Our gut microbiome: The evolving inner self
Open accessAbstract
The "holobiont" concept, defined as the collective contribution of the eukaryotic and prokaryotic counterparts to the multicellular organism, introduces a complex definition of individuality enabling a new comprehensive view of human evolution and personalized characteristics. Here, we provide snapshots of the evolving microbial-host associations and relations during distinct milestones across the lifespan of a human being. We discuss the current knowledge of biological symbiosis between the microbiome and its host and portray the challenges in understanding these interactions and their potential effects on human physiology, including microbiome-nervous system inter-relationship and its relevance to human variation and individuality.
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Reduced levels of intestinal mucus and production of microbe-derived short-chain fatty acids may be a mechanism by which the host experiences increased intestinal permeability, resulting in increased risk of local inflammation across the intestinal canal.
“Reduced levels of intestinal mucus and the production of microbe-derived SCFAs may therefore be a mechanism by which the host experiences increased intestinal permeability, resulting in an increased risk of local inflammation across the intestinal canal.37,39”
From The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options (2021) · cites this paper as [39]
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Experimental — accuracy not yet measuredThe gut microbiome changes continuously over life, with distinctive features at different ages.
“A comprehensive view of the gut microbiome in both pediatric and adult FGIDs is important in order to account for the dynamics of the gut microbiome as it exhibits a continuum across the lifespan, with hallmark characteristics in different phases of life192.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [192]
A comprehensive view of the gut microbiome in pediatric and adult FGIDs is important to account for its dynamics across the lifespan.
“A comprehensive view of the gut microbiome in both pediatric and adult FGIDs is important in order to account for the dynamics of the gut microbiome as it exhibits a continuum across the lifespan, with hallmark characteristics in different phases of life192.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [192]
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Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391 · see citing works
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works
Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774 · see citing works
Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease
Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622 · see citing works
Gut microbiota composition correlates with diet and health in the elderly
Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314 · see citing works
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283 · see citing works
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228 · see citing works
Self-citationWhy do many psychiatric disorders emerge during adolescence?
Paus, T., Keshavan, M., & Giedd, J. N. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2513 · Cited by 3,123 · see citing works
Personalized nutrition by prediction of glycemic responses
Zeevi, D., Korem, T., Zmora, N., Israeli, D., Rothschild, D., Weinberger, A., Ben-Yacov, O., Lador, D., Avnit-Sagi, T., Lotan-Pompan, M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.001 · Cited by 2,929 · see citing works
Self-citationDevelopment of the Human Infant Intestinal Microbiota
Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050177 · Cited by 2,877 · see citing works
Succession of microbial consortia in the developing infant gut microbiome
Koenig, J. E., Spor, A., Scalfone, N., Fricker, A. D., Stombaugh, J., Knight, R., Angenent, L. T., & Ley, R. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000081107 · Cited by 2,540 · see citing works
The gut microbiota influences blood-brain barrier permeability in mice
Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., Tóth, M., Korecka, A., Bakocevic, N., Ng, L. G., Kundu, P., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009759 · Cited by 2,530 · see citing works
Self-citationThe Placenta Harbors a Unique Microbiome
Aagaard, K., Ma, J., Antony, K. M., Ganu, R., Petrosino, J., & Versalovic, J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008599 · Cited by 2,494 · see citing works
Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy
Koren, O., Goodrich, J. K., Cullender, T. C., Spor, A., Laitinen, K., Kling Bäckhed, H., Gonzalez, A., Werner, J. J., Angenent, L. T., Knight, R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.07.008 · Cited by 2,165 · see citing works
Artificial sweeteners induce glucose intolerance by altering the gut microbiota
Suez, J., Korem, T., Zeevi, D., Zilberman-Schapira, G., Thaiss, C. A., Maza, O., Israeli, D., Zmora, N., Gilad, S., Weinberger, A., et al. (2014) · Nature · doi:10.1038/nature13793 · Cited by 2,067 · cited 2× · see citing works
“…recent studies suggest that it may serve as a good predictor for disease risk (Griffin et al., 2015), determination of the post-prandial glycemic responses (Korem et al., 2017; Suez et al., 2014; Zeevi et al., 2015), the risk of re-gaining weight after weight loss (Thaiss et al., 2016) and more.”
Self-citationSex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
Markle, J. G. M., Frank, D. N., Mortin-Toth, S., Robertson, C. E., Feazel, L. M., Rolle-Kampczyk, U., von Bergen, M., McCoy, K. D., Macpherson, A. J., & Danska, J. S. (2013) · Science · doi:10.1126/science.1233521 · Cited by 2,025 · see citing works
Gut microbiota are related to Parkinson's disease and clinical phenotype
Scheperjans, F., Aho, V., Pereira, P. A. B., Koskinen, K., Paulin, L., Pekkonen, E., Haapaniemi, E., Kaakkola, S., Eerola‐Rautio, J., Pohja, M., et al. (2015) · Movement Disorders · doi:10.1002/mds.26069 · Cited by 1,968 · see citing works
Experience-dependent structural synaptic plasticity in the mammalian brain
Holtmaat, A., & Svoboda, K. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2699 · Cited by 1,934 · see citing works
The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age
Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V., Sokol, H., Doré, J., Corthier, G., & Furet, J.-P. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-123 · Cited by 1,755 · see citing works
Composition, variability, and temporal stability of the intestinal microbiota of the elderly
Claesson, M. J., Cusack, S., O'Sullivan, O., Greene-Diniz, R., de Weerd, H., Flannery, E., Marchesi, J. R., Falush, D., Dinan, T., Fitzgerald, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000097107 · Cited by 1,754 · see citing works
The interplay between the intestinal microbiota and the brain
Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611 · cited 2× · see citing works
“The ‘‘microbiome-gut-brain axis’’ (Braniste et al., 2014; Collins et al., 2012; Diaz Heijtz et al., 2011; O’Mahony et al., 2011; Rhee et al., 2009) represents the complex crosstalk between the gut, its microbiome, and the brain.”
The central nervous system and the gut microbiome
Sharon, G., Sampson, T. R., Geschwind, D. H., & Mazmanian, S. K. (2016) · Cell · doi:10.1016/j.cell.2016.10.027 · Cited by 1,513 · see citing works
Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians
Biagi, E., Nylund, L., Candela, M., Ostan, R., Bucci, L., Pini, E., Nikkïla, J., Monti, D., Satokari, R., Franceschi, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010667 · Cited by 1,483 · see citing works
Principles and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · cited 2× · see citing works
“The ‘‘microbiome-gut-brain axis’’ (Braniste et al., 2014; Collins et al., 2012; Diaz Heijtz et al., 2011; O’Mahony et al., 2011; Rhee et al., 2009) represents the complex crosstalk between the gut, its microbiome, and the brain.”
Thevaranjan, N., Puchta, A., Schulz, C., Naidoo, A., Szamosi, J. C., Verschoor, C. P., Loukov, D., Schenck, L. P., Jury, J., Foley, K. P., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.002 · Cited by 1,322 · see citing works
The maturing architecture of the brain's default network
Fair, D. A., Cohen, A. L., Dosenbach, N. U. F., Church, J. A., Miezin, F. M., Barch, D. M., Raichle, M. E., Petersen, S. E., & Schlaggar, B. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800376105 · Cited by 1,314 · see citing works
Zhang, L., Hou, D., Chen, X., Li, D., Zhu, L., Zhang, Y., Li, J., Bian, Z., Liang, X., Cai, X., et al. (2012) · Cell Research · doi:10.1038/cr.2011.158 · Cited by 1,216 · see citing works
Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor
Smith, M. I., Yatsunenko, T., Manary, M. J., Trehan, I., Mkakosya, R., Cheng, J., Kau, A. L., Rich, S. S., Concannon, P., Mychaleckyj, J. C., et al. (2013) · Science · doi:10.1126/science.1229000 · Cited by 1,173 · see citing works
Temporal and spatial variation of the human microbiota during pregnancy
DiGiulio, D. B., Callahan, B. J., McMurdie, P. J., Costello, E. K., Lyell, D. J., Robaczewska, A., Sun, C. L., Goltsman, D. S. A., Wong, R. J., Shaw, G., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1502875112 · Cited by 1,129 · see citing works
Collado, M. C., Rautava, S., Aakko, J., Isolauri, E., & Salminen, S. (2016) · Scientific Reports · doi:10.1038/srep23129 · Cited by 1,098 · see citing works
Perez-Muñoz, M. E., Arrieta, M.-C., Ramer-Tait, A. E., & Walter, J. (2017) · Microbiome · doi:10.1186/s40168-017-0268-4 · Cited by 1,096 · see citing works
Microbiota and neurodevelopmental windows: implications for brain disorders
Borre, Y. E., O’Keeffe, G. W., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.002 · Cited by 1,089 · see citing works
Psychobiotics and the manipulation of bacteria–gut–brain signals
Sarkar, A., Lehto, S. M., Harty, S., Dinan, T. G., Cryan, J. F., & Burnet, P. W. J. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.09.002 · Cited by 1,068 · see citing works
Genetic determinants of the gut microbiome in UK twins
Goodrich, J. K., Davenport, E. R., Beaumont, M., Jackson, M. A., Knight, R., Ober, C., Spector, T. D., Bell, J. T., Clark, A. G., & Ley, R. E. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.04.017 · Cited by 1,048 · see citing works
Gut Microbiota and Extreme Longevity
Biagi, E., Franceschi, C., Rampelli, S., Severgnini, M., Ostan, R., Turroni, S., Consolandi, C., Quercia, S., Scurti, M., Monti, D., et al. (2016) · Current Biology · doi:10.1016/j.cub.2016.04.016 · Cited by 1,025 · see citing works
Gastrointestinal Dysfunction in Parkinson’s Disease
Fasano, A., Visanji, N. P., Liu, L. W. C., Lang, A. E., & Pfeiffer, R. F. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00007-1 · Cited by 1,016 · see citing works
The core gut microbiome, energy balance and obesity
Turnbaugh, P. J., & Gordon, J. I. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.174136 · Cited by 993 · see citing works
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism
Cabreiro, F., Au, C., Leung, K.-Y., Vergara-Irigaray, N., Cochemé, H. M., Noori, T., Weinkove, D., Schuster, E., Greene, N. D. E., & Gems, D. (2013) · Cell · doi:10.1016/j.cell.2013.02.035 · Cited by 967 · see citing works
Is meconium from healthy newborns actually sterile?
Jiménez, E., Marín, M. L., Martı́n, R., Odriozola, J. M., Olivares, M. M., Xaus, J., Fernández, L., & Rodríguez, J. M. (2008) · Research in Microbiology · doi:10.1016/j.resmic.2007.12.007 · Cited by 944 · see citing works
Gastrointestinal dysfunction in Parkinson's disease
Pfeiffer, R. F. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00307-7 · Cited by 925 · see citing works
Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota
Harach, T., Marungruang, N., Duthilleul, N., Cheatham, V., Mc Coy, K. D., Frisoni, G., Neher, J. J., Fåk, F., Jucker, M., Lasser, T., et al. (2017) · Scientific Reports · doi:10.1038/srep41802 · Cited by 901 · see citing works
Sela, D. A., Chapman, J., Adeuya, A., Kim, J., Chen, F., Whitehead, T. R., Lapidus, A. L., Rokhsar, D. S., Lebrilla, C. B., German, J. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809584105 · Cited by 878 · see citing works
Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes
Kurokawa, K., Itoh, T., Kuwahara, T., Oshima, K., Toh, H., Toyoda, A., Takami, H., Morita, H., Sharma, V. K., Srivastava, T. P., et al. (2007) · DNA Research · doi:10.1093/dnares/dsm018 · Cited by 869 · see citing works
Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women
Collado, M. C., Isolauri, E., Laitinen, K., & Salminen, S. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.894 · Cited by 863 · see citing works
Molecular Monitoring of Succession of Bacterial Communities in Human Neonates
Favier, C. F., Vaughan, E. E., de Vos, W. M., & Akkermans, A. D. L. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.1.219-226.2002 · Cited by 859 · see citing works
The human milk microbiota: Origin and potential roles in health and disease
Fernández, L., Langa, S., Martín, V., Maldonado‐Barragán, A., Jiménez, E., Martı́n, R., & Rodríguez, J. M. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.09.001 · Cited by 849 · see citing works
Gut Microbiota Orchestrates Energy Homeostasis during Cold
Chevalier, C., Stojanović, O., Colin, D. J., Suarez-Zamorano, N., Tarallo, V., Veyrat-Durebex, C., Rigo, D., Fabbiano, S., Stevanović, A., Hagemann, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.004 · Cited by 829 · see citing works
The effect of host genetics on the gut microbiome
Bonder, M. J., Kurilshikov, A., Tigchelaar, E. F., Mujagic, Z., Imhann, F., Vila, A. V., Deelen, P., Vatanen, T., Schirmer, M., Smeekens, S. P., et al. (2016) · Nature Genetics · doi:10.1038/ng.3663 · Cited by 819 · see citing works
Storelli, G., Defaye, A., Erkoşar, B., Pascal Hols, A., Royet, J., & Leulier, F. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.07.012 · Cited by 804 · see citing works
Human milk is a source of lactic acid bacteria for the infant gut
Martín, R., Langa, S., Reviriego, C., Jimínez, E., Marín, M. L., Xaus, J., Fernández, L., & Rodríguez, J. M. (2003) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2003.09.028 · Cited by 792 · see citing works
Jiménez, E., Fernández, L., Marín, M. L., Martı́n, R., Odriozola, J. M., Nueno‐Palop, C., Narbad, A., Olivares, M. M., Xaus, J., & Rodríguez, J. M. (2005) · Current Microbiology · doi:10.1007/s00284-005-0020-3 · Cited by 681 · see citing works
Wang, J., Thingholm, L. B., Skiecevičienė, J., Rausch, P., Kummen, M., Hov, J. R., Degenhardt, F., Heinsen, F.-A., Rühlemann, M. C., Szymczak, S., et al. (2016) · Nature Genetics · doi:10.1038/ng.3695 · Cited by 625 · see citing works
Inhibition of Staphylococcus aureus by the commensal bacteria of human milk
Heikkilä, M., & Saris, P. E. J. (2003) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2003.02002.x · Cited by 501 · see citing works
Structural modulation of gut microbiota in life-long calorie-restricted mice
Zhang, C., Li, S., Yang, L., Huang, P., Li, W., Wang, S., Zhao, G., Zhang, M. H., Pang, X., Yan, Z., et al. (2013) · Nature Communications · doi:10.1038/ncomms3163 · Cited by 496 · see citing works
Persistent microbiome alterations modulate the rate of post-dieting weight regain
Thaiss, C. A., Itav, S., Rothschild, D., Meijer, M. T., Levy, M., Moresi, C., Dohnalová, L., Braverman, S., Rozin, S., Malitsky, S., et al. (2016) · Nature · doi:10.1038/nature20796 · Cited by 471 · see citing works
Self-citationPGRP-SC2 Promotes Gut Immune Homeostasis to Limit Commensal Dysbiosis and Extend Lifespan
Guo, L., Karpac, J., Tran, S. L., & Jasper, H. (2014) · Cell · doi:10.1016/j.cell.2013.12.018 · Cited by 463 · see citing works
Bezirtzoglou, E., Tsiotsias, A., & Welling, G. W. (2011) · Anaerobe · doi:10.1016/j.anaerobe.2011.03.009 · Cited by 453 · see citing works
Myelination of Cortical-hippocampal Relays During Late Adolescence
Benes, F. M. (1989) · Schizophrenia Bulletin · doi:10.1093/schbul/15.4.585 · Cited by 448 · see citing works
Changes in muscle mass and strength after menopause.
Maltais, M. L., Desroches, J., & Dionne, I. J. (2009) · PubMed · Cited by 438 · see citing works
Microbial shifts in the aging mouse gut
Langille, M. G., Meehan, C. J., Koenig, J. E., Dhanani, A. S., Rose, R. A., Howlett, S. E., & Beiko, R. G. (2014) · Microbiome · doi:10.1186/s40168-014-0050-9 · Cited by 437 · see citing works
Martı́n, R., Jiménez, E., Heilig, H. G. H. J., Fernández, L., Marín, M. L., Zoetendal, E. G., & Rodríguez, J. M. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.02063-08 · Cited by 434 · see citing works
Regulation of life span by the gut microbiota in the short-lived African turquoise killifish
Smith, P., Willemsen, D., Popkes, M., Metge, F., Gandiwa, E., Reichard, M., & Valenzano, D. R. (2017) · eLife · doi:10.7554/elife.27014 · Cited by 423 · see citing works
Maternal separation as a model of brain-gut axis dysfunction
O’Mahony, S. M., Hyland, N. P., Dinan, T. G., & Cryan, J. F. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2010-9 · Cited by 415 · see citing works
Le Huërou-Luron, I., Blat, S., & Boudry, G. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000065 · Cited by 407 · see citing works
Marked seasonal variation in the wild mouse gut microbiota
Maurice, C. F., Knowles, S. C. L., Ladau, J., Pollard, K. S., Fenton, A., Pedersen, A. B., & Turnbaugh, P. J. (2015) · The ISME Journal · doi:10.1038/ismej.2015.53 · Cited by 406 · see citing works
Structure and function of the healthy pre-adolescent pediatric gut microbiome
Hollister, E. B., Riehle, K., Luna, R. A., Weidler, E. M., Rubio-Gonzales, M., Mistretta, T.-A., Raza, S., Doddapaneni, H. V., Metcalf, G. A., Muzny, D. M., et al. (2015) · Microbiome · doi:10.1186/s40168-015-0101-x · Cited by 406 · see citing works
Stout, M. J., Conlon, B., Landeau, M., Lee, I., Bower, C., Zhao, Q., Roehl, K. A., Nelson, D. M., Macones, G. A., & Mysorekar, I. U. (2013) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2013.01.018 · Cited by 389 · see citing works
Convergent Evolution of Rumen Microbiomes in High-Altitude Mammals
Zhang, Z., Xu, D., Wang, L., Hao, J., Wang, J., Zhou, X., Wang, W., Qiu, Q., Huang, X., Zhou, J., et al. (2016) · Current Biology · doi:10.1016/j.cub.2016.05.012 · Cited by 389 · see citing works
Gosalbes, M. J., Llop, S., Vallès, Y., Moyá, A., Ballester, F., & Francino, M. P. (2012) · Clinical & Experimental Allergy · doi:10.1111/cea.12063 · Cited by 382 · see citing works
Moles, L., Gómez, M., Heilig, H. G. H. J., Bustos, G., Fuentes, S., de Vos, W. M., Fernández, L., Rodríguez, J. M., & Jiménez, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066986 · Cited by 379 · see citing works
Increased Internal and External Bacterial Load during Drosophila Aging without Life-Span Trade-Off
Ren, C., Webster, P. C., Finkel, S. E., & Tower, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.006 · Cited by 363 · see citing works
Microbiota controls the homeostasis of glial cells in the gut lamina propria
Kabouridis, P. S., Lasrado, R., McCallum, S., Chng, S. H., Snippert, H. J., Clevers, H., Pettersson, S., & Pachnis, V. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.037 · Cited by 358 · see citing works
Self-citationMicrobial Genetic Composition Tunes Host Longevity
Han, B., Sivaramakrishnan, P., Lin, C.-C., Neve, I. A. A., He, J., Tay, L. W. R., Sowa, J. N., Sizovs, A., Du, G., Wang, J., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.036 · Cited by 349 · see citing works
Biagi, E., Nylund, L., Candela, M., Ostan, R., Bucci, L., Pini, E., Nikkïla, J., Monti, D., Satokari, R., Franceschi, C., et al. (2010) · PLoS ONE · doi:10.1371/annotation/df45912f-d15c-44ab-8312-e7ec0607604d · Cited by 345 · see citing works
Agans, R., Rigsbee, L., Kenche, H., Michail, S., Khamis, H. J., & Paliy, O. (2011) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2011.01120.x · Cited by 343 · see citing works
Intestinal microbiota influence the early postnatal development of the enteric nervous system
Collins, J., Borojevic, R., Verdu, E. F., Huizinga, J. D., & Ratcliffe, E. M. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12236 · Cited by 318 · cited 2× · see citing works
“Even though the infant gut microbiota is less diverse, it has a significant impact on ENS development, as recently shown by the reduction of myenteric neurons in germ-free mice at postnatal day 3 compared to conventionally raised mice (Collins et al., 2014; Kabouridis et al., 2015).”
Bread Affects Clinical Parameters and Induces Gut Microbiome-Associated Personal Glycemic Responses
Korem, T., Zeevi, D., Zmora, N., Weissbrod, O., Bar, N., Lotan-Pompan, M., Avnit-Sagi, T., Kosower, N., Malka, G., Rein, M., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.002 · Cited by 318 · see citing works
Self-citationVerstraelen, H., Vilchez‐Vargas, R., Desimpel, F., Jáuregui, R., Vankeirsbilck, N., Weyers, S., Verhelst, R., Sutter, P. D., Pieper, D. H., & de Wiele, T. V. (2016) · PeerJ · doi:10.7717/peerj.1602 · Cited by 311 · see citing works
Diet-Induced Developmental Acceleration Independent of TOR and Insulin in C. elegans
MacNeil, L. T., Watson, E. V., Arda, H. E., Zhu, L. J., & Walhout, A. J. M. (2013) · Cell · doi:10.1016/j.cell.2013.02.049 · Cited by 309 · see citing works
Kelly, L. P., Carvey, P. M., Keshavarzian, A., Shannon, K. M., Shaikh, M., Bakay, R. A. E., & Kordower, J. H. (2014) · Movement Disorders · doi:10.1002/mds.25736 · Cited by 308 · see citing works
Possible association between amniotic fluid micro-organism infection and microflora in the mouth
Bearfield, C., Davenport, E. S., Sivapathasundaram, V., & Allaker, R. P. (2002) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2002.01349.x · Cited by 306 · see citing works
Bifidobacterium and Lactobacillus DNA in the human placenta
Satokari, R. M., Grönroos, T., Laitinen, K., Salminen, S., & Isolauri, E. (2008) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2008.02475.x · Cited by 304 · see citing works
Rautava, S., Collado, M. C., Salminen, S., & Isolauri, E. (2012) · Neonatology · doi:10.1159/000339182 · Cited by 289 · see citing works
Probiotic Potential of 3 Lactobacilli Strains Isolated From Breast Milk
Martı́n, R., Olivares, M. M., Marín, M. L., Fernández, L., Xaus, J., & Rodríguez, J. M. (2005) · Journal of Human Lactation · doi:10.1177/0890334404272393 · Cited by 279 · see citing works
Obata, Y., & Pachnis, V. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.07.044 · Cited by 278 · see citing works
Long‐term monitoring of the human intestinal microbiota composition
Rajilić-Stojanović, M. D., Heilig, H. G. H. J., Tims, S., Zoetendal, E. G., & de Vos, W. M. (2012) · Environmental Microbiology · doi:10.1111/1462-2920.12023 · Cited by 268 · see citing works
Microbiota of the seminal fluid from healthy and infertile men
Hou, D., Zhou, X., Zhong, X., Settles, M. L., Herring, J., Wang, L., Abdo, Z., Forney, L. J., & Xu, C. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.07.1991 · Cited by 266 · see citing works
Small intestinal length: a factor essential for gut adaptation.
Weaver, L. T., Austin, S., & Cole, T. J. (1991) · Gut · doi:10.1136/gut.32.11.1321 · Cited by 265 · see citing works
Accounting for reciprocal host–microbiome interactions in experimental science
Stappenbeck, T. S., & Virgin, H. W. (2016) · Nature · doi:10.1038/nature18285 · Cited by 265 · see citing works
Cultivation-independent assessment of the bacterial diversity of breast milk among healthy women
Martı́n, R., Heilig, H. G. H. J., Zoetendal, E. G., Jiménez, E., Fernández, L., Smidt, H., & Rodríguez, J. M. (2006) · Research in Microbiology · doi:10.1016/j.resmic.2006.11.004 · Cited by 261 · see citing works
Variation in human intestinal microbiota with age
Hopkins, M. J., Sharp, R., & Macfarlane, G. T. (2002) · Digestive and Liver Disease · doi:10.1016/s1590-8658(02)80157-8 · Cited by 249 · see citing works
Shoemark, D. K., & Allen, S. J. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141170 · Cited by 248 · see citing works
Gastric emptying time and gastric motility in patients with Parkinson's disease
Hardoff, R., Sula, M., Tamir, A., Soil, A., Front, A., Badarna, S., Honigman, S., & Giladi, N. (2001) · Movement Disorders · doi:10.1002/mds.1203 · Cited by 248 · see citing works
Comparative Metagenomics and Population Dynamics of the Gut Microbiota in Mother and Infant
Vaishampayan, P., Kuehl, J. V., Froula, J. L., Morgan, J. L., Ochman, H., & Francino, M. P. (2010) · Genome Biology and Evolution · doi:10.1093/gbe/evp057 · Cited by 236 · see citing works
Ringel-Kulka, T., Cheng, J., Ringel, Y., Salojärvi, J., Carroll, I., Palva, A., de Vos, W. M., & Satokari, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064315 · Cited by 230 · see citing works
Complementary seminovaginal microbiome in couples
Mändar, R., Punab, M., Borovkova, N., Lapp, E., Kiiker, R., Korrovits, P., Metspalu, A., Krjutškov, K., Nõlvak, H., Preem, J., et al. (2015) · Research in Microbiology · doi:10.1016/j.resmic.2015.03.009 · Cited by 223 · see citing works
The Gut-Brain Axis, BDNF, NMDA and CNS Disorders
Maqsood, R., & Stone, T. W. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2039-1 · Cited by 223 · see citing works
Albesharat, R., Ehrmann, M. A., Korakli, M., Yazaji, S., & Vogel, R. F. (2011) · Systematic and Applied Microbiology · doi:10.1016/j.syapm.2010.12.001 · Cited by 214 · see citing works
The Placental Microbiome Varies in Association with Low Birth Weight in Full-Term Neonates
Zheng, J., Xiao, X., Zhang, Q., Mao, L., Yu, M., & Xu, J. (2015) · Nutrients · doi:10.3390/nu7085315 · Cited by 200 · see citing works
Makino, H., Kushiro, A., Ishikawa, E., Muylaert, D., Kubota, H., Sakai, T., Oishi, K., Martı́n, R., Amor, K. B., Oozeer, R., et al. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.05346-11 · Cited by 197 · see citing works
Bacterial Nitric Oxide Extends the Lifespan of C. elegans
Gusarov, I., Gautier, L., Смоленцева, О. А., Shamovsky, I., Eremina, S. Y., Mironov, A. S., & Nudler, E. (2013) · Cell · doi:10.1016/j.cell.2012.12.043 · Cited by 194 · see citing works
Disease tolerance mediated by microbiome <i>E. coli</i> involves inflammasome and IGF-1 signaling
Schieber, A. M. P., Lee, Y. M., Chang, M. W., Leblanc, M., Collins, B., Downes, M., Evans, R. M., & Ayres, J. S. (2015) · Science · doi:10.1126/science.aac6468 · Cited by 189 · see citing works
Pediatric Fecal Microbiota Harbor Diverse and Novel Antibiotic Resistance Genes
Moore, A. M., Patel, S., Forsberg, K. J., Wang, B., Bentley, G. J., Razia, Y., Qin, X. G., Tarr, P. I., & Dantas, G. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078822 · Cited by 185 · see citing works
Gastrointestinal Motility Problems in Patients with Parkinsonʼs Disease
Jost, W. H. (1997) · Drugs & Aging · doi:10.2165/00002512-199710040-00002 · Cited by 178 · see citing works
Staphylococcus epidermidis: A differential trait of the fecal microbiota of breast-fed infants
Jiménez, E., Delgado, S., Maldonado‐Barragán, A., Arroyo, R., Albújar, M., García, N., Jariod, M., Fernández, L., Gómez, A., & Rodríguez, J. M. (2008) · BMC Microbiology · doi:10.1186/1471-2180-8-143 · Cited by 170 · see citing works
Stinson, L. F., Payne, M. S., & Keelan, J. A. (2016) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2016.1211088 · Cited by 167 · see citing works
Nisin-Producing Lactococcus lactis Strains Isolated from Human Milk
Beasley, S. S., & Saris, P. E. J. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.8.5051-5053.2004 · Cited by 146 · see citing works
Aging of the mammalian gastrointestinal tract: a complex organ system
Saffrey, M. J. (2013) · AGE · doi:10.1007/s11357-013-9603-2 · Cited by 139 · see citing works
Integration of metabolic and gene regulatory networks modulates the C. elegans dietary response
Watson, E., MacNeil, L. T., Arda, H. E., Zhu, L. J., & Walhout, A. J. M. (2013) · Cell · doi:10.1016/j.cell.2013.02.050 · Cited by 134 · see citing works
The path towards microbiome-based metabolite treatment
Suez, J., & Elinav, E. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.75 · Cited by 133 · see citing works
Self-citationThe female urinary microbiota, urinary health and common urinary disorders
Brubaker, L. T., & Wolfe, A. J. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2016.11.62 · Cited by 128 · see citing works
Matsumiya, Y., Kato, N., Watanabe, K., & Kato, H. (2002) · Journal of Infection and Chemotherapy · doi:10.1007/s101560200005 · Cited by 123 · see citing works
Excessive folate synthesis limits lifespan in the C. elegans: E. coliaging model
Virk, B., Correia, G. D. S., Dixon, D. P., Feyst, I., Jia, J., Oberleitner, N., Briggs, Z., Hodge, E., Edwards, R., Ward, J. M., et al. (2012) · BMC Biology · doi:10.1186/1741-7007-10-67 · Cited by 123 · see citing works
Chen, C., Lin, C., & Kao, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0144589 · Cited by 113 · see citing works
Jiménez, E., Delgado, S., Fernández, L., García, N., Albújar, M., Gómez, A., & Rodríguez, J. M. (2008) · Research in Microbiology · doi:10.1016/j.resmic.2008.09.001 · Cited by 103 · see citing works
Value of Placental Microbial Evaluation in Diagnosing Intra-amniotic Infection
Pettker, C. M., Buhimschi, I. A., Magloire, L. K., Sfakianaki, A. K., Hamar, B. D., & Buhimschi, C. S. (2007) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000255663.47512.23 · Cited by 100 · see citing works
Does Our Gut Microbiome Predict Cardiovascular Risk?
Griffin, J. L., Wang, X., & Stanley, E. G. (2015) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.114.000219 · Cited by 92 · see citing works
Ottaviani, E., Ventura, N., Mandrioli, M., Candela, M., Franchini, A., & Franceschi, C. (2011) · Biogerontology · doi:10.1007/s10522-011-9352-5 · Cited by 74 · see citing works
Biliary Mucosal Barrier and Microbiome
Verdier, J., Luedde, T., & Sellge, G. (2015) · Visceral Medicine · doi:10.1159/000431071 · Cited by 71 · see citing works
Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system
Lee, H. U., McPherson, Z. E., Tan, B., Korecka, A., & Pettersson, S. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1486-0 · Cited by 64 · see citing works
Self-citationChang, J. Y., Shin, S. M., Chun, J., Lee, J., & Seo, J. K. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e318227e518 · Cited by 63 · see citing works
Host-Microbe Interactions inCaenorhabditis elegans
Zhang, R., & Hou, A. (2013) · ISRN Microbiology · doi:10.1155/2013/356451 · Cited by 53 · see citing works
The Influence of Prebiotics on Neurobiology and Behavior
Kao, A. C.-C., Harty, S., & Burnet, P. W. J. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.08.007 · Cited by 50 · see citing works
Experimental metagenomics and ribosomal profiling of the human skin microbiome
Ferretti, P., Farina, S., Cristofolini, M., Girolomoni, G., Tett, A., & Segata, N. (2016) · Experimental Dermatology · doi:10.1111/exd.13210 · Cited by 47 · see citing works
Assié, A., Borowski, C., van der Heijden, K., Raggi, L., Geier, B., Leisch, N., Schimak, M. P., Dubilier, N., & Petersen, J. M. (2016) · Environmental Microbiology Reports · doi:10.1111/1758-2229.12442 · Cited by 45 · see citing works
Estrogen deficiency accelerates lumbar facet joints arthritis
Chen, H., Zhu, H. H., Zhang, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-01427-7 · Cited by 38 · see citing works
Markenson, G. R., Adams, L. A., Hoffman, D. E., & Reece, M. T. (2003) · PubMed · Cited by 15 · see citing works
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Inflammaging: a new immune–metabolic viewpoint for age-related diseases
Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0059-4 · Cited by 3,586 · see citing works
Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes
Riquelme, E., Zhang, Y., Zhang, L., Montiel, M., Zoltan, M., Dong, W., Quesada, P., Sahin, I., Chandra, V., San Lucas, A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.008 · Cited by 1,577 · see citing works
Facing up to the global challenges of ageing
Partridge, L., Deelen, J., & Slagboom, P. E. (2018) · Nature · doi:10.1038/s41586-018-0457-8 · Cited by 1,475 · see citing works
The Human Gut Microbiome: From Association to Modulation
Schmidt, T. S. B., Raes, J., & Bork, P. (2018) · Cell · doi:10.1016/j.cell.2018.02.044 · Cited by 845 · see citing works
Potential roles of gut microbiome and metabolites in modulating ALS in mice
Blacher, E., Bashiardes, S., Shapiro, H., Rothschild, D., Mor, U., Dori-Bachash, M., Kleimeyer, C., Moresi, C., Harnik, Y., Zur, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1443-5 · Cited by 700 · see citing works
Self-citationThe microbiome–gut–brain axis in Parkinson disease — from basic research to the clinic
Tan, A. H., Lim, S. Y., & Lang, A. E. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00681-2 · Cited by 392 · see citing works
Live biotherapeutic products: The importance of a defined regulatory framework
Cordaillat-Simmons, M., Rouanet, A., & Pot, B. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0437-6 · Cited by 328 · see citing works
The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options
Wang, Q., Luo, Y., Ray Chaudhuri, K., Reynolds, R., Tan, E.-K., & Pettersson, S. (2021) · Brain · doi:10.1093/brain/awab156 · Cited by 281 · see citing works
Self-citationHost-microbe-drug-nutrient screen identifies bacterial effectors of metformin therapy
Pryor, R., Norvaisas, P., Marinos, G., Best, L., Thingholm, L. B., Quintaneiro, L. M., De Haes, W., Esser, D., Waschina, S., Lujan, C., et al. (2019) · Cell · doi:10.1016/j.cell.2019.08.003 · Cited by 274 · see citing works
Frankiensztajn, L. M., Elliott, E., & Koren, O. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.12.003 · Cited by 248 · see citing works
Saccon, T. D., Nagpal, R., Yadav, H., Cavalcante, M. B., Nunes, A. D. D. C., Schneider, A., Gesing, A., Hughes, B., Yousefzadeh, M., Tchkonia, T., et al. (2021) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glab002 · Cited by 247 · see citing works
Maternal vertical transmission affecting early-life microbiota development
Wang, S., Ryan, C. A., Boyaval, P., Dempsey, E. M., Ross, R. P., & Stanton, C. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2019.07.010 · Cited by 243 · see citing works
Dysbiosis of the Gut Microbiome in Lung Cancer
Zhuang, H., Cheng, L., Wang, Y., Zhang, Y.-K., Zhao, M.-F., Liang, G.-D., Zhang, M.-C., Li, Y.-G., Zhao, J.-B., Gao, Y.-N., et al. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00112 · Cited by 235 · see citing works
The Microbiome as a Modifier of Neurodegenerative Disease Risk
Fang, P., Kazmi, S. A., Jameson, K. G., & Hsiao, E. Y. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.06.008 · Cited by 226 · see citing works
Intestinal microbiota in early life and its implications on childhood health
Zhuang, L., Chen, H., Zhang, S., Zhuang, J., Li, Q., & Feng, Z. (2019) · Genomics, Proteomics & Bioinformatics · doi:10.1016/j.gpb.2018.10.002 · Cited by 219 · see citing works
Versatility of bacterial outer membrane vesicles in regulating intestinal homeostasis
Wang, X., Lin, S., Wang, L., Cao, Z., Zhang, M., Zhang, Y., Liu, R., & Liu, J. (2023) · Science Advances · doi:10.1126/sciadv.ade5079 · Cited by 220 · see citing works
Microbiota effects on cancer: From risks to therapies
Rea, D., Coppola, G., Palma, G., Barbieri, A., Luciano, A., Del Prete, P., Rossetti, S., Berretta, M., Facchini, G., Perdonà, S., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24681 · Cited by 208 · see citing works
Kundu, P., Lee, H. U., Garcia-Perez, I., Tay, E. X. Y., Kim, H., Faylon, L. E., Martin, K. A., Purbojati, R., Drautz-Moses, D. I., Ghosh, S., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau4760 · Cited by 201 · see citing works
Self-citationCrosstalk between the microbiota-gut-brain axis and depression
Du, Y., Gao, X.-R., Peng, L., & Ge, J.-F. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04097 · Cited by 191 · see citing works
Microbiota and Lifestyle: A Special Focus on Diet
Redondo-Useros, N., Nova, E., González-Zancada, N., Díaz, L. E., Gómez-Martínez, S., & Marcos, A. (2020) · Nutrients · doi:10.3390/nu12061776 · Cited by 189 · see citing works
Qi, B., & Han, M. (2018) · Cell · doi:10.1016/j.cell.2018.07.032 · Cited by 164 · see citing works
Role of gut microbiota in intestinal wound healing and barrier function
Alam, A., & Neish, A. (2018) · Tissue Barriers · doi:10.1080/21688370.2018.1539595 · Cited by 166 · see citing works
The gut Microbiome in adult and pediatric functional gastrointestinal disorders
Shin, A., Preidis, G. A., Shulman, R., & Kashyap, P. C. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.054 · Cited by 163 · see citing works
Role of the intestinal microbiome, intestinal barrier and psychobiotics in depression
Trzeciak, P., & Herbet, M. (2021) · Nutrients · doi:10.3390/nu13030927 · Cited by 139 · see citing works
The role of the microbiome in the neurobiology of social behaviour
Sarkar, A., Harty, S., Johnson, K. V. ‐., Moeller, A. H., Carmody, R. N., Lehto, S. M., Erdman, S. E., Dunbar, R. I. M., & Burnet, P. W. J. (2020) · Biological Reviews · doi:10.1111/brv.12603 · Cited by 135 · see citing works
The alteration of gut microbiome and metabolism in amyotrophic lateral sclerosis patients
Zeng, Q., Shen, J., Chen, K., Zhou, J., Liao, Q., Lu, K., Yuan, J., & Bi, F. (2020) · Scientific Reports · doi:10.1038/s41598-020-69845-8 · Cited by 127 · see citing works
Immunology of the ageing kidney
Sato, Y., & Yanagita, M. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0185-9 · Cited by 126 · see citing works
Association of the gut microbiota with cognitive function in midlife
Meyer, K., Lulla, A., Debroy, K., Shikany, J. M., Yaffe, K., Meirelles, O., & Launer, L. J. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.43941 · Cited by 110 · see citing works
Intestinal alkaline phosphatase targets the gut barrier to prevent aging
Kühn, F., Adiliaghdam, F., Cavallaro, P. M., Hamarneh, S. R., Tsurumi, A., Hoda, R. S., Munoz, A. R., Dhole, Y., Ramirez, J. M., Liu, E., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.134049 · Cited by 107 · see citing works
Enduring behavioral effects induced by birth by caesarean section in the mouse
Morais, L. H., Golubeva, A. V., Moloney, G. M., Moya-Pérez, A., Ventura-Silva, A. P., Arboleya, S., Bastiaanssen, T. F. S., O’Sullivan, O., Rea, K., Borre, Y., et al. (2020) · Current Biology · doi:10.1016/j.cub.2020.07.044 · Cited by 104 · see citing works
Prospective views for whey protein and/or resistance training against age-related sarcopenia
Liao, Y., Peng, Z., Chen, L., Zhang, Y., Cheng, Q., Nüssler, A. K., Bao, W., Liu, L., & Yang, W. (2019) · Aging and Disease · doi:10.14336/ad.2018.0325 · Cited by 68 · see citing works
Kentner, A. C., Cryan, J. F., & Brummelte, S. (2019) · Developmental Psychobiology · doi:10.1002/dev.21775 · Cited by 64 · see citing works
Huang, S., Jiang, S., Huo, D., Allaband, C., Estaki, M., Cantu, V., Belda-Ferre, P., Vázquez-Baeza, Y., Zhu, Q., Ma, C., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01102-0 · Cited by 61 · see citing works
Revisiting the intestinal microbiome and its role in Diarrhea and constipation
Iancu, M. A., Profir, M., Roşu, O. A., Ionescu, R. F., Cretoiu, S. M., & Gaspar, B. S. (2023) · Microorganisms · doi:10.3390/microorganisms11092177 · Cited by 53 · see citing works
“Depending on the severity of the dysbiosis, patients can experience a diverse palette of symptoms, from mild effects like cramps, diarrhea, and constipation to more serious chronic conditions [18,19].”
BackgroundLi, Z., Zhang, F., Sun, M., Liu, J., Zhao, L., Liu, S., Li, S., & Wang, B. (2023) · PeerJ · doi:10.7717/peerj.15122 · Cited by 43 · see citing works
“The microbiome, a diverse ecosystem of mostly commensals and mutualists that occupies different niches in the human body, is assumed to interact with most organs of the host ( Kundu et al., 2017 ).”
Zhang, L., Zhuang, Z., Zhang, G., Huang, T., & Fan, D. (2022) · BMC Neurology · doi:10.1186/s12883-021-02522-z · Cited by 31 · see citing works
Lewis, N., Villani, A., & Lagopoulos, J. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.01.031 · Cited by 25 · see citing works
Gut microbiota and sepsis and sepsis-related death: a Mendelian randomization investigation
Shang, W., Zhang, S., Qian, H., Huang, S., Li, H., Liu, J., & Chen, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1266230 · Cited by 23 · see citing works
- Authors
- Kundu, P., Blacher, E., Elinav, E., & Pettersson, S.
- Affiliations
- Nanyang Technological University (SG)
- Weizmann Institute of Science (IL)
- Corresponding author
- Kundu, Parag
- Elinav, Eran
- Pettersson, Sven
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 171
- Issue
- 7
- Pages
- 1481-1493
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2774516418
- Semantic Scholar
- bdfaad14f282daba51e4c453fd979e4833781e70
- Cited by
- 633
- References
- 128
- Citations by year
- 2026: 31 · 2025: 52 · 2024: 54 · 2023: 87 · 2022: 89 · 2021: 81 · 2020: 107 · 2019: 71 · 2018: 60
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- DR-NTU (Nanyang Technological University) (submittedVersion)
- Funders
- Y. and R. Ungar
- Abisch Frenkel Foundation for the Promotion of Life Sciences
- Gurwin Family Fund for Scientific Research
- Leona M. and Harry B. Helmsley Charitable Trust
- Crown Endowment Fund for Immunological Research
- Benoziyo Endowment Fund for the Advancement of Science
- Adelis Foundation
- French National Center for Scientific Research (CNRS)
- V.R. Schwartz Research Fellow Chair
- European Research Council
- Marie Curie Integration
- German-Israeli Foundation for Scientific Research and Development
- Israel Science Foundation
- Minerva Foundation
- Rising Tide Foundation
- Helmholtz Foundation
- European Foundation for the Study of Diabetes
- Lee Kong Chian School of Medicine (SUG 2017-001)
- Singapore Centre on Environmental Life Sciences Engineering (50025000)
- Nanyang Technological University (2016-T1-002-070)
- Ministry Of Education
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- gut microbiota, holobiont, host-microbe symbiosis, human lifespan, human evolution, individuality, human diversity
- MeSH terms
- Gastrointestinal Microbiome, Aging, Animals, Bacteria, Biological Evolution, Humans, Infant, Newborn, Organ Specificity, Puberty, Symbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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