The metabolic syndrome and cognitive decline in the Atherosclerosis Risk in Communities Study (ARIC).
Open accessAbstract
Background: Midlife metabolic syndrome (MetS) may impact cognitive health as a construct independently of hypertension, hyperlipidemia and other components. Methods: 10,866 participants aged 45-64 years at baseline were assessed for MetS and completed cognitive testing at two later time points (3 and 9 years from the baseline visit). Results: MetS is associated with increased odds of low cognitive performance in the domains of executive function and word fluency, but not with 6-year cognitive decline. Individual MetS components explained this association (hypertension, diabetes, low HDL, elevated triglycerides and increased waist circumference). Conclusions: A focus on the individual risk factors as opposed to MetS during midlife is important to reduce the incidence of cognitive impairment in later life.
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Maxmudova, D. (2026) · Central Asian Journal of Academic Research · doi:10.70413/cajar-v4-i9-57303
- Authors
- Dearborn, J. L., Knopman, D., Sharrett, A. R., Schneider, A. L. C., Jack Jr., C. R., Coker, L. H., Alonso, A., Selvin, E., Mosley, T. H., Wagenknecht, L. E., Windham, B. G., & Gottesman, R. F.
- Affiliations
- Johns Hopkins University (US)
- Mayo Clinic (US)
- Wake Forest University Health Sciences (US)
- University of Mississippi Medical Center (US)
- ORCID
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2014
- Volume
- 38
- Issue
- 5-6
- Pages
- 337-346
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- PMC
- PMC4201882
- OpenAlex
- W2145572375
- Cited by
- 32
- References
- 33
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2022: 4 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 8 · 2016: 4 · 2015: 2 · 2014: 1
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5u01hl096902-08)
- National Heart, Lung, and Blood Institute (HHSN268201 100012C, HHSN268201100007I, HHSN268201100007C, HHSN2682 01100008C, HH-SN-268201100006C, HHSN268201100011C, HHSN2682011-00005I, HHSN2682011-00009I, HHSN268201100005C, HHSN268201100005G, HHSN268201100010C, HHSN268201100011I, U01HL096814, HHSN26820 1100009C, U01-HL-096902, HHSN2682011-00008I, U01HL096917, U01HL096812)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- metabolic syndrome, cognitive decline, midlife, executive function, verbal fluency, hypertension, diabetes mellitus, low HDL cholesterol, triglyceride elevation, waist circumference, cognitive impairment, Atherosclerosis Risk in Communities Study
- MeSH terms
- Cognition Disorders, Female, Humans, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Risk Factors, Metabolic Syndrome
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