Extracellular RNA sensing by pattern recognition receptors

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129 · see citing works

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., & Bauer, S. (2004) · Science · doi:10.1126/science.1093620 · Cited by 3,947 · see citing works

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., et al. (2006) · Nature · doi:10.1038/nature04734 · Cited by 3,888 · see citing works

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444 · see citing works

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA

Karikó, K., Buckstein, M., Ni, H., & Weissman, D. (2005) · Immunity · doi:10.1016/j.immuni.2005.06.008 · Cited by 2,728 · see citing works

Immune Signaling by RIG-I-like Receptors

Loo, Y.-M., & Gale, M. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.003 · Cited by 1,875 · see citing works

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

Kato, H., Takeuchi, O., Mikamo, E., Hirai, R., Kawai, T., Matsushita, K., Hiiragi, A., Dermody, T. S., Fujita, T., & Akira, S. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080091 · Cited by 1,590 · see citing works

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T., & Seya, T. (2003) · Nature Immunology · doi:10.1038/ni886 · Cited by 1,208 · see citing works

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

Chiu, Y., MacMillan, J. B., & Chen, Z. J. (2009) · Cell · doi:10.1016/j.cell.2009.06.015 · Cited by 1,185 · see citing works

TLR3 Deficiency in Patients with Herpes Simplex Encephalitis

Zhang, S., Jouanguy, E., Ugolini, S., Smahi, A., Elain, G., Romero, P. J., Segal, D. M., Sancho‐Shimizu, V., Lorenzo, L., Puel, A., et al. (2007) · Science · doi:10.1126/science.1139522 · Cited by 1,165 · see citing works

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

Wang, T., Town, T., Alexopoulou, L., Anderson, J. F., Fikrig, E., & Flavell, R. A. (2004) · Nature Medicine · doi:10.1038/nm1140 · Cited by 1,142 · see citing works

mRNA is an endogenous ligand for toll-like receptor 3

Karikó, K., Ni, H., Capodici, J., Lamphier, M., & Weissman, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310175200 · Cited by 1,062 · see citing works

Double-Stranded RNA Is Produced by Positive-Strand RNA Viruses and DNA Viruses but Not in Detectable Amounts by Negative-Strand RNA Viruses

Weber, F., Wagner, V., Rasmussen, S. B., Hartmann, R., & Paludan, S. R. (2006) · Journal of Virology · doi:10.1128/jvi.80.10.5059-5064.2006 · Cited by 957 · see citing works

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

Tabeta, K., Georgel, P., Janssen, E. M., Du, X., Hoebe, K. H. N., Crozat, K., Mudd, S., Shamel, L., Sovath, S., Goode, J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400525101 · Cited by 956 · see citing works

Regulating Intracellular Antiviral Defense and Permissiveness to Hepatitis C Virus RNA Replication through a Cellular RNA Helicase, RIG-I

Sumpter, R., Loo, Y., Foy, E. M., Li, K., Yoneyama, M., Fujita, T., Lemon, S. M., & Gale, M. (2005) · Journal of Virology · doi:10.1128/jvi.79.5.2689-2699.2005 · Cited by 900 · see citing works

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

Ablasser, A., Bauernfeind, F. G., Hartmann, G., Latz, E., Fitzgerald, K. A., & Hornung, V. (2009) · Nature Immunology · doi:10.1038/ni.1779 · Cited by 892 · see citing works

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

Schlee, M., Roth, A. H. F. J., Hornung, V., Hagmann, C. A., Wimmenauer, V., Barchet, W., Coch, C., Janke, M., Mihailovic, A., Wardle, G. S., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.008 · Cited by 792 · see citing works

Transcription and Processing of Human microRNA Precursors

Cullen, B. R. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.12.002 · Cited by 760 · see citing works

Herpes Simplex Virus Encephalitis in Human UNC-93B Deficiency

Casrouge, A., Zhang, S.-Y., Eidenschenk, C., Jouanguy, E., Puel, A., Yang, K., Alcais, A., Picard, C., Mahfoufi, N., Nicolas, N., et al. (2006) · Science · doi:10.1126/science.1128346 · Cited by 749 · see citing works

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

Liu, L., Botos, I., Wang, Y., Leonard, J. N., Shiloach, J., Segal, D. M., & Davies, D. R. (2008) · Science · doi:10.1126/science.1155406 · Cited by 733 · see citing works

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

Kim, Y., Brinkmann, M. M., Paquet, M.-È., & Ploegh, H. L. (2008) · Nature · doi:10.1038/nature06726 · Cited by 699 · see citing works

Small self-RNA generated by RNase L amplifies antiviral innate immunity

Malathi, K., Dong, B., Gale, M., & Silverman, R. H. (2007) · Nature · doi:10.1038/nature06042 · Cited by 636 · see citing works

Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection

Li, X., Liu, C., Xue, W., Zhang, Y., Jiang, S., Yin, Q.-F., Wei, J., Yao, R.-W., Yang, L. C., & Chen, L. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.05.023 · Cited by 629 · see citing works

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates

Goubau, D., Schlee, M., Deddouche, S., Pruijssers, A. J., Zillinger, T., Goldeck, M., Schuberth, C., Van der Veen, A. G., Fujimura, T., Rehwinkel, J., et al. (2014) · Nature · doi:10.1038/nature13590 · Cited by 557 · see citing works

Detrimental Contribution of the Toll-Like Receptor (TLR)3 to Influenza A Virus–Induced Acute Pneumonia

Goffic, R. L., Balloy, V., Lagranderie, M., Alexopoulou, L., Escriou, N., Flavell, R. A., Chignard, M., & Si‐Tahar, M. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020053 · Cited by 512 · see citing works

Sensing Self and Foreign Circular RNAs by Intron Identity

Chen, Y. G., Kim, M. V., Chen, X., Batista, P. J., Aoyama, S., Wilusz, J. E., Iwasaki, A., & Chang, H. Y. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.05.022 · Cited by 475 · see citing works

Short-Range Exosomal Transfer of Viral RNA from Infected Cells to Plasmacytoid Dendritic Cells Triggers Innate Immunity

Dreux, M., Garaigorta, U., Boyd, B. S., Décembre, É., Chung, J., Whitten-Bauer, C., Wieland, S. F., & Chisari, F. V. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.08.010 · Cited by 471 · see citing works

Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection

Pichlmair, A., Schulz, O., Tan, C.-P., Rehwinkel, J., Kato, H., Takeuchi, O., Akira, S., Way, M., Schiavo, G., & Sousa, C. R. E. (2009) · Journal of Virology · doi:10.1128/jvi.00770-09 · Cited by 469 · see citing works

Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer

Nabet, B. Y., Qiu, Y., Shabason, J. E., Wu, T. J., Yoon, T., Kim, B. C., Benci, J. L., DeMichele, A. M., Tchou, J. C., Marcotrigiano, J., et al. (2017) · Cell · doi:10.1016/j.cell.2017.06.031 · Cited by 453 · see citing works

Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling

Matsumoto, M., Kikkawa, S., Kohase, M., Miyake, K., & Seya, T. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00380-7 · Cited by 451 · see citing works

Ebola Virus VP35 Protein Binds Double-Stranded RNA and Inhibits Alpha/Beta Interferon Production Induced by RIG-I Signaling

Cardenas, W. B., Loo, Y., Gale, M., Hartman, A. L., Kimberlin, C. R., Martínez‐Sobrido, L., Saphire, E. O., & Basler, C. F. (2006) · Journal of Virology · doi:10.1128/jvi.02199-05 · Cited by 451 · see citing works

TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events

Cavassani, K. A., Ishii, M., Wen, H., Schaller, M. A., Lincoln, P., Lukacs, N. W., Hogaboam, C. M., & Kunkel, S. L. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081370 · Cited by 447 · see citing works

Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing

Baum, A., Sachidanandam, R., & García‐Sastre, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005077107 · Cited by 424 · see citing works

A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells

Marques, J. T., Devosse, T., Wang, D., Zamanian-Daryoush, M., Serbinowski, P., Hartmann, R., Fujita, T., Behlke, M. A., & Williams, B. R. G. (2006) · Nature Biotechnology · doi:10.1038/nbt1205 · Cited by 380 · see citing works

Toll-Like Receptor 3 Has a Protective Role against West Nile Virus Infection

Daffis, S., Samuel, M. A., Suthar, M. S., Gale, M., & Diamond, M. (2008) · Journal of Virology · doi:10.1128/jvi.00935-08 · Cited by 359 · see citing works

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

Mancuso, G., Gambuzza, M. E., Midiri, A., Biondo, C., Papasergi, S., Akira, S., Teti, G., & Beninati, C. (2009) · Nature Immunology · doi:10.1038/ni.1733 · Cited by 351 · see citing works

Human TRAF3 Adaptor Molecule Deficiency Leads to Impaired Toll-like Receptor 3 Response and Susceptibility to Herpes Simplex Encephalitis

de Diego, R. P., Sancho‐Shimizu, V., Lorenzo, L., Puel, A., Plancoulaine, S., Pïcard, C., Casadio, M., Cardon, A., Durandy, A., Bustamante, J. C., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.014 · Cited by 348 · see citing works

RIG-I, MDA5 and TLR3 Synergistically Play an Important Role in Restriction of Dengue Virus Infection

Nasirudeen, A. M. A., Wong, H. H., Thien, P., Xu, S., Lam, K., & Liu, D. X. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000926 · Cited by 314 · see citing works

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

Ewald, S. E., Engel, A., Lee, J., Wang, M., Bogyo, M. S., & Barton, G. M. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20100682 · Cited by 314 · see citing works

Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition

Peisley, A., Lin, C., Wu, B., Orme-Johnson, M., Liu, M., Walz, T., & Hur, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113651108 · Cited by 312 · see citing works

Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency

Sancho‐Shimizu, V., de Diego, R. P., Lorenzo, L., Halwani, R., Alangari, A., Israelsson, E., Fabrega, S., Cardon, A., Maluenda, J., Tatematsu, M., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci59259 · Cited by 310 · see citing works

Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity

Guo, Y., Audry, M., Ciancanelli, M. J., Alsina, L., Azevedo, J., Casadio, M., Anguiano, E., Sancho‐Shimizu, V., Lorenzo, L., Pauwels, E., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101568 · Cited by 310 · see citing works

Dephosphorylation of the RNA Sensors RIG-I and MDA5 by the Phosphatase PP1 Is Essential for Innate Immune Signaling

Wies, E., Wang, M. K., Maharaj, N. P., Chen, K., Zhou, S., Finberg, R. W., & Gack, M. U. (2013) · Immunity · doi:10.1016/j.immuni.2012.11.018 · Cited by 306 · see citing works

UNC93B1 mediates differential trafficking of endosomal TLRs

Lee, B. L., Moon, J. E., Shu, J. H., Yuan, L., Newman, Z. R., Schekman, R. W., & Barton, G. M. (2013) · eLife · doi:10.7554/elife.00291 · Cited by 284 · see citing works

Critical Role for Asparagine Endopeptidase in Endocytic Toll-like Receptor Signaling in Dendritic Cells

Sepulveda, F. E., Maschalidi, S., Colisson, R., Heslop, L., Ghirelli, C., Sakka, E., Lennon‐Duménil, A., Amigorena, S., Cabanié, L., & Manoury, B. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.013 · Cited by 280 · see citing works

The TLR3 signaling complex forms by cooperative receptor dimerization

Leonard, J. N., Ghirlando, R., Askins, J., Bell, J. K., Margulies, D. H., Davies, D. R., & Segal, D. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710779105 · Cited by 279 · see citing works

The Ubiquitin Ligase Riplet Is Essential for RIG-I-Dependent Innate Immune Responses to RNA Virus Infection

Oshiumi, H., Miyashita, M., Inoue, N., Okabe, M., Matsumoto, M., & Seya, T. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.11.008 · Cited by 264 · see citing works

Autoimmune Disorders Associated with Gain of Function of the Intracellular Sensor MDA5

Funabiki, M., Kato, H., Miyachi, Y., Toki, H., Motegi, H., Inoue, M., Minowa, O., Yoshida, A., Deguchi, K., Satō, H., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.12.014 · Cited by 262 · see citing works

Recognition of Double-stranded RNA by Human Toll-like Receptor 3 and Downstream Receptor Signaling Requires Multimerization and an Acidic pH

de BOUTEILLER, O., Merck, E., Hasan, U. A., Hubac, S., Benguigui, B., Trinchieri, G., Bates, E. E. M., & Caux, C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507163200 · Cited by 260 · see citing works

TLR Signaling

Akira, S. (2006) · Springer eBooks · doi:10.1007/3-540-32636-7_1 · Cited by 256 · see citing works

Double-Stranded RNA-Mediated TLR3 Activation Is Enhanced by CD14

Lee, H., Dunzendorfer, S., Soldau, K., & Tobias, P. S. (2006) · Immunity · doi:10.1016/j.immuni.2005.12.012 · Cited by 250 · see citing works

Ligand-regulated Chimeric Receptor Approach Reveals Distinctive Subcellular Localization and Signaling Properties of the Toll-like Receptors

Nishiya, T., & DeFranco, A. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311618200 · Cited by 236 · see citing works

Functional IRF3 deficiency in a patient with herpes simplex encephalitis

Andersen, L. L., Mørk, N., Reinert, L. S., Kofod‐Olsen, E., Narita, R., Jørgensen, S. E., Skipper, K. A., Höning, K., Gad, H. H., Østergaard, L. J., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20142274 · Cited by 235 · see citing works

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA

Sirois, C. M., Jin, T., Miller, A. L., Bertheloot, D., Nakamura, H., Horvath, G. L., Mian, A., Jiang, J., Schrum, J. E., Bossaller, L., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20120201 · Cited by 227 · see citing works

A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity

Negishi, H., OSAWA, T., Ogami, K., Ouyang, X., Sakaguchi, S., Koshiba, R., Yanai, H., Seko, Y., Shitara, H., Bishop, K., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810372105 · Cited by 223 · see citing works

Toll-like Receptor 7 Mitigates Lethal West Nile Encephalitis via Interleukin 23-Dependent Immune Cell Infiltration and Homing

Town, T., Bai, F., Wang, T., Kaplan, A. T., Qian, F., Montgomery, R. R., Anderson, J. F., Flavell, R. A., & Fikrig, E. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.012 · Cited by 217 · see citing works

MDA5 cooperatively forms dimers and ATP‐sensitive filaments upon binding double‐stranded RNA

Berke, I. C., & Modis, Y. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.19 · Cited by 205 · see citing works

Flavivirus Activation of Plasmacytoid Dendritic Cells Delineates Key Elements of TLR7 Signaling beyond Endosomal Recognition

Wang, J. P., Liu, P., Latz, E., Golenbock, D. T., Finberg, R. W., & Libraty, D. H. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7114 · Cited by 203 · see citing works

Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells

Blasius, A. L., Arnold, C. N., Georgel, P., Rutschmann, S., Xia, Y., Lin, P., Ross, C., Li, X., Smart, N. G., & Beutler, B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014051107 · Cited by 203 · see citing works

The Essential, Nonredundant Roles of RIG-I and MDA5 in Detecting and Controlling West Nile Virus Infection

Errett, J. S., Suthar, M. S., McMillan, A., Diamond, M., & Gale, M. (2013) · Journal of Virology · doi:10.1128/jvi.01488-13 · Cited by 201 · see citing works

Trafficking of endosomal Toll-like receptors

Lee, B. L., & Barton, G. M. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.12.002 · Cited by 196 · see citing works

Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling

Garcia-Cattaneo, A., Gobert, F.-X., Müller, M., Toscano, F., Flores, M., Lescure, A., Nery, E. D., & Benaroch, P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115091109 · Cited by 183 · see citing works

Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury

Harðarson, H. S., Baker, J. S., Zhao, Y., Purevjav, E., Huang, C., Alexopoulou, L., Li, N., Flavell, R. A., Bowles, N. E., & Vallejo, J. G. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00398.2006 · Cited by 177 · see citing works

The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling

Funami, K. (2004) · International Immunology · doi:10.1093/intimm/dxh115 · Cited by 175 · see citing works

Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses

Ugolini, M., Gerhard, J., Burkert, S., Jensen, K. J., Georg, P., Ebner, F., Volkers, S. M., Thada, S., Dietert, K., Bauer, L. L., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0068-4 · Cited by 162 · see citing works

An Accessory to the ‘Trinity’: SR-As Are Essential Pathogen Sensors of Extracellular dsRNA, Mediating Entry and Leading to Subsequent Type I IFN Responses

DeWitte‐Orr, S. J., Collins, S. E., Bauer, C. M. T., Bowdish, D. M. E., & Mossman, K. L. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000829 · Cited by 139 · see citing works

RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP

Malathi, K., Saito, T., Crochet, N., Barton, D. J., Gale, M., & Silverman, R. H. (2010) · RNA · doi:10.1261/rna.2244210 · Cited by 136 · see citing works

Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA

Tatematsu, M., Nishikawa, F., Seya, T., & Matsumoto, M. (2013) · Nature Communications · doi:10.1038/ncomms2857 · Cited by 131 · see citing works

Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo

Matsumoto, M., Tatematsu, M., Nishikawa, F., Azuma, M., Ishii, N., Morii-Sakai, A., Shime, H., & Seya, T. (2015) · Nature Communications · doi:10.1038/ncomms7280 · Cited by 130 · see citing works

SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

Nguyen, T. A., Smith, B. R. C., Tate, M. D., Belz, G. T., Barrios, M. H., Elgass, K., Weisman, A. S., Baker, P. J., Preston, S., Whitehead, L. W., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.007 · Cited by 130 · see citing works

Differential Type I IFN-Inducing Abilities of Wild-Type versus Vaccine Strains of Measles Virus

Shingai, M., Ebihara, T., Begum, N. A., Kato, A., Honma, T., Matsumoto, K., Saito, H., Ogura, H., Matsumoto, M., & Seya, T. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.9.6123 · Cited by 124 · see citing works

Structural basis for Marburg virus VP35–mediated immune evasion mechanisms

Ramanan, P., Edwards, M. R., Shabman, R. S., Leung, D. W., Endlich-Frazier, A., Borek, D., Otwinowski, Z., Liu, G., Huh, J., Basler, C. F., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213559109 · Cited by 122 · see citing works

The Toll-Like Receptor 3-Mediated Antiviral Response Is Important for Protection against Poliovirus Infection in Poliovirus Receptor Transgenic Mice

Abe, Y., Fujii, K., Nagata, N., Takeuchi, O., Akira, S., Oshiumi, H., Matsumoto, M., Seya, T., & Koike, S. (2011) · Journal of Virology · doi:10.1128/jvi.05245-11 · Cited by 105 · see citing works

Evasion of innate and adaptive immune responses by influenza A virus

Schmolke, M., & García‐Sastre, A. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01475.x · Cited by 101 · see citing works

Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA

Krüger, A., Oldenburg, M., Chebrolu, C., Beisser, D., Kolter, J., Sigmund, A. M., Steinmann, J., Schäfer, S., Hochrein, H., Rahmann, S., et al. (2015) · The EMBO Reports · doi:10.15252/embr.201540861 · Cited by 99 · see citing works

Proteolytic Processing Regulates Toll-like Receptor 3 Stability and Endosomal Localization

Qi, R., Singh, D., & Kao, C. C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.387803 · Cited by 95 · see citing works

TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition of Streptococcus pyogenes

Eigenbrod, T., Pelka, K., Latz, E., Kreikemeyer, B., & Dalpke, A. H. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403173 · Cited by 90 · see citing works

Raftlin Is Involved in the Nucleocapture Complex to Induce Poly(I:C)-mediated TLR3 Activation

Watanabe, A., Tatematsu, M., Saeki, K., Shibata, S., Shime, H., Yoshimura, A., Obuse, C., Seya, T., & Matsumoto, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.185793 · Cited by 90 · see citing works

CD11b/CD18 (Mac-1) Is a Novel Surface Receptor for Extracellular Double-Stranded RNA To Mediate Cellular Inflammatory Responses

Zhou, H., Liao, J., Aloor, J. J., Nie, H., Wilson, B. C., Fessler, M. B., Gao, H., & Hong, J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202136 · Cited by 89 · see citing works

Processing of Human Toll-like Receptor 7 by Furin-like Proprotein Convertases Is Required for Its Accumulation and Activity in Endosomes

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Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases

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