The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Human Plasma Phospholipid Transfer Protein Increases the Antiatherogenic Potential of High Density Lipoproteins in Transgenic Mice
Open accessAbstract
Abstract —Plasma phospholipid transfer protein (PLTP) transfers phospholipids between lipoprotein particles and alters high density lipoprotein (HDL) subfraction patterns in vitro, but its physiological function is poorly understood. Transgenic mice that overexpress human PLTP were generated. Compared with wild-type mice, these mice show a 2.5- to 4.5-fold increase in PLTP activity in plasma. This results in a 30% to 40% decrease of plasma levels of HDL cholesterol. Incubation of plasma from transgenic animals at 37°C reveals a 2- to 3-fold increase in the formation of pre-β-HDL compared with plasma from wild-type mice. Although pre-β-HDL is normally a minor subfraction of HDL, it is known to be a very efficient acceptor of peripheral cell cholesterol and a key mediator in reverse cholesterol transport. Further experiments show that plasma from transgenic animals is much more efficient in preventing the accumulation of intracellular cholesterol in macrophages than plasma from wild-type mice, despite lower total HDL concentrations. It is concluded that PLTP can act as an antiatherogenic factor preventing cellular cholesterol overload by generation of pre-β-HDL.
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Cited by
Cholesterol Efflux and Atheroprotection: Advancing the Concept of Reverse Cholesterol Transport
Rosenson, R. S., Brewer, H. B., Davidson, W. S., Fayad, Z. A., Fuster, V., Goldstein, J., Hellerstein, M., Jiang, X.-C., Phillips, M. C., Rader, D. J., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.066589 · Cited by 953
The liver X receptor gene team: Potential new players in atherosclerosis
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Formation and Metabolism of Prebeta-Migrating, Lipid-Poor Apolipoprotein A-I
Rye, K.-A., & Barter, P. J. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000104029.74961.f5 · Cited by 309
Mutka, A., Haapanen, A., Käkelä, R., Lindfors, M., Wright, A. K., Inkinen, T., Hermansson, M., Rokka, A., Corthals, G., Jauhiainen, M., et al. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06440.x · Cited by 34
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Metadata
- Authors
- van Haperen, R., van Tol, A., Vermeulen, P., Jauhiainen, M., van Gent, T., van den Berg, P., Ehnholm, S., Grosveld, F., van der Kamp, A., & de Crom, R.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2000-04
- Volume
- 20
- Issue
- 4
- Pages
- 1082-1088
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2136100132
- Cited by
- 203
- References
- 6
- FWCI
- 18.78
- Type
- journal article
- Language
- en
- Open access
- green
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- van Haperen, R., van Tol, A., Vermeulen, P., Jauhiainen, M., van Gent, T., van den Berg, P., Ehnholm, S., Grosveld, F., van der Kamp, A., & de Crom, R. (2000). Human Plasma Phospholipid Transfer Protein Increases the Antiatherogenic Potential of High Density Lipoproteins in Transgenic Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/01.atv.20.4.1082
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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