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Cited by 40Mindfulness and Compassion InterventionsDementia and Cognitive Impairment ResearchAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Effects of a Mindfulness-Based Intervention versus Health Self-Management on Subclinical Anxiety in Older Adults with Subjective Cognitive Decline: The SCD-Well Randomized Superiority Trial

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Marchant, Natalie L., Barnhofer, Thorsten, Coueron, Roxane, Wirth, Miranka, Lutz, Antoine, Arenaza-Urquijo, Eider M., Collette, Fabienne, Poisnel, Géraldine +16 more·2021·Psychotherapy and Psychosomatics
DOI 10.1159/000515669
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Abstract

Introduction: Older adults experiencing subjective cognitive decline (SCD) have a heightened risk of developing dementia and frequently experience subclinical anxiety, which is itself associated with dementia risk. Objective: To understand whether subclinical anxiety symptoms in SCD can be reduced through behavioral interventions. Methods: SCD-Well is a randomized controlled trial designed to determine whether an 8-week mindfulness-based intervention (caring mindfulness-based approach for seniors; CMBAS) is superior to a structurally matched health self-management program (HSMP) in reducing subclinical anxiety. Participants were recruited from memory clinics at 4 European sites. The primary outcome was change in anxiety symptoms (trait subscale of the State-Trait Anxiety Inventory; trait-STAI) from pre- to postintervention. Secondary outcomes included a change in state anxiety and depression symptoms postintervention and 6 months postrandomization (follow-up). Results: One hundred forty-seven participants (mean [SD] age: 72.7 [6.9] years; 64.6% women; CMBAS, n = 73; HSMP, n = 74) were included in the intention-to-treat analysis. There was no difference in trait-STAI between groups postintervention (adjusted change difference: –1.25 points; 95% CI –4.76 to 2.25) or at follow-up (adjusted change difference: –0.43 points; 95% CI –2.92 to 2.07). Trait-STAI decreased postintervention in both groups (CMBAS: –3.43 points; 95% CI –5.27 to –1.59; HSMP: –2.29 points; 95% CI –4.14 to –0.44) and reductions were maintained at follow-up. No between-group differences were observed for change in state anxiety or depression symptoms. Conclusions: A time-limited mindfulness intervention is not superior to health self-management in reducing subclinical anxiety symptoms in SCD. The sustained reduction observed across both groups suggests that subclinical anxiety symptoms in SCD are modifiable. ClinicalTrials.gov identifier: NCT03005652.

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  • The only study that was performed in a randomized controlled manner and in a large cohort of individuals with SCD revealed effects of both an MBSR-based intervention and a health self-management program, on mental health and quality of life at 6 months follow-up, but no group differences.

    “The only study that was performed in a randomized controlled manner and in a large cohort of individuals with SCD revealed effects of both an MBSR-based intervention and a health self-management program, on mental health and quality of life at 6 months follow-up, but no group differences [69].”

    From Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review (2022) · cites this paper as [69]

    The Study Design and Discussion sections describe a large randomized trial in older adults with SCD and report reduced trait anxiety in both groups, maintained at six months, without a significant between-group difference. The Outcomes section lists anxiety and depressive symptoms, but our copy does not report a quality-of-life outcome; the Discussion also cautions that, without a passive control, the changes cannot be attributed directly to the interventions. It does not establish that this was the only randomized study in a large SCD cohort. Page numbers were unavailable in our copy. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • With regard to psychotherapeutic interventions, no data in individuals with SCD were identified, while data regarding psychoeducational approaches addressing individuals with SCD are available from four research groups.

    “With regard to psychotherapeutic interventions, no data in individuals with SCD were identified, while data regarding psychoeducational approaches addressing individuals with SCD are available from four research groups [55, 56, 61, 66, 68, 69].”

    From Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review (2022) · cites this paper as [69]

    The Interventions section describes psychoeducational components customized for people with SCD, so this paper supports the availability of such an approach. It does not establish that data came from four research groups or that no psychotherapeutic-intervention data in SCD were identified; the latter is a broader literature-survey claim. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • All 6 papers focusing on interventions for individuals with SCD were carried out within randomized controlled trials.

    “All were carried out within randomized controlled trials [55, 56, 61, 66, 68, 69].”

    From Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review (2022) · cites this paper as [69]

  • A total of four research groups described psychoeducational interventions for individuals with SCD alone or in combination with cognitive training and CBT-based interventions and MBSR-based interventions.

    “A total of four research groups described psychoeducational interventions alone [61] or in combination with cognitive training and CBT-based interventions [66] and MBSR-based interventions [55, 56, 68, 69]”

    From Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review (2022) · cites this paper as [69]

  • Two research groups investigated the effects of psychoeducation with MBSR-based therapy on individuals with SCD (n = 147, n = 38).

    “Two research groups investigated the effects of psychoeducation with MBSR-based therapy on individuals with SCD (n = 147 [68, 69], n = 38 [55, 56]).”

    From Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review (2022) · cites this paper as [69]

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Cites

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Research works printed but not linked: 5

  1. Rabin LA, Smart CM, Amariglio RE. Subjec- tive Cognitive Decline in Preclinical Alzheim- er's Disease. Annu Rev Clin Psychol. 2017 May;13(1):369-96.
  2. Devilly GJ, Borkovec TD. Psychometric prop- erties of the credibility/expectancy question- naire. J Behav Ther Exp Psychiatry. 2000 Jun;31(2):73-86.
  3. Spielberger CD, Gorsuch RL, Lushene R, Vagg PR, Jacobs GA. Manual for the State- Trait Anxiety Inventory. Palo Alto (CA): Consulting Psychologists Press; 1983.
  4. Sheikh JI, Yesavage JA. Geriatric Depression Scale (GDS): recent evidence and develop- ment of a shorter version. Clin Gerontol J Ag- ing Ment Health. 1986;5(1-2):165-73.
  5. Bondi MW, Edmonds EC, Jak AJ, Clark LR, Delano-Wood L, McDonald CR, et al. Neuro- psychological criteria for mild cognitive im- pairment improves diagnostic precision, bio- marker associations, and progression rates. J Alzheimers Dis. 2014;42(1):275-89.

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Authors
Marchant, N. L., Barnhofer, T., Coueron, R., Wirth, M., Lutz, A., Arenaza-Urquijo, E. M., Collette, F., Poisnel, G., Demnitz-King, H., Schild, A.-K., Coll-Padros, N., Delphin-Combe, F., Whitfield, T., Schlosser, M., Gonneaud, J., Asselineau, J., Walker, Z., Krolak-Salmon, P., Molinuevo, J. L., Frison, E., Chételat, G., Jessen, F., Klimecki, O. M., & The Medit-Ageing Research Group
Affiliations
  • University College London (GB)
  • University of Exeter (GB)
  • Université de Bordeaux (FR)
  • Humboldt-Universität zu Berlin (DE)
  • University of Liège (BE)
  • Inserm (FR)
  • University of Cologne (DE)
  • University of Geneva (CH)
ORCID
Venue
Psychotherapy and Psychosomatics
Publisher
S. Karger AG
Published
2021
Volume
90
Issue
5
Pages
341-350
ISSN
  • 0033-3190 (ISSN-L)
  • 1423-0348
DOI
10.1159/000515669
OpenAlex
W3153823154
Cited by
40
References
43
Citations by year
2026: 8 · 2025: 6 · 2024: 5 · 2023: 9 · 2022: 11 · 2012: 1
FWCI
4.26
Type
journal article
Language
en
Open access
Licence
Locations
  • Psychotherapy and Psychosomatics (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
  • Kölner Universitäts PublikationsServer (Universität zu Köln) (acceptedVersion)
  • ORBi (University of Liège) (submittedVersion, other-oa)
  • HAL (submittedVersion, cc-by-nc)
  • UCL Discovery (University College London) (submittedVersion)
  • Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion, cc-by-nc)
  • DZNE Pub (submittedVersion, cc-by-nc)
  • Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion, cc-by-nc)
Funders
  • Alzheimer's Society
  • European Commission
  • Institut National de la Santé et de la Recherche Médicale
  • Inserm Transfert
Topics
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
subjective cognitive decline, subclinical anxiety, mindfulness-based interventions, health self-management, older adults, dementia risk, trait anxiety, state anxiety, depression, behavioral interventions
MeSH terms
Self-Management, Aged, Anxiety, Anxiety Disorders, Female, Humans, Male, Cognitive Dysfunction, Mindfulness

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