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Low-Density Lipoprotein, Non-High-Density Lipoprotein, and Apolipoprotein B as Targets of Lipid-Lowering Therapy
Abstract
lthough low-density lipoprotein (LDL) is widely recognized as the major atherogenic lipoprotein and the primary target of lipid-lowering therapy, 1 other lipoprotein species nonetheless appear to be involved in atherogenesis.These include very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), and highdensity lipoproteins (HDL).Both VLDL and IDL are triglyceride-rich lipoproteins (TGRLP).Thus, in the aftermath of unequivocal evidence that LDL lowering reduces risk for major coronary events and stroke, 2 the field of lipid study is turning more of its attention to the other lipoproteins that appear to be involved in atherosclerosis.The recent Adult Treatment Panel III (ATP III) report 1 of the National Cholesterol Education Program has summarized our current understanding of the relationship between other lipoprotein species and risk for coronary heart disease (CHD).
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“A related and potential secondary target is an elevated total apoB 158 ; this measure denotes the number of atherogenic lipoproteins in circulation.”
From Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement (2005) · cites this paper as [158]
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Metadata
- Authors
- Grundy, S. M.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Grundy, Scott M.
- ORCID
- Grundy, Scott M.
- Venue
- Circulation
- Published
- 2002-11-12
- Volume
- 106
- Issue
- 20
- Pages
- 2526-2529
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2135020991
- Cited by
- 309
- References
- 25
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 8 · 2020: 5 · 2019: 9 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 14 · 2014: 20 · 2013: 22 · 2012: 20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- low-density lipoprotein, non-HDL cholesterol, apolipoprotein B, lipid-lowering therapy, VLDL, intermediate density lipoprotein, high-density lipoprotein, triglyceride-rich lipoproteins, atherogenesis, coronary heart disease risk, stroke risk, Adult Treatment Panel III
- MeSH terms
- Hypolipidemic Agents, Apolipoproteins B, Cholesterol, Coronary Artery Disease, Coronary Disease, Humans, Lipoproteins, Cholesterol, HDL, Lipoproteins, LDL, Prognosis, Risk Factors, Drug Delivery Systems
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