Increased Endothelial Tetrahydrobiopterin Synthesis by Targeted Transgenic GTP-Cyclohydrolase I Overexpression Reduces Endothelial Dysfunction and Atherosclerosis in ApoE-Knockout Mice

Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress

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Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

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Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

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Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus

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Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus

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Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.

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Endothelial Regulation of Vasomotion in ApoE-Deficient Mice: Implications for Interactions Between Peroxynitrite and Tetrahydrobiopterin

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Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols

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Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.

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Oxidation of Tetrahydrobiopterin by Peroxynitrite: Implications for Vascular Endothelial Function

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Novel diallyldisulfide analogs ameliorate cardiovascular remodeling in rats with L-NAME-induced hypertension

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Relationships between nitric oxide‐mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS–GTP cyclohydrolase 1 double transgenic mice

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Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice

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Role of Interferon Alpha in Endothelial Dysfunction: Insights Into Endothelial Nitric Oxide Synthase–Related Mechanisms

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Caveolin1/protein arginine methyltransferase1/sirtuin1 axis as a potential target against endothelial dysfunction

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Maintenance of Endothelial Guanosine Triphosphate Cyclohydrolase I Ameliorates Diabetic Nephropathy

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Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability

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Radiochemical HPLC detection of arginine metabolism: Measurement of nitric oxide synthesis and arginase activity in vascular tissue

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Redox modification of caveolar proteins in the cardiovascular system- role in cellular signalling and disease

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C-Terminus of Heat Shock Protein 70–Interacting Protein–Dependent GTP Cyclohydrolase I Degradation in Lambs with Increased Pulmonary Blood Flow

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Increased vascular biosynthesis of tetrahydrobiopterin in apolipoprotein E-deficient mice

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Traditional Chinese medicine xin-mai-jia recouples endothelial nitric oxide synthase to prevent atherosclerosis in vivo

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Twenty-five years since the discovery of endothelium-derived relaxing factor (EDRF): does a dysfunctional endothelium contribute to the development of type 2 diabetes?

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CCR2-Mediated Antiinflammatory Effects of Endothelial Tetrahydrobiopterin Inhibit Vascular Injury-Induced Accelerated Atherosclerosis

Ali, Z. A., Bursill, C. A., Douglas, G., McNeill, E., Papaspyridonos, M., Tatham, A. L., Bendall, J. K., Akhtar, A. M., Alp, N. J., Greaves, D. R., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.753558 · Cited by 28

Dual Role of Endothelial Nitric Oxide Synthase in Oxidized LDL-Induced, p66Shc-Mediated Oxidative Stress in Cultured Human Endothelial Cells

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Tetrahydrobiopterin: Mediator of Endothelial Protection

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Antioxidant Properties of Oral Antithrombotic Therapies in Atherosclerotic Disease and Atrial Fibrillation

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l-Phenylalanine Restores Vascular Function in Spontaneously Hypertensive Rats Through Activation of the GCH1-GFRP Complex

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Low dose dietary nitrate improves endothelial dysfunction and plaque stability in the ApoE−/− mouse fed a high fat diet

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Tetrahydrobiopterin: A Vascular Redox Target to Improve Endothelial Function

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Endothelial GTPCH in eNOS Uncoupling and Atherosclerosis

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Apolipoprotein E Deficiency Causes Endothelial Dysfunction in the Mouse Retina

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A Pivotal Role for Tryptophan 447 in Enzymatic Coupling of Human Endothelial Nitric Oxide Synthase (eNOS)

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Donor Pretreatment with Tetrahydrobiopterin Saves Pancreatic Isografts from Ischemia Reperfusion Injury in a Mouse Model

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Vascular Redox Signaling, Redox Switches in Endothelial Nitric Oxide Synthase (eNOS Uncoupling), and Endothelial Dysfunction

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Signaling Pathways in Inflammation and Cardiovascular Diseases: An Update of Therapeutic Strategies

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Vasodilator-stimulated phosphoprotein protects against vascular inflammation and insulin resistance

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Endothelial Nitric Oxide Synthase Stimulates Aneurysm Growth in Aged Mice

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Nitric Oxide and its Role in Cardiovascular Diseases

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Guanosine Triphosphate Cyclohydrolase I Expression and Enzymatic Activity Are Present in Caveolae of Endothelial Cells

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Tetrahydrobiopterin Determines Vascular Remodeling Through Enhanced Endothelial Cell Survival and Regeneration

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Naringenin upregulates GTPCH1/eNOS to ameliorate high glucose‑induced retinal endothelial cell injury

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Neopterin derivatives – a novel therapeutic target rather than biomarker for atherosclerosis and related diseases

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Recent developments in the effects of nitric oxide-donating statins on cardiovascular disease through regulation of tetrahydrobiopterin and nitric oxide

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The regulation of vascular tetrahydrobiopterin bioavailability

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Reduced cardiac functional reserve in apolipoprotein E knockout mice

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A new era of stroke prevention in atrial fibrillation: comparing a new generation of oral anticoagulants with warfarin

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Sirtuin 1 (SIRT1) and Oxidative Stress

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ENDOTHELIUM‐TARGETED TRANSGENIC GTP‐CYCLOHYDROLASE I OVEREXPRESSION INHIBITS NEOINTIMA FORMATION IN MOUSE CAROTID ARTERY

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Is tetrahydrobiopterin a therapeutic option in diabetic hypertensive patients?

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Computational analysis of interactions of oxidative stress and tetrahydrobiopterin reveals instability in eNOS coupling

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Caveolin-1 Regulation of Endothelial Nitric Oxide Synthase (eNOS) Function and Oxidative Stress in the Endothelium

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Circulating tetrahydrobiopterin as a novel biomarker for abdominal aortic aneurysm

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Tetrahydrobiopterin Plays a Functionally Significant Role in Lipogenesis in the Oleaginous Fungus Mortierella alpina

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Dexamethasone, tetrahydrobiopterin and uncoupling of endothelial nitric oxide synthase.

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The Protein Partners of GTP Cyclohydrolase I in Rat Organs

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Tetrahydrobiopterin

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Redox Modulation of Insulin Signaling and Endothelial Function

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Increasing tetrahydrobiopterin in cardiomyocytes adversely affects cardiac redox state and mitochondrial function independently of changes in NO production

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Effects of BM-573 on Endothelial Dependent Relaxation and Increased Blood Pressure at Early Stages of Atherosclerosis

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Transcribing the Cross-Talk of Cytokine-Induced Tetrahydrobiopterin Synthesis in Endothelial Cells

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Endothelial Cell Tetrahydrobiopterin

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Thinking Outside the Therapeutic Box: The Potential of Polyphenols in Preventing Chemotherapy-Induced Endothelial Dysfunction

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Current Insights on the Role of Irisin in Endothelial Dysfunction

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Exendin‑4 reverses endothelial dysfunction in mice fed a high‑cholesterol diet by a GTP cyclohydrolase‑1/tetrahydrobiopterin pathway

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Biology of Nitric Oxide Synthases

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An adverse outcome pathway for cigarette smoke-mediated oxidative stress in plaque formation

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Nitric Oxide in Biomaterial-Based Therapies for Coronary Heart Disease: Mechanistic Insights, Current Advances, and Translational Prospects

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High-fat diet causes endothelial dysfunction in the mouse ophthalmic artery

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Novel Concept for the Regulation of eNOS (Endothelial Nitric Oxide Synthase) Activity

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The machinery of healthy vasoconstriction: an overview

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Exploring the therapeutic potential of tetrahydrobiopterin for heart failure with preserved ejection fraction: A path forward

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Cloning, expression and enzymatic properties analysis of dihydrofolate reductase gene from the silkworm, Bombyx mori

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Studies on the Effects of Hypercholesterolemia on Mouse Ophthalmic Artery Reactivity

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Role of Oxidative Stress and Cardiovascular Risk Factors in Ischemic Heart Disease

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Nitric Oxide Synthesis in Vascular Physiology and Pathophysiology

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Nitric Oxide and Cardiovascular Diseases: Cardioprotection, Complications and Therapeutics

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HIGH‐CHOLESTEROL DIET AUGMENTS ENDOTHELIAL DYSFUNCTION VIA ELEVATED OXIDATIVE STRESS AND REDUCED TETRAHYDROBIOPTERIN IN INS2AKITA MICE, AN AUTOSOMAL DOMINANT MUTANT TYPE 1 DIABETIC MODEL

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Role of the Scavenger Receptor Class B Type I in Lipoprotein Metabolism and Atherosclerosis: Insight from Genetically Altered Mice

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Oxidase Interactions in Cardiovascular Disease

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Implications of Inflammation in Aging and Age-Related Diseases

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Vasodilators

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Uncoupling of Endothelial Nitric Oxide Synthase in Atherosclerosis

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Inhibition of cardiac allograft arteriosclerosis by NOS (eNOS or iNOS) specific expression in smooth muscle or endothelial cells

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Tetrahydrobiopterin Slows the Progression of Atherosclerosis

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