The age-well randomized controlled trial of the Medit-ageing European project: effect of meditation or foreign language training on brain and mental health in older adults
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INTRODUCTION: The Age-Well clinical trial is an ongoing monocentric, randomized, controlled trial aiming to assess an 18-month preventive meditation-based intervention directly targeting the attentional and emotional dimensions of aging to promote mental health and well-being in elderly people. METHODS: One hundred thirty-seven cognitively unimpaired older adults are randomized to either an 18-month meditation-based intervention, a structurally matched foreign language training, or a passive control arm. The impact of the intervention and underlying mechanisms are assessed with detailed cognitive, behavioral, biological, neuroimaging and sleep examinations. RESULTS: Recruitment began in late 2016 and ended in May 2018. The interventions are ongoing and will be completed by early 2020. DISCUSSION: This is the first trial addressing the emotional and cognitive dimension of aging with a long-term nonpharmacological approach and using comprehensive assessments to investigate the mechanisms. Results are expected to foster the development of preventive strategies reducing the negative impact of mental conditions and disorders.
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Liens entre apnées du sommeil et altérations cérébrales évaluées par imagerie chez le sujet âgé
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Effects of amyloid and APOE4 on medial temporal lobe subregions in cognitively unimpaired elderlyPreprint
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- Authors
- Poisnel, G., Arenaza‐Urquijo, E., Collette, F., Klimecki, O. M., Marchant, N. L., Wirth, M., de La Sayette, V., Rauchs, G., Salmon, E., Vuilleumier, P., Frison, E., Maillard, A., Vivien, D., Lutz, A., Chételat, G., & Medit‐Ageing Research Group
- Affiliations
- Inserm (FR)
- University of Liège (BE)
- University of Geneva (CH)
- University College London (GB)
- Humboldt-Universität zu Berlin (DE)
- Université Normandie, Inserm, Université de Caen‐Normandie Inserm UMR‐S U1077, GIP Cyceron Caen France
- GIGA‐CRC, In Vivo Imaging Université de Liège Liège Belgium
- EUCLID/F‐CRIN Clinical Trials Platform University of Bordeaux, INSERM, Bordeaux Population Health Center Bordeaux France
- Université de Bordeaux (FR)
- Lyon Neuroscience Research Center INSERM U1028 CNRS UMR5292 Lyon University Lyon France
- Corresponding author
- Poisnel, Géraldine
- Chételat, Gaël
- ORCID
- Venue
- Alzheimer's & Dementia: Translational Research & Clinical Interventions
- Publisher
- Wiley
- Published
- 2018-01
- Volume
- 4
- Issue
- 1
- Pages
- 714-723
- ISSN
- 2352-8737 (ISSN-L)
- PMC
- PMC6296161
- OpenAlex
- W2904520264
- Cited by
- 103
- References
- 42
- Citations by year
- 2026: 5 · 2025: 18 · 2024: 17 · 2023: 13 · 2022: 15 · 2021: 14 · 2020: 14 · 2019: 7
- FWCI
- 10.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Alzheimer s & Dementia Translational Research & Clinical Interventions (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- ORBi (University of Liège) (submittedVersion, other-oa)
- HAL (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion, cc-by-nc-nd)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by-nc-nd)
- Funders
- Inserm
- Horizon 2020
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Keywords
- meditation, foreign language training, older adults, mental health, well-being, aging, attention, emotion regulation, cognitive aging, neuroimaging, sleep, non-pharmacological treatment, preventive interventions
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