Cited by 310Trace Elements in HealthAtherosclerosis and Cardiovascular DiseasesIron Metabolism and Disorders

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Direct Detection and Quantification of Transition Metal Ions in Human Atherosclerotic Plaques: Evidence for the Presence of Elevated Levels of Iron and Copper

Stadler, Nadina, Lindner, Robyn A., Davies, Michael J.·2004·Arteriosclerosis, Thrombosis, and Vascular Biology

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Abstract

Objective—The involvement of transition metals in atherosclerosis is controversial. Some epidemiological studies have reported a relationship between iron (Fe) and cardiovascular disease, whereas others have not. Experimental studies have reported elevated levels of iron and copper (Cu) in diseased human arteries but have often used methods that release metal ions from proteins. Methods and Results—In this study, we have used the minimally invasive technique of electron paramagnetic resonance (EPR) spectroscopy and inductively coupled plasma mass spectroscopy (ICPMS) to quantify iron and copper in ex vivo healthy human arteries and carotid lesions. The EPR spectra detected are characteristic of nonheme Fe(III) complexes. Statistically elevated levels of iron were detected in the intima of lesions compared with healthy controls (0.370 versus 0.022 nmol/mg tissue for EPR, 0.525 versus 0.168 nmol/mg tissue by ICPMS,P<0.05 in each cases). Elevated levels of copper were also detected (7.51 versus 2.01 pmol/mg tissue, lesion versus healthy control, respectively,P<0.05). Iron levels did not correlate with the gender or age of the donor, or tissue protein or calcium levels, but cholesterol levels correlated positively with iron accumulation, as measured by EPR. Conclusions—These data support the hypothesis that iron accumulates in human lesions and may contribute to disease progression.

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Authors: Stadler, N., Lindner, R. A., & Davies, M. J.
Affiliations: The Heart Research Institute (AU)
ORCID: Stadler, Nadina
Davies, Michael J.
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-05
Volume: 24
Issue: 5
Pages: 949-954
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.0000124892.90999.cb
OpenAlex: W2158913228
Cited by: 310
References: 51
Citations by year: 2026: 8 · 2025: 12 · 2024: 14 · 2023: 11 · 2022: 12 · 2021: 13 · 2020: 13 · 2019: 11 · 2018: 8 · 2017: 10 · 2016: 13 · 2015: 13 · 2014: 13 · 2013: 23 · 2012: 16
FWCI: 14.32
Type: journal article
Language: en
Open access: closed
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: Medical Research Council
Australian Research Council
National Health and Medical Research Council
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords: atherosclerosis, transition metal ions, iron accumulation, copper, carotid plaque, cholesterol, human arteries
MeSH terms: Aged, Aged, 80 and over, Aorta, Coronary Artery Bypass, Carotid Arteries, Carotid Artery Diseases, Cholesterol, Copper, Electron Spin Resonance Spectroscopy, Female, Humans, Iron, Male, Mammary Arteries, Middle Aged, Mass Spectrometry, Endarterectomy, Carotid, Radial Artery, Tunica Intima

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Direct Detection and Quantification of Transition Metal Ions in Human Atherosclerotic Plaques: Evidence for the Presence of Elevated Levels of Iron and Copper

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