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Effects of Monounsaturated Fatty Acids on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis
Abstract
The appropriate pattern of macronutrient distribution for dietary protocols aimed at treating or preventing obesity and its associated cardiovascular diseases is still a controversial topic of discussion. Recommendations considering a specific percentage or range for monounsaturated fatty acids (MUFA) are rare. It was the aim of this study to analyze long-term, randomized, controlled dietary intervention trials and to investigate the effects of MUFA on the biomarkers of obesity and cardiovascular risk factors. Dietary regimens with a high amount of MUFA (>12%) were compared to those with ≤12%. The biomarkers taken into account were weight, waist circumference, fat mass, total cholesterol, LDL cholesterol, HDL cholesterol, triacylglycerols, systolic and diastolic blood pressure, as well as C-reactive protein. A total of 12 studies met the inclusion criteria. Data analysis was performed using the Review Manager 5.0.25 software. Significant differences between high- and low-MUFA protocols could be observed with respect to fat mass [–1.94 kg (confidence interval –3.72, –0.17), p = 0.03], systolic blood pressure [–2.26 mm Hg (confidence interval –4.28, –0.25), p = 0.03] and diastolic blood pressure [–1.15 mm Hg (confidence interval –1.96, –0.34), p = 0.005] favoring the dietary protocols with >12% MUFA. Therefore, MUFA might represent a useful tool in the design of dietary regimens for obesity and cardiovascular disease.
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“Monounsaturated fat improves BP and cholesterol353 and, when consumed in place of saturated fat, lowers glucose among those predisposed to insulin resistance.354”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [354]
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Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J. M., Gavaghan, D. J., & McQuay, H. J. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(95)00134-4 · Cited by 17,582
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873
Prevalence and Trends in Obesity Among US Adults, 1999-2008
Flegal, K. M. (2010) · JAMA · doi:10.1001/jama.2009.2014 · Cited by 7,580
Heart Disease and Stroke Statistics—2010 Update: A Report From the American Heart Association
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R. J., Brown, T. M., Carnethon, M., Dai, S., De Simone, G., Ferguson, T. B., Ford, E., Furie, K., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192667 · Cited by 5,700
High density lipoprotein as a protective factor against coronary heart disease
Gordon, T., Castelli, W. P., Hjortland, M. C., Kannel, W. B., & Dawber, T. R. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90874-9 · Cited by 5,059
Mensink, R. P., Zock, P. L., Kester, A. D., & Katan, M. B. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.5.1146 · Cited by 2,811
Lichtenstein, A. H., Appel, L. J., Brands, M., Carnethon, M., Daniels, S., Franch, H. A., Franklin, B., Kris-Etherton, P., Harris, W. S., Howard, B., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.176158 · Cited by 2,705
General and abdominal adiposity and risk of death in Europe
Pischon, T., Boeing, H., Hoffmann, K., Bergmann, M., Schulze, M. B., Overvad, K., van der Schouw, Y. T., Spencer, E., Moons, K. G. M., Tjønneland, A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0801891 · Cited by 2,155
Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet
Shai, I., Schwarzfuchs, D., Henkin, Y., Shahar, D. R., Witkow, S., Greenberg, I., Golan, R., Fraser, D., Bolotin, A., Vardi, H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708681 · Cited by 2,143
Esposito, K., Marfella, R., Ciotola, M., Di Palo, C., Giugliano, F., Giugliano, G., D'Armiento, M., D'Andrea, F., & Giugliano, D. (2004) · JAMA · doi:10.1001/jama.292.12.1440 · Cited by 2,126
Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates
Sacks, F. M., Bray, G. A., Carey, V. J., Smith, S. R., Ryan, D. H., Anton, S. D., McManus, K., Champagne, C. M., Bishop, L. M., Laranjo, N., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0804748 · Cited by 1,966
Boulé, N. G., Haddad, E., Kenny, G. P., Wells, G. A., & Sigal, R. J. (2001) · JAMA · doi:10.1001/jama.286.10.1218 · Cited by 1,889
Adherence to Mediterranean diet and health status: meta-analysis
Sofi, F., Cesari, F., Abbate, R., Gensini, G. F., & Casini, A. (2008) · BMJ · doi:10.1136/bmj.a1344 · Cited by 1,717
Whelton, P. K. (2002) · JAMA · doi:10.1001/jama.288.15.1882 · Cited by 1,481
Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials
Mensink, R. P., & Katan, M. B. (1992) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.12.8.911 · Cited by 1,477
Krauss, R. M., Eckel, R. H., Howard, B., Appel, L. J., Daniels, S. R., Deckelbaum, R. J., Erdman, J. W., Kris-Etherton, P., Goldberg, I. J., Kotchen, T. A., et al. (2000) · Circulation · doi:10.1161/01.cir.102.18.2284 · Cited by 1,458
EFSA Panel on Dietetic Products, N. (2010) · EFSA Journal · doi:10.2903/j.efsa.2010.1461 · Cited by 1,353
de Koning, L., Merchant, A. T., Pogue, J., & Anand, S. S. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm026 · Cited by 1,073
Hypertriglyceridemia as a cardiovascular risk factor
Austin, M. A., Hokanson, J. E., & Edwards, K. L. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00031-9 · Cited by 1,066
Trends in the leading causes of death in the United States, 1970-2002.
Jemal, A., Ward, E. M., Hao, Y.-P., & Thun, M. (2005) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.294.10.1255 · Cited by 1,054
Avenell, A., Broom, J., Brown, T., Poobalan, A., Aucott, L., Stearns, S., Smith, W., Jung, R., Campbell, M., & Grant, A. (2004) · Health Technology Assessment · doi:10.3310/hta8210 · Cited by 1,041
Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies
Clarke, R. C., Frost, C. D., Collins, R., Appleby, P. N., & Peto, R. (1997) · BMJ · doi:10.1136/bmj.314.7074.112 · Cited by 645
Esposito, K., Maiorino, M. I., Ciotola, M., Palo, C. D., Scognamiglio, P., Gicchino, M., Petrizzo, M., Saccomanno, F., Beneduce, F., Ceriello, A., et al. (2010) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0b013e3181e5a159 · Cited by 465
Iqbal, R., Anand, S., Ounpuu, S., Islam, S., Zhang, X., Rangarajan, S., Chifamba, J., Al-Hinai, A., Keltai, M., & Yusuf, S. (2008) · Circulation · doi:10.1161/circulationaha.107.738716 · Cited by 447
High-monounsaturated-fat diets for patients with diabetes mellitus: a meta-analysis
Garg, A. (1998) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.3.577s · Cited by 428
Howard, B. V., Manson, J. E., Stefanick, M. L., Beresford, S. A., Frank, G., Jones, B., Rodabough, R. J., Snetselaar, L., Thomson, C., Tinker, L., et al. (2006) · JAMA · doi:10.1001/jama.295.1.39 · Cited by 426
Hession, M., Rolland, C., Kulkarni, U., Wise, A., & Broom, J. I. (2008) · Obesity Reviews · doi:10.1111/j.1467-789x.2008.00518.x · Cited by 408
Position of the American Dietetic Association and Dietitians of Canada: Dietary Fatty Acids
Kris‐Etherton, P. M., Innis, S. M., Assocition, A. D., & Canada, D. O. (2007) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2007.07.024 · Cited by 372
McManus, K., Antinoro, L., & Sacks, F. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801796 · Cited by 353
Buckland, G., Gonzalez, C. A., Agudo, A., Vilardell, M., Berenguer, A., Amiano, P., Ardanaz, E., Arriola, L., Barricarte, A., Basterretxea, M., et al. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp282 · Cited by 344
Wolever, T. M., Gibbs, A. L., Mehling, C., Chiasson, J.-L., Connelly, P. W., Josse, R. G., Leiter, L. A., Maheux, P., Rabasa-Lhoret, R., Rodger, N. W., et al. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.114 · Cited by 333
Trends in Waist Circumference among U.S. Adults
Ford, E. S., Mokdad, A. H., & Giles, W. H. (2003) · Obesity Research · doi:10.1038/oby.2003.168 · Cited by 327
Elhayany, A., Lustman, A., Abel, R., Attal‐Singer, J., & Vinker, S. (2010) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2009.01151.x · Cited by 298
Implications of the INTERSALT study.
Stamler, R. (1991) · Hypertension · doi:10.1161/01.hyp.17.1_suppl.i16 · Cited by 288
Olive Oil and Reduced Need for Antihypertensive Medications
Ferrara, L. A., Raimondi, A. S., d'Episcopo, L., Guida, L., Russo, A. D., & Marotta, T. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.6.837 · Cited by 288
Cooney, M. T., Dudina, A., De Bacquer, D., Wilhelmsen, L., Sans, S., Menotti, A., De Backer, G., Jousilahti, P., Keil, U., Thomsen, T., et al. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.02.041 · Cited by 250
Almonds vs complex carbohydrates in a weight reduction program
Wien, M., Sabaté, J., Iklé, D. N., Cole, S., & KANDEEL, F. R. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802411 · Cited by 221
Resch, K. (2008) · PubMed · Cited by 202
Brehm, B. J., Lattin, B. L., Summer, S. S., Boback, J. A., Gilchrist, G. M., Jandacek, R. J., & D’Alessio, D. A. (2009) · Diabetes Care · doi:10.2337/dc08-0687 · Cited by 196
Jebb, S. A., Lovegrove, J. A., Griffin, B. A., Frost, G. S., Moore, C. S., Chatfield, M. D., Bluck, L. J., Williams, C. M., & Sanders, T. A. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.29096 · Cited by 192
Dietary fat plays a major role in obesity: no
Willett, W. C. (2002) · Obesity Reviews · doi:10.1046/j.1467-789x.2002.00060.x · Cited by 189
The Metabolic Syndrome, Its Component Risk Factors, and Progression of Coronary Atherosclerosis
Bayturan, Ö. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.551 · Cited by 154
Due, A., Larsen, T. M., Mu, H., Hermansen, K., Stender, S., & Astrup, A. V. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2007.25695 · Cited by 127
Shah, M., ADAMS-HUET, B. A., & Garg, A. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.5.1251 · Cited by 109
Summary of a scientific conference on preventive nutrition: pediatrics to geriatrics.
Deckelbaum, R., Fisher, E. A., Winston, M., Kumanyika, S., Lauer, R., Pi-Sunyer, F., Jeor, S. S. S., Schaefer, E. J., & Weinstein, I. (1999) · Circulation · doi:10.1161/01.cir.100.4.450 · Cited by 89
YARNELL, J. W. G., Patterson, C. C., Sweetnam, P. M., Thomas, H. F., Bainton, D., Elwood, P. C., Bolton, C., & Miller, N. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0801.093505 · Cited by 64
Howard, B. V., Curb, J. D., Eaton, C. B., Kooperberg, C. L., Ockene, J. K., Kostis, J. B., Pettinger, M. B., Rajkovic, A., Robinson, J. G., Rossouw, J. E., et al. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28034 · Cited by 54
Keogh, J. B., Luscombe-Marsh, N. D., Noakes, M., Wittert, G. A., & Clifton, P. M. (2007) · British Journal of Nutrition · doi:10.1017/s0007114507252687 · Cited by 48
Overweight and Obesity as Determinants of Cardiovascular Risk: The Framingham Experience
Wilson, P. W. F., D'Agostino, R. B., Sullivan, L., Parise, H., & Kannel, W. B. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.16.1867 · Cited by 22
Due, A. (2008) · American Journal of Clinical Nutrition · Cited by 15
Esposito, K., Maiorino, M. I., Ciotola, M., Di Palo, C., Scognamiglio, P., Gicchino, M., Petrizzo, M., Saccomanno, F., Beneduce, F., Ceriello, A., et al. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-5-200909010-00004 · Cited by 13
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Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813
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Self-citation
Metadata
- Authors
- Schwingshackl, L., Strasser, B., & Hoffmann, G.
- Affiliations
- UMIT TIROL - Private University for Health Sciences and Health Technology (AT)
- Venue
- Annals of Nutrition and Metabolism
- Publisher
- S. Karger AG
- Published
- 2011
- Volume
- 59
- Issue
- 2-4
- Pages
- 176-186
- ISSN
- 0250-6807 (ISSN-L)
- 1421-9697
- OpenAlex
- W2014433485
- Cited by
- 150
- References
- 53
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 13 · 2021: 15 · 2020: 6 · 2019: 9 · 2018: 12 · 2017: 11 · 2016: 15 · 2015: 14 · 2014: 12 · 2013: 14 · 2012: 4
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Nutrition and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Nuts composition and effects
- Keywords
- monounsaturated fatty acids, dietary fat composition, obesity, cardiovascular risk factors, weight loss, fat mass, waist circumference, blood pressure, cholesterol, triglycerides, C-reactive protein, dietary intervention, macronutrient distribution
- MeSH terms
- Adipose Tissue, Blood Pressure, Body Weight, C-Reactive Protein, Energy Intake, Cardiovascular Diseases, Dietary Fats, Unsaturated, Fatty Acids, Monounsaturated, Humans, Cholesterol, HDL, Cholesterol, LDL, Obesity, Risk Factors, Triglycerides, Biomarkers, Randomized Controlled Trials as Topic, Waist Circumference
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