Cited by 310Trace Elements in HealthAtherosclerosis and Cardiovascular DiseasesIron Metabolism and Disorders

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Direct Detection and Quantification of Transition Metal Ions in Human Atherosclerotic Plaques: Evidence for the Presence of Elevated Levels of Iron and Copper

Stadler, Nadina, Lindner, Robyn A., Davies, Michael J.·2004·Arteriosclerosis, Thrombosis, and Vascular Biology

Open this paper in CoChat — free account

Abstract

Objective—The involvement of transition metals in atherosclerosis is controversial. Some epidemiological studies have reported a relationship between iron (Fe) and cardiovascular disease, whereas others have not. Experimental studies have reported elevated levels of iron and copper (Cu) in diseased human arteries but have often used methods that release metal ions from proteins. Methods and Results—In this study, we have used the minimally invasive technique of electron paramagnetic resonance (EPR) spectroscopy and inductively coupled plasma mass spectroscopy (ICPMS) to quantify iron and copper in ex vivo healthy human arteries and carotid lesions. The EPR spectra detected are characteristic of nonheme Fe(III) complexes. Statistically elevated levels of iron were detected in the intima of lesions compared with healthy controls (0.370 versus 0.022 nmol/mg tissue for EPR, 0.525 versus 0.168 nmol/mg tissue by ICPMS,P<0.05 in each cases). Elevated levels of copper were also detected (7.51 versus 2.01 pmol/mg tissue, lesion versus healthy control, respectively,P<0.05). Iron levels did not correlate with the gender or age of the donor, or tissue protein or calcium levels, but cholesterol levels correlated positively with iron accumulation, as measured by EPR. Conclusions—These data support the hypothesis that iron accumulates in human lesions and may contribute to disease progression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/01.atv.0000124892.90999.cb

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Beyond Cholesterol
Epstein, F. H., Steinberg, D. I., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201407 · Cited by 6,425
A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis
Stary, H. C., Chandler, A. B., Dinsmore, R. E., Fuster, V., Glagov, S. K., Insull, W., Rosenfeld, M. E., Schwartz, C. J., Wagner, W. D., & Wissler, R. W. (1995) · Circulation · doi:10.1161/01.cir.92.5.1355 · Cited by 3,506
Plaque fissuring--the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina.
Davies, M. J., & Thomas, A. C. (1985) · Heart · doi:10.1136/hrt.53.4.363 · Cited by 1,985
Self-citation
Intraplaque Hemorrhage and Progression of Coronary Atheroma
Kolodgie, F. D., Gold, H. K., BURKE, A. P., Fowler, D. R., Kruth, H. S., Weber, D. K., Farb, A. A., Guerrero, L. J., Hayase, M., Kutys, R., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035655 · Cited by 1,491
IRON AND THE SEX DIFFERENCE IN HEART DISEASE RISK
Sullivan, J. (1981) · The Lancet · doi:10.1016/s0140-6736(81)92463-6 · Cited by 969
3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.
Hazen, S. L., & Heinecke, J. W. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119379 · Cited by 842
Superoxide accelerates DNA damage by elevating free-iron levels
Keyer, K., & Imlay, J. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13635 · Cited by 841
Presence of hypochlorite-modified proteins in human atherosclerotic lesions.
Hazell, L. J., Arnold, L., Flowers, D., Waeg, G., Malle, E., & Stocker, R. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118576 · Cited by 592
Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture.
Heinecke, J. W., Rosen, H., & Chait, A. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111609 · Cited by 536
Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis
Heinecke, J. W. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00173-7 · Cited by 462

Show all 51 references

Research works printed but not linked: 7

1998, Atherosclerosis, 141, 1
1996, Cell Mol Biol, 42, 103
1996, Cell Mol Biol, 42, 89
10.1161/circ.99.7.852 · DOI
10.1161/atvb.15.9.1512 · DOI
1988, Free Radic Res, 5, 11
10.1161/atvb.21.8.1373 · DOI

Sorted by citations

Items 101–200 of 309

Iron Chelation Inhibits NF-κB–Mediated Adhesion Molecule Expression by Inhibiting p22 phox Protein Expression and NADPH Oxidase Activity
Li, L., & Frei, B. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000245820.34238.da · Cited by 49
A nuclear microscopy study of trace elements Ca, Fe, Zn and Cu in atherosclerosis
Watt, F., Rajendran, R., Ren, M. Q., Tan, B. K. H., & Halliwell, B. (2006) · Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms · doi:10.1016/j.nimb.2006.03.073 · Cited by 48
Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities
Shan, D., Jinling, S., Ren, Y., Zhang, Y., Ba, Y., Luo, P., Cheng, Q., Xu, H., Weng, S., Zuo, A., et al. (2025) · 癌症：英文版 · doi:10.1002/cac2.70005 · Cited by 53
A facile colorimetric method for the quantification of labile iron pool and total iron in cells and tissue specimens
Abbasi, U., Abbina, S., Gill, A., Bhagat, V., & Kizhakkedathu, J. N. (2021) · Scientific Reports · doi:10.1038/s41598-021-85387-z · Cited by 47
Iron-induced calcification in human aortic vascular smooth muscle cells through interleukin-24 (IL-24), with/without TNF-alpha
Kawada, S., Nagasawa, Y., Kawabe, M., Ohyama, H., Kida, A., Kato‐Kogoe, N., Nanami, M., Hasuike, Y., Kuragano, T., Kishimoto, H., et al. (2018) · Scientific Reports · doi:10.1038/s41598-017-19092-1 · Cited by 46
Physicochemical study of floranol, its copper(II) and iron(III) complexes, and their inhibitory effect on LDL oxidation
Botelho, F. V., Alvarez-Leite, J. I., Lemos, V. S., Pimenta, A. M. C., Calado, H. D. R., Matencio, T., Miranda, C. T., & Pereira-Maia, E. C. (2007) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2007.03.007 · Cited by 45
Protecting the beneficial functionality of lipoproteins by 1-Fe, a corrole-based catalytic antioxidant
Haber, A., Aviram, M., & Gross, Z. (2010) · Chemical Science · doi:10.1039/c0sc00448k · Cited by 45
Binding of myeloperoxidase to the extracellular matrix of smooth muscle cells and subsequent matrix modification
Cai, H., Chuang, C. Y., Hawkins, C. L., & Davies, M. J. (2020) · Scientific Reports · doi:10.1038/s41598-019-57299-6 · Cited by 45
Self-citation
Glycation of low‐density lipoprotein results in the time‐dependent accumulation of cholesteryl esters and apolipoprotein B‐100 protein in primary human monocyte‐derived macrophages
Brown, B. E., Rashid, I., van Reyk, D. M., & Davies, M. J. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05699.x · Cited by 47
Self-citation
The effect of flavonoids on the reduction of cupric ions, the copper-driven Fenton reaction and copper-triggered haemolysis
Lomozová, Z., Hrubša, M., Conte, P. F., Papastefanaki, E., Moravcová, M., Catapano, M. C., Proietti Silvestri, I., Karlíčková, J., Kučera, R., Macáková, K., et al. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.133461 · Cited by 44
Iron overload, oxidative stress and vascular dysfunction: Evidences from clinical studies and animal models
dos SANTOS, L., Bertoli, S. R., Ávila, R. A., & Marques, V. B. (2022) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2022.130172 · Cited by 44
Association of Catalytic Iron With Cardiovascular Disease
Rajapurkar, M. M., Shah, S. V., Lele, S. S., Hegde, U. N., Lensing, S., Gohel, K., Mukhopadhyay, B. N., Gang, S. D., & Eigenbrodt, M. L. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.09.032 · Cited by 44
Hepcidin and HFE protein: Iron metabolism as a target for the anemia of chronic kidney disease
Canavesi, E. (2012) · World Journal of Nephrology · doi:10.5527/wjn.v1.i6.166 · Cited by 43
Do Hemochromatosis Mutations Protect Against Iron-Mediated Atherogenesis?
Sullivan, J. L. (2009) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.109.906230 · Cited by 43
Is There a Link between Zinc Intake and Status with Plasma Fatty Acid Profile and Desaturase Activities in Dyslipidemic Subjects?
Knez, M., Pantović, A., Zeković, M., Pavlović, Z., Glibetić, M., & Zec, M. M. (2019) · Nutrients · doi:10.3390/nu12010093 · Cited by 43
Non-Transferrin-Bound Iron in the Spotlight: Novel Mechanistic Insights into the Vasculotoxic and Atherosclerotic Effect of Iron
Vinchi, F. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8167 · Cited by 46
Highly Sensitive and Selective Spiropyran-Based Sensor for Copper(II) Quantification
Trevino, K. M., Tautges, B. K., Kapre, R., Franco, F. C., Or, V. W., Balmond, E. I., Shaw, J. T., Garcia, J., & Louie, A. Y. (2021) · ACS Omega · doi:10.1021/acsomega.1c00392 · Cited by 43
Detection of mitochondrial dysfunction by EPR technique in mouse model of dilated cardiomyopathy
Elas, M., Bielańska, J., Pustelny, K., Plonka, P. M., Drelicharz, Ł., Skórka, T., Tyrankiewicz, U., Woźniak, M., Heinze, S., Walski, M., et al. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.016 · Cited by 42
Photodamage Generates 7‐keto‐ and 7‐hydroxycholesterol in the Rat Retina via a Free Radical‐mediated Mechanism
Rodríguez, I. R., & Fliesler, S. J. (2009) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2009.00568.x · Cited by 42
Macrophage antioxidant protection within atherosclerotic plaques
Steven, P. G. (2009) · Frontiers in bioscience · doi:10.2741/3305 · Cited by 42
Accumulation of Zinc in Human Atherosclerotic Lesions Correlates With Calcium Levels But Does Not Protect Against Protein Oxidation
Stadler, N., Stanley, N., Heeneman, S., Vacata, V., Daemen, M. J. A. P., Bannon, P. G., Waltenberger, J. L., & Davies, M. J. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.162735 · Cited by 41
Self-citation
Prolonged Exposure to LPS Increases Iron, Heme, and p22 phox Levels and NADPH Oxidase Activity in Human Aortic Endothelial Cells
Li, L., & Frei, B. B. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.183210 · Cited by 42
Degradation of extracellular matrix and its components by hypobromous acid
Rees, M. D., McNiven, T. N., & Davies, M. J. (2006) · Biochemical Journal · doi:10.1042/bj20061236 · Cited by 43
Self-citation
A novel approach to quantify different iron forms in ex-vivo human brain tissue
Kumar, P., Bulk, M., WEBB, A. G., van der Weerd, L., Oosterkamp, T. H., Huber, M., & Bossoni, L. (2016) · Scientific Reports · doi:10.1038/srep38916 · Cited by 40
Foam cell death induced by 7β-hydroxycholesterol is mediated by labile iron-driven oxidative injury: Mechanisms underlying induction of ferritin in human atheroma
Li, W., Hellsten, A., Xu, L.-H., Zhuang, D., Jansson, K., Brunk, U. T., & Yuan, X. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.05.006 · Cited by 40
Oxidatively modified high density lipoprotein promotes inflammatory response in human monocytes–macrophages by enhanced production of ROS, TNF-α, MMP-9, and MMP-2
Soumyarani, V. S., & Jayakumari, N. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1306-y · Cited by 42
Reduced Serum Levels of Zinc and Superoxide Dismutase in Obese Individuals
Torkanlou, K., Bibak, B., Abbaspour, A., Abdi, H., Moghaddam, M. S., Tayefi, M., Mohammadzadeh, E., Bana, H. S., Aghasizade, M., Ferns, G. A., et al. (2016) · Annals of Nutrition and Metabolism · doi:10.1159/000454894 · Cited by 38
Signalling, Metabolic Pathways and Iron Homeostasis in Endothelial Cells in Health, Atherosclerosis and Alzheimer’s Disease
Bosseboeuf, E., & Raimondi, C. (2020) · Cells · doi:10.3390/cells9092055 · Cited by 38
Hydrogen peroxide restrains endothelium-derived nitric oxide bioactivity—Role for iron-dependent oxidative stress
Thomas, S. R., Schulz, E., & Keaney, J. F. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.05.012 · Cited by 37
Lipids and Lipoproteins in Health and Disease: Focus on Targeting Atherosclerosis
Lee, C., Liao, C., Meng, S., Wu, W., Chiang, J., & Wu, M. (2021) · Biomedicines · doi:10.3390/biomedicines9080985 · Cited by 39
The tandem stenosis mouse model: Towards understanding, imaging, and preventing atherosclerotic plaque instability and rupture
Noonan, J. E., Bobik, A., & Peter, K. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15356 · Cited by 37
Cuproptosis and Cu: a new paradigm in cellular death and their role in non-cancerous diseases
Yang, Z., Feng, R., & Hai, Z. (2024) · APOPTOSIS · doi:10.1007/s10495-024-01993-y · Cited by 39
Functional Imaging of Carotid Atheromatous Plaques
Warburton, L., & Gillard, J. H. (2006) · Journal of Neuroimaging · doi:10.1111/j.1552-6569.2006.00045.x · Cited by 34
A novel cuproptosis-related diagnostic gene signature and differential expression validation in atherosclerosis
Cui, Y., Chen, Y., Gan, N., Li, M., Liao, W., Zhou, Y., Xiang, Q., Gong, X., Guo, Q., Hu, P., et al. (2023) · Molecular Biomedicine · doi:10.1186/s43556-023-00131-5 · Cited by 34
Article Commentary: Effects of Environmental Pollutants on Cellular Iron Homeostasis and Ultimate Links to Human Disease
Schreinemachers, D. M., & Ghio, A. J. (2016) · Environmental Health Insights · doi:10.4137/ehi.s36225 · Cited by 32
Novel interaction of antioxidant-1 with TRAF4: role in inflammatory responses in endothelial cells
Das, A., Varadarajan, S., Ushio‐Fukai, M., & Fukai, T. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00264.2019 · Cited by 32
Oxidative damage to rat brain in iron and copper overloads
Musacco-Sebio, R., Ferrarotti, N., Saporito-Magriñá, C., Semprine, J., Fuda, J., Torti, H., Boveris, A., & Repetto, M. G. (2014) · Metallomics · doi:10.1039/c3mt00378g · Cited by 31
Unexpected Role of MPO-Oxidized LDLs in Atherosclerosis: In between Inflammation and Its Resolution
Tangeten, C., Boudjeltia, K. Z., Delporte, C., Antwerpen, P. V., & Korpak, K. (2022) · Antioxidants · doi:10.3390/antiox11050874 · Cited by 31
Prognostic Evaluation of Catalytic Iron in Patients With Acute Coronary Syndromes
Steen, D. L., Cannon, C. P., Lele, S. S., Rajapurkar, M. M., Mukhopadhyay, B. N., Scirica, B. M., Murphy, S. A., & Morrow, D. A. (2013) · Clinical Cardiology · doi:10.1002/clc.22089 · Cited by 32
Copper and zinc concentrations in atherosclerotic plaque and serum in relation to lipid metabolism in patients with carotid atherosclerosis
Tasić, N., Tasić, D., Otašević, P., Veselinović, M., Jakovljevic, V. L., Djuric, D. M., & Radak, D. J. (2014) · Vojnosanitetski pregled · doi:10.2298/vsp140417074t · Cited by 30
Iron Oxide Magnetic Resonance Imaging for Atherosclerosis Therapeutic Evaluation
Fayad, Z. A., Razzouk, L., Briley-Saebo, K. C., & Mani, V. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.03.021 · Cited by 30
Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes
Xu, M., Li, X., Xiong, J., Xia, M., Gulbins, E., Zhang, Y., & Li, P. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.09.015 · Cited by 29
Metabolic phenotyping of human atherosclerotic plaques: Metabolic alterations and their biological relevance in plaque-containing aorta
Jung, S., Song, S., Lee, S., Kim, S. H., Ann, S.-J., Cheon, E. J., Yi, G., Choi, E., Lee, S. H., Joo, H., et al. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.11.034 · Cited by 29
Flow field-flow fractionation: Recent applications for lipidomic and proteomic analysis
Moon, M. H. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.05.024 · Cited by 29
Identification of Three Cuproptosis-specific Expressed Genes as Diagnostic Biomarkers and Therapeutic Targets for Atherosclerosis
Chen, Y.-T., Xu, X., Lin, L., Tian, S., & Wu, G. (2023) · International Journal of Medical Sciences · doi:10.7150/ijms.83009 · Cited by 31
Potential intervention target of atherosclerosis: Ferroptosis (Review)
Li, J., Xu, L., Zuo, Y., Chang, X., & Chi, H. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12859 · Cited by 28
Untitled work
(2009) · PubMed Central
Arsenic association with circulating oxidized low-density lipoprotein in a Native American community
Harmon, M. E., Lewis, J. L., Miller, C. P., Hoover, J. H., Ali, A.-M. S., Shuey, C., Cajero, M., Lucas, S., Pacheco, B., Erdei, E., et al. (2018) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2018.1443860 · Cited by 27
Atherosclerotic lesion-specific copper delivery suppresses atherosclerosis in high-cholesterol-fed rabbits
Wang, N., Xu, X., Hua-lin, L., Feng, Q., Wang, H., & Kang, Y. J. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211046541 · Cited by 27
A versatile rhodamine B-derived fluorescent probe for selective copper(II) sensing
Gauthama, B. U., Narayana, B., Sarojini, B. K., Kodlady, S. N., Sangappa, Y., Kudva, A. K., & Raghu, S. V. (2022) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2022.109501 · Cited by 27
The use of metabolomics in the study of metals in biological systems
Jones, O. A. H., Dias, D. A., Callahan, D. L., Kouremenos, K. A., Beale, D. J., & Roessner, U. (2014) · Metallomics · doi:10.1039/c4mt00123k · Cited by 27
Cadmium biosorption by yeast, Candida tropicalis CBL-1, isolated from industrial wastewater
Rehman, A., Anjum, M. S., & Hasnain, S. (2010) · The Journal of General and Applied Microbiology · doi:10.2323/jgam.56.359 · Cited by 27
Combining nanotechnology with current biomedical knowledge for the vascular imaging and treatment of atherosclerosis
SLEVIN, M. A., Badimón, L., Grau-Olivares, M., Ramis, M., Sendra, J., Morrison, M., & Krupiński, J. (2009) · Molecular BioSystems · doi:10.1039/b916175a · Cited by 27
Biosorption of copper by yeast, Loddermyces elongisporus, isolated from industrial effluents: its potential use in wastewater treatment
Rehman, A., Farooq, H., & Hasnain, S. (2008) · Journal of Basic Microbiology · doi:10.1002/jobm.200700324 · Cited by 26
Vascular metallomics: Copper in the vasculature
Easter, R. N., Chan, Q., Lai, B. C. H., Ritman, E. L., Caruso, J. A., & Qin, Z. (2009) · Vascular Medicine · doi:10.1177/1358863x09346656 · Cited by 26
Sulfite facilitates LDL lipid oxidation by transition metal ions: A pro‐oxidant in wine?
Laggner, H., Hermann, M., Sturm, B., Gmeiner, B. M. K., & Kapiotis, S. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.10.045 · Cited by 26
Copper transporter ATP7A interacts with IQGAP1, a Rac1 binding scaffolding protein: role in PDGF-induced VSMC migration and vascular remodeling
Ashino, T., Kohno, T., Varadarajan, S., Ash, D., Ushio‐Fukai, M., & Fukai, T. (2018) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00230.2018 · Cited by 25
Use of Ultrasmall Superparamagnetic Iron Oxide Particles for Imaging Carotid Atherosclerosis
Usman, A., Sadat, U., Patterson, A. J., Tang, T. Y., Varty, K., Boyle, J. R., Armon, M. P., Hayes, P. D., Graves, M. J., & Gillard, J. H. (2015) · Nanomedicine · doi:10.2217/nnm.15.136 · Cited by 25
Serum copper levels and risk of major adverse cardiovascular events: a systematic review and meta-analysis
Muñoz-Bravo, C., Soler‐Iborte, E., Lozano‐Lorca, M., Kouiti, M., Torres, C. G., Barrios‐Rodríguez, R., & Jiménez‐Moleón, J. J. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1217748 · Cited by 24
Deciphering the Role of Copper Homeostasis in Atherosclerosis: From Molecular Mechanisms to Therapeutic Targets
Lv, X., Zhao, L., Song, Y., Chen, W., & Tuo, Q. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111462 · Cited by 25
Relevance of the ability of fructose 1,6-bis(phosphate) to sequester ferrous but not ferric ions
Bajić, A., Zakrzewska, J., Gođevac, D. M., Anđjus, P. R., Jones, D. R., Spasić, M. B., & Spasojević, I. (2010) · Carbohydrate Research · doi:10.1016/j.carres.2010.12.008 · Cited by 23
Therapeutic Effects of an Oral Chelator Targeting Skeletal Tissue Damage in Experimental Postmenopausal Osteoporosis in Rats
Liu, G., Men, P., KENNER, G. H., & Miller, S. C. (2008) · Hemoglobin · doi:10.1080/03630260701726707 · Cited by 23
Online Miniaturized Asymmetrical Flow Field-Flow Fractionation and Inductively Coupled Plasma Mass Spectrometry for Metalloprotein Analysis of Plasma from Patients with Lung Cancer
Kim, J. Y., Lim, H. B., & Moon, M. H. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b02775 · Cited by 24
Trace element balance is changed in infected organs during acute Chlamydophila pneumoniae infection in mice
Edvinsson, M., Frisk, P., Molin, Y., Hjelm, E., & Ilbäck, N.-G. (2008) · BioMetals · doi:10.1007/s10534-007-9114-7 · Cited by 22
Safety Issues in Iron Treatment in CKD
Vaziri, N. D. (2016) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2016.02.005 · Cited by 23
In Vitro Interaction Between Homocysteine and Copper Ions: Potential Redox Implications
Carrasco‐Pozo, C., Álvarez‐Lueje, A., Olea‐Azar, C., López‐Alarcón, C., & Speisky, H. (2006) · Experimental Biology and Medicine · doi:10.1177/153537020623100918 · Cited by 22
Systemic administration of a pharmacologic iron chelator reduces cartilage lesion development in the Dunkin-Hartley model of primary osteoarthritis
Burton, L. H., Afzali, M. F., Radakovich, L. B., Campbell, M. A., Culver, L. A., Olver, C. S., & Santangelo, K. S. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.12.257 · Cited by 21
Prevention of early renal disease, dyslipidaemia and lipid peroxidation in STZ-diabetic rats by LR-9 and LR-74, novel AGE inhibitors
Figarola, J. L., Scott, S., Loera, S., Xi, B., Synold, T. W., Weiss, L. M., & Rahbar, S. (2005) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.550 · Cited by 21
Atomic spectrometry update. Clinical and biological materials, foods and beverages
Taylor, A., Branch, S., Halls, D., Patriarca, M., & White, M. (2005) · Journal of Analytical Atomic Spectrometry · doi:10.1039/b501936b · Cited by 21
Herbal medicines provide regulation against iron overload in cardiovascular diseases: Informing future applications
Liu, J., Deng, L., Qu, L., Li, X., Wang, T., Chen, Y., Jiang, M., & Zou, W. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117941 · Cited by 20
The role of transferrin in atherosclerosis
Kibel, A., Belovari, T., & Drenjančević, I. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2007.07.039 · Cited by 20
A Highly Sensitive and Selective Fluorescein-Based Cu2+ Probe and Its Bioimaging in Cell
Leng, X., She, M., Jin, X., Chen, J., Ma, X., Chen, F., Li, J., & Yang, B. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.932826 · Cited by 19
Intracellular labile iron promotes firm adhesion of human monocytes to endothelium under flow and transendothelial migration
Kartikasari, A. E. R., Visseren, F. L. J., Marx, J. J. M., van Mullekom, S., van Kats-Renaud, J. H., van Asbeck, B. S., Ulfman, L. H., & Georgiou, N. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.12.031 · Cited by 19
Fe(III) distribution varies substantially within and between atherosclerotic plaques
Gustafsson, H., Hallbeck, M., Norell, M., Lindgren, M., Engström, M., Rosén, A., & Zachrisson, H. (2013) · Magnetic Resonance in Medicine · doi:10.1002/mrm.24687 · Cited by 19
Vascular Damage in Patients with Nonalcoholic Fatty Liver Disease: Possible Role of Iron and Ferritin
Pisano, G., Lombardi, R., & Fracanzani, A. L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050675 · Cited by 19
Decoding ferroptosis: Revealing the hidden assassin behind cardiovascular diseases
Zhang, Z., Yang, Z., Wang, S., Wang, X., & Mao, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116761 · Cited by 18
Activatable Photoacoustic/Near-Infrared Probes for the Detection of Copper Ions of Cardiovascular Disease In Vivo and in Urine
Wang, K., Gu, K.-F., Cao, J., Yang, Y., Zhu, H., Shang, J., & Zhou, J.-L. (2024) · ACS Sensors · doi:10.1021/acssensors.4c01490 · Cited by 18
In Situ Conversion of Atherosclerotic Plaques’ Iron into Nanotheranostics
Pan, W., Shao, S., Cao, X., Dai, X., Zheng, Y., Cheng, J., Feng, W., Wu, R., & Chen, Y. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.4c15068 · Cited by 18
Safety of intravenous iron in hemodialysis patients
Li, X., Kshirsagar, A. V., & Brookhart, M. A. (2017) · Hemodialysis International · doi:10.1111/hdi.12558 · Cited by 18
The Nature of Iron Deposits Differs between Symptomatic and Asymptomatic Carotid Atherosclerotic Plaques
Kopriva, D., Kisheev, A., Meena, D. K., Pelle, S., Karnitsky, M., Lavoie, A., & Buttigieg, J. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143138 · Cited by 18
Distribution of selected elements in atherosclerotic plaques of apoE/LDLR‐double knockout mice assessed by synchrotron radiation‐induced micro‐XRF spectrometry
Gajda, M., Banaś, K., Banaś, A., Jawień, J., Mateuszuk, Ł., Chłopicki, S., Kwiatek, W. M., Cichocki, T., & Falkenberg, G. (2008) · X-Ray Spectrometry · doi:10.1002/xrs.1075 · Cited by 18
Mechanism of the antioxidant to pro-oxidant switch in the behavior of dehydroascorbate during LDL oxidation by copper(II) ions
Horsley, E. T. M., Burkitt, M. J., Jones, C. M., Patterson, R. A., Harris, L. K., Moss, N. J., del Rio, J. D., & Leake, D. S. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.07.005 · Cited by 18
Natural products and ferroptosis: A novel approach for heart failure management
Zhang, Z., Yang, Z., Wang, S., Wang, X., & Mao, J. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156783 · Cited by 17
Copper Tolerant Yeast, Candida tropicalis, Isolated from Industrial Effluents: its Potential use in Wastewater Treatment
Rehman, A., Farooq, H., & Shakoori, A. R. (2007) · Cited by 17
Cuproptosis and copper deficiency in ischemic vascular injury and repair
Gu, J., Huang, W., Duanmu, Z., Zhuang, R., & Yang, X. (2024) · APOPTOSIS · doi:10.1007/s10495-024-01969-y · Cited by 16
Serum Hepcidin Predicts Uremic Accelerated Atherosclerosis in Chronic Hemodialysis Patients with Diabetic Nephropathy
Li, H., Feng, S., Su, L., Wang, W., Zhang, X., & Wang, S. (2015) · Chinese Medical Journal · doi:10.4103/0366-6999.156781 · Cited by 16
High-dose intravenous iron reduces myocardial infarction in patients on haemodialysis
Petrie, M. C., Jhund, P. S., Connolly, E. C., Mark, P. B., MacDonald, M. R., Robertson, M., Anker, S. D., Bhandari, S., Farrington, K., Kalra, P. A., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab317 · Cited by 16
Association of Low Serum Iron Levels with Low-grade Inflammation and Hyperadiponectinemia in Community-living Elderly Women
Tsuboi, A., Watanabe, M., Kazumi, T., & Fukuo, K. (2013) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.16071 · Cited by 16
Iron enhances endothelial cell activation in response to Cytomegalovirus or Chlamydia pneumoniae infection
Kartikasari, A. E. R., Georgiou, N., Geest, M. D., van Kats-Renaud, J. H., Bouwman, J. J. M., van Asbeck, B. S., Marx, J. J. M., & Visseren, F. L. J. (2006) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2006.01709.x · Cited by 16
Iron, Human Growth, and the Global Epidemic of Obesity
Sangani, R. G., & Ghio, A. J. (2013) · Nutrients · doi:10.3390/nu5104231 · Cited by 15
Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?
Ismael, F. O., Barrett, T. J., Sheipouri, D., Brown, B. E., Davies, M. J., & Hawkins, C. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168844 · Cited by 15
Self-citation
Preparations from Various Organs of Sea Buckthorn (Elaeagnus rhamnoides (L.) A. Nelson) as Important Regulators of Hemostasis and Their Role in the Treatment and Prevention of Cardiovascular Diseases
Olas, B., & Skalski, B. (2022) · Nutrients · doi:10.3390/nu14050991 · Cited by 15
Iron Boosts Antitumor Type 1 T-cell Responses and Anti-PD1 Immunotherapy
Porte, S., Audemard‐Verger, A., Wu, C., Durand, A., Level, T., Giraud, L., Lombès, A., Germain, M., Pierre, R., Saintpierre, B., et al. (2024) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-0739 · Cited by 14
Regulation of dynein-mediated autophagosomes trafficking by ASM in CASMCs
Zhang, Y. (2015) · Frontiers in bioscience · doi:10.2741/4415 · Cited by 16
Vascular Aging and Damage in Patients with Iron Metabolism Disorders
Młodziński, K., Świątczak, M., Rohun, J., Wolf, J., Narkiewicz, K., Hellmann, M., & Daniłowicz‐Szymanowicz, L. (2022) · Diagnostics · doi:10.3390/diagnostics12112817 · Cited by 14
Acidic pH promotes oxidation-induced dissociation of C-reactive protein
Li, S., Feng, J.-R., Zhou, H., Zhang, C., Lv, G.-B., Tan, Y.-B., Ge, Z.-B., & Wang, M. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.09.021 · Cited by 14
The Fungal Iron Chelator Desferricoprogen Inhibits Atherosclerotic Plaque Formation
Potor, L., Sikura, K. É., Hegedüs, H., Pethő, D., Szabó, Z., Szigeti, Z. M., Pócsi, I., Trencsényi, G., Szikra, D., Garai, I., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134746 · Cited by 14
Reduced metal ion concentrations in atherosclerotic plaques from subjects with Type 2 diabetes mellitus
Stadler, N., Heeneman, S., Vöö, S. A., Stanley, N., Giles, G. I., Gang, B. P., Croft, K. D., Mori, T. A., Vacata, V., Daemen, M. J. A. P., et al. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.03.015 · Cited by 14
Self-citation
Elucidation of the effects of a high fat diet on trace elements in rabbit tissues using atomic absorption spectroscopy
Abdelhalim, M. A. K., Alhadlaq, H. A., & Moussa, S. A. A. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-2 · Cited by 14
Targeting ion homeostasis in metabolic diseases: Molecular mechanisms and targeted therapies
Zhang, Y., Ma, K., Fang, X., Zhang, Y., Miao, R., Guan, H., & Tian, J. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107579 · Cited by 13

Authors: Stadler, N., Lindner, R. A., & Davies, M. J.
Affiliations: The Heart Research Institute (AU)
ORCID: Stadler, Nadina
Davies, Michael J.
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-05
Volume: 24
Issue: 5
Pages: 949-954
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.0000124892.90999.cb
OpenAlex: W2158913228
Cited by: 310
References: 51
Citations by year: 2026: 8 · 2025: 12 · 2024: 14 · 2023: 11 · 2022: 12 · 2021: 13 · 2020: 13 · 2019: 11 · 2018: 8 · 2017: 10 · 2016: 13 · 2015: 13 · 2014: 13 · 2013: 23 · 2012: 16
FWCI: 14.32
Type: journal article
Language: en
Open access: closed
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: Medical Research Council
Australian Research Council
National Health and Medical Research Council
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords: atherosclerosis, transition metal ions, iron accumulation, copper, carotid plaque, cholesterol, human arteries
MeSH terms: Aged, Aged, 80 and over, Aorta, Coronary Artery Bypass, Carotid Arteries, Carotid Artery Diseases, Cholesterol, Copper, Electron Spin Resonance Spectroscopy, Female, Humans, Iron, Male, Mammary Arteries, Middle Aged, Mass Spectrometry, Endarterectomy, Carotid, Radial Artery, Tunica Intima

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Direct Detection and Quantification of Transition Metal Ions in Human Atherosclerotic Plaques: Evidence for the Presence of Elevated Levels of Iron and Copper

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks