Role of Protein Kinase C in Bipolar Disorder: A Review of the Current Literature
Open accessAbstract
Bipolar disorder (BD) is a major health problem. It causes significant morbidity and imposes a burden on the society. Available treatments help a substantial proportion of patients but are not beneficial for an estimated 40-50%. Thus, there is a great need to further our understanding the pathophysiology of BD to identify new therapeutic avenues. The preponderance of evidence pointed towards a role of protein kinase C (PKC) in BD. We reviewed the literature pertinent to the role of PKC in BD. We present recent advances from preclinical and clinical studies that further support the role of PKC. Moreover, we discuss the role of PKC on synaptogenesis and neuroplasticity in the context of BD. The recent development of animal models of BD, such as stimulant-treated and paradoxical sleep deprivation, and the ability to intervene pharmacologically provide further insights into the involvement of PKC in BD. In addition, the effect of PKC inhibitors, such as tamoxifen, in the resolution of manic symptoms in patients with BD further points in that direction. Furthermore, a wide variety of growth factors influence neurotransmission through several molecular pathways that involve downstream effects of PKC. Our current understanding identifies the PKC pathway as a potential therapeutic avenue for BD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Based on these studies and human clinical data, the pathophysiology of environmental circadian disruption underlying bipolar mania may be via altered protein kinase C activity affecting neuronal signaling in frontal and limbic brain regions.
“Based on these studies and human clinical data, the pathophysiology of environmental circadian disruption underlying bipolar mania may be via altered protein kinase c activity affecting neuronal signaling in frontal and limbic brain regions139.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [139]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Yatham, L. N., & Malhi, G. S. (2011) · Oxford University Press eBooks · doi:10.1093/med/9780199562305.001.0001 · Cited by 3,515 · see citing works
Animal models of neuropsychiatric disorders
Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023 · see citing works
Grande, I., Berk, M., Birmaher, B., & Vieta, E. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00241-x · Cited by 1,710 · see citing works
The extended protein kinase C superfamily
MELLOR, H., & Parker, P. J. (1998) · Biochemical Journal · doi:10.1042/bj3320281 · Cited by 1,539 · see citing works
GAP-43: an intrinsic determinant of neuronal development and plasticity
Benowitz, L. I., & Routtenberg, A. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10072-2 · Cited by 1,332 · see citing works
Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
Stambolic, V., Ruel, L., & Woodgett, J. R. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70790-2 · Cited by 1,321 · see citing works
Chelerythrine is a potent and specific inhibitor of protein kinase C.
Herbert, J., Augereau, J., Gleye, J., & Maffrand, J. (1990) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/0006-291x(90)91544-3 · Cited by 1,260 · see citing works
Essential Role for TrkB Receptors in Hippocampus-Mediated Learning
Minichiello, L., Korte, M., Wolfer, D., Kühn, R., Unsicker, K., Cestari, V., Rossi-Arnaud, C., Lipp, H.-P., Bonhoeffer, T., & Klein, R. (1999) · Neuron · doi:10.1016/s0896-6273(00)80853-3 · Cited by 799 · see citing works
Hartwig, J. H., Thelen, M., Resen, A., Janmey, P. A., Nairn, A. C., & Aderem, A. A. (1992) · Nature · doi:10.1038/356618a0 · Cited by 730 · see citing works
Baum, A. E., Akula, N., Cabanero, M., Cardona, I., Corona, W., Klemens, B., Schulze, T. G., Cichon, S., Rietschel, M., Nöthen, M. M., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002012 · Cited by 700 · see citing works
Oxidative stress markers in bipolar disorder: A meta-analysis
Andreazza, A. C., Kauer-Sant'Anna, M., Frey, B. N., Bond, D. J., Kapczinski, F., Young, L. T., & Yatham, L. N. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.04.013 · Cited by 526 · see citing works
Identification of intracellular receptor proteins for activated protein kinase C.
Mochly‐Rosen, D., Khaner, H., & Lopez, J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3997 · Cited by 500 · see citing works
Induction of Mania with Selective Serotonin Re-uptake Inhibitors and Tricyclic Antidepressants
Peet, M. (1994) · The British Journal of Psychiatry · doi:10.1192/bjp.164.4.549 · Cited by 476 · see citing works
Brain Metabolic Alterations in Medication-Free Patients With BipolarDisorder
Dager, S. R., Friedman, S. D., Parow, A. M., Demopulos, C. M., Stoll, A. L., Lyoo, I. K., Dünner, D. L., & Renshaw, P. F. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.5.450 · Cited by 453 · see citing works
Tissue and cellular distribution of the extended family of protein kinase C isoenzymes
Wetsel, W. C., Khan, W. A., Merchenthaler, I. J., Rivera, H., Halpern, A. E., Phung, H., Negro-Vilar, A. F., & Hannun, Y. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.117.1.121 · Cited by 440 · see citing works
The Mood‐Stabilizing Agent Valproate Inhibits the Activity of Glycogen Synthase Kinase‐3
Chen, G., Huang, L., Jiang, Y., & Manji, H. K. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0721327.x · Cited by 439 · see citing works
Diacylglycerol kinases: at the hub of cell signalling
Mérida, I., Ávila‐Flores, A., & Merino, E. (2007) · Biochemical Journal · doi:10.1042/bj20071040 · Cited by 427 · see citing works
The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged?
Rizo, J., & Südhof, T. (2012) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155818 · Cited by 423 · see citing works
Neuroplasticity Mediated by Altered Gene Expression
McClung, C. A., & Nestler, E. J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301544 · Cited by 347 · see citing works
Müller-Oerlinghausen, B., Berghöfer, A., & Bauer, M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07450-0 · Cited by 333 · see citing works
Protein kinase C overactivity impairs prefrontal cortical regulation of working memory
Birnbaum, S. G., Yuan, P. X., Wang, M., Vijayraghavan, S., Bloom, A. K., Davis, D. J., Gobeske, K. T., Sweatt, J. D., Manji, H. K., & Arnsten, A. F. T. (2004) · Science · doi:10.1126/science.1100021 · Cited by 318 · see citing works
Competitive inhibition by diacylglycerol of specific phorbol ester binding.
Sharkey, N. A., Leach, K. L., & Blumberg, P. M. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.2.607 · Cited by 306 · see citing works
Neurotrophin signaling: many exciting surprises!
Arévalo, J. C., & Wu, S. H. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6010-1 · Cited by 281 · see citing works
Cellular Plasticity Cascades: Targets for the Development of Novel Therapeutics for Bipolar Disorder
Zarate, C. A., Singh, J. B., & Manji, H. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.021 · Cited by 276 · see citing works
Baudier, J., Deloulme, J., DORSSELAER, A. V., Black, D. M., & Matthes, H. W. D. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52425-x · Cited by 274 · see citing works
Abnormalities in Mitochondrial Structure in Cells from Patients with Bipolar Disorder
Cataldo, A. M., McPhie, D. L., Lange, N. T., Punzell, S., Elmiligy, S., Ye, N. Z., Froimowitz, M. P., Hassinger, L. C., Menesale, E. B., Sargent, L. W., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.081068 · Cited by 269 · see citing works
Inhibition of noradrenaline release by antibodies to B-50 (GAP-43)
Dekker, L. V., Graan, P. N. E. D., Oestreicher, A. B., Versteeg, D. H. G., & Gispen, W. H. (1989) · Nature · doi:10.1038/342074a0 · Cited by 265 · see citing works
The cognitive and neurophysiological basis of emotion dysregulation in bipolar disorder.
Green, M., Cahill, C., & Malhi, G. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.01.024 · Cited by 247 · see citing works
Phosphorylation of 25-kDa Synaptosome-associated Protein
Shimazaki, Y., Nishiki, T., Omori, A., Sekiguchi, M., Kamata, Y., Kozaki, S., & Takahashi, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.24.14548 · Cited by 247 · see citing works
Principles of Rat Communication: Quantitative Parameters of Ultrasonic Calls in Rats
Brudzynski, S. M. (2005) · Behavior Genetics · doi:10.1007/s10519-004-0858-3 · Cited by 242 · see citing works
Manji, H. K., & Lenox, R. H. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00235-8 · Cited by 241 · see citing works
Bioactive effects of quercetin in the central nervous system: Focusing on the mechanisms of actions
Suganthy, N., Devi, K. P., Nabavi, S. F., Braidy, N., & Nabavi, S. M. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.10.011 · Cited by 236 · see citing works
Hains, A. B., Vu, M. A. T., Maciejewski, P. K., van Dyck, C. H., Gottron, M., & Arnsten, A. F. T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908563106 · Cited by 234 · see citing works
Gigante, A. D., Bond, D. J., Lafer, B., Lam, R. W., Young, L. T., & Yatham, L. N. (2012) · Bipolar Disorders · doi:10.1111/j.1399-5618.2012.01033.x · Cited by 226 · see citing works
Schwarz, E., Prabakaran, S., Whitfield, P. D., Major, H. J., Leweke, F. M., Koethe, D., McKenna, P. J., & Bahn, S. (2008) · Journal of Proteome Research · doi:10.1021/pr800188y · Cited by 222 · see citing works
Brain SPECT Imaging of Amphetamine-Induced Dopamine Release in Euthymic Bipolar Disorder Patients
Anand, A., Verhoeff, P., Seneca, N., Zoghbi, S. S., Seibyl, J. P., Charney, D. S., & Innis, R. B. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.7.1108 · Cited by 222 · see citing works
Yildiz, A., Guleryuz, S., Ankerst, D. P., Öngür, D., & Renshaw, P. F. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.43 · Cited by 213 · see citing works
Identifying blood biomarkers for mood disorders using convergent functional genomics
Le-Niculescu, H., Kurian, S. M., Yehyawi, N., Dike, C., Patel, S. D., Edenberg, H. J., Tsuang, M. T., Salomon, D. R., Nürnberger, J. I., & Niculescu, A. B. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.11 · Cited by 211 · see citing works
Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot study
Zarate, C. A., Singh, J. B., Carlson, P. J., Quiroz, J., Jolkovsky, L., Luckenbaugh, D. A., & Manji, H. K. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00530.x · Cited by 208 · see citing works
Neurometabolites in schizophrenia and bipolar disorder — A systematic review and meta-analysis
Kraguljac, N. V., Reid, M. A., White, D. M., Jones, R., den Hollander, J., Lowman, D., & Lahti, A. C. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2012.02.003 · Cited by 204 · see citing works
Lithium and brain signal transduction systems
Jope, R. S., & Williams, M. B. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90172-4 · Cited by 198 · see citing works
Protein kinase C pharmacology: refining the toolbox
Wu-Zhang, A. X., & Newton, A. C. (2013) · Biochemical Journal · doi:10.1042/bj20130220 · Cited by 195 · see citing works
Altered platelet protein kinase C activity in bipolar affective disorder, manic episode
Friedman, E., Hoau-Yan-Wang, Levinson, D. F., Connell, T. A., & Singh, H. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90006-y · Cited by 194 · see citing works
Discovery and validation of blood biomarkers for suicidality
Le-Niculescu, H., Levey, D. F., Ayalew, M., Palmer, L., Gavrin, L. M., Jain, N., Winiger, E., Bhosrekar, S., Shankar, G., Radel, M., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.95 · Cited by 193 · see citing works
Ohno, S., & Nishizuka, Y. (2002) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a003249 · Cited by 191 · see citing works
Essential Role for the PKC Target MARCKS in Maintaining Dendritic Spine Morphology
Calabrese, B., & Halpain, S. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.027 · Cited by 187 · see citing works
Scaini, G., Rezin, G. T., Carvalho, A. F., STRECK, E. L., Berk, M., & Quevedo, J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.040 · Cited by 184 · see citing works
Self-citationOzaki, N., & Chuang, D. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69062336.x · Cited by 179 · see citing works
Valproate in the Treatment of Bipolar Disorder
McElroy, S. L., Keck, P. E., Pope, H. G., & Hudson, J. I. (1992) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199202001-00007 · Cited by 171 · see citing works
Chronic Sodium Valproate Selectively Decreases Protein Kinase C α and ε In Vitro
Chen, G., Manji, H. K., Hawver, D. B., Wright, C. B., & Potter, W. Z. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63062361.x · Cited by 171 · see citing works
Enhanced protein kinase C activity and translocation in bipolar affective disorder brains
Wang, H.-Y., & Friedman, E. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00611-7 · Cited by 169 · see citing works
Quercetin: A Pleiotropic Kinase Inhibitor Against Cancer
Russo, G. L., Russo, M., Spagnuolo, C., Tedesco, I., Bilotto, S., Iannitti, R., & Palumbo, R. (2013) · Cancer treatment and research · doi:10.1007/978-3-642-38007-5_11 · Cited by 168 · see citing works
Regulation of Cellular Plasticity Cascades in the Pathophysiology and Treatment of Mood Disorders
Zarate, C. A., Du, J., Quiroz, J. A., GRAY, N. A., Denicoff, K. D., Singh, J., Charney, D. S., & Manji, H. K. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.017 · Cited by 164 · see citing works
A model of the mitochondrial basis of bipolar disorder
Morris, G., Walder, K., McGee, S. L., Dean, O. M., Tye, S. J., Maes, M., & Berk, M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.014 · Cited by 162 · see citing works
Turco, E., Tang, W., Topham, M. K., Sakane, F., Marcheselli, V. L., Chen, C., Taketomi, A., Prescott, S. M., & Bazan, N. G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081536298 · Cited by 160 · see citing works
Validating GSK3 as an in vivo target of lithium action
O'Brien, W. T., & Klein, P. S. (2009) · Biochemical Society Transactions · doi:10.1042/bst0371133 · Cited by 157 · see citing works
A Preliminary Investigation of a Protein Kinase C Inhibitor in the Treatment of Acute Mania
Bebchuk, J. M., Arfken, C. L., Manji, S., Murphy, J., Hasanat, K., & Manji, H. K. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.95 · Cited by 152 · see citing works
Genome-Wide Association Study of Suicide Attempts in Mood Disorder Patients
Perlis, R. H., Huang, J., Purcell, S., D, M. F. M., Rush, A. J., Sullivan, P. F., Hamilton, S. P., McMahon, F. J., Schulze, T. G., Potash, J. B., et al. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10040541 · Cited by 147 · see citing works
Mood Symptoms, Functional Impairment, and Disability in People With Bipolar Disorder
Simon, G. E., Bauer, M. S., Ludman, E. J., Operskalski, B. H., & Unützer, J. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0811 · Cited by 146 · see citing works
Gigante, A. D., Young, L. T., Yatham, L. N., Andreazza, A. C., Nery, F. G., Grinberg, L. T., Heinsen, H., & Lafer, B. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571000146x · Cited by 143 · see citing works
Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients
Dubovsky, S. L., Murphy, J. R., Thomas, M. R., & Rademacher, J. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.1.118 · Cited by 140 · see citing works
Gould, T. D., Picchini, A. M., Einat, H., & Manji, H. K. (2006) · Current Drug Targets · doi:10.2174/1389450110607011399 · Cited by 129 · see citing works
Abnormalities in protein kinase C signaling and the pathophysiology of bipolar disorder
Hahn, C., & Friedman, E. (1999) · Bipolar Disorders · doi:10.1034/j.1399-5618.1999.010204.x · Cited by 127 · see citing works
Adenylate cyclase regulates elongation of mammalian primary cilia
Ou, Y., Ruan, Y., Cheng, M., Moser, J. J., Rattner, J. B., & van der Hoorn, F. A. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.06.028 · Cited by 124 · see citing works
Signaling networks in the pathophysiology and treatment of mood disorders
Gould, T. D., & Manji, H. K. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00426-9 · Cited by 123 · see citing works
Protein Kinase C Inhibitors: Rationale for Use and Potential in the Treatment of Bipolar Disorder
Zarate, C. A., & Manji, H. K. (2009) · CNS Drugs · doi:10.2165/00023210-200923070-00003 · Cited by 122 · see citing works
Manji, H. K., & Lenox, R. H. (1994) · Synapse · doi:10.1002/syn.890160103 · Cited by 121 · see citing works
Ouimet, C., Wang, J. K., Walaas, S. I., et al. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-05-01683.1990 · Cited by 119 · see citing works
Einat, H., Yuan, P., Szabo, S. T., Dogra, S., & Manji, H. K. (2007) · Neuropsychobiology · doi:10.1159/000106054 · Cited by 119 · see citing works
Disturbance of the Glutamatergic System in Mood Disorders
Jun, C. S., Choi, Y., Lim, S. M., Bae, S., Hong, Y. S., Kim, J. E., & Lyoo, I. K. (2014) · Experimental Neurobiology · doi:10.5607/en.2014.23.1.28 · Cited by 118 · see citing works
Kerner, B. (2014) · The Application of Clinical Genetics · doi:10.2147/tacg.s39297 · Cited by 115 · see citing works
Kulkarni, J., Garland, K. A., Scaffidi, A., Headey, B., Anderson, R., de Castella, A. R., Fitzgerald, P. B., & Davis, S. R. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.11.001 · Cited by 113 · see citing works
GSK-3: New Thoughts on an Old Enzyme
Ferkey, D. M., & Kimelman, D. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9816 · Cited by 113 · see citing works
Valproate robustly enhances AP-1 mediated gene expression
Chen, G., Yuan, P.-X., Jiang, Y., Huang, L., & Manji, H. K. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00303-9 · Cited by 101 · see citing works
Deloulme, J., Janet, T., Au, D. C., Storm, D. R., Sensenbrenner, M., & Baudier, J. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.4.1559 · Cited by 97 · see citing works
Szabo, S. T., Machado‐Vieira, R., Yuan, P., Wang, Y., Wei, Y., Falke, C., Cirelli, C., Tononi, G., Manji, H. K., & Du, J. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.015 · Cited by 95 · see citing works
Modulation of Protein Kinase C Isozymes and Substrates by Lithium: The Role of Myo-inositol
Manji, H. K. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00243-7 · Cited by 94 · see citing works
Wang, H.-Y., Markowitz, P., Levinson, D. F., Undie, A. S., & Friedman, E. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(98)90057-7 · Cited by 93 · see citing works
Hahn, C.-G., Umapathy, Wang, H.-Y., Koneru, R., Levinson, D. F., & Friedman, E. (2004) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2004.10.007 · Cited by 93 · see citing works
Amrollahi, Z., Rezaei, F., Salehi, B., Modabbernia, A., Maroufi, A., Esfandiari, G.-R., Naderi, M., Ghebleh, F., Abhari, S. A. A., Sadeghi, M., et al. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.08.015 · Cited by 92 · see citing works
Melemedjian, O. K., Tillu, D. V., Asiedu, M. N., Mandell, E. K., Moy, J. K., Blute, V. M., Taylor, C. J., Ghosh, S., & Price, T. J. (2013) · Molecular Pain · doi:10.1186/1744-8069-9-12 · Cited by 91 · see citing works
Lithium regulates PKC‐mediated intracellular cross‐talk and gene expression in the CNS in vivo
Chen, G., Masana, M. I., & Manji, H. K. (2000) · Bipolar Disorders · doi:10.1034/j.1399-5618.2000.20303.x · Cited by 90 · see citing works
Lithium inhibition of protein kinase C activation-induced serotonin release
Wang, H., & Friedman, E. (1989) · Psychopharmacology · doi:10.1007/bf00442810 · Cited by 89 · see citing works
Ahmad, A., Shahabuddin, S., Sheikh, S., et al. (2010) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2010.196 · Cited by 82 · see citing works
Sakane, F., & Kanoh, H. (1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(97)00037-x · Cited by 82 · see citing works
Amphetamine-induced appetitive 50-kHz calls in rats: a marker of affect in mania?
Pereira, M., Andreatini, R., Schwarting, R. K. W., & Brenes, J. C. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3413-1 · Cited by 81 · see citing works
Weiss, S., Ellis, J. E., Hendley, D. D., et al. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09152.x · Cited by 81 · see citing works
Lithium Increases Synapse Formation between Hippocampal Neurons by Depleting Phosphoinositides
Kim, H. J., & Thayer, S. A. (2009) · Molecular Pharmacology · doi:10.1124/mol.108.052357 · Cited by 81 · see citing works
Animal Studies on the Role of Sleep in Memory: From Behavioral Performance to Molecular Mechanisms
Havekes, R., Meerlo, P., & Abel, T. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_369 · Cited by 78 · see citing works
Casebolt, T. L., & Jope, R. S. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)91285-y · Cited by 76 · see citing works
Long-term potentiation and synaptic protein phosphorylation
Pasinelli, P., Ramakers, G. M. J., Urban, I. J. A., Hens, J. J. H., Oestreicher, A. B., Graan, P. N. E. D., & Gispen, W. H. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(94)00124-x · Cited by 76 · see citing works
Meta-analysis of 12 genomic studies in bipolar disorder
Elashoff, M. R., Higgs, B. W., Yolken, R. H., Knable, M. B., Weis, S., Webster, M. J., Barci, B. M., & Torrey, Ε. F. (2007) · Journal of Molecular Neuroscience · doi:10.1385/jmn:31:03:221 · Cited by 75 · see citing works
Xu, P., Rosen, K. M., Hedstrom, K. L., Rey, O., Guha, S., Hart, C., & Corfas, G. (2013) · Glia · doi:10.1002/glia.22491 · Cited by 73 · see citing works
Turner, R. S., Raynor, R. L., Mazzei, G. J., et al. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.10.3143 · Cited by 70 · see citing works
Watson, D. G., & Lenox, R. H. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67020767.x · Cited by 70 · see citing works
Barbier, E., & Wang, J. B. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-132 · Cited by 69 · see citing works
Pandey, G. N. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00327-x · Cited by 68 · see citing works
Lithium stimulates gene expression through the AP-1 transcription factor pathway
Yuan, P.-X., Chen, G., Huang, L., & Manji, H. K. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00114-4 · Cited by 68 · see citing works
Kirshenboim, N., Plotkin, B., Shlomo, S. B., et al. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:24:2:237 · Cited by 68 · see citing works
Angoline and Chelerythrine, Benzophenanthridine Alkaloids That Do Not Inhibit Protein Kinase C
Lee, S. K., Qing, W. G., Mar, W., Luyengi, L., Mehta, R. G., Kawanishi, K., Fong, H. H. S., Beecher, C., Kinghorn, A. D., & Pezzuto, J. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.31.19829 · Cited by 68 · see citing works
Toward a Deeper Understanding of the Genetics of Bipolar Disorder
Kerner, B. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00105 · Cited by 64 · see citing works
Broadbelt, K. G., Ramprasaud, A., & Jones, L. B. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.04.028 · Cited by 64 · see citing works
High levels of Gs alpha in platelets of euthymic patients with bipolar affective disorder
Mitchell, P. B., Manji, H. K., Chen, G., Jolkovsky, L., Smith‐Jackson, E. E., Denicoff, K. D., Schmidt, M. E., & Potter, W. Z. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.2.218 · Cited by 60 · see citing works
Supersensitivity to Amphetamine in Protein Kinase-C Interacting Protein/HINT1 Knockout Mice
Barbier, E., Zapata, A., Oh, E. J., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301301 · Cited by 59 · see citing works
Amadio, M., Battaini, F., & Pascale, A. (2006) · Pharmacological Research · doi:10.1016/j.phrs.2006.08.002 · Cited by 59 · see citing works
Kanazawa, L. K. S., Vecchia, D. D., Wendler, E., Hocayen, P. D. A. S., Lívero, F. A. D. R., Stipp, M. C., Barcaro, I. M. R., Acco, A., & Andreatini, R. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.07.027 · Cited by 59 · see citing works
Nam, Y., Wie, M., Shin, E., Nguyen, T. L., Nah, S.-Y., Ko, S. K., Jeong, J. H., Jang, C., & Kim, H. (2014) · Journal of Applied Toxicology · doi:10.1002/jat.3093 · Cited by 57 · see citing works
Intracellular phosphatidylinositol pathway abnormalities in bipolar disorder patients.
Soares, J. C., & Mallinger, A. G. (1997) · PubMed · Cited by 56 · see citing works
Increased anxiety-related behaviour in Hint1 knockout mice
Varadarajulu, J., Lebar, M., Krishnamoorthy, G., et al. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.02.012 · Cited by 56 · see citing works
Shoji‐Kasai, Y., Itakura, M., Kataoka, M., et al. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01972.x · Cited by 56 · see citing works
Lee, J. G., Cho, H. Y., Park, S. W., Seo, M. K., & Kim, Y. H. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.05.013 · Cited by 56 · see citing works
Cellular mechanisms and second messengers: relevance to the psychopharmacology of bipolar disorders
Brunello, N., & Tascedda, F. (2003) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145703003419 · Cited by 55 · see citing works
Wang, H.-Y., & Friedman, E. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01147-7 · Cited by 53 · see citing works
Abrial, E., Bétourné, A., Etiévant, A., Lucas, G., Scarna, H., Lambás‐Señas, L., & Haddjeri, N. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu031 · Cited by 53 · see citing works
Association of the gene encoding neurogranin with schizophrenia in males
Ruano, D., Aulchenko, Y. S., Macedo, A., Soares, M. J., Valente, J., Azevedo, M. H., Hutz, M. H., Gama, C. S., Lobato, M. I. R., Belmonte-de-Abreu, P. S., et al. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.10.008 · Cited by 52 · see citing works
Protein kinase C regulates mood-related behaviors and adult hippocampal cell proliferation in rats
Abrial, E., Etiévant, A., Betry, C., Scarna, H., Lucas, G., Haddjeri, N., & Lambás‐Señas, L. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.11.015 · Cited by 51 · see citing works
Soares, J. C., Chen, G., Dippold, C. S., Wells, K. F., Frank, E., Kupfer, D. J., Manji, H. K., & Mallinger, A. G. (2000) · Psychiatry Research · doi:10.1016/s0165-1781(00)00175-x · Cited by 51 · see citing works
Modeling mania in preclinical settings: A comprehensive review
Sharma, A. N., Fries, G. R., Galvez, J. F., Valvassori, S. S., Soares, J. C., Carvalho, A. F., & Quevedo, J. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.11.001 · Cited by 51 · see citing works
Self-citationArmani, F., Andersen, M. L., Andreatini, R., Frussa‐Filho, R., Tufik, S., & Galduróz, J. C. F. (2011) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00224.x · Cited by 50 · see citing works
Lithium and tamoxifen modulate cellular plasticity cascades in animal model of mania
Recco, K. C. C., Valvassori, S. S., Varela, R. B., Resende, W. R., Arent, C. O., Vitto, M. F., da Luz, G., de Souza, C. T., & Quevedo, J. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112463124 · Cited by 50 · see citing works
Self-citationZeng, Z., Wang, T., Li, T., Li, Y., Chen, P., Zhao, Q., Liu, J., Li, J., Feng, G., He, L., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.86 · Cited by 47 · see citing works
Muriel, M., Lambeng, N., Darios, F. D., Michel, P. P., Hirsch, É. C., Agid, Y., & Ruberg, M. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001016)426:2 · Cited by 46 · see citing works
Saxena, A., Little, J. T., Nedungadi, T. P., & Cunningham, J. T. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00747.2014 · Cited by 46 · see citing works
Self-citationLithium treatment inhibits protein kinase C translocation in rat brain cortex
Wang, H.-Y., Johnson, G., & Friedman, E. (2001) · Psychopharmacology · doi:10.1007/s002130100834 · Cited by 46 · see citing works
Increased gene expression of diacylglycerol kinase eta in bipolar disorder
Moya, P. R., Murphy, D. L., McMahon, F. J., & Wendland, J. R. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000593 · Cited by 45 · see citing works
HINT1 inhibits β‐catenin/TCF4, USF2 and NFκB activity in human hepatoma cells
Wang, L., Li, H., Zhang, Y., et al. (2008) · International Journal of Cancer · doi:10.1002/ijc.24072 · Cited by 45 · see citing works
Watterson, J. M., Watson, D. G., Meyer, E. M., et al. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02362-4 · Cited by 44 · see citing works
Mallinger, A. G., Thase, M. E., Haskett, R., Buttenfield, J., Luckenbaugh, D. A., Frank, E., Kupfer, D. J., & Manji, H. K. (2008) · Bipolar Disorders · doi:10.1111/j.1399-5618.2008.00636.x · Cited by 44 · see citing works
Endoxifen is a new potent inhibitor of PKC: A potential therapeutic agent for bipolar disorder
Ali, S. M., Ahmad, A., Shahabuddin, S., et al. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.02.024 · Cited by 44 · see citing works
Parthasarathy, L. K., Ratnam, L., Seelan, R. S., et al. (2006) · Springer eBooks · doi:10.1007/0-387-27600-9_12 · Cited by 42 · see citing works
Karege, F., Schwald, M., Papadimitriou, P., Lachausse, C., & Cissé, M. (2003) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00463-9 · Cited by 42 · see citing works
Downregulation of BDNF Expression by PKC and by TNF-α in Human Endothelial Cells
Xu, H., Czerwinski, P., Xia, N., Förstermann, U., & Li, H. (2015) · Pharmacology · doi:10.1159/000430823 · Cited by 40 · see citing works
Calcium-Dependent PKC Isoforms Have Specialized Roles in Short-Term Synaptic Plasticity
Chu, Y., Fioravante, D., Leitges, M., & Regehr, W. G. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.003 · Cited by 40 · see citing works
Tian, S. Y., Wang, J., Bezchlibnyk, Y. B., & Young, L. T. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.10.031 · Cited by 38 · see citing works
Kulkarni, J., Berk, M., Wang, W., Mu, L., Scarr, E., Rheenen, T. E. V., Worsley, R., Gurvich, C., Gavrilidis, E., de Castella, A. R., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.02.004 · Cited by 38 · see citing works
Talaeı, A., Pourgholami, M., Khatibi-Moghadam, H., Farıdhosseını, F., Farhoudi, F., Askari-Noghani, A., & Sadeghi, R. (2016) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000492 · Cited by 38 · see citing works
Beyond the therapeutic shackles of the monoamines: new mechanisms in bipolar disorder biology
Data-Franco, J., Singh, A., Popovic, D., Ashton, M., Berk, M., Vieta, E., Figueira, M. L., & Dean, O. M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.09.004 · Cited by 38 · see citing works
Zhang, Y. H., Kays, J. S., Hodgdon, K. E., Sacktor, T. C., & Nicol, G. D. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00030.2011 · Cited by 37 · see citing works
Deficiency of diacylglycerol kinase η induces lithium‐sensitive mania‐like behavior
Isozaki, T., Komenoi, S., Lu, Q., Usuki, T., Tomokata, S., Matsutomo, D., Sakai, H., Bando, K., Kiyonari, H., & Sakane, F. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13661 · Cited by 37 · see citing works
Ahmad, A., Sheikh, S., Shah, T. S., Reddy, M., Prasad, B., Verma, K., Chandrakant, B., Paithankar, M., Kale, P., Solanki, R., et al. (2016) · Clinical and Translational Science · doi:10.1111/cts.12407 · Cited by 37 · see citing works
Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha
Carroll, L. S., Williams, N. M., Moskvina, V., Russell, E., Norton, N., Williams, H. J., Peirce, T., Georgieva, L., Dwyer, S., Grozeva, D., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.96 · Cited by 36 · see citing works
Protein Kinase C and Oxidative Stress in an Animal Model of Mania
Steckert, A. V., Valvassori, S. S., Mina, F., Lopes-Borges, J., Varela, R. B., Kapczinski, F. P., Dal‐Pizzol, F., & Quevedo, J. (2012) · Current Neurovascular Research · doi:10.2174/156720212799297056 · Cited by 32 · see citing works
Self-citationTrafficking of Kainate Receptors
Pahl, S., Tapken, D., Haering, S., & Hollmann, M. (2014) · Membranes · doi:10.3390/membranes4030565 · Cited by 31 · see citing works
Hayashi, A., Gal, K. L., Södersten, K., Vizlin‐Hodzic, D., Ågren, H., & Funa, K. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.104 · Cited by 31 · see citing works
Altered Rap1 endogenous phosphorylation and levels in platelets from patients with bipolar disorder
Pérez, J., Tardito, D., Mori, S., et al. (2000) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00047-3 · Cited by 30 · see citing works
Structural and Dynamic Characterization of a Neuron-Specific Protein Kinase C Substrate, Neurogranin
Ran, X., Miao, H., Sheu, F., & Yang, D. (2003) · Biochemistry · doi:10.1021/bi0271751 · Cited by 30 · see citing works
Kanazawa, L. K. S., Vecchia, D. D., Wendler, E., Hocayen, P. D. A. S., Beirão, P. S. L., de Mélo, M. L., Lívero, F. A. D. R., Corso, C. R., Stipp, M. C., Acco, A., et al. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.01.007 · Cited by 30 · see citing works
Chronic Li+ attenuates agonist- and phorbol ester-mediated Na+/H+ antiporter activity in HL-60 cells
Bitran, J. A., Potter, W. Z., Manji, H. K., & Gusovsky, F. (1990) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(90)90002-f · Cited by 29 · see citing works
PKC links Gq‐coupled receptors to DAT‐mediated dopamine release
Opazo, F., Schulz, J. B., & Falkenburger, B. H. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06788.x · Cited by 28 · see citing works
Young, L. T., Wang, J., Woods, C. M., et al. (1999) · Neuropsychobiology · doi:10.1159/000026598 · Cited by 28 · see citing works
Hadley, S. H., Bahia, P. K., & Taylor‐Clark, T. E. (2014) · Molecular Pharmacology · doi:10.1124/mol.113.091272 · Cited by 27 · see citing works
Kinase Targets in Cns Drug Discovery
Gunosewoyo, H., Yu, L.-F., Munoz, L., & Kassiou, M. (2017) · Future Medicinal Chemistry · doi:10.4155/fmc-2016-0214 · Cited by 27 · see citing works
Reshef, A., Sperling, O., & Zoref‐Shani, E. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00841-0 · Cited by 25 · see citing works
Bioinformatic prediction and analysis of eukaryotic protein kinases in the rat genome
Kazi, J. U., Kabir, N. N., & Soh, J. (2008) · Gene · doi:10.1016/j.gene.2007.12.003 · Cited by 24 · see citing works
Effect of Tamoxifen and Lithium on Treatment of Acute Mania Symptoms in Children and Adolescents.
Fallah, E., Arman, S., Najafi, M., & Shayegh, B. (2016) · Iranian journal of child neurology. · doi:10.22037/ijcn.v10i2.8304 · Cited by 24 · see citing works
Pandey, G. N., Ren, X., Dwivedi, Y., & Pavuluri, M. N. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.11.004 · Cited by 22 · see citing works
GAP-43: putting constraints on neuronal plasticity.
Mc, F. (1996) · PubMed · Cited by 22 · see citing works
Kabir, N. N., & Kazi, J. U. (2011) · Genetics and Molecular Biology · doi:10.1590/s1415-47572011005000035 · Cited by 20 · see citing works
Tian-chao, Y., & Lin, W. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.08.059 · Cited by 20 · see citing works
Stress-induced phosphorylation of SNAP-25
Yamamori, S., Sugaya, D., Iida, Y., Kokubo, H., Itakura, M., Suzuki, E., Kataoka, M., Miyaoka, H., & Takahashi, M. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2013.12.044 · Cited by 18 · see citing works
Functional Diversification of the Four MARCKS Family Members in Zebrafish Neural Development
Prieto, D., & Zolessi, F. R. (2016) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.22691 · Cited by 18 · see citing works
Saavedra, A., Fernández‐García, S., Cases‐Cunillera, S., Puigdellívol, M., Alcalá‐Vida, R., Martín‐Flores, N., Alberch, J., Ginés, S., Malagelada, C., & Pérez‐Navarro, E. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.01.021 · Cited by 18 · see citing works
Kittel‐Schneider, S., Wobrock, T., Scherk, H., Schneider-Axmann, T., Trost, S., Zilles‐Wegner, D., Wolf, C., Schmitt, A., Malchow, B., Hasan, A., et al. (2014) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0513-9 · Cited by 17 · see citing works
Akimoto, T., Kusumi, I., Suzuki, K., et al. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.08.008 · Cited by 16 · see citing works
DGKH genetic risk variant influences gene expression in bipolar affective disorder
Kittel‐Schneider, S., Lorenz, C., Auer, J., Weißflog, L., & Reif, A. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.03.041 · Cited by 16 · see citing works
Chronic lithium treatment increases the phosphorylation of a 64-kDa protein in rat brains
Klein, E., Patel, J. B., McDevitt, R. E., et al. (1987) · Brain Research · doi:10.1016/0006-8993(87)91109-7 · Cited by 14 · see citing works
Overexpression of Diacylglycerol Kinase η Enhances Gαq-Coupled G Protein–Coupled Receptor Signaling
Rittiner, J. E., Brings, V. E., & Zylka, M. J. (2014) · Molecular Pharmacology · doi:10.1124/mol.113.091280 · Cited by 14 · see citing works
Carpenter, C., Sorenson, R. J., Jin, Y., et al. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.09.002 · Cited by 14 · see citing works
Yıldız, A., Aydın, B., Gökmen, N., Yurt, A., Cohen, B. M., Keskinoğlu, P., Öngür, D., & Renshaw, P. F. (2015) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2015.12.002 · Cited by 13 · see citing works
Phosphorylation of brain synaptosomal proteins in lithium-treated rats
Vatal, M., & Aiyar, A. S. (1984) · Biochemical Pharmacology · doi:10.1016/0006-2952(84)90470-2 · Cited by 12 · see citing works
Levetiracetam, Calcium Antagonism, and Bipolar Disorder
Dubovsky, S. L., Daurignac, E. C., Leonard, K. E., & Serotte, J. C. (2015) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000343 · Cited by 12 · see citing works
Emergent treatments based on the pathophysiology of bipolar disorder: A selective review
Brady, R. O., & Keshavan, M. S. (2015) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2015.07.017 · Cited by 11 · see citing works
Bipolar disorder: defining symptoms and comorbidities – Authors' reply
Vieta, E., Berk, M., Birmaher, B. B., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30966-7 · Cited by 11 · see citing works
Recent Patents Concerning Modulators of Protein Kinase C
Sánchez‐Bautista, S., & Nicolás, F. E. (2013) · Recent Patents on DNA & Gene Sequences · doi:10.2174/1872215611307010011 · Cited by 10 · see citing works
Kandaswamy, R., McQuillin, A., Curtis, D., & Gurling, H. (2012) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32014 · Cited by 10 · see citing works
Voutilainen-Myllylä, S., Tavi, P., & Weckström, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01541-3 · Cited by 9 · see citing works
Nigam, S., & Müller, S. (1989) · Free Radical Research Communications · doi:10.3109/10715768909087939 · Cited by 7 · see citing works
Potential Novel Therapeutics for Bipolar Disorders
Machado‐Vieira, R., Manji, H. K., & Zarate, C. A. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_51 · Cited by 5 · see citing works
Concomitant Use of Lorazepam With Tamoxifen in Bipolar Mania Clinical Trials
Kruszewski, S. P., & Paczynski, R. P. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.505 · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 12
- Grande I, Berk M, Birmaher B, Vieta E: Bipo- lar disorder. Lancet 2016; 387: 1561-1572.
- Sharma AN, Fries GR, Galvez JF, Valvassori SS, Soares JC, Carvalho AF, Quevedo J: Mod- eling mania in preclinical settings: a compre- hensive review. Prog Neuropsychopharmacol Biol Psychiatry 2016; 66: 22-34.
- Talaei A, Pourgholami M, Khatibi-Moghad- am H, Faridhosseini F, Farhoudi F, Askari- Noghani A, Sadeghi R: Tamoxifen: a protein kinase C inhibitor to treat mania: a system- atic review and meta-analysis of randomized, placebo-controlled trials. J Clin Psychophar- macol 2016; 36: 272-275.
- Ohno S, Nishizuka Y: Protein kinase C iso- types and their specific functions: prologue. J Biochem 2002; 132: 509-511.
- Naik MU, Benedikz E, Hernandez I, Libien J, Hrabe J, Valsamis M, Dow-Edwards D, Os- man M, Sacktor TC: Distribution of protein kinase Mzeta and the complete protein kinase C isoform family in rat brain. J Comp Neurol 2000; 426: 243-258.
- Hadley SH, Bahia PK, Taylor-Clark TE: Sen- sory nerve terminal mitochondrial dysfunc- tion induces hyperexcitability in airway noci- ceptors via protein kinase C. Mol Pharmacol 2014; 85: 839-848.
- Soares JC, Mallinger AG: Intracellular phos- phatidylinositol pathway abnormalities in bi- polar disorder patients. Psychopharmacol Bull 1997; 33: 685-691.
- Sharkey NA, Leach KL, Blumberg PM: Com- petitive inhibition by diacylglycerol of specif- ic phorbol ester binding. Proc Natl Acad Sci USA 1984; 81: 607-610.
- Dager SR, Friedman SD, Parow A, Demopu- los C, Stoll AL, Lyoo IK, Dunner DL, Renshaw PF: Brain metabolic alterations in medica- tion-free patients with bipolar disorder. Arch Gen Psychiatry 2004; 61: 450-458.
- Broadbelt K, Ramprasaud A, Jones LB: Evi- dence of altered neurogranin immunoreac- tivity in areas 9 and 32 of schizophrenic pre- frontal cortex. Schizophr Res 2006; 87: 6-14.
- Shimazaki Y, Nishiki T, Omori A, Sekiguchi M, Kamata Y, Kozaki S, Takahashi M: Phos- phorylation of 25-kDa synaptosome-associ- ated protein. Possible involvement in pro- tein kinase C-mediated regulation of neu- rotransmitter release. J Biol Chem 1996; 271: 14548-14553. 120
- Sakane F, Kanoh H: Molecules in focus: dia- cylglycerol kinase. Int J Biochem Cell Biol 1997; 29: 1139-1143. 158
Cited by
Sorted by citations
Circadian rhythm disruption and mental health
Walker, W. H., Walton, J. C., DeVries, A. C., & Nelson, R. J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0694-0 · Cited by 1,030 · see citing works
Protein Kinase C as a Therapeutic Target in Non-Small Cell Lung Cancer
Sadeghi, M. M., Salama, M. F., & Hannun, Y. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115527 · Cited by 31 · see citing works
- Authors
- Saxena, A., Scaini, G., Bavaresco, D. V., Leite, C., Valvassoria, S. S., Carvalho, A. F., & Quevedo, J.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- The University of Texas System (US)
- Venue
- Complex Psychiatry
- Publisher
- S. Karger AG
- Published
- 2017
- Volume
- 3
- Issue
- 2
- Pages
- 108-124
- ISSN
- 2673-298X (ISSN-L)
- 2673-3005
- PMC
- PMC5701269
- OpenAlex
- W2763250674
- Cited by
- 85
- References
- 179
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 7 · 2023: 6 · 2022: 13 · 2021: 24 · 2020: 14 · 2019: 7 · 2018: 4
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Complex Psychiatry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina
- Universidade do Extremo Sul Catarinense
- Instituto Mente e Cérebro - Neurociência
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- protein kinase C, bipolar disorder, pathophysiology, synaptogenesis, neuroplasticity, REM sleep deprivation, tamoxifen, PKC inhibitors, growth factors, neurotransmission, manic symptoms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
