Cited by 278Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stress

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Coronary Artery Superoxide Production and Nox Isoform Expression in Human Coronary Artery Disease

Open access

Guzik, Tomasz J., Sadowski, Jerzy, Guzik, Bartlomiej, Jopek, Andrew, Kapelak, Boguslaw, Przybyłowski, Piotr, Wierzbicki, Karol, Korbut, Ryszard, Harrison, David G., Channon, Keith M.·2006·Arteriosclerosis, Thrombosis, and Vascular Biology

DOI 10.1161/01.atv.0000196651.64776.51

Open this paper in CoChat — free account

Abstract

Background— Oxidative stress plays important role in the pathogenesis of atherosclerosis and coronary artery disease (CAD). We aimed to determine the sources and selected molecular mechanisms of oxidative stress in CAD. Methods and Results— We examined basal and NAD(P)H oxidase-mediated superoxide (O 2 · − ) production using lucigenin chemiluminescence, ferricytochrome c and dihydroethidium fluorescence in human coronary arteries from 19 CAD and 17 non-CAD patients undergoing heart transplantation. NAD(P)H oxidase subunits and xanthine oxidase expression were measured. Superoxide production was greater in coronary arteries from patients with CAD, even in vessels without overt atherosclerotic plaques, and was doubled within branching points of coronary arteries. Studies using pharmacological inhibitors and specific substrates showed that NAD(P)H oxidases (60%) and xanthine oxidase (25%) are primary sources of O 2 · − in CAD. Losartan significantly inhibited superoxide production in coronary arteries. NAD(P)H oxidase activity and protein levels of the NADPH oxidase subunits p22phox, p67 phox , and p47 phox were significantly increased in CAD, as were mRNA levels for p22phox and nox2, and no NAD(P)H oxidase subunit mRNA levels correlated with NAD(P)H oxidase activity in vessels from individual patients. Activity and protein expression of xanthine oxidase were increased in CAD, whereas xanthine dehydrogenase levels were not changed. Conclusions— Increased expression and activity of NAD(P)H oxidase subunits and xanthine oxidase, in part mediated through angiotensin II and PKC-dependent pathways, are important mechanisms underlying increased oxidative stress in human coronary artery disease.

Integrity signals

Registry

Crossref · 10.1161/01.atv.0000196651.64776.51

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients With Coronary Artery Disease
Heitzer, T., Schlinzig, T., Krohn, K., Meinertz, T., & Münzel, T. (2001) · Circulation · doi:10.1161/hc4601.099485 · Cited by 1,961
Cell transformation by the superoxide-generating oxidase Mox1
Suh, Y.-A., Arnold, R. S., Lassegue, B., Shi, J., Xu, X., Sorescu, D., Chung, A. B., Griendling, K. K., & Lambeth, J. D. (1999) · Nature · doi:10.1038/43459 · Cited by 1,480
Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus
Guzik, T. J., Mussa, S., Gastaldi, D., Sadowski, J., Ratnatunga, C., Pillai, R. G., & Channon, K. M. (2002) · Circulation · doi:10.1161/01.cir.0000012748.58444.08 · Cited by 979
Self-citation
Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis
Sorescu, D., Weiss, D., Lassègue, B., Clempus, R. E., Szöcs, K., Sorescu, G. P., Valppu, L., Quinn, M. T., Lambeth, J. D., Vega, J. D., et al. (2002) · Circulation · doi:10.1161/01.cir.0000012917.74432.66 · Cited by 847
Novel gp91 phox Homologues in Vascular Smooth Muscle Cells: nox1 Mediates Angiotensin II–Induced Superoxide Formation and Redox-Sensitive Signaling Pathways
Lassègue, B., Sorescu, D., Szöcs, K., Yin, Q., Akers, M., Zhang, Y., Grant, S. L., Lambeth, J. D., & Griendling, K. K. (2001) · Circulation Research · doi:10.1161/hh0901.090299 · Cited by 839
Vascular Superoxide Production by NAD(P)H Oxidase
Guzik, T. J., West, N. E. J., Black, E., McDonald, D., Ratnatunga, C., Pillai, R. G., & Channon, K. M. (2000) · Circulation Research · doi:10.1161/01.res.86.9.e85 · Cited by 584
Self-citation
Interactions of oxidants with vascular signaling systems
Wolin, M. S. (2000) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.20.6.1430 · Cited by 463
Upregulation of Nox-Based NAD(P)H Oxidases in Restenosis After Carotid Injury
Szöcs, K., Lassegue, B. P., Sorescu, D., Hilenski, L. L., Valppu, L., Couse, T. L., Wilcox, J. N., Quinn, M. T., Lambeth, J. D., & Griendling, K. K. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0102.102189 · Cited by 443
Oxidative Stress in Arterial Hypertension
Zalba, G., José, G. S., Moreno, M. U., Fortuño, M. A., Fortuño, A., Beaumont, J., & Dı́ez, J. (2001) · Hypertension · doi:10.1161/hy1201.099611 · Cited by 414
Contrasting Roles of NADPH Oxidase Isoforms in Pressure-Overload Versus Angiotensin II–Induced Cardiac Hypertrophy
Byrne, J., Grieve, D., Bendall, J. K., Li, J., Gove, C. D., Lambeth, J. D., Cave, A. C., & Shah, A. M. (2003) · Circulation Research · doi:10.1161/01.res.0000099504.30207.f5 · Cited by 412

Show all 22 references

Research works printed but not linked: 12

10.1161/atvb.20.6.1430 · DOI
10.1161/atvb.22.1.21 · DOI
10.1161/circ.104.22.2673 · DOI
10.1161/hyp.38.6.1395 · DOI
10.1161/circ.100.14.1494 · DOI
10.1161/res.86.9.e85 · DOI
10.1161/circ.82.4.2401058 · DOI
10.1161/circ.101.18.2206 · DOI
10.1161/res.88.9.888 · DOI
10.1161/atvb.20.8.1903 · DOI
10.1161/circ.100.3.292 · DOI
10.1161/circ.104.15.1767 · DOI

Sorted by citations

Items 201–277 of 277

Differential Effect of Amylin on Endothelial-Dependent Vasodilation in Mesenteric Arteries from Control and Insulin Resistant Rats
Assar, M. E., Angulo, J., Santos-Ruiz, M., Moreno, P., Novials, A., Villanueva‐Peñacarrillo, M. L., & Rodríguez‐Mañas, L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120479 · Cited by 14
p47phox: A Central Regulator of NADPH Oxidase Function and a Promising Therapeutic Target in Redox-Related Diseases
Gamble, M. E., Sureshkumar, S., Espinoza, M. J. C., Hakim, N. L., Espitia, C. M., Bi, F., Kelly, K. R., Wang, W., Nawrocki, S. T., & Carew, J. S. (2025) · Cells · doi:10.3390/cells14141043 · Cited by 14
Low-density lipoprotein reduction by simvastatin is accompanied by angiotensin II type 1 receptor downregulation, reduced oxidative stress, and improved endothelial function in patients with stable coronary artery disease
Kiliszek, M., Ma̧czewski, M., Styczyński, G., Duda, M. K., Opolski, G., & Berȩsewicz, A. (2007) · Coronary Artery Disease · doi:10.1097/mca.0b013e32802c7cb0 · Cited by 13
Abdominal paracentesis drainage ameliorates myocardial injury in severe experimental pancreatitis rats through suppressing oxidative stress
Wen, Y., Sun, H., Tan, Z., Liu, R., Huang, S.-Q., Chen, G.-Y., Qi, H., & Tang, L. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i1.35 · Cited by 13
The Synergistic Effect of Valsartan and LAF237 [(S)-1-[(3-Hydroxy-1-Adamantyl)Ammo]acetyl-2-Cyanopyrrolidine] on Vascular Oxidative Stress and Inflammation in Type 2 Diabetic Mice
Shen, M., Sun, D., Li, W., Liu, B., Wang, S., Zhang, Z., & Cao, F. (2012) · Experimental Diabetes Research · doi:10.1155/2012/146194 · Cited by 12
Disfunción endotelial y estrés oxidativo
Reyes, G. C., Ramírez‐Sánchez, I., Calzada‐Mendoza, C. C., & Olivares-Corichi, I. M. (2006) · Revista de Endocrinología y Nutrición · Cited by 12
Aging and Antithrombotic Treatment
Valeriani, E., Bartimoccia, S., Pignatelli, P., & Pastori, D. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0373 · Cited by 11
Vascular relaxation induced by Eucommiae Ulmoides Oliv. and its compounds Oroxylin A and wogonin: implications on their cytoprotection action.
Akinyi, M., Gao, X. M., Li, Y. H., Wang, B. Y., Liu, E. W., Chai, L. J., JawoBah, A., & Fan, G. W. (2014) · PubMed Central · Cited by 10
Impairment by Hypoxia or Hypoxia/Reoxygenation of Nitric Oxide–Mediated Relaxation in Isolated Monkey Coronary Artery: the Role of Intracellular Superoxide
Tawa, M., Yamamizu, K., Geddawy, A., Shimosato, T., Imamura, T., Ayajiki, K., & Okamura, T. (2011) · Journal of Pharmacological Sciences · doi:10.1254/jphs.11031fp · Cited by 10
Oxidants and Endothelial Dysfunction
Lund, A. K. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.00712-0 · Cited by 12
Effects of superoxide anion attack on the lipoprotein HDL
Napolitano, G., Fasciolo, G., Tomajoli, M. T. M., Carlucci, A., Ascione, E., & Alfonso, S. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04563-5 · Cited by 9
Reducing Proteoglycan Synthesis and NOX Activity by ROCK Inhibitors: Therapeutic Targets in Atherosclerosis
Babaahmadi‐Rezaei, H., Rezaei, M., Ghaderi-Zefrehi, H., Azizi, M., Nasab, H. B., & Mehta, J. L. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666220606090801 · Cited by 9
Oxidative Stress and Cardiovascular Fibrosis
Pennathur, S., Hecker, L., & Thannickal, V. J. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-600-9_22 · Cited by 8
Greater coronary lipid core plaque assessed by near-infrared spectroscopy intravascular ultrasound in patients with elevated xanthine oxidoreductase: a mechanistic insight
Saito, Y., Mori, N., Murase, T., Nakamura, T., Akari, S., Saito, K., Matsuoka, T., Tateishi, K., Kadohira, T., Kitahara, H., et al. (2020) · Heart and Vessels · doi:10.1007/s00380-020-01730-w · Cited by 8
Electrophilic Nitro-Fatty Acids: Nitric Oxide and Nitrite-Derived Metabolic and Inflammatory Signaling Mediators
Freeman, B. Α., Pekarová, M., Rubbo, H., & Trostchansky, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804273-1.00016-8 · Cited by 7
Nitric oxide and related factors linked to oxidation and inflammation as possible biomarkers of heart failure
Bonafede, R. J., & Manucha, W. A. (2018) · Clínica e Investigación en Arteriosclerosis (English Edition) · doi:10.1016/j.artere.2017.12.003 · Cited by 7
The natural polyphenol fisetin in atherosclerosis prevention: a mechanistic review
Yu, W. J., Zhao, Y., Ilyas, I., Wang, L., Little, P. J., & Xu, S. (2024) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgae053 · Cited by 6
Activation of Coronary Arteriolar PKCβ2 Impairs Endothelial NO-Mediated Vasodilation: Role of JNK/Rho Kinase Signaling and Xanthine Oxidase Activation
Thengchaisri, N., Hein, T. W., Ren, Y., & Kuo, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189763 · Cited by 6
Role of Oxidative Stress in the Pathophysiology of Arterial Hypertension and Heart Failure
Sousa, T., Reina‐Couto, M., & Gomes, P. (2019) · Springer eBooks · doi:10.1007/978-981-13-8273-4_23 · Cited by 6
Mechanisms of N-acetylcysteine in reducing monocrotaline-induced pulmonary hypertension in rats: Inhibiting the expression of Nox1 in pulmonary vascular smooth muscle cells
Yu, W., Ji, W., Mi, L., & Chen, L. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7326 · Cited by 6
The nitrite reductase activity of xanthine oxidoreductase sustains cardiovascular health as mice age
Dyson, N., Khambata, R. S., Parakaw, T., Massimo, G., Khuat, N. H., Noor, A. A., Gee, L. C., Lim, I., Siddique, U., Sullivan, A. J., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103923 · Cited by 6
Evaluation of a Targeted Drug‐Eluting Intravascular Nanotherapy to Prevent Neointimal Hyperplasia in an Atherosclerotic Rat Model
Newton, E. R., Gillis, D. C., Sun, K., Dandurand, B. R., Siletzky, R. M., Biswas, S., Karver, M. R., Tsihlis, N. D., Stupp, S. I., & Kibbe, M. R. (2021) · Advanced NanoBiomed Research · doi:10.1002/anbr.202000093 · Cited by 5
Redox imbalance driven epigenetic reprogramming and cardiovascular dysfunctions: phytocompounds for prospective epidrugs
Jyotirmaya, S. S., Rath, S., & Dandapat, J. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156380 · Cited by 5
Delineating the NOX-Mediated Promising Therapeutic Strategies for the Management of Various Cardiovascular Disorders: A Comprehensive Review
Upadhyay, R. K., Kumar, K., Vishwakarma, V. K., Singh, N., Narang, R., Parakh, N., Yadav, M., Yadav, S., Kumar, S., Goyal, A., et al. (2024) · Current Vascular Pharmacology · doi:10.2174/0115701611308870240910115023 · Cited by 6
Oxidative Stress in Vascular Disease
Gorenne, I., & Bennett, M. R. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-602-3_10 · Cited by 5
NAD(P)H oxidase isoforms as therapeutic targets for diabetic complications
Gray, S. P., Jha, J. C., Marco, E. D., & Jandeleit-Dahm, K. A. M. (2014) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2014.887984 · Cited by 5
Role of Oxidative Stress and Cardiovascular Risk Factors in Ischemic Heart Disease
Barteková, M., Ferenczyová, K., Jelemenský, M., & Dhalla, N. S. (2019) · Springer eBooks · doi:10.1007/978-981-13-8273-4_16 · Cited by 6
New insights to atherosclerosis management: Role of nanomaterials
Li, Z., Jiang, C. S., Chai, L., Fan, T., Li, C., Chen, Z., Huang, W., Zhang, B., Al‐Hartomy, O. A., Al‐Ghamdi, A. A., et al. (2022) · Applied Materials Today · doi:10.1016/j.apmt.2022.101466 · Cited by 5
Oxidants and Endothelial Dysfunction
Lund, A. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65250-9 · Cited by 6
All Oxidase Roads Lead to Angiotensin, Too
Lerman, L. O., & Lerman, A. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000260389.74074.47 · Cited by 5
Functional Implications of Reactive Oxygen Species (ROS) in Human Blood Vessels
Guzik, T. J., Schramm‐Luc, A., & Cześnikiewicz‐Guzik, M. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_178 · Cited by 4
Self-citation
E-vaporating benefits of e-vaping
Siedliński, M., Harrison, D. G., & Guzik, T. J. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz875 · Cited by 4
Self-citation
Myricetin alleviates the mechanism of IL-1β production caused by the endocrine-disrupting chemical Di(2-ethylhexyl) phthalate in RAW 264.7 cells
Park, J., & Lee, S. (2024) · Tissue and Cell · doi:10.1016/j.tice.2024.102683 · Cited by 4
Oxidative Stress and Cardiovascular Disease in Diabetes
Pop‐Busui, R., Mehta, M., & Pennathur, S. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4899-8035-9_11 · Cited by 3
Reactive Oxygen Species (ROS) and Cardiac Ischemia and Reperfusion Injury
Camara, A. K. S., & Stowe, D. F. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_75 · Cited by 3
EFFECTS OF NOVEL PLANT ANTIOXIDANTS
Pryjma, J. R., Naruszewicz, M., Korbut, R., & Guzik, T. J. (2006) · Cited by 3
Self-citation
Atherosclerosis
Land, W. G. (2020) · Springer eBooks · doi:10.1007/978-3-030-53868-2_10 · Cited by 3
Reactive Oxygen Species and Diabetes-Associated Atherosclerosis – Evidence from Experimental Models and Targeted Antioxidant Therapy
Sharma, A., & de Haan, J. B. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_155 · Cited by 3
NADPH Oxidases: Structure and Function
Quinn, M. T. (2013) · Wiley eBooks · doi:10.1002/9781118355886.ch7 · Cited by 3
Oxidants and Endothelial Dysfunction
Lund, A. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00071-1 · Cited by 2
Study of isoforms of nicotinamide adenine dinucleotide phosphate oxidase of the heart in a model of rats fed on several vegetable oils
Koffi, K. G., Jover, B. F., Badia, É., Djohan, Y. F., Raynaud, F., Dere, L., Niamkey, G., Gauze-Gnagne, C., Monde, A., Adéoti, F. M., et al. (2021) · African Journal of Biochemistry Research · doi:10.5897/ajbr2021.1128 · Cited by 2
Implications of Inflammation in Aging and Age-Related Diseases
Tan, B. L., & Norhaizan, M. E. (2021) · Springer eBooks · doi:10.1007/978-3-030-82859-2_5 · Cited by 2
Exercise Training Improves Endothelial Function in Human Cardiovascular Disease – Role of Oxidative Stress
Winzer, E. B., & Linke, A. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_168 · Cited by 2
Roles of Hydrogen Peroxide in the Regulation of Vascular Tone
Stanley, C. P., Maghzal, G. J., & Stocker, R. (2017) · CRC Press eBooks · doi:10.1201/9781315154831-24 · Cited by 2
Reactive Oxygen Species Signals Leading to Vascular Dysfunction and Atherosclerosis
Madamanchi, N. R., Vendrov, A. E., & Runge, M. S. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-369420-1.00056-1 · Cited by 2
Getting to the Heart of the Matter: Exploring the Intersection of Cardiovascular Disease, Sex and Race and How Exercise, and Gut Microbiota Influence these Relationships
Guers, J. J., Heffernan, K. S., & Campbell, S. C. (2025) · Reviews in Cardiovascular Medicine · doi:10.31083/rcm26430 · Cited by 1
Nitric Oxide Regulating Proteins as Biochemical and Genetic Markers of Coronary Artery Disease
Gad, M. Z., Abdel-Maksoud, S. M., Hassanein, S. I., Hashad, I. M., Rahman, M. F. A., el Maaty, M. A. A., Shaban, G. M., & Abou‐Aisha, K. (2015) · Springer eBooks · doi:10.1007/978-94-007-7741-5_34-1 · Cited by 1
Vascular pathophysiology of hypertension
Guzik, T. J., & Touyz, R. M. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780198755777.003.0019 · Cited by 1
Self-citation
NADPH Oxidase and Atherosclerosis
Jeremy, J. Y., Muzaffar, S., Mill, C., & Shukla, N. (2010) · Atherosclerosis · doi:10.1002/9783527629589.ch13 · Cited by 1
Factores de risco cardiovascular na infância de doença com expressão clínica na idade adulta
Guerra, A. (2014) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · doi:10.25754/pjp.2008.4543 · Cited by 1
Role of 5-Lipoxygenase in Interleukin-4-Induced Oxidative Stress and Inflammation in Vascular Endothelium
Kim, P. H. (2010) · VTechWorks (Virginia Tech) · Cited by 1
O Papel dos Polimorfismos Genéticos na Doença Cardíaca Isquémica
Sá, A. C. M. E. (2010) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/pa2d-5870 · Cited by 1
Effects of exogenous hydrogen sulfide administration on cardiac function and reactive oxygen species production : a study in hearts from normal rats and rats with heart hypertrophy or ischemia
Paunas, T. I. (2011) · NORA - Norwegian Open Research Archives · Cited by 1
The Multi-Ethnic Investigation of Gene and Gene-Environment Interactions for Biochemical Markers associated with Cardiovascular Disease
Ellis, J. (2013) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/gcaq-x895
Functional Studies of NADPH Oxidases in Human Vasculature
Guzik, T. J. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-600-9_8
Self-citation
SOLUBLE GUANYLYL CYCLASE MODULATES REDOX- DEPENDENT REGULATION OF THE CARDIAC SODIUM POTASSIUM PUMP
Chia, K. K. M. (2013) · The Sydney eScholarship Repository (The University of Sydney)
Regulation of Nox4 expression by histone deacetylases in human endothelial cells: involvement of epigenetic mechanisms
der Naturwissenschaften, D. (2013)
NADPH Oxidase as a Mechanistic Link Between Erectile Dysfunction Peripheral and Coronary Endothelial Dysfunction in Obesity
La, F. J. D. (2012)
Investigation of the distribution of nitrite and nitrate and nitrite reductase activity in models of cardiovascular disease
Ghosh, S. M. (2014)
Studies on the regulation of endothelial nitric oxide synthase in endothelial dysfunction
Cerrato, R. (2016) · Figshare
The blood pressure independent effect of exercise and salt on endothelial function
Guers, J. J. (2016) · Library, Museums and Press - UDSpace (University of Delaware) · doi:10.58088/27k5-0d64
Computational Modeling of Oxidative Stress: an Analysis of NAD(P)H Effects on Nitric Oxide and Superoxide During Hypertension
Strobel, A. (2008) · Journal of the Arkansas Academy of Science
Redox-Related Genetic Markers of Cardiovascular Diseases
Delles, C., & Dominiczak, A. F. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-600-9_10
Biological activity of anthocyanins and their phenolic degradation products and metabolites in human vascular endothelial cells
Edwards, M. (2013) · UEA Digital Repository (University of East Anglia)
Glutathione peroxidase in acute coronary syndromes
Holley, A. (2016) · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare) · doi:10.26686/wgtn.17014508
Free Radical Signaling in Reactions Catalyzed by Enzymes—Producers of Reactive Oxygen and Nitrogen Species
(2009) · CRC Press eBooks · doi:10.1201/9781420073751.ch2
BIBLIOGRAPHY
(2007) · Elsevier eBooks · doi:10.1016/b978-012373657-4/50008-8
Nitric Oxide Regulating Proteins as Biochemical and Genetic Markers of Coronary Artery Disease
Gad, M. Z., Abdel-Maksoud, S. M., Hassanein, S. I., Hashad, I. M., Rahman, M. F. A., el Maaty, M. A. A., Shaban, G. M., & Abou‐Aisha, K. (2016) · Springer eBooks · doi:10.1007/978-94-007-7678-4_34
Can age be a modifiable risk factor? the impact of dietary patterns on the molecular mechanisms that underlie cardiovascular aging
Lewis, S. A., Britt, W. M., Koch, R. L., Razavi, A. C., Patel, P., Sperling, L. S., & Souza, M. S. D. (2023) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2023.1 · Cited by 1
Methods to Measure Reactive Oxygen Species Production by NADPH Oxidases
Zielonka, J., & Juric, M. (2023) · Springer eBooks · doi:10.1007/978-3-031-23752-2_20
Creatine monohydrate supplementation and NOX impact skeletal muscle microvascular blood flow: a pilot study
Baker, P. A., Clarke, H. E., Meza, C., Ali, M. M., & Hickner, R. C. (2025) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-025-03090-8
Molecular mechanisms of reactive oxygen species and regulation of gene expression in cardiometabolic syndrome
Fronczek, M., Banach, M., Goławski, M., & Osadnik, T. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27333-9.00013-0
Effets d’une exposition chronique au césium 137 à faibles doses sur la progression de l’athérosclérose
Gallic, C. L. (2015) · theses.fr (ABES) · doi:10.70675/71430d4dz07cez4cc3za153ze7c0b63eada2
Les peptides mimétiques de la Thiorédoxine-1 : nouvelle stratégie thérapeutique pour les maladies cardiovasculaires
Canesi, F. (2018) · theses.fr (ABES) · doi:10.70675/dc6d6a54zef3az4618z86fez723cf797aa26
Oxidative stress and atherosclerosis: from LDL oxidation and foam cell formation to plaque instability – three decades of evidence and remaining therapeutic challenges
Ji, L., & Du, H. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1968314
BindingDB Entry 50047795: Synthesis and biological evaluation of 3-substituted 5-benzylidene-1-methyl-2-thiohydantoins as potent NADPH oxidase (NOX) inhibitors.
BindingDB (2017) · UC San Diego · doi:10.7270/q2xk8hht
BindingDB Entry 50032268: Small-molecule inhibitors of NADPH oxidase 4.
BindingDB (2011) · UC San Diego · doi:10.7270/q2f18zz5

Authors: Guzik, T. J., Sadowski, J., Guzik, B., Jopek, A., Kapelak, B., Przybyłowski, P., Wierzbicki, K., Korbut, R., Harrison, D. G., & Channon, K. M.
Affiliations: Jagiellonian University (PL)
From the Department of Cardiovascular Medicine (T.J.G., K.M.C.), University of Oxford, John Radcliffe Hospital, United Kingdom; Departments of Medicine, Cardiovascular Surgery, and Transplantology and Pharmacology (T.J.G., J.S., B.G., A.J., B.K., P.P., K.W., R.K.), Jagiellonian University School of Medicine, Krakow, Poland; and the Division of Cardiology (D.G.H., T.J.G.), Emory University, Atlanta, Ga.
ORCID: Guzik, Tomasz J.
Sadowski, Jerzy
Przybyłowski, Piotr
Korbut, Ryszard
Harrison, David G.
Channon, Keith M.
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-02
Volume: 26
Issue: 2
Pages: 333-339
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.0000196651.64776.51
OpenAlex: W2130904954
Cited by: 278
References: 22
Citations by year: 2026: 1 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 8 · 2021: 12 · 2020: 10 · 2019: 9 · 2018: 6 · 2017: 23 · 2016: 15 · 2015: 14 · 2014: 20 · 2013: 21 · 2012: 18
FWCI: 7.59
Type: journal article
Language: en
Open access: green
ruj.uj.edu.pl
Licence: cc-by-nc-nd
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
Funders: Wellcome Trust
British Heart Foundation
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: coronary artery disease, superoxide production, NADPH oxidase, xanthine oxidase, oxidative stress, NOX isoforms, p22phox, p67phox, p47phox, NOX2, angiotensin II, protein kinase C, losartan, human coronary arteries, atherosclerosis
MeSH terms: Adult, Angiotensin II, Coronary Artery Disease, Coronary Vessels, Female, Humans, Male, Middle Aged, Phosphoproteins, Protein Kinase C, Superoxides, Vasoconstrictor Agents, Xanthine Oxidase, Oxidative Stress, NADPH Oxidases, Membrane Transport Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Coronary Artery Superoxide Production and Nox Isoform Expression in Human Coronary Artery Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks