The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Probiotics Modulate Host-Microbe Interaction in the Placenta and Fetal Gut: A Randomized, Double-Blind, Placebo-Controlled Trial
Abstract
Background: Early host-microbe interaction provides important maturational stimuli for the developing immune system. The role of prenatal microbial contact remains elusive. Objectives: Our aim was to investigate whether microbes in placenta or amniotic fluid affect fetal innate immune gene expression during late pregnancy and whether innate immune gene expression profiles in the placenta and the fetal gut may be modulated by dietary supplementation with specific probiotics. Methods: Altogether 43 pregnant women were randomized to receive (1) Bifidobacterium lactis, (2) B. lactis in combination with Lactobacillus rhamnosus GG (LGG) or (3) placebo for 14 days before elective cesarian section at full term in a double-blind clinical trial. Bacteria in amniotic fluid and placenta were detected by quantitative (q)PCR. The expression of Toll-like receptor (TLR)-related genes in the placenta and meconium samples was assessed by qPCR. Gene expression patterns in meconium were interpreted to reflect immune physiology in the fetal gut. Results: The study was completed by 29 mother-infant pairs. Bacterial DNA was detected in all placenta samples. Microbial DNA in amniotic fluid and placenta was associated with changes in TLR-related gene expression in the fetal intestine. Maternal probiotic supplementation significantly modulated the expression of TLR-related genes both in the placenta and in the fetal gut. Conclusions: Microbial contact in utero is associated with changes in fetal intestinal innate immune gene expression profile. Fetal and placental immune physiology may be modulated by maternal dietary intervention using specific probiotics.
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Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
Vijay-Kumar, M., Aitken, J. D., Carvalho, F. A., Cullender, T. C., Mwangi, S., Srinivasan, S., Sitaraman, S. V., Knight, R., Ley, R. E., & Gewirtz, A. T. (2010) · Science · doi:10.1126/science.1179721 · Cited by 2,068
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Early differences in fecal microbiota composition in children may predict overweight
Kalliomäki, M., Carmen Collado, M., Salminen, S., & Isolauri, E. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.3.534 · Cited by 1,062
Self-citationMaternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero
Mold, J. E., Michaëlsson, J., Burt, T. D., Muench, M. O., Beckerman, K. P., Busch, M. P., Lee, T.-H., Nixon, D. F., & McCune, J. M. (2008) · Science · doi:10.1126/science.1164511 · Cited by 836
Collado, M. C., Isolauri, E., Laitinen, K., & Salminen, S. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29877 · Cited by 381
Self-citationIntestinal Microbial Ecology in Premature Infants Assessed with Non–Culture-Based Techniques
Mshvildadze, M., Neu, J., Shuster, J., Theriaque, D., Li, N., & Mai, V. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.06.063 · Cited by 369
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Self-citationConrad, M. L., Ferstl, R., Teich, R., Brand, S., Blümer, N., Yildirim, A. Ö., Patrascan, C. C., Hanuszkiewicz, A., Akira, S., Wagner, H., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20090845 · Cited by 320
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Self-citationBifidobacterium and Lactobacillus DNA in the human placenta
Satokari, R., Grönroos, T., Laitinen, K., Salminen, S., & Isolauri, E. (2009) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2008.02475.x · Cited by 303
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Cited by
Perez-Muñoz, M. E., Arrieta, M.-C., Ramer-Tait, A. E., & Walter, J. (2017) · Microbiome · doi:10.1186/s40168-017-0268-4 · Cited by 1,096
Microbiota and neurodevelopmental windows: implications for brain disorders
Borre, Y. E., O’Keeffe, G. W., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.002 · Cited by 1,089
The infant microbiome development: Mom matters
Mueller, N. T., Bakacs, E., Combellick, J., Grigoryan, Z., & Dominguez-Bello, M. G. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.12.002 · Cited by 943
Our gut microbiome: The evolving inner self
Kundu, P., Blacher, E., Elinav, E., & Pettersson, S. (2017) · Cell · doi:10.1016/j.cell.2017.11.024 · Cited by 633
Microbial Changes during Pregnancy, Birth, and Infancy
Nuriel-Ohayon, M., Neuman, H., & Koren, O. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01031 · Cited by 620
Metadata
- Authors
- Rautava, S., Collado, M. C., Salminen, S., & Isolauri, E.
- Venue
- Neonatology
- Publisher
- S. Karger AG
- Published
- 2012
- Volume
- 102
- Issue
- 3
- Pages
- 178-184
- ISSN
- 1661-7800 (ISSN-L)
- 1661-7819
- OpenAlex
- W2056270090
- Cited by
- 289
- References
- 18
- FWCI
- 26.39
- Type
- journal article
- Language
- en
- Open access
- closed
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