The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Inhibition of low density lipoprotein synthesis by dietary omega-3 fatty acids in humans.
Open accessAbstract
Diets rich in omega-3 fatty acids derived from fish oils lower the plasma concentrations of low density lipoproteins (LDL) and very low density lipoproteins in humans. The present study was designed to examine the mechanism(s) by which diets enriched in omega-3 fatty acids reduce plasma LDL cholesterol levels in normal subjects. Seven healthy volunteers with normal plasma lipid levels consumed two metabolically controlled diets for a period of 4 weeks each. The control diet contained predominantly saturated and monounsaturated fatty acids, whereas the fish-oil diet contained 24 gm of omega-3 fatty acids per day. The total fat and cholesterol content of the two diets were similar for each subject. Total and LDL cholesterol levels decreased from 162 +/- 26 mg/dl and 103 +/- 27 mg/dl on the control diet to 124 +/- 26 mg/dl and 82 +/- 27 mg/dl on the omega-3-rich diet. Triglyceride levels fell from 91 +/- 34 mg/dl to 52 +/- 19 mg/dl. Kinetic studies of 125I-LDL metabolism disclosed a significantly lower rate of synthesis of LDL apoprotein B on the omega-3-rich diet (9.5 +/- 1.3 mg/kg/day) as compared to the control diet (13.6 +/- 3.7 mg/kg/day; p less than 0.05). In contrast, the fractional catabolic rate was similar on both diets. We conclude that dietary omega-3 fatty acids lower plasma LDL levels in normal human subjects by reducing the rate of synthesis of apoprotein B.
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Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 317,331
Efficient Trace-labelling of Proteins with Iodine
McFARLANE, A. S. (1958) · Nature · doi:10.1038/182053a0 · Cited by 2,543
HÆMOSTATIC FUNCTION AND PLATELET POLYUNSATURATED FATTY ACIDS IN ESKIMOS
Dyerberg, J., & Bang, H. O. (1979) · The Lancet · doi:10.1016/s0140-6736(79)91490-9 · Cited by 1,001
Fatty acid composition of the plasma lipids in Greenland Eskimos
Dyerberg, J., Bang, H., & Hjørne, N. (1975) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/28.9.958 · Cited by 877
Polyunsaturated fatty acids, hyperlipidemia, and thrombosis.
Goodnight, S. H., Harris, W. S., Connor, W. E., & Illingworth, D. R. (1982) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.2.2.87 · Cited by 683
Self-citationThe metabolism of low density lipoprotein in familial type II hyperlipoproteinemia
Langer, T., Strober, W., & Levy, R. I. (1972) · Journal of Clinical Investigation · doi:10.1172/jci106949 · Cited by 629
Harris, W. S., Connor, W. E., & McMurry, M. P. (1983) · Metabolism · doi:10.1016/0026-0495(83)90226-3 · Cited by 420
Self-citationShepherd, J., Packard, C. J., Grundy, S. M., Yeshurun, D., Gotto, A. M., & Taunton, O. D. (1980) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39842-4 · Cited by 357
Sigurdsson, G., Nicoll, A., & Lewis, B. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108229 · Cited by 308
Sanders, T. A. B., & Roshanai, F. (1983) · Clinical Science · doi:10.1042/cs0640091 · Cited by 308
Cited by
Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review
Harris, W. S. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38310-3 · Cited by 1,127
Self-citationWeintraub, M. S., Zechner, R., Brown, A., Eisenberg, S., & Breslow, J. L. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113806 · Cited by 331
Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids
Harris, W. S., Connor, W. E., Alam, N., & Illingworth, D. R. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38424-8 · Cited by 321
Self-citationVidgren, H. M., Ågren, J. J., Schwab, U., Rissanen, T., Hänninen, O., & Uusitupa, M. I. J. (1997) · Lipids · doi:10.1007/s11745-997-0089-x · Cited by 236
Chan, D. C., Watts, G. F., Mori, T. A., Barrett, P. H. R., Redgrave, T. G., & Beilin, L. J. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.2.300 · Cited by 185
Metadata
- Authors
- Illingworth, D. R., Harris, W. S., & Connor, W. E.
- Venue
- Arteriosclerosis: An Official Journal of the American Heart Association, Inc.
- Published
- 1984-05
- Volume
- 4
- Issue
- 3
- Pages
- 270-275
- ISSN
- 0276-5047 (ISSN-L)
- OpenAlex
- W1995245409
- Cited by
- 254
- References
- 17
- FWCI
- 15.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Illingworth, D. R., Harris, W. S., & Connor, W. E. (1984). Inhibition of low density lipoprotein synthesis by dietary omega-3 fatty acids in humans. Arteriosclerosis: An Official Journal of the American Heart Association, Inc. https://doi.org/10.1161/01.atv.4.3.270
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
