOMA-IR did not differ significantly between high- and low-MUFA diets.

Key findings

HbA1c was significantly reduced with high- vs low-MUFA diets: WMD −0.21% (95% CI −0.40 to −0.02; p = 0.03; 5 studies, 667 participants; I² = 15%). The high-MUFA vs low-fat subgroup also showed a significant reduction: WMD −0.28% (95% CI −0.52 to −0.03; p = 0.03).
Fasting plasma glucose did not differ significantly: WMD −3.02 mg/dl (95% CI −6.66 to 0.63; p = 0.11; 9 studies, 1,545 participants; I² = 81%).
Fasting plasma insulin did not differ significantly: WMD −0.05 (95% CI −1.60 to 1.49; p = 0.94; 9 studies, 1,547 participants; I² = 84%).
HOMA-IR did not differ significantly: WMD −0.26 (95% CI −0.75 to 0.24; p = 0.31; 6 studies, 1,355 participants; I² = 86%).

Methods

Systematic review and meta-analysis of RCTs in participants with abnormal glucose metabolism (IGT, T2D, IR), BMI ≥25, intervention/follow-up ≥6 months, and nutritional counselling by a dietician. Searches covered Medline (1966–May 2011), Embase (1980–May 2011), and the Cochrane Trial Register (until May 2011).
Included 9 RCTs with 1,547 participants; intervention durations ranged from 6 months to 4 years. High-MUFA diets were defined as ≥12% of total energy content (TEC); low-MUFA diets as ≤12% TEC, including low-fat, low/high glycaemic index, high-protein, and control diets.
Random-effects meta-analysis using Review Manager 5.0.25; outcomes were fasting plasma glucose, fasting plasma insulin, HOMA-IR, and HbA1c. Results reported as weighted mean differences (WMDs) with 95% CIs; heterogeneity assessed with Q and I²; funnel plots assessed publication bias; Jadad score assessed study quality.

Limitations

Stated: unpublished data were not considered; included publications varied in diet types, MUFA definitions, study populations, intervention time, and follow-up protocols; drug regimens were not identical across participants; mixed IGT, IR, and T2D populations were included, and effects might be especially strong in T2D. The funnel plot for HbA1c showed little asymmetry/small potential publication bias.
Evident: heterogeneity was substantial for fasting plasma glucose, fasting plasma insulin, and HOMA-IR (I² >80%), so those pooled null estimates should be interpreted cautiously; the significant HbA1c finding rests on 5 studies and 667 participants.

Model-written summary. Check it against the paper before relying on it.

Integrity signals

Registry

Crossref · 10.1159/000331214

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

0 of 29 cited sources checked · 0 supported · 0 flagged

A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The pooled estimates of effects of high-versus low-MUFA diets on fasting plasma glucose were -3.02 mg/dl, which was statistically not significant (95% CI -6.66 to 0.63; p = 0.11).”
- Also stated in: § Abstract · plain
  “fasting plasma glucose, fasting plasma insulin as well as the homeostasis model assessment of insulin resistance were not affected by the amounts of MUFA in the dietary protocols.”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Outcome Measures Fasting Glucose
Strength:plain· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes
- The authors state this as an assumption: Imputing the baseline standard deviation for one trial is a valid procedure because baseline and post-intervention standard deviations were similar in the other included trials.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Decreases in HOMA-IR did not differ significantly between high-and low-MUFA dietary protocols (WMD -0.26, 95% CI -0.75 to 0.24; p = 0.31).”
- Also stated in: § Abstract · plain
  “fasting plasma glucose, fasting plasma insulin as well as the homeostasis model assessment of insulin resistance were not affected by the amounts of MUFA in the dietary protocols.”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > HOMA Insulin Resistance
Strength:plain· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes
- The authors state this as an assumption: Imputing the baseline standard deviation for one trial is a valid procedure because baseline and post-intervention standard deviations were similar in the other included trials.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The post-hoc analyses showed that the HbA1c reduction was significant following a high-MUFA as compared to LF diets (WMD -0.28%, 95% CI -0.52 to -0.03; p = 0.03) ( fig. 1 ).”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Haemoglobin A1c
Load-bearingStrength:plain· not yet calibratedCausal:direct· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes
- The authors state this as an assumption: Imputing the baseline standard deviation for one trial is a valid procedure because baseline and post-intervention standard deviations were similar in the other included trials.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Fasting insulin was assessed in a total of 1,547 subjects.WMD for the effects of high-versus low-MUFA regimens was -0.05 mg/dl (95% CI -1.60 to 1.49; p = 0.94), which was not statistically significant.”
- Also stated in: § Abstract · plain
  “fasting plasma glucose, fasting plasma insulin as well as the homeostasis model assessment of insulin resistance were not affected by the amounts of MUFA in the dietary protocols.”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Fasting Insulin
Strength:plain· not yet calibratedn = 1,547
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes
- The authors state this as an assumption: Imputing the baseline standard deviation for one trial is a valid procedure because baseline and post-intervention standard deviations were similar in the other included trials.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Significant differences in HbA1c were found (weighted mean difference -0.21%, 95% CI -0.40 to -0.02; p = 0.03), favouring the high MUFA groups.”
- Also stated in: § Haemoglobin A1c · plain
  “High-MUFA diets were associated with significantly decreased values of HbA1c compared to low-MUFA settings (WMD -0.21%, 95% CI -0.40 to -0.02; p = 0.03).”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Abstract
Load-bearingStrength:plain· not yet calibratedCausal:direct· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes
- The authors state this as an assumption: Imputing the baseline standard deviation for one trial is a valid procedure because baseline and post-intervention standard deviations were similar in the other included trials.
In the paper
“A total of 9 studies, recruiting 1,547 participants met the inclusion criteria [18,[20][21][22][23][24][25][26][27] .”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Characteristics of Studies and Participants
What the sources say
- Not checked yetcites [18,[20][21][22][23][24][25][26][27]
Load-bearingStrength:plain· not yet calibratedn = 1,547
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes
- The authors state this as an assumption: Imputing the baseline standard deviation for one trial is a valid procedure because baseline and post-intervention standard deviations were similar in the other included trials.
In the paper
“The homeostasis model assessment of insulin resistance (HOMA-IR) is an independent predictor of CVD in T2D [7] .”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Introduction
What the sources say
- Not checked yetcites [7] source
Strength:plain· not yet calibratedCausal:correlational· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes

Show all 18 claims

It may state two separate claims as one. 12
Probably not a substantial claim. 17

In the paper
“Kinsell et al. [10] reported that the type of fat consumed might influence insulin action in humans.”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Introduction
What the sources say
- Not checked yetcites [10] source
Strength:hedged· not yet calibratedCausal:conditional· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passes
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“The improvement in IR might have beneficial effects, not only on glucose control, but also on CVD in patients with T2D [7] .”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Introduction
What the sources say
- Not checked yetcites [7] source
Strength:hedged· not yet calibratedCausal:conditional· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Previous meta-analyses, comparing diets with different amounts of fats in daily nutrition, reported an inconclusive impact of MUFA on biomarkers of CVD, which might be due to the fact that these meta-analyses included short-term intervention trials [12,13] .”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Introduction
What the sources say
- Not checked yetcites [12] source
- Not checked yetcites [13] source
Load-bearingStrength:hedged· not yet calibratedCausal:conditional· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes
It may state two separate claims as one.
In the paper
“In a retrospective study by Currie et al. [31] , investigating 47,970 patients with diabetes, HbA1c values 1 6.5% were correlated with an increased mortality rate.”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Discussion
What the sources say
- Not checked yetcites [31]
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedn = 47,970
Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passes
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Dietary composition could play a significant role in improving insulin sensitivity and reducing the risk of T2D as well as its associated complications [5] .”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Introduction
What the sources say
- Not checked yetcites [5] source
Load-bearingStrength:hedged· not yet calibratedCausal:conditional· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes
Probably not a substantial claim. It may state two separate claims as one.
In the paper
“A meta-analysis of observational studies showed that chronic hyperglycaemia is associated with an increased risk of CVD in persons with T2D [9] .”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Introduction
What the sources say
- Not checked yetcites [9] source
Strength:plain· not yet calibratedCausal:correlational· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passes
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“The outcome of this analysis shows that a high-MUFA diet had more favourable effects on glucose control in T2D than low-MUFA diets, while no effects on fasting insulin had been observed [12] .”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Introduction
What the sources say
- Not checked yetcites [12] source
Load-bearingStrength:plain· not yet calibratedCausal:direct· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes
Probably not a substantial claim. It may state two separate claims as one.
In the paper
“In the Framingham Heart Study, impaired fasting glucose was associated with increased coronary heart disease risk in women [8] .”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Introduction
What the sources say
- Not checked yetcites [8] source
Strength:plain· not yet calibratedCausal:correlational· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passes
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Long-term inter-vention trials have demonstrated a significant correlation between substantial weight loss or increased physical activity and a reduced incidence of T2D [3,4] .”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Introduction
What the sources say
- Not checked yetcites [3] source
- Not checked yetcites [4] source
Strength:boosted· not yet calibratedCausal:correlational· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passes
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Esposito et al. [18] reported significant improvements in adiponectin levels in the high-MUFA group, compared with an LF protocol after a 4-year intervention period with a simultaneous reduction in the need for antihyperglycaemic medication in the high-MUFA group.”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Discussion
What the sources say
- Not checked yetcites [18] source
Strength:plain· not yet calibratedCausal:direct· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes
It may state two separate claims as one.
In the paper
“Likewise, an HbA1c increase of 1 percentage point was associated with a relative risk for death from any cause of 1.24 in men and 1.28 in women [32] .”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Discussion
What the sources say
- Not checked yetcites [32]
Strength:plain· not yet calibratedCausal:correlational· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passes
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“In addition, high levels of adiponectin have been shown to be associated with a reduced risk of T2D [38] .”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Discussion
What the sources say
- Not checked yetcites [38]
Strength:plain· not yet calibratedCausal:correlational· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passes
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Specific recommendations for MUFA are given by the American Heart Association ( ^ 15% of TEC) and by the American Dietetic Association ( ! 20% of TEC) [40,41] , but not by the American Diabetes Association [11] .”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Discussion
What the sources say
- Not checked yetcites [40]
- Not checked yetcites [41]
- Not checked yetcites [11] source
Strength:plain· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passes
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“In a recently published review, Gillingham et al. [39] concluded that more and more epidemiological and human clinical trial data demonstrate the cardioprotective activity of the MUFA content of dietary fat.”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Discussion
What the sources say
- Not checked yetcites [39]
Strength:boosted· not yet calibratedCausal:direct· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passes
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“The authors concluded that the beneficial effect of dietary MUFA on insulin sensitivity is associated with a conserved IRS-1/PI3 kinase insulin signalling pathway, which was altered by saturated fatty acids [37] .”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Discussion
What the sources say
- Not checked yetcites [37]
Strength:plain· not yet calibratedCausal:correlational· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Early pancreatic ␤ -cell dysfunction causes IR and IGT [33,34] .”
§ Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis > Discussion
What the sources say
- Not checked yetcites [33]
- Not checked yetcites [34]
Strength:plain· not yet calibratedCausal:direct· not yet calibrated
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes
It may state two separate claims as one.

26 of 26

The authors state this as an assumption.
Imputing the baseline standard deviation for one trial is a valid procedure because baseline and post-intervention standard deviations were similar in the other included trials.
“We assumed that this is a valid procedure, since the baseline and post-intervention SD were found to be similar within the other trials included in the metaanalysis.”

1 of 1

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Each contradiction between two passages listed here was confirmed by an independent check.

Table describes change scores, but methods specify endpoint values
Major
Table 2 says its pooled effects are changes from baseline, whereas the methods say the meta-analysis compared post-intervention values. These are different outcome measures.
Esposito citation points to a different author
Minor
The discussion identifies reference [18] as an Esposito study, but entry 18 in the reference list is by Boulé and colleagues.
Fasting insulin is reported in incompatible units
Minor
The assessed-outcomes section specifies U/ml for fasting plasma insulin, but the fasting-insulin result reports its mean difference in mg/dl.

3 of 3

Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
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Diabetes Mellitus, Fasting Glucose, and Risk of Cause-Specific Death
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Diet and Lifestyle Recommendations Revision 2006: A Scientific Statement From the American Heart Association Nutrition Committee
Lichtenstein, A. H., Appel, L. J., Brands, M., Carnethon, M., Daniels, S., Franch, H. A., Franklin, B., Kris-Etherton, P., Harris, W. S., Howard, B., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.176158 · Cited by 2,705
Obesity and Diabetes in the Developing World — A Growing Challenge
Hossain, P., Kawar, B., & El Nahas, M. (2007) · New England Journal of Medicine · doi:10.1056/nejmp068177 · Cited by 2,200
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes
Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-002-1009-0 · Cited by 2,166
Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet
Shai, I., Schwarzfuchs, D., Henkin, Y., Shahar, D. R., Witkow, S., Greenberg, I., Golan, R., Fraser, D., Bolotin, A., Vardi, H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708681 · Cited by 2,143
Effect of a Mediterranean-Style Diet on Endothelial Dysfunction and Markers of Vascular Inflammation in the Metabolic Syndrome: A Randomized Trial
Esposito, K., Marfella, R., Ciotola, M., Di Palo, C., Giugliano, F., Giugliano, G., D'Armiento, M., D'Andrea, F., & Giugliano, D. (2004) · JAMA · doi:10.1001/jama.292.12.1440 · Cited by 2,126
Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom prospective diabetes study (UKPDS: 23)
Turner, R. C., Millns, H., Neil, H. A. W., Stratton, I. M., Manley, S. E., Matthews, D. R., & Holman, R. R. (1998) · BMJ · doi:10.1136/bmj.316.7134.823 · Cited by 2,014
Effects of Exercise on Glycemic Control and Body Mass in Type 2 Diabetes Mellitus: A Meta-analysis of Controlled Clinical Trials
Boulé, N. G., Haddad, E., Kenny, G. P., Wells, G. A., & Sigal, R. J. (2001) · JAMA · doi:10.1001/jama.286.10.1218 · Cited by 1,889

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Sorted by citations

Items 101–149 of 149

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Tranidou, A., Tsakiridis, I. G., Magriplis, E., Apostolopoulou, A., Chroni, V., Tsekitsidi, E., Kalaitzopoulou, I., Pazaras, N., Chourdakis, M., & Dagklis, T. (2024) · Biomedicines · doi:10.3390/biomedicines13010057 · Cited by 6
“Notably, if the increased MUFA intake stems from processed or high-calorie foods, rather than healthy sources like olive oil, it may contribute to excess energy intake and weight gain, thereby exacerbating the risk of GDM [22].”
A Descriptive Analysis of Macronutrient, Fatty Acid Profile, and Some Immunomodulatory Nutrients in Standard and Disease-Specific Enteral Formulae in Europe
Ruperto, M., Montero-Bravo, A., Partearroyo, T., Puga, A. M., Varela‐Moreiras, G., & Samaniego-Vaesken, M. D. L. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.877875 · Cited by 6
A randomised crossover trial: Exploring the dose–response effect of carbohydrate restriction on glycaemia in people with well‐controlled type 2 diabetes
Al‐Ozairi, E., ABDUL-GHANI, M., Oliver, N., Whitcher, B., Awadi, R. A., Samad, A. E., Taghadom, E., Al-Kandari, J., & Guess, N. D. (2022) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.13030 · Cited by 6
Associations between Metabolomic Biomarkers of Avocado Intake and Glycemia in the Multi-Ethnic Study of Atherosclerosis
Wood, A. C., Goodarzi, M. O., Senn, M. K., Gadgil, M. D., Graça, G., Allison, M., Tzoulaki, I., Mi, M., Greenland, P., Ebbels, T. M. D., et al. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.07.013 · Cited by 6
“These prior ﬁ ndings represent an emerging pattern of results across multiple studies, whereby the association of MUFA and MUFA-containing foods with glycemia differ by dysglycemia status [32 – 35], highlighting the importance of individual differences in diet-health associations.”
Result
A Novel Interaction between a 23-SNP Genetic Risk Score and Monounsaturated Fatty Acid Intake on HbA1c Levels in Southeast Asian Women
Sekar, P., Aji, A. S., Ariyasra, U., Sari, S. R., Tasrif, N., Yani, F. F., Lovegrove, J. A., Sudji, I. R., Lipoeto, N. I., & Vimaleswaran, K. S. (2024) · Nutrients · doi:10.3390/nu16173022 · Cited by 5
“Previous studies have provided insights into a plausible molecular mechanism suggesting that a dietary regimen characterized by low levels of MUFA intake could potentially contribute to elevated HbA1c levels in patients with abnormal glucose metabolism [52].”
BackgroundInfluential
Lifestyle Therapy for Diabetes Mellitus
Garvey, W. T., & Arathuzik, G. (2016) · Springer eBooks · doi:10.1007/978-3-319-24687-1_22 · Cited by 6
Mediterranean diet and role of olive oil
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Professional Practice Committee
Aiello, L. P., Colberg, S. R., Condon, J. E., Coustan, D. R., Inzucchi, S. E., King, G. L., Kuo, S., Lamster, I. B., Maynard, G., Morton-Eggleston, E., et al. (2015) · Diabetes Care · doi:10.2337/dc16-s002 · Cited by 5
Effect of olive oil consumption on diabetes risk: a dose-response meta-analysis
Du, Y., & Zhou, H. (2025) · Journal of Health, Population and Nutrition · doi:10.1186/s41043-025-00866-7 · Cited by 5
“Second, some previous clinical studies found beneficial effects of MUFAs on metabolic risk factors in T2D patients [13–15].”
Lifestyle Issues: Diet
Guess, N. D. (2016) · Wiley eBooks · doi:10.1002/9781118924853.ch25 · Cited by 2
Unsaturated fatty acid profiles and prognostic significance in epilepsy patients: A comprehensive analysis using UPLC-MS/MS and SVM algorithm
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Influential
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Background
Causality of Genetically Determined Monounsaturated Fatty Acids on Risk of Cardiovascular Disease: A Mendelian Randomization StudyPreprint
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Examples of successful microbiome-based interventions in developing countries
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Microbial Oil Production by Yarrowia lipolytica Under Semi-Continuous Cultivation and Potential Utility of Spent Supernatant
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Authors: Schwingshackl, L., Strasser, B., & Hoffmann, G.
Affiliations: UMIT TIROL - Private University for Health Sciences and Health Technology (AT)
ORCID: Schwingshackl, L.
Strasser, B.
Hoffmann, G.
Venue: Annals of Nutrition and Metabolism
Publisher: S. Karger AG
Published: 2011
Volume: 58
Issue: 4
Pages: 290-296
ISSN: 0250-6807 (ISSN-L)
1421-9697
DOI: 10.1159/000331214
OpenAlex: W1973429542
Semantic Scholar: daac3f77ce897816a7166330a66056e99aa7339f
Cited by: 147
References: 41
Citations by year: 2026: 3 · 2025: 3 · 2024: 7 · 2023: 14 · 2022: 9 · 2021: 18 · 2020: 13 · 2019: 8 · 2018: 11 · 2017: 7 · 2016: 14 · 2015: 11 · 2014: 13 · 2013: 9 · 2012: 6
FWCI: 1.12
Type: journal article
Language: en
Open access: closed
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Annals of Nutrition and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
Keywords: monounsaturated fatty acids, glycemic control, type 2 diabetes, impaired glucose tolerance, insulin resistance, HbA1c, fasting blood glucose, fasting insulin, dietary fat composition, abnormal glucose metabolism, obesity
MeSH terms: Adult, Diabetes Mellitus, Type 2, Fatty Acids, Monounsaturated, Glycated Hemoglobin, Humans, Hyperglycemia, Hypoglycemia, Insulin Resistance, Randomized Controlled Trials as Topic, Practice Guidelines as Topic, Glucose Intolerance, Overweight

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Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis

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