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Effects of Monounsaturated Fatty Acids on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis
Abstract
The appropriate pattern of macronutrient distribution for dietary protocols aimed at treating or preventing obesity and its associated cardiovascular diseases is still a controversial topic of discussion. Recommendations considering a specific percentage or range for monounsaturated fatty acids (MUFA) are rare. It was the aim of this study to analyze long-term, randomized, controlled dietary intervention trials and to investigate the effects of MUFA on the biomarkers of obesity and cardiovascular risk factors. Dietary regimens with a high amount of MUFA (>12%) were compared to those with ≤12%. The biomarkers taken into account were weight, waist circumference, fat mass, total cholesterol, LDL cholesterol, HDL cholesterol, triacylglycerols, systolic and diastolic blood pressure, as well as C-reactive protein. A total of 12 studies met the inclusion criteria. Data analysis was performed using the Review Manager 5.0.25 software. Significant differences between high- and low-MUFA protocols could be observed with respect to fat mass [–1.94 kg (confidence interval –3.72, –0.17), p = 0.03], systolic blood pressure [–2.26 mm Hg (confidence interval –4.28, –0.25), p = 0.03] and diastolic blood pressure [–1.15 mm Hg (confidence interval –1.96, –0.34), p = 0.005] favoring the dietary protocols with >12% MUFA. Therefore, MUFA might represent a useful tool in the design of dietary regimens for obesity and cardiovascular disease.
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“Monounsaturated fat improves BP and cholesterol353 and, when consumed in place of saturated fat, lowers glucose among those predisposed to insulin resistance.354”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [354]
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Metadata
- Authors
- Schwingshackl, L., Strasser, B., & Hoffmann, G.
- Affiliations
- UMIT TIROL - Private University for Health Sciences and Health Technology (AT)
- Venue
- Annals of Nutrition and Metabolism
- Publisher
- S. Karger AG
- Published
- 2011
- Volume
- 59
- Issue
- 2-4
- Pages
- 176-186
- ISSN
- 0250-6807 (ISSN-L)
- 1421-9697
- OpenAlex
- W2014433485
- Cited by
- 150
- References
- 53
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 13 · 2021: 15 · 2020: 6 · 2019: 9 · 2018: 12 · 2017: 11 · 2016: 15 · 2015: 14 · 2014: 12 · 2013: 14 · 2012: 4
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Nutrition and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Nuts composition and effects
- Keywords
- monounsaturated fatty acids, dietary fat composition, obesity, cardiovascular risk factors, weight loss, fat mass, waist circumference, blood pressure, cholesterol, triglycerides, C-reactive protein, dietary intervention, macronutrient distribution
- MeSH terms
- Adipose Tissue, Blood Pressure, Body Weight, C-Reactive Protein, Energy Intake, Cardiovascular Diseases, Dietary Fats, Unsaturated, Fatty Acids, Monounsaturated, Humans, Cholesterol, HDL, Cholesterol, LDL, Obesity, Risk Factors, Triglycerides, Biomarkers, Randomized Controlled Trials as Topic, Waist Circumference
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