Morbidity in depressive disorders
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Conceptualizations about Mood DisordersKraepelin's introduction of the broad category of manic-depressive illness in the mid 1890s was followed by efforts to differentiate and define limits of potentially separable syndromes included in the original concept [2,3] .These efforts led to differentiation of BD and unipolar
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The diagnosis of major depressive disorder is likely causally heterogeneous.
“Further, the diagnosis of major depressive disorder (MDD) is likely causally heterogeneous.”
From Risk factors for relapse and recurrence of depression in adults and how they operate: A four-phase systematic review and meta-synthesis (2018) · cites this paper as Baldessarini et al., 2017
The paper’s Abstract says the MDD diagnosis grouped a broad range of depressive conditions and describes the MDD concept as heterogeneous. It does not specify that this heterogeneity is causal, so it supports the broader point but not that qualifier. The indexed passage has no page number. (LLM, conf=0.82)
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“We hypothesized that (1) smoking and alcohol consumption increase the risk of depression; (2) regular physical activity decreases the risk of depression; (3) a discrepancy in these associations exists between premenopausal and postmenopausal women.”
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“However, because MDD is a heterogenous condition, and patients with MDD exhibit multiple variable symptoms, which make the correct diagnosis difficult (2).”
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“Background Depression is a common psychiatric disorder associated with significant morbidity [1].”
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Psychological Function, Iyengar Yoga, and Coherent Breathing: A Randomized Controlled Dosing Study
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“It is complicated by accelerated biological aging[2] and increased mortality from chronic lifestyle diseases.[3,4] The cure for MDD is still”
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“Given the extraordinary morbidity of major depressive disorder (Baldessarini et al., 2017), the limited efficacy of current drug treatments for depression represents an extraordinary need for discovering and applying novel antidepressant mechanisms beyond the monoamines (Papakostas and Ionescu, 2015; Newport et al.”
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“Depressive disorders are associated with significant morbidity.(1) The largest study of standard antidepressant treatment outcomes in major depressive disorder (MDD) reported an overall cumulative remission rate of only 67% for a multistep treatment involving both antidepressant medications and cognitive therapy,(2) w…”
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“INTRODUCTION Major depressive disorder (MDD) is a leading cause of global disability [1] and morbidity [2] and is among the most common mental health disorders [3].”
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“Reduced perseveration and greater cognitive and neural flexibility hold important implications for suicidality, which is a concerning symptom of depression (59).”
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“Depression is a major mental illness that is associated with significant morbidity (Baldessarini et al., 2017) and causes significant global burden and disability (Park and Zarate, 2019).”
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“We hypothesized that (1) the increase in prefrontal cortical activity during a cognitive task is smaller in young adult patients with MDD than in HCs, and (2) differences in prefrontal hemodynamic changes occur during a cognitive task involving MDD patients with and without suicidality.”
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“Individuals with MDD are five times more likely to experience suicidal thoughts and behaviors [3], as well as complete suicide [4].”
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An Internet-based survey of the dance fitness program OULA
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Translational Neuropsychopharmacology for Major Depression: Targeting Neurotransmitter Systems
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- Authors
- Baldessarini, R. J., Forte, A., Selle, V., Sim, K., Tondo, L., Undurraga, J., & Vázquez, G. H.
- Affiliations
- McLean Hospital (US)
- Harvard University (US)
- Universidad del Desarrollo (CL)
- Queen's University (CA)
- Venue
- Psychotherapy and Psychosomatics
- Publisher
- S. Karger AG
- Published
- 2017
- Volume
- 86
- Issue
- 2
- Pages
- 65-72
- ISSN
- 0033-3190 (ISSN-L)
- 1423-0348
- OpenAlex
- W2588483919
- Cited by
- 63
- References
- 93
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 10 · 2021: 5 · 2020: 6 · 2019: 13 · 2018: 9 · 2017: 2
- FWCI
- 6.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Psychotherapy and Psychosomatics (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Funders
- Aretaeus Foundation of Rome
- Bruce J. Anderson Foundation
- National Commission for Science and Technology
- Clínica Alemana de Santiago
- Comisión Nacional de Investigación Científica y Tecnológica (ACT1414)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
- Keywords
- depressive disorders, morbidity, mood disorders, bipolar disorder, major depressive disorder, history of psychiatry
- MeSH terms
- Antidepressive Agents, Depressive Disorder, Humans, Morbidity, Risk Factors, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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