Incorporation of n‐3 fatty acids into plasma lipid fractions, and erythrocyte membranes and platelets during dietary supplementation with fish, fish oil, and docosahexaenoic acid‐rich oil among healthy young men

Vidgren, Helvi M.; Ågren, Jyrki J.; Schwab, Ursula; Rissanen, Tiina; Hänninen, Osmo; Uusitupa, Matti I. J.

doi:10.1007/s11745-997-0089-x

Cited by 236Fatty Acid Research and HealthAquaculture Nutrition and GrowthEdible Oils Quality and Analysis

Incorporation of n‐3 fatty acids into plasma lipid fractions, and erythrocyte membranes and platelets during dietary supplementation with fish, fish oil, and docosahexaenoic acid‐rich oil among healthy young men

Vidgren, Helvi M., Ågren, Jyrki J., Schwab, Ursula, Rissanen, Tiina, Hänninen, Osmo, Uusitupa, Matti I. J.·1997·Lipids

DOI 10.1007/s11745-997-0089-x

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Abstract

The effects of n‐3 fatty acid supplementation in the form of fresh fish, fish oil, and docosahexaenoic acid (DHA) oil on the fatty acid composition of plasma lipid fractions, and platelets and erythrocyte membranes of young healthy male students were examined. Altogether 59 subjects (aged 19–32 yr, body mass index 16.8–31.3 kg/m 2) were randomized into the following diet groups: (i) control group; (ii) fish diet group eating fish meals five times per week [0.38±0.04 g eicosapentaenoic acid (EPA) and 0.67±0.09 g DHA per day]; (iii) DHA oil group taking algae‐derived DHA oil capsules (1.68 g/d DHA oil group taking algae‐derived DHA oil capsules (1.68 g/d DHA in triglyceride form); and (iv) fish oil group (1.33 g EPA and 0.95 g DHA/d as free fatty acids) for 14 wk. The fatty acid composition of plasma lipids, platelets, and erythrocyte membranes was analyzed by gas chromatography. The subjects kept 4‐d food records four times during the study to estimate the intake of nutrients. In the fish diet, in DHA oil, and in fish oil groups, the amounts of n‐3 fatty acids increased and those of n‐6 fatty acids decreased significantly in plasma lipid fractions and in platelets and erythrocyte membranes. A positive relationship was shown between the total n‐3 polyunsaturated fatty acids (PUFA) and EPA and DHA intake and the increase in total n‐3 PUFA and EPA and DHA in all lipid fractions analyzed. DHA was preferentially incorporated into phospholipid (PL) and triglyceride (TG) and there was very little uptake in cholesterol ester (CE), while EPA was preferentially incorporated into PL and CE. The proportion of EPA in plasma lipids and platelets and erythrocyte membranes increased also by DHA supplementation, and the proportion of linoleic acid increased in platelets and erythrocyte membranes in the DHA oil group as well. These results suggest retroconversion of DHA to EPA and that DHA also interferes with linoleic acid metabolism.

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Dietary DHA is preferentially esterified into TGs.
“Dietary DHA is preferentially esterified into TGs”
From Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review (2017) · cites this paper as [16]
EPA is more evenly esterified into TGs, cholesterol esters and phospholipids than DHA.
“while EPA is more evenly esterified into TGs, cholesterol esters and phospholipids.”
From Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review (2017) · cites this paper as [16]

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Authors: Vidgren, H. M., Ågren, J. J., Schwab, U., Rissanen, T., Hänninen, O., & Uusitupa, M. I. J.
Affiliations: University of Eastern Finland (FI)
Department of Physiology University of Kuopio Kuopio Finland
Corresponding author: Vidgren, Helvi M.
ORCID: Schwab, Ursula
Rissanen, Tiina
Uusitupa, Matti I. J.
Venue: Lipids
Publisher: Wiley
Published: 1997-07
Volume: 32
Issue: 7
Pages: 697-705
ISSN: 0024-4201 (ISSN-L)
1558-9307
DOI: 10.1007/s11745-997-0089-x
OpenAlex: W2047504901
Cited by: 236
References: 44
Citations by year: 2026: 2 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 1 · 2021: 5 · 2020: 5 · 2019: 13 · 2018: 8 · 2017: 8 · 2016: 11 · 2015: 10 · 2014: 15 · 2013: 11 · 2012: 17
FWCI: 4.54
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Lipids (publishedVersion)
PubMed (publishedVersion)
Funders: Academy of Finland
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Keywords: omega-3 fatty acids, docosahexaenoic acid, eicosapentaenoic acid, fish oil, fish diet, dietary supplementation, erythrocyte membrane, platelets, phospholipids, triglycerides, cholesterol esters, linoleic acid metabolism, retroconversion, omega-6 fatty acids, young men
MeSH terms: Adult, Animals, Blood Platelets, Cholesterol Esters, Dietary Fats, Docosahexaenoic Acids, Eating, Erythrocyte Membrane, Fatty Acids, Fish Oils, Fishes, Food, Fortified, Humans, Lipids, Male, Phospholipids, Triglycerides, Eicosapentaenoic Acid, Fatty Acids, Omega-3

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Incorporation of n‐3 fatty acids into plasma lipid fractions, and erythrocyte membranes and platelets during dietary supplementation with fish, fish oil, and docosahexaenoic acid‐rich oil among healthy young men

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