Nox1, 2, 4, 5: Counting out oxidative stress

Wingler, K; Hermans, JJR; Schiffers, P; Moens, AL; Paul, M; Schmidt, HHHW

doi:10.1111/j.1476-5381.2011.01249.x

Cited by 114Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Nox1, 2, 4, 5: Counting out oxidative stress

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Wingler, K, Hermans, JJR, Schiffers, P, Moens, AL, Paul, M, Schmidt, HHHW·2011·British Journal of Pharmacology

DOI 10.1111/j.1476-5381.2011.01249.xPMC PMC3195911

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Abstract

For decades, oxidative stress has been discussed as a key mechanism of endothelial dysfunction and cardiovascular disease. However, attempts to validate and exploit this hypothesis clinically by supplementing antioxidants have failed. Nevertheless, this does not disprove the oxidative stress hypothesis. As a certain degree of reactive oxygen species (ROS) formation appears to be physiological and beneficial. To reduce oxidative stress therapeutically, two alternative approaches are being developed. One is the repair of key signalling components that are compromised by oxidative stress. These include uncoupled endothelial nitric oxide (NO) synthase and oxidized/heme‐free NO receptor soluble guanylate cyclase. A second approach is to identify and effectively inhibit the relevant source(s) of ROS in a given disease condition. A highly likely target in this context is the family of NADPH oxidases. Animal models, including NOX knockout mice and new pharmacological inhibitors of NADPH oxidases have opened up a new era of oxidative stress research and have paved the way for new cardiovascular therapies. LINKED ARTICLES This article is part of a themed issue on Vascular Endothelium in Health and Disease. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2011.164.issue‐3

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Apocynin directly scavenges ROS due to its antioxidant capacities.
“Instead, apocynin directly scavenges ROS due to its antioxidant capacities [340,395,396,397,398].”
From Functions of ROS in Macrophages and Antimicrobial Immunity (2021) · cites this paper as [340]
Apocynin was long considered as a specific Nox2 inhibitor, but several studies have shown that this is not the case.
“Apocynin was long considered as specific Nox2 inhibitor. However, several studies have shown that this is indeed not the case.”
From Functions of ROS in Macrophages and Antimicrobial Immunity (2021) · cites this paper as [340]

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The ‘A’s and ‘O’s of NADPH oxidase regulation: A commentary on “Subcellular localization and function of alternatively spliced Noxo1 isoforms”
Opitz, N., Drummond, G. R., Selemidis, S., Meurer, S., & Schmidt, H. H. H. W. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.11.003 · Cited by 60 · see citing works
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Decision Analysis Supports the Paradigm That Indiscriminate Supplementation of Vitamin E Does More Harm than Good
Dotan, Y., Pinchuk, I., Lichtenberg, D. A., & Leshno, M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.178699 · Cited by 60 · see citing works
Protective Effects of BAY 41-2272 (sGC Stimulator) on Hypertension, Heart, and Cardiomyocyte Hypertrophy Induced by Chronic L-NAME Treatment in Rats
Zanfolin, M., Faro, R., de Araújo, E. G., Guaraldo, A. M. A., Antunes, E., & Nucci, G. D. (2006) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000210071.54828.9b · Cited by 56 · see citing works
Small-Molecule Inhibitors of NADPH Oxidase 4
Borbély, G., Szabadkai, I., Horváth, Z., Markó, P., Varga, Z. V., Breza, N., Baska, F., Vántus, T., Huszár, M., Geiszt, M., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm1004368 · Cited by 53 · see citing works
Reactive oxygen species are involved in regulating α1-adrenoceptor-activated vascular smooth muscle contraction
Tsai, M.-H., & Jiang, M. J. (2010) · Journal of Biomedical Science · doi:10.1186/1423-0127-17-67 · Cited by 51 · see citing works
Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress
Zhou, Z., Pyriochou, A., Kotanidou, A. N., Dalkas, G. A., van Eickels, M., Spyroulias, G. A., Roussos, C., & Papapetropoulos, A. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.51.2008 · Cited by 50 · see citing works
The NADPH oxidase inhibitor diphenyleneiodonium is also a potent inhibitor of cholinesterases and the internal Ca2+pump
Tazzeo, T., Worek, F., & Janssen, L. J. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00394.x · Cited by 42 · see citing works
Contribution of different Nox homologues to cardiac remodeling in two-kidney two-clip renovascular hypertensive rats: Effect of valsartan
Wang, P., Tang, F., Li, R., Zhang, H., Chen, S., Liu, P., & Huang, H. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.01.016 · Cited by 40 · see citing works
Adherence to 2005 Dietary Guidelines for Americans is associated with a reduced progression of coronary artery atherosclerosis in women with established coronary artery disease
Imamura, F., Jacques, P. F., Herrington, D. M., Dallal, G. E., & Lichtenstein, A. H. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27576 · Cited by 39 · see citing works
Sildenafil in hypoxic pulmonary hypertension potentiates a compensatory up‐regulation of NO‐cGMP signaling
Kirsch, M., Kemp‐Harper, B. K., Weißmann, N., Grimminger, F., & Schmidt, H. H. H. W. (2007) · The FASEB Journal · doi:10.1096/fj.06-7526com · Cited by 34 · see citing works
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Expression of NAD(P)H Oxidase Subunits and Their Contribution to Cardiovascular Damage in Aldosterone/Salt-Induced Hypertensive Rat
Park, Y. M., Lim, B. H., Touyz, R. M., & Park, J. B. (2008) · Journal of Korean Medical Science · doi:10.3346/jkms.2008.23.6.1039 · Cited by 34 · see citing works
Role of gp91phox-containing NADPH oxidase in the deoxycorticosterone acetate-salt-induced hypertension
Fujii, A., Nakano, D., Katsuragi, M., Ohkita, M., Takaoka, M., Ohno, Y., & Matsumura, Y. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.09.039 · Cited by 32 · see citing works
Effects of the sGC Stimulator BAY 41-2272 Are Not Mediated by Phosphodiesterase 5 Inhibition
Bischoff, E., & Stasch, J. (2004) · Circulation · doi:10.1161/01.cir.0000142209.28862.12 · Cited by 32 · see citing works
Intrarenal artery superoxide is mainly NADPH oxidase-derived and modulates endothelium-dependent dilation in elderly patients
Schluter, T., Zimmermann, U., Protzel, C., Miehe, B., Klebingat, K.-J., Rettig, R., & Grisk, O. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp346 · Cited by 27 · see citing works
Handbook of Experimental Pharmacology 191. cGMP: generators, effectors and therapeutic implications. Preface.
Schmidt, H. H. H. W., Hofmann, F. B., & Stasch, J. (2009) · PubMed · Cited by 26 · see citing works
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Pravastatin Decreases Blood Pressure in Hypertensive and Hypercholesterolemic Patients Receiving Antihypertensive Treatment
Kawano, H., & Yano, K. (2006) · Circulation Journal · doi:10.1253/circj.70.1116 · Cited by 20 · see citing works
Methods to Evaluate the Pharmacology of Oral Antiplatelet Drugs
Weber, A., Adamzik, M., Bachmann, H. S., Görlinger, K., Grandoch, M., Leineweber, K., Müller-Beißenhirtz, H., Wenzel, F., & Naber, C. K. (2008) · Herz · doi:10.1007/s00059-008-3132-2 · Cited by 18 · see citing works
Vitamin E supplementation: what's the harm in that?
Miller, E. R., & Güallar, E. (2009) · Clinical Trials · doi:10.1177/1740774509103248 · Cited by 10 · see citing works
Regulation of Adhesion Molecules: A New Target for the Treatment of Chronic Venous Insufficiency
Verbeuren, T. J., Bouskela, E., Cohen, R. A., & Vanhoutte, P. M. (2000) · Microcirculation · doi:10.1111/j.1549-8719.2000.tb00150.x · Cited by 8 · see citing works

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Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets
Drummond, G. R., Selemidis, S., Griendling, K. K., & Sobey, C. G. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3403 · Cited by 899 · see citing works
Functions of ROS in Macrophages and Antimicrobial Immunity
Herb, M., & Schramm, M. (2021) · Antioxidants · doi:10.3390/antiox10020313 · Cited by 633 · see citing works
Antioxidant effects of resveratrol in the cardiovascular system
Xia, N., Daiber, A., Förstermann, U., & Li, H. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13492 · Cited by 576 · see citing works
NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets
Zhang, Y., Murugesan, P., Huang, K., & Cai, H. “. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0260-8 · Cited by 546 · see citing works
Evolution of nadph oxidase inhibitors: Selectivity and mechanisms for target engagement
Altenhöfer, S., Radermacher, K. A., Kleikers, P. W. M., Wingler, K., & Schmidt, H. H. H. W. (2015) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5814 · Cited by 521 · see citing works
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M1 and M2 Macrophages: The Chicken and the Egg of Immunity
Mills, C. D., & Ley, K. F. (2014) · Journal of Innate Immunity · doi:10.1159/000364945 · Cited by 401 · see citing works
The NOX toolbox: validating the role of NADPH oxidases in physiology and disease
Altenhöfer, S., Kleikers, P. W. M., Radermacher, K. A., Scheurer, P., Rob Hermans, J. J., Schiffers, P., Ho, H., Wingler, K., & Schmidt, H. H. H. W. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1010-9 · Cited by 371 · see citing works
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NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis
Gray, S. P., Di Marco, E., Okabe, J., Szyndralewiez, C., Heitz, F., Montezano, A. C., de Haan, J. B., Koulis, C., El-Osta, A., Andrews, K. L., et al. (2013) · Circulation · doi:10.1161/circulationaha.112.132159 · Cited by 386 · see citing works
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Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy
Jha, J. C., Gray, S. P., Barit, D., Okabe, J., El-Osta, A., Namikoshi, T., Thallas-Bonke, V., Wingler, K., Szyndralewiez, C., Heitz, F., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013070810 · Cited by 352 · see citing works
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Endothelial NADPH oxidases: which NOX to target in vascular disease?
Drummond, G. R., & Sobey, C. G. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2014.06.012 · Cited by 315 · see citing works
Mechanisms and consequences of endothelial nitric oxide synthase dysfunction in hypertension
Li, Q., Youn, J.-Y., & Cai, H. “. (2015) · Journal of Hypertension · doi:10.1097/hjh.0000000000000587 · Cited by 237 · see citing works
Targeting NADPH oxidases in vascular pharmacology
Schramm‐Luc, A., Matusik, P. T., Osmenda, G., & Guzik, T. J. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.02.012 · Cited by 229 · see citing works
Inducible nitric oxide synthase: Good or bad?
Lind, M., Hayes, A., Caprnda, M., Petrovic, D., Rodrigo, L., Kruzliak, P., & Zulli, A. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.06.036 · Cited by 229 · see citing works
Redox signaling in cardiovascular health and disease
Madamanchi, N. R., & Runge, M. S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.001 · Cited by 223 · see citing works
NADPH oxidases as a source of oxidative stress and molecular target in ischemia/reperfusion injury
Kleikers, P. W. M., Wingler, K., Hermans, J. J. R., Diebold, I., Altenhöfer, S., Radermacher, K. A., Janssen, B. J., Görlach, A., & Schmidt, H. H. H. W. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0963-3 · Cited by 172 · see citing works
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Organic Nitrate Therapy, Nitrate Tolerance, and Nitrate-Induced Endothelial Dysfunction: Emphasis on Redox Biology and Oxidative Stress
Daiber, A., & Münzel, T. F. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6376 · Cited by 167 · see citing works
NADPH oxidase family proteins: signaling dynamics to disease management
Begum, R., Thota, S., Abdulkadir, A. S., Kaur, G., Bagam, P., & Batra, S. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00858-1 · Cited by 148 · see citing works
Neuroprotection After Stroke by Targeting NOX4 As a Source of Oxidative Stress
Radermacher, K. A., Wingler, K., Langhauser, F., Altenhöfer, S., Kleikers, P. W. M., Hermans, J. J. R., de Angelis, M. H., Kleinschnitz, C., & Schmidt, H. H. H. W. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4797 · Cited by 147 · see citing works
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Stress-related Transcription Factor AtfB Integrates Secondary Metabolism with Oxidative Stress Response in Aspergilli
Roze, L. V., Chanda, A., Wee, J., Awad, D. W., & Linz, J. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.253468 · Cited by 144 · see citing works
NADPH oxidases as therapeutic targets in ischemic stroke
Kahles, T., & Brandes, R. P. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1011-8 · Cited by 133 · see citing works
Natural Compounds as Modulators of NADPH Oxidases
Maraldi, T. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/271602 · Cited by 132 · see citing works
On the Clinical Pharmacology of Reactive Oxygen Species
Casas, A. I., Nogales, C., Mucke, H. A., Petraina, A., Cuadrado, A., Rojo, A. I., Ghezzi, P., Jaquet, V., Augsburger, F., Dufrasne, F., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019422 · Cited by 128 · see citing works
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Which NADPH Oxidase Isoform Is Relevant for Ischemic Stroke? The Case for Nox 2
Kahles, T., & Brandes, R. P. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4721 · Cited by 125 · see citing works
NADPH Oxidase, NOX1, Mediates Vascular Injury in Ischemic Retinopathy
Wilkinson‐Berka, J. L., Deliyanti, D., Rana, I., Miller, A. G., Agrotis, A., Armani, R., Szyndralewiez, C., Wingler, K., Touyz, R. M., Cooper, M. E., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5357 · Cited by 123 · see citing works
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Ferroptosis Mediated by Lipid Reactive Oxygen Species: A Possible Causal Link of Neuroinflammation to Neurological Disorders
Cheng, Y., Song, Y., Chen, H., Li, Q., Gao, Y. Z., Lu, G., & Luo, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5005136 · Cited by 122 · see citing works
Updates of reactive oxygen species in melanoma etiology and progression
Liu, F., Dellinger, R. W., & Meyskens, F. L. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.04.007 · Cited by 116 · see citing works
Bone targeting antioxidative nano-iron oxide for treating postmenopausal osteoporosis
Zheng, L., Zhuang, Z., Li, Y., Shi, T., Fu, K., Yan, W., Zhang, L., Wang, P., Li, L., & Jiang, Q. Y. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.11.012 · Cited by 109 · see citing works
Redox-related biomarkers in human cardiovascular disease - classical footprints and beyond
Daiber, A., Hahad, O., Andreadou, I., Steven, S., Daub, S., & Münzel, T. F. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101875 · Cited by 107 · see citing works
Suppression of NADPH oxidase- and mitochondrion-derived superoxide by Notoginsenoside R1 protects against cerebral ischemia–reperfusion injury through estrogen receptor-dependent activation of Akt/Nrf2 pathways
Meng, X., Wang, M., Wang, X., Sun, G., Ye, J., Xu, H., & Sun, X. (2014) · Free Radical Research · doi:10.3109/10715762.2014.911853 · Cited by 106 · see citing works
Inhibition of myeloperoxidase oxidant production by N-acetyl lysyltyrosylcysteine amide reduces brain damage in a murine model of stroke
Yu, G., Liang, Y. S., Huang, Z., Jones, D. W., Pritchard, K. A., & Zhang, H. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0583-x · Cited by 103 · see citing works
Neuroinflammation, oxidative stress and their interplay in neuropathic pain: Focus on specialized pro-resolving mediators and NADPH oxidase inhibitors as potential therapeutic strategies
Teixeira-Santos, L., Albino‐Teixeira, A., & Pinho, D. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105280 · Cited by 103 · see citing works
Oxidative and nitrosative stress in the maintenance of myocardial function
Zhang, Y., Tocchetti, C. G., Krieg, T., & Moens, A. L. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.010 · Cited by 96 · see citing works
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NOXious signaling in pain processing
Kallenborn-Gerhardt, W., Schröder, K., Geißlinger, G., & Schmidtko, A. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.11.001 · Cited by 91 · see citing works
Pharmacology and Clinical Drug Candidates in Redox Medicine
Dao, V. T.-V., Casas, A. I., Maghzal, G. J., Seredenina, T., Kaludercic, N., Robledinos-Anton, N., Di Lisa, F., Stocker, R., Ghezzi, P., Jaquet, V., et al. (2015) · Antioxidants & Redox Signaling · doi:10.1089/ars.2015.6430 · Cited by 88 · see citing works
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Reactive Oxygen Species: Not Omnipresent but Important in Many Locations
Herb, M., Gluschko, A., & Schramm, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.716406 · Cited by 88 · see citing works
Elimination of NADPH Oxidase Activity Promotes Reductive Stress and Sensitizes the Heart to Ischemic Injury
Yu, Q., Lee, C. F., Wang, W., Karamanlidis, G., Kuroda, J., Matsushima, S., Sadoshima, J., & Tian, R. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000555 · Cited by 84 · see citing works
Angiotensin II Decreases Endothelial Nitric Oxide Synthase Phosphorylation via AT1R Nox/ROS/PP2A Pathway
Ding, J., Yu, M., Jiang, J., Luo, Y., Zhang, Q., Wang, S., Yang, F., Wang, A., Wang, L., Zhuang, M., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.566410 · Cited by 80 · see citing works
Isoform-selective NADPH oxidase inhibitor panel for pharmacological target validation
Dao, V. T.-V., Elbatreek, M. H., Altenhöfer, S., Casas, A. I., Pachado, M. P., Neullens, C. T., Knaus, U. G., & Schmidt, H. H. H. W. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.12.038 · Cited by 77 · see citing works
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Molecular mechanisms of diabetic retinopathy: Potential therapeutic targets
El‐Remessy, A. B., Coucha, M. M., Elshaer, S. L., Eldahshan, W., & Mysona, B. A. (2015) · Middle East African Journal of Ophthalmology · doi:10.4103/0974-9233.154386 · Cited by 76 · see citing works
NADPH oxidases: Pathophysiology and therapeutic potential in age-associated pulmonary fibrosis
Kato, K., & Hecker, L. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101541 · Cited by 67 · see citing works
Medicinal Plant Polyphenols Attenuate Oxidative Stress and Improve Inflammatory and Vasoactive Markers in Cerebral Endothelial Cells during Hyperglycemic Condition
Taïlé, J., Arcambal, A., Clerc, P., Gauvin‐Bialecki, A., & Gonthier, M. (2020) · Antioxidants · doi:10.3390/antiox9070573 · Cited by 67 · see citing works
Exploiting the Pleiotropic Antioxidant Effects of Established Drugs in Cardiovascular Disease
Steven, S., Münzel, T. F., & Daiber, A. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160818185 · Cited by 66 · see citing works
VAS2870 is a pan-NADPH oxidase inhibitor
Wingler, K., Altenhöfer, S., Kleikers, P. W. M., Radermacher, K. A., Kleinschnitz, C., & Schmidt, H. H. H. W. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1107-1 · Cited by 66 · see citing works
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The emerging role of NADPH oxidase NOX5 in vascular disease
Jha, J. C., Watson, A. M. D., Mathew, G., de Vos, L. C., & Jandeleit-Dahm, K. A. M. (2017) · Clinical Science · doi:10.1042/cs20160846 · Cited by 58 · see citing works
Boldine Ameliorates Vascular Oxidative Stress and Endothelial Dysfunction
Lau, Y. S., Ling, W. C., Murugan, D. D., & Mustafa, M. R. (2014) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000185 · Cited by 60 · see citing works
Grape Seed Proanthocyanidin Ameliorates Cardiac Toxicity Induced by Boldenone Undecylenate through Inhibition of NADPH Oxidase and Reduction in the Expression of NOX2 and NOX4
Tousson, E., Elgharabawy, R. M., & El-Masry, T. A. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9434385 · Cited by 58 · see citing works
Characterization of NADPH oxidase 5 expression in human tumors and tumor cell lines with a novel mouse monoclonal antibody
Antony, S., Wu, Y., Hewitt, S. M., Anver, M. R., Butcher, D. O., Jiang, G., Meitzler, J. L., Liu, H., Juhasz, A. N., Lu, J., et al. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.07.005 · Cited by 58 · see citing works
Hyperglycemia modulates redox, inflammatory and vasoactive markers through specific signaling pathways in cerebral endothelial cells: Insights on insulin protective action
Arcambal, A., Taïlé, J., Rondeau, P., Viranaïcken, W., Meilhac, O., & Gonthier, M. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.430 · Cited by 51 · see citing works
NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression
Ohata, H., Shiokawa, D., Obata, Y., Sato, A., Sakai, H., Fukami, M., Hara, W., Taniguchi, H., Ono, M., Nakagama, H., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.085 · Cited by 50 · see citing works
HIV, Combination Antiretroviral Therapy, and Vascular Diseases in Men and Women
Kovács, L., Kress, T. C., & de Chantemèle, E. J. B. (2022) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2021.10.017 · Cited by 49 · see citing works
Transforming growth factor‐β1 requires NADPH oxidase 4 for angiogenesisin vitroandin vivo
Peshavariya, H., Chan, E. C., Liu, G., Jiang, F., & Dusting, G. J. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12263 · Cited by 49 · see citing works
Nox4-Generated Superoxide Drives Angiotensin II-Induced Neural Stem Cell Proliferation
Topchiy, E., Panzhinskiy, E., Griffin, W. S. T., Barger, S. W., Das, M., & Zawada, W. M. (2013) · Developmental Neuroscience · doi:10.1159/000350502 · Cited by 49 · see citing works
Correlation of Total Antioxidant Capacity with Reactive Oxygen Species (ROS) Consumption Measured by Oxidative Conversion
Çekiç, S. D., Çetinkaya, A., Avan, A. N., & Apak, R. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf3051297 · Cited by 49 · see citing works
Reactive oxygen species delay control of lymphocytic choriomeningitis virus
Lang, P. A., Xu, H. C., Grusdat, M., McIlwain, D. R., Pandyra, A. A., Harris, I. S., Shaabani, N., Honke, N., Maney, S. K., Lang, E., et al. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2012.167 · Cited by 51 · see citing works
NADPH oxidase enzymes in skin fibrosis: molecular targets and therapeutic agents
Babalola, O., Mamalis, A., Lev‐Tov, H. A., & Jagdeo, J. R. (2013) · Archives of Dermatological Research · doi:10.1007/s00403-013-1416-8 · Cited by 47 · see citing works
NADPH oxidase-2 inhibition restores contractility and intracellular calcium handling and reduces arrhythmogenicity in dystrophic cardiomyopathy
González, D. R., Treuer, A. V., Lamirault, G., Mayo, V., Cao, Y., Dulce, R. A., & Hare, J. M. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00890.2013 · Cited by 45 · see citing works
The 1027th target candidate in stroke: Will NADPH oxidase hold up?
Radermacher, K. A., Wingler, K., Kleikers, P. W. M., Altenhöfer, S., Hermans, J. J. R., Kleinschnitz, C., & Schmidt, H. H. H. W. (2012) · Experimental & Translational Stroke Medicine · doi:10.1186/2040-7378-4-11 · Cited by 43 · see citing works
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Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors
Cifuentes-Pagano, E., Saha, J., Csányi, G., Ghouleh, I. A., Sahoo, S., Rodriguez, A. I., Wipf, P., Pagano, P. J., & Skoda, E. M. (2013) · MedChemComm · doi:10.1039/c3md00061c · Cited by 39 · see citing works
Sex differences in the role of NADPH oxidases in endothelium-dependent vasorelaxation in porcine isolated coronary arteries
Wong, P. S., Randall, M. D., & Roberts, R. E. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.04.001 · Cited by 38 · see citing works
Activation of the Notch‑Nox4‑reactive oxygen species signaling pathway induces cell death in high glucose‑treated human retinal endothelial cells
Jiao, W., Ji, J., Li, F., Guo, J., Zheng, Y., Li, S., & Xu, W. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9637 · Cited by 37 · see citing works
Purified NADH-cytochrome b5 reductase is a novel superoxide anion source inhibited by apocynin: sensitivity to nitric oxide and peroxynitrite
Samhan-Arias, A. K., & Gutiérrez‐Merino, C. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.04.033 · Cited by 35 · see citing works
Whole-cell and nuclear NADPH oxidases levels and distribution in human endocardial endothelial, vascular smooth muscle, and vascular endothelial cells
Ahmarani, L., Avedanian, L., Al-Khoury, J., Perreault, C., Jacques, D., & Bkaily, G. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2012-0265 · Cited by 34 · see citing works
N-Methyl-D-Aspartate Receptor Signaling and Function in Cardiovascular Tissues
McGee, M. A., & Abdel‐Rahman, A. A. (2016) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000398 · Cited by 31 · see citing works
Extracellular Vesicles from Ecklonia cava and Phlorotannin Promote Rejuvenation in Aged Skin
Batsukh, S., Oh, S., Lee, J., Joo, J. H. J., Son, K. H., & Byun, K. (2024) · Marine Drugs · doi:10.3390/md22050223 · Cited by 31 · see citing works
VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC
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Authors: Wingler, K., Hermans, J., Schiffers, P., Moens, A., Paul, M., & Schmidt, H.
Affiliations: Maastricht University (NL)
Maastricht University Medical Centre (NL)
ORCID: Schiffers, P
Paul, M
Venue: British Journal of Pharmacology
Publisher: Wiley
Published: 2011-09-08
Volume: 164
Issue: 3
Pages: 866-883
ISSN: 0007-1188 (ISSN-L)
1476-5381
DOI: 10.1111/j.1476-5381.2011.01249.x
PMC: PMC3195911
OpenAlex: W1512037315
Cited by: 113
References: 176
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 6 · 2018: 8 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 12 · 2013: 15 · 2012: 15
FWCI: 1.54
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: British Journal of Pharmacology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion, other-oa)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Funders: ZonMw
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Servier
Medical Research Council
National Health and Medical Research Council
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: oxidative stress, NADPH oxidase, NOX1, NOX2, NOX4, NADPH oxidase 5, reactive oxygen species, endothelial dysfunction, cardiovascular disease, antioxidant supplementation, soluble guanylate cyclase, NADPH oxidase inhibitors
MeSH terms: Animals, Cardiovascular Agents, Cardiovascular Diseases, Humans, Oxidative Stress, NADPH Oxidases

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