Effect of mother’s weight on infant’s microbiota acquisition, composition, and activity during early infancy: a prospective follow-up study initiated in early pregnancy
Open accessAbstract
Background It has been reported that deviations in gut microbiota composition may predispose toward obesity, and specific groups of commensal gut bacteria may harvest energy from food more efficiently than others. Alterations in microbiota compositions of mothers may be transferred to infants and lead to an increased risk of overweight. Objective We analyzed the fecal microbiota composition of infants of overweight and normal-weight mothers and assessed the relations of weight and excessive weight gain of mothers during pregnancy on the microbiota of infants. Design Mothers (n = 16) whose prepregnancy body mass index (BMI; in kg/m²) was ≥25 were selected with their infants from a prospective follow-up study of 256 women. Women with a BMI <25 (n = 26) and their infants served as control subjects. At the ages of 1 and 6 mo, infant stool samples were available for the analysis of microbiota composition by fluorescence in situ hybridization combined with flow cytometry and quantitative real-time polymerase chain reaction. Results Infants' fecal microbial composition was related to the weight and weight gain of their mothers during pregnancy. Fecal Bacteroides and Staphylococcus concentrations were significantly higher in infants of overweight mothers during the first 6 mo. Higher weights and BMIs of mothers were related to higher concentrations of Bacteroides, Clostridium, and Staphylococcus and lower concentrations of the Bifidobacterium group. Prevalences of Akkermansia muciniphila, Staphylococcus, and Clostridium difficile groups were lower in infants of normal-weight mothers and of mothers with normal weight gains during pregnancy. Conclusion The composition and development of infant gut microbiota are influenced by BMI, weight, and weight gain of mothers during pregnancy.
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Bifidobacteria dysbiosis has been reported to precede obesity.
“Additionally, bifidobacteria dysbiosis has been reported to precede obesity [105] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [105]
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- Authors
- Collado, M. C., Isolauri, E., Laitinen, K., & Salminen, S.
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 92
- Issue
- 5
- Pages
- 1023-1030
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2119611447
- Cited by
- 381
- References
- 39
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 25 · 2023: 27 · 2022: 37 · 2021: 32 · 2020: 32 · 2019: 30 · 2018: 24 · 2017: 28 · 2016: 21 · 2015: 16 · 2014: 19 · 2013: 22 · 2012: 21
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- maternal obesity, gestational weight gain, infant gut microbiota, fecal microbiota composition, Bacteroides, Staphylococcus, Clostridium, Bifidobacterium, Akkermansia muciniphila, Clostridium difficile, maternal body mass index, early infancy
- MeSH terms
- Adult, Bacteria, Feces, Female, Follow-Up Studies, Humans, Infant, Newborn, Mothers, Pregnancy, Prospective Studies, Reference Values, Colony Count, Microbial, Weight Gain, Body Mass Index, Reverse Transcriptase Polymerase Chain Reaction, Gastrointestinal Tract, Overweight
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