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Cited by 943Gut microbiota and healthInfant Nutrition and HealthInfant Health and Development

The infant microbiome development: Mom matters

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Mueller, Noel T., Bakacs, Elizabeth, Combellick, Joan, Grigoryan, Zoya, Dominguez-Bello, Maria G.·2015·Trends in Molecular Medicine
DOI 10.1016/j.molmed.2014.12.002PMC PMC4464665
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Abstract

The infant microbiome plays an essential role in human health and its assembly is determined by maternal-offspring exchanges of microbiota. This process is affected by several practices, including Cesarean section (C-section), perinatal antibiotics, and formula feeding, that have been linked to increased risks of metabolic and immune diseases. Here we review recent knowledge about the impacts on infant microbiome assembly, discuss preventive and restorative strategies to ameliorate the effects of these impacts, and highlight where research is needed to advance this field and improve the health of future generations.

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  • In humans, skin microbiota is acquired at birth because the skin is sterile in utero; colonization occurs minutes after birth by the mother's commensal microorganisms, and this neonatal process is crucial to establish immune tolerance towards them.

    “In humans, skin microbiota is acquired at birth since, in utero, the skin is sterile; skin colonization occurs a few minutes after birth by the mother’s commensal microorganisms, and this process in the neonatal stage is crucial to establish immune tolerance towards them [6,7].”

    From Recreating Human Skin In Vitro: Should the Microbiota Be Taken into Account? (2024) · cites this paper as [6]

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Cited by

Sorted by citations

Authors
Mueller, N. T., Bakacs, E., Combellick, J., Grigoryan, Z., & Dominguez-Bello, M. G.
Affiliations
  • Columbia University Irving Medical Center (US)
  • New York University (US)
ORCID
Venue
Trends in Molecular Medicine
Publisher
Elsevier BV
Published
2015-02
Volume
21
Issue
2
Pages
109-117
ISSN
1471-4914 (ISSN-L)
DOI
10.1016/j.molmed.2014.12.002
PMC
PMC4464665
OpenAlex
W2143197985
Cited by
943
References
13
Citations by year
2026: 33 · 2025: 46 · 2024: 73 · 2023: 113 · 2022: 97 · 2021: 105 · 2020: 95 · 2019: 117 · 2018: 102 · 2017: 81 · 2016: 57 · 2015: 23
FWCI
5.05
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Molecular Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (T32DK091227)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Health Sciences › Health Professions › Pharmacy › Infant Health and Development
Keywords
infant microbiome, microbiota assembly, cesarean section, bottle feeding, metabolic disorders, immune disorders, preventive strategies
MeSH terms
Female, Humans, Infant, Infant Welfare, Male, Mothers, Pregnancy, Gastrointestinal Tract, Microbiota

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