The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Apolipoprotein E polymorphism and atherosclerosis.
Abstract
The apo E locus contributes to determining the variation in plasma cholesterol levels of healthy and diseased populations. It also influences the expression of hyperlipidemia and appears to modulate the susceptibility to atherosclerosis in a complex multifactorial interaction. There is evidence that the presence of apo E2 is protective, whereas that of apo E4 predisposes to coronary artery disease. The burden of proof, however, lies on future, well-designed clinical trials and prospective studies. The study of the biological significance of the apo E polymorphism in humans has emphasized the importance of gene-gene and gene-environment interactions in the pathogenesis of hyperlipidemia and atherosclerosis. The apo E polymorphism involves the coding region of the apo E gene and results in alterations of the gene product which, in turn, either directly or secondarily affect the metabolic fate of the lipoprotein particles. Rapid advances in knowledge over the last decade have provided a metabolic explanation for the observation of the opposite effects of the epsilon 4 and the epsilon 2 alleles on lipoprotein levels. Apo E2 has lower receptor binding affinity which results in delayed clearance of apo E2-bearing lipoprotein particles from plasma. Apo E4 is distributed differently from apo E3 between VLDL and HDL, is degraded more rapidly than apo E3, and may enhance the catabolism of E4-bearing particles, leading to other alterations in lipoprotein metabolism which result in elevated levels of LDL. In view of the significant opposite impacts of the epsilon 4 and the epsilon 2 alleles on plasma LDL cholesterol concentrations, it is evident that determination of the apo E phenotype will become a useful adjunct to the assessment of the cardiovascular risk profile of an individual. In addition, the relationship between the epsilon 2 allele and type III hyperlipoproteinemia provides a valuable model for the study of complex genetic interactions in the pathogenesis of hyperlipidemia. The further study of apo E and its interactions shows great promise for a deeper comprehension of the pathogenesis of atherosclerosis.
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In the citing paper
“The critical role of APOE in lipid metabolism is underscored by evidence showing that APOE2 homozygosity can lead to Hyperlipoproteinemia type III (HLP), characterized by mixed hypercholesterolemia and hypertriglyceridemia [35–39].”
In the citing paper
“This observation, coupled with evident mixed hypercholesterolemia and hypertriglyceridemia, supports the characterization of APOE2hAβ rats as a model for type III HLP”
In the citing paper
“Both the ε2 and the ε4 alleles are associated with unfavorable lipid profiles [8][9][10][11][12][13].”
From APOE and vascular disease: Sequencing and genotyping in general population cohorts (2023) · cites this paper as [13]
In the citing paper
“It is estimated that less than one in 20 individuals with the ε22 genotype will have overt type III hyperlipoproteinemia [24].”
From Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review (2016) · cites this paper as [24]
In the citing paper
“At the level of an individual the effect of the APOE polymorphism on plasma lipid levels is moderate, however since the APOE polymorphism is common, it contributes substantially to the total phenotypic variability in plasma lipid levels in the general population [21,24,58].”
From Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review (2016) · cites this paper as [24]
In the citing paper
“The pattern of associations between the six common APOE genotypes and plasma lipid levels is similar across populations, although the magnitude of the associations differs between populations and subgroups within populations; thus both context-dependent and invariant associations could be suggested [9,24,30].”
From Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review (2016) · cites this paper as [24]
In the citing paper
“Both ɛ2 and ɛ4 alleles are associated with unfavourable lipid profiles,12–19”
From Plasma levels of apolipoprotein E, APOE genotype, and all-cause and cause-specific mortality in 105 949 individuals from a white general population cohort (2019) · cites this paper as [18]
In the citing paper
“a decreased risk of coronary artery disease (unless it is associated with type III hyperlipoproteinemia), 42,43”
From Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E (1996) · cites this paper as [42]
Citations
Cites
Boyles, J. K., Pitas, R. E., Wilson, E., Mahley, R. W., & Taylor, J. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112130 · Cited by 829
Weisgraber, K. H., Rall, S. C., & Mahley, R. W. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52510-8 · Cited by 777
Lipoprotein receptors and cholesterol homeostasis
Mahley, R. W., & Innerarity, T. L. (1983) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(83)90001-1 · Cited by 756
Human apolipoprotein E. The complete amino acid sequence
Rall, S. C., Weisgraber, K. H., & Mahley, R. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34702-1 · Cited by 741
(1985) · PubMed · Cited by 706
Self-citationPolymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man
UTERMANN, G., HEES, M., & STEINMETZ, A. (1977) · Nature · doi:10.1038/269604a0 · Cited by 666
Zannis, V. I., & Breslow, J. L. (1981) · Biochemistry · doi:10.1021/bi00507a059 · Cited by 563
Polymorphism of apolipoprotein E
Utermann, G., Vogelberg, K. H., Steinmetz, A., Schoenborn, W., Pruin, N., Jaeschke, M., Hees, M. T. I. W. S.-V., & Canzler, H. (1979) · Clinical Genetics · doi:10.1111/j.1399-0004.1979.tb02027.x · Cited by 408
Apolipoprotein E polymorphism in health and disease
Utermann, G. (1987) · American Heart Journal · doi:10.1016/0002-8703(87)90610-7 · Cited by 389
Elshourbagy, N. A., Liao, W. S., Mahley, R. W., & Taylor, J. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.1.203 · Cited by 376
Cited by
Sorted by citations
Items 801–900 of 1,005
Does apolipoprotein E genotype relate to BMD and bone markers in postmenopausal women?
Heikkinen, A. M., Kröger, H., NISKANEN, L. K., Komulainen, M. H., Ryynänen, M., Parviainen, M. T., Tuppurainen, M. T., Honkanen, R., & Saarikoski, S. (2000) · Maturitas · doi:10.1016/s0378-5122(99)00084-5 · Cited by 36
Apolipoprotein E Phenotyping: A Word of Caution
Wenham, P. R., Sedky, A., & Spooner, R. J. (1991) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456329102800610 · Cited by 36
Reilly, S. L., Kottke, B. A., & Sing, C. F. (1990) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(90)90076-2 · Cited by 36
Self-citationSharman, M. J., Shui, G., Fernandis, A. Z., Lim, W. L. F., Berger, T., Hone, E., Taddei, K., Martins, I. J., Ghiso, J., Buxbaum, J. D., et al. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-1348 · Cited by 35
Genetic Risk Factors for Perinatal Arterial Ischemic Stroke
Gelfand, A. A., Croen, L., Torres, A., & Wu, Y. W. (2013) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2012.09.016 · Cited by 35
DNA methylation in APOE: The relationship with Alzheimer's and with cardiovascular health
Mur, J., McCartney, D. L., Walker, R. M., Campbell, A. I., Bermingham, M. L., Morris, S. W., Porteous, D. J., McIntosh, A. M., Deary, I. J., Evans, K. L., et al. (2020) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12026 · Cited by 35
Pharmacogenetics of Target Genes Across the Warfarin Pharmacological Pathway
Lal, S., Jada, S. R., Xiang, X., Lim, W., Lee, E. J. D., & Chowbay, B. (2006) · Clinical Pharmacokinetics · doi:10.2165/00003088-200645120-00004 · Cited by 35
Effects of apolipoprotein E genotypes on the development of exfoliation syndrome
Yılmaz, A., Tamer, L., Ateş, N. A., Ankaralı, H. Ç., & Değirmenci, U. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2004.12.018 · Cited by 35
The distribution of apolipoprotein E alleles in Scottish perinatal deaths
Becher, J., Keeling, J. W., McIntosh, N., Wyatt, B., & Bell, J. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2005.033936 · Cited by 37
Influence of apolipoprotein E genotype on fat-soluble plasma antioxidants in Spanish children
Ortega, H., Castilla, P., Gómez‐Coronado, D., Garcés, C., Benavente, M., Rodríguez‐Artalejo, F., de Oya, M., & Lasunción, M. A. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.3.624 · Cited by 36
Liu, S., Ma, J., Ridker, P. M., Breslow, J. L., & Stampfer, M. J. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(02)00335-0 · Cited by 35
Schwanke, C. H. A., da Cruz, I. B. M., Leal, N. F., Scheibe, R., Moriguchi, Y., & Moriguchi, E. H. (2002) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2002000600004 · Cited by 35
Rivellese, A. A., Riccardi, G., Romanò, G., Giacco, R., Patti, L., Marotta, G., Annuzzi, G., & Mancini, M. (1988) · Diabetologia · doi:10.1007/bf00265371 · Cited by 35
Hypolipidemic and Hyperlipidemic Phenotypes in Transgenic Mice Expressing Human Apolipoprotein E2
Huang, Y., Schwendner, S. W., Rall, S. C., & Mahley, R. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.46.29146 · Cited by 35
Iyengar, S., Seaman, M., Deinard, A., Rosenbaum, H. C., Sirugo, G., Castiglione, C. M., Kidd, J., & Kidd, K. (1998) · DNA Sequence · doi:10.3109/10425179809034076 · Cited by 36
Estrogen Replacement Therapy, Serum Lipids, and Polymorphism of the Apolipoprotein E Gene
Garry, P. J., Baumgartner, R., Brodie, S. G., Montoya, G. D., Liang, H. C., Lindeman, R. D., & Williams, T. M. (1999) · Clinical Chemistry · doi:10.1093/clinchem/45.8.1214 · Cited by 35
Kamboh, M. I., Bhatia, K., & Ferrell, R. E. (1990) · American Journal of Human Biology · doi:10.1002/ajhb.1310020103 · Cited by 35
Kushwaha, R. S., Foster, D. M., Barrett, P. H. R., Carey, K. D., & Bernard, M. G. (1991) · Metabolism · doi:10.1016/0026-0495(91)90198-6 · Cited by 35
Corella, D., Portolés, O., Arriola, L., Chirlaque, M. D., Barrricarte, A., Francès, F., Huerta, J. M., Larrañaga, N., Martínez, C., Martínez‐Camblor, P., et al. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.04.003 · Cited by 35
Falsetti, L., Viticchi, G., Buratti, L., Grigioni, F., Capucci, A., & Silvestrini, M. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170544 · Cited by 34
Optical Nanoparticles for Cardiovascular Imaging
Hu, J., Ortgies, D. H., Rodríguez, E. M., Rivero, F., Aguilar, R., Alfonso, F., Fernández, N., Carreño‐Tarragona, G., Monge, L., Sanz-Rodríguez, F., et al. (2018) · Advanced Optical Materials · doi:10.1002/adom.201800626 · Cited by 36
Perugini, M. A., Schuck, P., & Howlett, G. J. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.03319.x · Cited by 35
Gene Polymorphism and Coronary Risk Factors in Indian Population
Ashavaid, T. F., Shalia, K. K., Kondkar, A. A., Todur, S. P., Nair, K. G., & Nair, S. (2002) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2002.171 · Cited by 34
Borenstein, A. R., Wu, Y., Bowen, J. D., McCormick, W. C., Uomoto, J. M., McCurry, S. M., Schellenberg, G. D., & Larson, E. B. (2013) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3182a2e32f · Cited by 34
Peripheral cholesterol metabolic disorders and Alzheimer s disease
Maria, D. L. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/368 · Cited by 35
Anuurad, E., Rubin, J., Lu, G., Pearson, T. A., Holleran, S., Ramakrishnan, R., & Berglund, L. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600288-jlr200 · Cited by 34
Hooft, F. M. V. '., Jormsjö, S., Lundahl, B., Tornvall, P., Eriksson, P. O., & Hamsten, A. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33415-5 · Cited by 34
Exercise-Induced Silent Myocardial Ischemia in Master Athletes
Katzel, L. I., Fleg, J. L., Busby‐Whitehead, M. J., Sorkin, J. D., Becker, L. C., Lakatta, E. G., & Goldberg, A. P. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00898-9 · Cited by 34
Lifestyle, genetics, and disease in Sami.
Ross, A. B., Johansson, Å., Ingman, M., & Gyllensten, U. B. (2006) · PubMed Central · Cited by 34
Gajra, B., Candlish, J. K., Saha, N., Heng, C., Soemantri, A., & Tay, J. S. H. (1994) · Genetic Epidemiology · doi:10.1002/gepi.1370110103 · Cited by 34
Genetic predictors of common disease: Apolipoprotein E genotype as a paradigm
Jarvik, G. P. (1997) · Annals of Epidemiology · doi:10.1016/s1047-2797(97)00028-8 · Cited by 34
Enhanced APOE2 transmission rates in families with autistic probands
Persico, A. M., D’Agruma, L., Zelante, L., Militerni, R., Bravaccio, C., Schneider, C., Melmed, R. D., Trillo, S., Montecchi, F., Elia, M., et al. (2004) · Psychiatric Genetics · doi:10.1097/01.ypg.0000128768.37838.17 · Cited by 34
Hanon, O., Girerd, X. J., Luong, V., Jeunemaı̂tre, X., Laurent, S., & Safar, M. E. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018040-00012 · Cited by 34
Apolipoprotein ε4 homozygosity — a determinant of restenosis after coronary angioplasty
VANBOCKXMEER, F., Mamotte, C. D. S., Gibbons, F. A., & TAYLOR, R. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)90204-6 · Cited by 34
Meusel, M. (1995) · Biosensors and Bioelectronics · doi:10.1016/0956-5663(95)96933-p · Cited by 34
Matsunaga, A., & Saito, T. (2014) · Clinical and Experimental Nephrology · doi:10.1007/s10157-013-0918-1 · Cited by 33
Association between Genetic Polymorphisms and Sites of Cervicocerebral Artery Atherosclerosis
Chutinet, A., Suwanwela, N. C., Snabboon, T., Chaisinanunkul, N. N., Furie, K. L., & Phanthumchinda, K. (2011) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2010.10.002 · Cited by 33
Apolipoprotein E Gene Polymorphism And Its Effect On Plasma Lipids In Arteriosclerosis
Zende, P. D. (2013) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2013/6195.3455 · Cited by 34
The role of full-length apoE in clearance of Gram-negative bacteria and their endotoxins
Petruk, G., Elvén, M., Hartman, E., Davoudi, M., Schmidtchen, A., Puthia, M., & Petrlová, J. (2021) · Journal of Lipid Research · doi:10.1016/j.jlr.2021.100086 · Cited by 33
Kalman, J. L., Juhász, A., Császár, A., Kanka, A., Rimanóczy, Á., Janka, Z., & Raskó, I. (1998) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1998.tb07288.x · Cited by 33
APOEpolymorphism distribution among Native Americans and related populations
Demarchi, D. A., Salzano, F. M., Altuna, M. E., Fiegenbaum, M., Hill, K. R., Hurtado, A. M., Tsuneto, L. T., Petzl‐Erler, M. L., & Hutz, M. H. (2005) · Annals of Human Biology · doi:10.1080/03014460500097237 · Cited by 33
Watts, G. F., Moroz, P., & Barrett, P. H. R. (2000) · Metabolism · doi:10.1053/meta.2000.8621 · Cited by 33
Ketomäki, A., Gylling, H., Siimes, M. A., Vuorio, A. F., & Miettinen, T. A. (2003) · Pediatric Research · doi:10.1203/01.pdr.0000055771.28409.40 · Cited by 33
Apolopoprotein-E gene polymorphism and lipid profiles in Alzheimer's disease
İşbir, T., Ağaçhan, B., Yılmaz, H., Aydın, M., Kara, İ., Eker, E., & Eker, D. (2001) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/153331750101600207 · Cited by 33
Weers, P. M. M., Narayanaswami, V., Choy, N., Luty, R., Hicks, L. D., Kay, C. M., & Ryan, R. O. (2002) · Biophysical Chemistry · doi:10.1016/s0301-4622(02)00300-9 · Cited by 33
Tian, J., Shi, J., Bailey, K. L., Harris, J. M., Pritchard, A. L., Lambert, J., Chartier‐Harlin, M., Pickering-Brown, S. M., Lendon, C. L., & Mann, D. M. A. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.09.072 · Cited by 33
Haraki, T., Takegoshi, T., Kitoh, C., WAKASUGI, T., Saga, T., Hirai, J. ‐., Aoyama, T., Inazu, A., & Mabuchi, H. (2002) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2002.01011.x · Cited by 33
Sijbrands, E. J. G., Hoffer, M. J. V., Meinders, A. E., Havekes, L. M., Frants, R. R., Smelt, A. H. M., & de Knijff, P. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.11.2722 · Cited by 34
Harringtonaa, C. R., Anderson, J. R., & Chan, K. K. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(94)11108-u · Cited by 33
APOE alleles in Alzheimer's disease and vascular dementia in a population aged 85+
Sulkava, R. O., Kainulainen, K., Verkkoniemi, A., Niinistö, L., Sobel, E. L., Davanipour, Z., Polvikoski, T. M., Haltia, M., & KONTULA, K. K. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00023-1 · Cited by 33
Traykov, L. D., Rigaud, A., Caputo, L., Couderc, R., Coste, J., Michot, J., de Rotrou, J., Amouyel, P., Forette, F., & Boller, F. (1999) · European Journal of Neurology · doi:10.1046/j.1468-1331.1999.640415.x · Cited by 33
Asakimori, Y., Yorioka, N., Tanaka, J., & Kohno, N. (2003) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(03)00030-1 · Cited by 33
Cerebral lipid deposition in aged apolipoprotein-E-deficient mice.
Walker, L. C., Parker, C. A., Lipinski, W. J., Callahan, M. J., Carroll, R. T., Gandy, S., Smith, J. D., Jucker, M., & Bisgaier, C. L. (1997) · Europe PMC (PubMed Central) · Cited by 33
Apolipoprotein E phenotype and cholesterol metabolism in familial hypercholesterolemia
GYLLING, H., Kuusi, T., Vanhanen, H., & Miettinen, T. A. (1989) · Atherosclerosis · doi:10.1016/0021-9150(89)90064-6 · Cited by 33
Lambrechts, P., Vanherle, G., & Davidson, C. L. (1981) · PubMed · Cited by 33
Srinivasan, S. R., Ehnholm, C., Wattigney, W. A., Bao, W., & Berenson, G. S. (1996) · Atherosclerosis · doi:10.1016/0021-9150(95)05762-5 · Cited by 33
Jansen, D., Zerbi, V., Janssen, C. I. F., van Rooij, D., Zinnhardt, B., Dederen, P. J. W. C., Wright, A. J., Broersen, L. M., Lütjohann, D., Heerschap, A., et al. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0606-7 · Cited by 35
Dergunov, A. D. (2011) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2011.04.003 · Cited by 34
Coexisting dysbetalipoproteinemia and familial hypercholesterolemia
Carmena, R., Roy, M., Roederer, G. O., Minnich, A., & Davignon, J. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00212-9 · Cited by 32
Self-citationLiang, S., Pan, M., Geng, H.-H., Chen, H., Gu, L.-Q., Qin, X., Qian, J.-J., Zhu, J., & Liu, C.-F. (2008) · Molecular Biology Reports · doi:10.1007/s11033-008-9305-5 · Cited by 32
Human apolipoprotein E isoforms differentially affect bone mass and turnover in vivo
Dieckmann, M., Beil, F. T., Mueller, B., Bartelt, A., Marshall, R. P., Koehne, T., Amling, M., Ruether, W., Cooper, J. A., Humphries, S. E., et al. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1757 · Cited by 34
Fuzikawa, A. K., Peixoto, S. V., Taufer, M., Moriguchi, E. H., & Lima‐Costa, M. F. (2008) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2008000200002 · Cited by 32
The ApoE ε4 Isoform: Can the Risk of Diseases be Reduced by Environmental Factors?
Bos, M. M., Noordam, R., Blauw, G. J., Slagboom, P. E., Rensen, P. C. N., & van Heemst, D. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly226 · Cited by 32
Evolutionary Perspectives on Fat Ingestion and Metabolism in Humans
Leonard, W. R., Snodgrass, J., & Robertson, M. L. (2009) · Frontiers in neuroscience · doi:10.1201/9781420067767-c1 · Cited by 32
Association of apolipoprotein E gene polymorphism with essential hypertension and its complications
Li, X., Du, Y., Du, Y., & Huang, X. (2003) · Clinical and Experimental Medicine · doi:10.1007/s102380300003 · Cited by 32
Viiri, L. E., Loimaala, A., Nenonen, A., Islam, S., VUORI, I. M., Karhunen, P. J., & Lehtimäki, T. J. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.10.004 · Cited by 32
Corbo, R. M., Vilardo, T., Mantuano, E., Ruggeri, M., Gemma, A. T., & Scacchi, R. (1997) · Clinical Genetics · doi:10.1111/j.1399-0004.1997.tb02522.x · Cited by 32
Kamboh, M. I., Mh, C., Aston, C. E., & Leonard, W. R. (1996) · PubMed · Cited by 32
(1996) · PubMed Central · Cited by 32
Joven, J., Simó, J. M., Vilella, E., Camps, J., Masana, L., de Febrer, G., Camprubí, M., Richart, C., Bardajı́, A., Casao, E., et al. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00076-8 · Cited by 32
Strategies for the assessment of genetic coronary artery disease risk
Funke, H., & Assmann, G. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199906000-00011 · Cited by 32
Association of apolipoprotein E with α2-macroglobulin in human plasma
Krimbou, L., Tremblay, M., Davignon, J., & Cohn, J. S. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33316-2 · Cited by 26
Self-citationStuyt, P. M. J., Brenninkmeijer, B. J., Demacker, P. N. M., Hendriks, J. C. M., van Elteren, P., Stalenhoef, A. F. H., & Laar, A. V. '. (1991) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519109091636 · Cited by 32
Pharmacogenomics and pharmacogenetics of neurodegenerative diseases: towards new targets
Amouyel, P. (2002) · Pharmacogenomics · doi:10.1517/14622416.3.1.1 · Cited by 32
Eto, M., Sato, T., Watanabe, K., Iwashima, Y., & Makino, I. (1990) · Atherosclerosis · doi:10.1016/0021-9150(90)90007-6 · Cited by 32
Evidence for differential effects of apoE3 and apoE4 on HDL metabolism
Hopkins, P. C. R., Huang, Y., McGuire, J. G., & Pitas, R. E. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200172-jlr200 · Cited by 31
Lack of Association Between Apolipoprotein E Polymorphism and Vascular Dementia in Koreans
Kim, K. W., Youn, J., Han, M., Paik, N., Lee, T. J., Park, J. H., Lee, S. B., Choo, I. H., Lee, D. Y., Jhoo, J. H., et al. (2008) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988707311028 · Cited by 31
Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men
Shinomiya, S., Sasaki, J., Kiyohara, C., Tsuji, E., Inoue, H., Marugame, T., D, K. H. M., Hayabuchi, H., Hamada, H., Eguchi, H., et al. (2001) · Cancer Letters · doi:10.1016/s0304-3835(00)00724-2 · Cited by 31
Gerdes, L. U., Vestergaard, P., Hermann, A. P., & Mosekilde, L. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.10.1906 · Cited by 31
Régis-Bailly, A., Visvikis‐Siest, S., Steinmetz, J., Feldmann, L., Briançon, S., Danchin, N., Zannad, F. M., & Siest, G. (1996) · Clinical Genetics · doi:10.1111/j.1399-0004.1996.tb02385.x · Cited by 31
Riches, F. M., Watts, G. F., BOCKXMEER, F. M. V., Hua, J., Song, S. E., Humphries, S. E., & Talmud, P. J. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32162-3 · Cited by 31
Nolting, P. R. W. D. S., Twickler, M., Dallinga‐Thie, G. M., Buirma, R. J. A., Hutten, B. A., & Kastelein, J. J. P. (2002) · Circulation · doi:10.1161/01.cir.0000025586.89221.4b · Cited by 31
Apolipoprotein E allele frequencies in argyrophilic grain disease
Tolnay, M., Probst, A., Monsch, A. U., Staehelin, H. B., & Egensperger, R. (1998) · Acta Neuropathologica · doi:10.1007/s004010050887 · Cited by 31
Huang, Y., Rall, S. C., & Mahley, R. W. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2817 · Cited by 31
The molecular genetics of Alzheimer's disease
MULLAN, M. J., & Crawford, F. (1994) · Molecular Neurobiology · doi:10.1007/bf02816100 · Cited by 32
Zaiou, M., Visvikis‐Siest, S., Gueguen, R., Parra, H., Fruchart, J., & Siest, G. (1994) · Clinical Genetics · doi:10.1111/j.1399-0004.1994.tb04235.x · Cited by 31
Series, J. J., Cameron, I., CASLAKE, M. J., Gaffney, D. F., Packard, C. J., & Shepherd, J. (1989) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(89)90253-1 · Cited by 31
Evans, A. J., Huff, M. W., & Wolfe, B. M. J. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38218-3 · Cited by 31
Bezgin, T., Kaymaz, C., Akbal, Ö. Y., Yılmaz, F., Tokgöz, H. C., & Özdemir, N. (2016) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029616672585 · Cited by 30
Plasma cholesterol in Alzheimer’s disease and frontotemporal dementia
Wang, P., Zhang, H., Wang, Y., Zhang, M., & Zhou, Y. (2020) · Translational Neuroscience · doi:10.1515/tnsci-2020-0098 · Cited by 30
Wang, B., Zhao, H., Li, Z., Dai, X., Wang, D., Cao, J., & Niu, W. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.09.013 · Cited by 30
Apolipoprotein E polymorphism in the Tunisian population: Frequency and effect on lipid parameters
Jemaa, R., Elasmi, M., Naouali, C., Feki, M., Kallel, A., Souissi, M., Sanhaji, H., Taieb, S. H., Souheil, O., & Kaabachi, N. (2006) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2006.04.018 · Cited by 30
Hirayama, T. T., Mizokami, Y., Honda, A., Homma, Y., Ikegami, T., Saito, Y., Miyazaki, T., & Matsuzaki, Y. (2009) · Hepatology Research · doi:10.1111/j.1872-034x.2008.00450.x · Cited by 33
Apolipoprotein E gene polymorphism in cerebrovascular disease: a case–controlstudy
Luthra, K., Prasad, K., Kumar, P., Dwivedi, M., Pandey, R., & Das, N. (2002) · Clinical Genetics · doi:10.1034/j.1399-0004.2002.620105.x · Cited by 30
Ravaja, N., Räikkönen, K., Lyytinen, H., Lehtimäki, T. J., & Keltikangas‐Järvinen, L. (1997) · Journal of Behavioral Medicine · doi:10.1023/a:1025518524884 · Cited by 30
Scacchi, R., Gambina, G., Broggio, E., Moretto, G., Ruggeri, M., & Corbo, R. M. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.05.111 · Cited by 30
Survival in Finnish Centenarians in Relation to Apolipoprotein E Polymorphism
Louhija, J., Viitanen, M. H., Agüero‐Torres, H., & Tilvis, R. S. (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.49199.x · Cited by 30
Nassar, B. A., Rockwood, K. J., Kirkland, S., Ransom, T. P. P., Darvesh, S., MacPherson, K. M., Johnstone, D. E., O’Neill, B. J., Bata, I. R., Andreou, P., et al. (2005) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2005.10.002 · Cited by 30
Apolipoprotein E allele in centenarians
Asada, T., Kariya, T., Yamagata, Z., Kinoshita, T., & Asaka, A. (1996) · Neurology · doi:10.1212/wnl.46.5.1484 · Cited by 30
DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid profile
Kamboh, M. I., Aston, C. E., & Hamman, R. F. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00459-1 · Cited by 30
Metadata
- Authors
- Davignon, J., Gregg, R. E., & Sing, C. F.
- Affiliations
- Montreal Clinical Research Institute (CA)
- Venue
- Arteriosclerosis: An Official Journal of the American Heart Association, Inc.
- Published
- 1988-01
- Volume
- 8
- Issue
- 1
- Pages
- 1-21
- ISSN
- 0276-5047 (ISSN-L)
- OpenAlex
- W2066644955
- Cited by
- 1,981
- References
- 98
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 17 · 2023: 10 · 2022: 9 · 2021: 21 · 2020: 21 · 2019: 21 · 2018: 27 · 2017: 28 · 2016: 23 · 2015: 33 · 2014: 31 · 2013: 40 · 2012: 49
- FWCI
- 83.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arteriosclerosis An Official Journal of the American Heart Association Inc (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL24489, HL-39107)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- APOE polymorphism, atherosclerosis, coronary artery disease, hyperlipidemia, LDL cholesterol, lipoprotein metabolism, gene-environment interaction, type III hyperlipoproteinemia, cardiovascular risk assessment, genetic susceptibility
- MeSH terms
- Alleles, Apolipoproteins, Apolipoproteins E, Arteriosclerosis, Coronary Disease, Humans, Lipids, Lipoproteins, Phenotype, Polymorphism, Genetic, Radiography, Risk Factors
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