The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia
Open accessAbstract
Hypertriglyceridemia (triglycerides > 150 mg/dL) affects ~25 % of the United States (US) population and is associated with increased cardiovascular risk. Severe hypertriglyceridemia (≥ 500 mg/dL) is also a risk factor for pancreatitis. Three omega-3 fatty acid (OM3FA) prescription formulations are approved in the US for the treatment of adults with severe hypertriglyceridemia: (1) OM3FA ethyl esters (OM3EE), a mixture of OM3FA ethyl esters, primarily eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (Lovaza®, Omtryg™, and generics); (2) icosapent ethyl (IPE), EPA ethyl esters (Vascepa®); and (3) omega-3 carboxylic acids (OM3CA), a mixture of OM3FAs in free fatty acid form, primarily EPA, DHA, and docosapentaenoic acid (Epanova®). At approved doses, all formulations substantially reduce triglyceride and very-low-density lipoprotein levels. DHA-containing formulations may also increase low-density lipoprotein cholesterol. However, this is not accompanied by increased non-high-density lipoprotein cholesterol, which is thought to provide a better indication of cardiovascular risk in this patient population. Proposed mechanisms of action of OM3FAs include inhibition of diacylglycerol acyltransferase, increased plasma lipoprotein lipase activity, decreased hepatic lipogenesis, and increased hepatic β-oxidation. OM3CA bioavailability (area under the plasma concentration-time curve from zero to the last measurable concentration) is up to 4-fold greater than that of OM3FA ethyl esters, and unlike ethyl esters, the absorption of OM3CA is not dependent on pancreatic lipase hydrolysis. All three formulations are well tolerated (the most common adverse events are gastrointestinal) and demonstrate a lack of drug-drug interactions with other lipid-lowering drugs, such as statins and fibrates. OM3FAs appear to be an effective treatment option for patients with severe hypertriglyceridemia.
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Combined EPA + DHA formulations, such as omega-3 carboxylic acids and ethyl esters, effectively lower TG levels by reducing hepatic VLDL synthesis and enhancing fatty acid oxidation.
“Combined EPA + DHA formulations, such as omega-3 carboxylic acids and ethyl esters, effectively lower TG levels by reducing hepatic VLDL synthesis and enhancing fatty acid oxidation [87].”
From Targeting triglycerides for cardiovascular risk reduction (2026) · cites this paper as [87]
The Background’s efficacy section reports significant triglyceride reductions with omega-3 carboxylic acids and ethyl esters. Its mechanism-of-action section describes reduced substrate for VLDL synthesis and increased fatty-acid β-oxidation as proposed mechanisms, but says the exact triglyceride-lowering mechanisms are not completely understood. The claim presents that causal explanation as established. (LLM, conf=0.86)
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Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2002) · Civil War Book Review · Cited by 12,198 · see citing works
Standards of Medical Care in Diabetes
Power, D. V. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1593 · Cited by 8,672 · see citing works
Stone, N. J., Robinson, J. G., Lichtenstein, A. H., Bairey Merz, C. N., Blum, C. B., Eckel, R. H., Goldberg, A. C., Gordon, D., Levy, D., Lloyd-Jones, D. M., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437738.63853.7a · Cited by 7,081 · see citing works
Standards of medical care in diabetes—2014
American Diabetes Association (2014) · Diabetes Care · doi:10.2337/dc14-s014 · Cited by 4,572 · see citing works
Stone, N. J., Robinson, J. G., Lichtenstein, A. H., Bairey Merz, C. N., Blum, C. B., Eckel, R. H., Goldberg, A. C., Gordon, D., Levy, D., Lloyd-Jones, D. M., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.002 · Cited by 3,845 · see citing works
Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease
Kris-Etherton, P. M., Harris, W. S., & Appel, L. J. (2002) · Circulation · doi:10.1161/01.cir.0000038493.65177.94 · Cited by 3,707 · see citing works
ESC/EAS Guidelines for the management of dyslipidaemias
Reiner, Ž., Catapano, A. L., De Backer, G., Graham, I., Taskinen, M.-R., Wiklund, O., Agewall, S., Alegria, E., Chapman, M. J., Durrington, P., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr158 · Cited by 3,549 · see citing works
Complementary and Alternative Medicine Use Among Adults and Children: United States, 2007
Barnes, P. M., Bloom, B. E., & Nahin, R. L. (2008) · PsycEXTRA Dataset · doi:10.1037/e623942009-001 · Cited by 3,131 · see citing works
Kavey, R., Simons-Morton, D., & de Jesus, J. D. (2011) · Pediatrics · doi:10.1542/peds.2009-2107c · Cited by 2,131 · see citing works
Fish Intake, Contaminants, and Human Health: Evaluating the Risks and the Benefits
Mozaffarian, D., & Rimm, E. B. (2006) · JAMA · doi:10.1001/jama.296.15.1885 · Cited by 1,966 · see citing works
Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association
Miller, M., Stone, N. J., Ballantyne, C., Bittner, V., Criqui, M. H., Ginsberg, H. N., Goldberg, A. C., Howard, W. J., Jacobson, M. S., Kris-Etherton, P. M., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182160726 · Cited by 1,871 · see citing works
Triglycerides and cardiovascular disease
Nordestgaard, B. G., & Varbo, A. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61177-6 · Cited by 1,419 · see citing works
Chapman, M. J., Ginsberg, H. N., Amarenco, P., Andreotti, F., Borén, J., Catapano, A. L., Descamps, O. S., Fisher, E., Kovanen, P. T., Kuivenhoven, J. A., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr112 · Cited by 1,227 · see citing works
(2017) · Arzneimittelforschung · doi:10.1055/s-00000175 · Cited by 1,134 · see citing works
Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline
Berglund, L., Brunzell, J. D., Goldberg, A. C., Goldberg, I. J., Sacks, F., Murad, M. H., & Stalenhoef, A. F. H. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3213 · Cited by 887 · cited 2× · see citing works
“Like the 2014 NLA guideline, a number of other guidelines pertaining to the treatment and management of hypertriglyceridemia also recommend the use of TGlowering drugs (including high-dose OM3FAs), alone or in combination with statin therapy, in patients who continue to have elevated TG or non-HDL-C levels despite bei…”
BackgroundMethodEffects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review
Balk, E. M., Lichtenstein, A. H., Chung, M., Kupelnick, B., Chew, P., & Lau, J. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.02.012 · Cited by 732 · see citing works
ESC/EAS Guidelines for the management of dyslipidaemias
Catapano, A. L., Reiner, Ž., De Backer, G., Graham, I., Taskinen, M.-R., Wiklund, O., Agewall, S., Alegria, E., Chapman, M. J., Durrington, P., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.06.028 · Cited by 706 · see citing works
Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
Horton, J. D., Bashmakov, Y. K., Shimomura, I., & Shimano, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.5987 · Cited by 669 · see citing works
Hegele, R. A., Ginsberg, H. N., Chapman, M. J., Nordestgaard, B. G., Kuivenhoven, J. A., Averna, M., Borén, J., Bruckert, E., Catapano, A. L., Descamps, O. S., et al. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70191-8 · Cited by 635 · see citing works
Miller, M., Cannon, C. P., Murphy, S. A., Qin, J., Ray, K. K., & Braunwald, E. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.10.038 · Cited by 610 · see citing works
DHA Effects in Brain Development and Function
Lauritzen, L., Brambilla, P., Mazzocchi, A., Harsløf, L. B. S., Ciappolino, V., & Agostoni, C. V. (2016) · Nutrients · doi:10.3390/nu8010006 · Cited by 566 · see citing works
Jellinger, P. S., Smith, D. A., Mehta, A., Ganda, O. P., Handelsman, Y., Rodbard, H. W., Shepherd, M. D., & Seibel, J. A. (2012) · Endocrine Practice · doi:10.4158/ep.18.s1.1 · Cited by 527 · see citing works
Jacobson, T. A., Ito, M. K., Maki, K. C., Orringer, C. E., Bays, H. E., Jones, P. H., McKenney, J. M., Grundy, S. M., Gill, E. A., Wild, R. A., et al. (2014) · Journal of clinical lipidology · doi:10.1016/j.jacl.2014.07.007 · Cited by 464 · see citing works
Safety considerations with fibrate therapy
Davidson, M. H., Armani, A., McKenney, J. M., & Jacobson, T. A. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.11.016 · Cited by 408 · see citing works
Mori, T. A., Bao, D. Q., Burke, V., Puddey, I. B., & Beilin, L. J. (1999) · Hypertension · doi:10.1161/01.hyp.34.2.253 · Cited by 407 · see citing works
Why do omega-3 fatty acids lower serum triglycerides?
Harris, W. S., & Bulchandani, D. (2006) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000236363.63840.16 · Cited by 398 · see citing works
Davidson, M. H., Stein, E. A., Bays, H. E., Maki, K. C., Doyle, R. T., Shalwitz, R. A., Ballantyne, C. M., & Ginsberg, H. N. (2007) · Clinical Therapeutics · doi:10.1016/j.clinthera.2007.07.018 · Cited by 385 · see citing works
Bays, H. E., Ballantyne, C. M., Kastelein, J. J., Isaacsohn, J. L., Braeckman, R. A., & Soni, P. N. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.04.015 · Cited by 358 · see citing works
Nutraceuticals and dyslipidaemia: Beyond the common therapeutics
Scicchitano, P., Cameli, M., Maiello, M. R., Modesti, P. A., Muiesan, M. L., Novo, S., Palmiero, P., Saba, P. S., Pedrinelli, R., & Ciccone, M. M. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2013.12.006 · Cited by 351 · see citing works
Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance
Park, Y., & Harris, W. S. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200282-jlr200 · Cited by 348 · see citing works
Ballantyne, C. M., Bays, H. E., Kastelein, J. J., Stein, E., Isaacsohn, J. L., Braeckman, R. A., & Soni, P. N. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.05.031 · Cited by 342 · see citing works
Grundy, S. M. (2002) · Circulation · doi:10.1161/01.cir.0000038419.53000.d6 · Cited by 309 · see citing works
Safety and Efficacy of Omacor in Severe Hypertriglyceridemia
Harris, W. S., Ginsberg, H. N., Arunakul, N., Shachter, N. S., Windsor, S. L., Adams, M., Berglund, L., & Osmundsen, K. (1997) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/174182679700400511 · Cited by 306 · see citing works
Wei, M. Y., & Jacobson, T. A. (2011) · Current Atherosclerosis Reports · doi:10.1007/s11883-011-0210-3 · Cited by 284 · see citing works
Schwartz, G. G., Abt, M., Bao, W., DeMicco, D., Kallend, D., Miller, M., Mundl, H., & Olsson, A. G. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.03.544 · Cited by 272 · see citing works
Safety considerations with niacin therapy
Guyton, J. R., & Bays, H. E. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.11.018 · Cited by 269 · see citing works
Bays, H. E., Tighe, A. P., D, R. S. M., & Davidson, M. H. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.3.391 · Cited by 263 · see citing works
Jacobson, T. A., Glickstein, S. B., Rowe, J. D., & Soni, P. N. (2012) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2011.10.018 · Cited by 263 · see citing works
Genetics and causality of triglyceride-rich lipoproteins in atherosclerotic cardiovascular disease
Rosenson, R. S., Davidson, M. H., Hirsh, B. J., Kathiresan, S., & Gaudet, D. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.09.042 · Cited by 260 · see citing works
Safety and efficacy of Omacor in severe hypertriglyceridemia
Harris, W. S., Ginsberg, H. N., Arunakul, N., Shachter, N. S., Windsor, S. L., Adams, M., Berglund, L., & Osmundsen, K. (1997) · Journal of Cardiovascular Risk · doi:10.1097/00043798-199710000-00011 · Cited by 252 · see citing works
Cawood, A. L., Ding, R., Napper, F. L., Young, R. H., Williams, J. A., Ward, M. J., Gudmundsen, O., Vige, R., Payne, S. P. K., Ye, S., et al. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.05.022 · Cited by 245 · see citing works
Fish oil supplements in New Zealand are highly oxidised and do not meet label content of n-3 PUFA
Albert, B. B., Derraik, J. G. B., Cameron-Smith, D., Hofman, P. L., Tumanov, S., Villas-Boas, S. G., Garg, M. L., & Cutfield, W. S. (2015) · Scientific Reports · doi:10.1038/srep07928 · Cited by 238 · see citing works
Safety Considerations with Omega-3 Fatty Acid Therapy
Bays, H. E. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.11.020 · Cited by 235 · see citing works
Kastelein, J. J. P., Maki, K. C., Susekov, A., Ezhov, M., Nordestgaard, B. G., Machielse, B. N., Kling, D., & Davidson, M. H. (2014) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2013.10.003 · Cited by 233 · see citing works
Forsyth, J. S., Willatts, P., Agostoni, C., Bissenden, J., Casaer, P., & Boehm, G. (2003) · BMJ · doi:10.1136/bmj.326.7396.953 · Cited by 232 · see citing works
Hui, D. Y., & Howles, P. N. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r200013-jlr200 · Cited by 226 · see citing works
Serum Fatty Acids and the Risk of Coronary Heart Disease
Simon, J. A., Hodgkins, M. L., Browner, W. S., Neuhaus, J. M., Bernert, J. T., & Hulley, S. B. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117662 · Cited by 212 · see citing works
Woodman, R. J., Mori, T. A., Burke, V., Puddey, I. B., Barden, A. E., Watts, G. F., & Beilin, L. J. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00307-6 · Cited by 198 · see citing works
Clinical nutrition: 4. Omega-3 fatty acids in cardiovascular care.
Holub, B. J. (2002) · PubMed Central · Cited by 197 · see citing works
Expert Opinion: Omega-3 Fatty Acids and Bleeding—Cause for Concern?
Harris, W. S. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.11.021 · Cited by 191 · see citing works
Davidson, M. H., Johnson, J., Rooney, M. W., Kyle, M. L., & Kling, D. F. (2012) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2012.01.002 · Cited by 191 · see citing works
Pownall, H. J., Brauchi, D., Kilinç, C., Osmundsen, K., Pao, Q., Payton-Ross, C., Gotto, A. M., & Ballantyne, C. M. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(98)00301-3 · Cited by 179 · see citing works
Stark, K. D., & Holub, B. J. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.765 · Cited by 177 · see citing works
Chan, D. C., Watts, G. F., Barrett, P. H. R., Beilin, L. J., Redgrave, T. G., & Mori, T. A. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2377 · Cited by 160 · see citing works
Engler, M. M., Engler, M. B., Malloy, M. J., Chiu, E., Besio, D., Paul, S. M., Stuehlinger, M., Morrow, J. D., Ridker, P. M., Rifai, N., et al. (2004) · International Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cpp42672 · Cited by 150 · see citing works
Khan, S., Minihane, A.-M., Talmud, P. J., Wright, J. W., Murphy, M. C., Williams, C. M., & Griffin, B. A. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30473-9 · Cited by 145 · see citing works
Bays, H. E., Ballantyne, C. M., Braeckman, R. A., Stirtan, W. G., & Soni, P. N. (2013) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-012-0002-3 · Cited by 141 · see citing works
Fish Oil for the Treatment of Cardiovascular Disease
Weitz, D., Weintraub, H., Fisher, E., & Schwartzbard, A. Z. (2010) · Cardiology in Review · doi:10.1097/crd.0b013e3181ea0de0 · Cited by 138 · see citing works
Sun, Q., Ma, J., Campos, H., Rexrode, K. M., Albert, C. M., Mozaffarian, D., & Hu, F. B. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.1.216 · Cited by 129 · see citing works
Filion, K. B., Khoury, F. E., Bielinski, M., Schiller, I., Dendukuri, N., & Brophy, J. M. (2010) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-10-24 · Cited by 124 · see citing works
Ikeda, I., Sasaki, E., Yasunami, H., Nomiyama, S., Nakayama, M., Sugano, M., Imaizumi, K., & Yazawa, K. (1995) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(95)00180-8 · Cited by 110 · see citing works
Akiba, S., MURATA, T., Kitatani, K., & Sato, T. (2000) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.23.1293 · Cited by 108 · see citing works
Maki, K. C., Orloff, D. G., Nicholls, S. J., Dunbar, R. L., Roth, E. M., Curcio, D., Johnson, J., Kling, D., & Davidson, M. H. (2013) · Clinical Therapeutics · doi:10.1016/j.clinthera.2013.07.420 · Cited by 104 · see citing works
Kostapanos, M. S., Milionis, H. J., & Elisaf, M. (2010) · American Journal of Cardiovascular Drugs · doi:10.2165/13168600-000000000-00000 · Cited by 103 · see citing works
Very long chain N-3 fatty acids intake and carotid atherosclerosis
Hino, A., Adachi, H., Toyomasu, K., Yoshida, N., Enomoto, M., Hiratsuka, A., Hirai, Y., Satoh, A., & Imaizumi, T. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.04.020 · Cited by 102 · see citing works
楠知里, Liu, Y., Yoshizaki, T., Nakagawa, F., Ishikado, A., Kondo, M., Morino, K., Sekine, O., Ugi, S., Nishio, Y., et al. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.10.115 · Cited by 95 · see citing works
Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids
Jossic-Corcos, C. L., Gonthier‐Guéret, C., Zaghini, I., Logette, E., Shechter, I., & Bournot, P. (2005) · Biochemical Journal · doi:10.1042/bj20040933 · Cited by 90 · see citing works
Low-Dose Docosahexaenoic Acid Lowers Diastolic Blood Pressure in Middle-Aged Men and Women1
Theobald, H. E., Goodall, A. H., Sattar, N. A., Talbot, D. C. S., Chowienczyk, P., & Sanders, T. A. B. (2007) · Journal of Nutrition · doi:10.1093/jn/137.4.973 · Cited by 89 · see citing works
Davidson, M. H. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000019 · Cited by 87 · see citing works
Amano, T., Matsubara, T., Uetani, T., Kato, M., Kato, B., Yoshida, T., Harada, K., Kumagai, S., Kunimura, A., Shinbo, Y., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.05.030 · Cited by 83 · see citing works
Leng, G. C., Horrobin, D. F., Fowkes, F. G. R., Smith, F. B., Lowe, G. D. O., Donnan, P. T., & Ells, K. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.3.471 · Cited by 76 · see citing works
Overview of Prescription Omega-3 Fatty Acid Products for Hypertriglyceridemia
WEINTRAUB, H. S. (2014) · Postgraduate Medicine · doi:10.3810/pgm.2014.11.2828 · Cited by 74 · see citing works
Hypertriglyceridemia-induced recurrent acute pancreatitis: A case-based review
Kota, S., Kota, S. K., Jammula, S., Krishna, S., & Modi, K. (2012) · Indian journal of endocrinology and metabolism · doi:10.4103/2230-8210.91211 · Cited by 70 · see citing works
Ito, M. K. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.06.012 · Cited by 67 · see citing works
Trends in elevated triglyceride in adults: United States, 2001-2012.
Carroll, M. D., Kit, B. K., & Lacher, D. A. (2015) · PubMed · Cited by 64 · see citing works
Impaired Fetal Growth and Arterial Wall Thickening: A Randomized Trial of Omega-3 Supplementation
Skilton, M. R., Ayer, J. G., Harmer, J. A., Webb, K., Leeder, S., Marks, G. B., & Celermajer, D. S. (2012) · PEDIATRICS · doi:10.1542/peds.2011-2472 · Cited by 62 · see citing works
Beckermann, B., Beneke, M., & Seitz, I. (1990) · PubMed · Cited by 61 · see citing works
Skilton, M. R., Raitakari, O. T., & Celermajer, D. S. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.01030 · Cited by 59 · see citing works
Bays, H. E., McKenney, J., Maki, K. C., Doyle, R. T., Carter, R. N., & Stein, E. (2010) · Mayo Clinic Proceedings · doi:10.4065/mcp.2009.0397 · Cited by 54 · see citing works
Complexities of plasma apolipoprotein C-III metabolism
Frank M. Sacks, E. B., Zheng, C., & Jeffrey S. Cohn, E. B. (2011) · Journal of Lipid Research · doi:10.1194/jlr.e015701 · Cited by 51 · see citing works
The Synthesis of Fatty Acid Ethyl Ester by Carboxylester Lipase
Tsujita, T., & Okuda, H. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb19994.x · Cited by 49 · see citing works
McKenney, J. M., Swearingen, D., Spirito, M. D., Doyle, R. T., Pantaleon, C., Kling, D. F., & Shalwitz, R. A. (2006) · The Journal of Clinical Pharmacology · doi:10.1177/0091270006289849 · Cited by 40 · see citing works
Docosahexaenoic acid enrichment can reduce L929 cell necrosis induced by tumor necrosis factor
Kishida, E., Tajiri, M., & Masuzawa, Y. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.03.023 · Cited by 40 · see citing works
Milberg, P., Frommeyer, G., Kleideiter, A., Fischer, A., Osada, N., BREITHARDT, G. E., Fehr, M., & Eckardt, L. (2011) · Heart Rhythm · doi:10.1016/j.hrthm.2011.03.058 · Cited by 39 · see citing works
Zargar, A., & Ito, M. K. (2011) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2011.0004 · Cited by 39 · see citing works
Okumura, T., Fujioka, Y., Morimoto, S., Tsuboi, S., Masai, M., Tsujino, T., Ohyanagi, M., & Iwasaki, T. (2002) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200211000-00003 · Cited by 36 · see citing works
Morton, A. M., Furtado, J. D., Lee, J., Amerine, W., Davidson, M. H., & Sacks, F. M. (2016) · Journal of clinical lipidology · doi:10.1016/j.jacl.2016.09.005 · Cited by 32 · see citing works
Serebruany, V. L., Miller, M. J., Pokov, A. N., Lynch, D., Jensen, J. K., Hallén, J., & Atar, D. (2011) · Cardiology · doi:10.1159/000329300 · Cited by 31 · see citing works
Lee, M. W., Park, J. K., Hong, J. W., Kim, K. J., Shin, D. Y., Ahn, C. W., Song, Y. D., Cho, H. K., Park, S. W., & Lee, E. J. (2013) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2013.37.3.207 · Cited by 30 · see citing works
The Role of Omega-3 Polyunsaturated Fatty Acids Supplementation in Childhood: A Review
Ciccone, M. M., Scicchitano, P., Gesualdo, M., Zito, A., Carbonara, S., Ricci, G., Cortese, F., & Giordano, P. (2013) · Recent Advances in Cardiovascular Drug Discovery (Formerly Recent Patents on Cardiovascular Drug Discovery) · doi:10.2174/1574890111308010006 · Cited by 27 · see citing works
Gosai, P., Liu, J., Doyle, R. T., Johnson, J., Carter, R., Sica, D. A., & McKenney, J. M. (2008) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560802532640 · Cited by 25 · see citing works
Braeckman, R., Stirtan, W., & Soni, P. N. (2014) · Clinical drug investigation · doi:10.1007/s40261-014-0194-1 · Cited by 19 · see citing works
Spirito, M. D., Morelli, G., Doyle, R., Johnson, J., & McKenney, J. M. (2008) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560802233827 · Cited by 18 · see citing works
(2003) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 97 references couldn’t be matched to a known paper.
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The Short Overview on the Relevance of Fatty Acids for Human Cardiovascular Disorders
Шрамко, В. С., Polonskaya, Y. V., Kashtanova, E. V., Stakhneva, E. M., & Ragino, Y. I. (2020) · Biomolecules · doi:10.3390/biom10081127 · Cited by 214 · see citing works
Gioxari, A., Kaliora, A. C., Marantidou, F., & Panagiotakos, D. P. (2017) · Nutrition · doi:10.1016/j.nut.2017.06.023 · Cited by 203 · see citing works
Schunck, W., Konkel, A., Fischer, R., & Weylandt, K. H. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.10.016 · Cited by 196 · see citing works
Dellinger, R. W., Santos, S. R., Morris, M., Evans, M., Alminana, D., Guarente, L., & Marcotulli, E. (2017) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-017-0016-9 · Cited by 181 · see citing works
Marine Natural Products in Clinical Use
Haque, N., Parveen, S., Tang, T., Wei, J., & Huang, Z. (2022) · Marine Drugs · doi:10.3390/md20080528 · Cited by 166 · see citing works
Santos, H. O., Price, J. C., & Bueno, A. A. (2020) · Nutrients · doi:10.3390/nu12103159 · Cited by 157 · see citing works
Nutraceutical characteristics of the brown seaweed carotenoid fucoxanthin
Miyashita, K., Beppu, F., Hosokawa, M., Liu, X., & Wang, S. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108364 · Cited by 127 · see citing works
Elevated Serum Triglycerides in the Prognostic Assessment of Acute Pancreatitis
Wang, Q., Wang, G., Qiu, Z., He, X., & Liu, C. (2017) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000846 · Cited by 125 · see citing works
Maki, K. C., Palacios, O. M., Bell, M., & Toth, P. P. (2017) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2017.07.010 · Cited by 107 · see citing works
Patted, P. G., Masareddy, R. S., Patil, A. S., Kanabargi, R., & Bhat, C. T. (2024) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-024-00667-5 · Cited by 105 · see citing works
Effective Prevention of Oxidative Deterioration of Fish Oil: Focus on Flavor Deterioration
Miyashita, K., Uemura, M., & Hosokawa, M. (2018) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030117-012320 · Cited by 104 · see citing works
Inflammation and cardiovascular disease: are marine phospholipids the answer?
Lordan, R., Redfern, S., Τσούπρας, Α., & Zabetakis, I. (2020) · Food & Function · doi:10.1039/c9fo01742a · Cited by 103 · see citing works
Goyal, A., Tanwar, B., Sihag, M. K., & Sharma, V. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.131459 · Cited by 92 · see citing works
Bocanegra, A., Macho‐González, A., Garcimartín, A., Benedı́, J., & Sánchez-Muniz, F. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083816 · Cited by 84 · see citing works
From Life in the Sea to the Clinic: The Marine Drugs Approved and under Clinical Trial
Cappello, E., & Nieri, P. (2021) · Life · doi:10.3390/life11121390 · Cited by 81 · see citing works
Bae, J. H., Lim, H., & Lim, S. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.03.014 · Cited by 78 · see citing works
The emerging role of omega-3 fatty acids as a therapeutic option in neuropsychiatric disorders
Reimers, A., & Ljung, H. (2019) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125319858901 · Cited by 75 · see citing works
Chevalier, L., Vachon, A., & Plourde, M. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa458 · Cited by 60 · see citing works
Alexopoulos, A., Qamar, A., Hutchins, K., Crowley, M. J., Batch, B. C., & Guyton, J. R. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1136-3 · Cited by 60 · see citing works
The Role of Omega- 3 Polyunsaturated Fatty Acids in Diabetes Mellitus Management: A Narrative Review
Bayram, S. Ş., & Kızıltan, G. (2024) · Current Nutrition Reports · doi:10.1007/s13668-024-00561-9 · Cited by 58 · see citing works
PPAR-α agonists are still on the rise: an update on clinical and experimental findings
Ferri, N., Corsini, A., Sirtori, C. R., & Ruscica, M. (2017) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2017.1312339 · Cited by 56 · see citing works
Klingel, S. L., Metherel, A. H., Irfan, M., Rajna, A., Chabowski, A., Bazinet, R. P., & Mutch, D. M. (2019) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz234 · Cited by 54 · see citing works
Arca, M., Borghi, C., Pontremoli, R., Ferrari, G. M. D., Colivicchi, F., Desideri, G., & Temporelli, P. L. (2017) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2017.11.001 · Cited by 53 · see citing works
Jamilian, M., Tabassi, Z., Reiner, Ž., Panahandeh, I., Naderi, F., Aghadavod, E., Amirani, E., Taghizadeh, M., Shafabakhsh, R., Sattari, M., et al. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114519003416 · Cited by 51 · see citing works
Barrea, L., Vetrani, C., Verde, L., Frías-Toral, E., Ceriani, F., Cernea, S., Docimo, A., Graziadio, C., Tripathy, D., Savastano, S., et al. (2023) · Antioxidants · doi:10.3390/antiox12040904 · Cited by 55 · see citing works
Yanagisawa, R., He, C., Asai, A., Hellwig, M., Henle, T., & Toda, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012236 · Cited by 47 · see citing works
Lipoprotein Lipase: Is It a Magic Target for the Treatment of Hypertriglyceridemia
Moon, J. H., Kim, K., & Choi, S. H. (2022) · Endocrinology and Metabolism · doi:10.3803/enm.2022.402 · Cited by 49 · see citing works
de Souza, D. R., Pieri, B. L. D. S., Comin, V. H., Marques, S. D. O., Luciano, T. F., Rodrigues, M. S., & de Souza, C. T. (2020) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2020.107553 · Cited by 45 · see citing works
Omega-3 Fatty Acids as Druggable Therapeutics for Neurodegenerative Disorders
Chitre, N. M., Moniri, N. H., & Murnane, K. S. (2019) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527318666191114093749 · Cited by 48 · see citing works
Discovery of metabolic biomarkers for gestational diabetes mellitus in a Chinese population
Lu, W., Luo, M., Fang, X., Zhang, R., Li, S., Tang, M., Yu, X., & Hu, C. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00606-8 · Cited by 41 · see citing works
Calado, R., Leal, M. C., Gaspar, H., Santos, S., Marques, A., Nunes, M. L., & Vieira, H. (2018) · Grand challenges in biology and biotechnology · doi:10.1007/978-3-319-69075-9_9 · Cited by 39 · see citing works
Review of Cardiometabolic Effects of Prescription Omega-3 Fatty Acids
Burke, M. F., Burke, F. M., & Soffer, D. E. (2017) · Current Atherosclerosis Reports · doi:10.1007/s11883-017-0700-z · Cited by 39 · see citing works
Bioactive significance of fucoxanthin and its effective extraction
Miyashita, K., Beppu, F., Hosokawa, M., Liu, X., & Wang, S. (2020) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2020.101639 · Cited by 39 · see citing works
Elkin, R. G., & Harvatine, K. J. (2023) · Poultry Science · doi:10.1016/j.psj.2023.102938 · Cited by 38 · see citing works
Intracellular Cholesterol TraffickingPreprint
Ikonen, E., & Olkkonen, V. M. (2023) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041404 · Cited by 38 · see citing works
Chen, S., Wu, Q., Zhu, L., Zong, G., Li, H., Zheng, H., Zeng, R., Lin, X., & Sun, L. D. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab050 · Cited by 35 · see citing works
Blom, W. A. M., Koppenol, W. P., Hiemstra, H., Stojaković, T., Scharnagl, H., & Trautwein, E. A. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1706-1 · Cited by 34 · see citing works
Omega-3 Fatty Acids in Arterial Hypertension: Is There Any Good News?
Brosolo, G., Porto, A. D., Marcante, S., Picci, A., Capilupi, F., Capilupi, P., Bertin, N., Vivarelli, C., Bulfone, L., Vacca, A., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119520 · Cited by 42 · see citing works
Functional Lipids and Cardiovascular Disease Reduction: A Concise Review
Omachi, D. O., Aryee, A. N. A., & Onuh, J. O. (2024) · Nutrients · doi:10.3390/nu16152453 · Cited by 36 · see citing works
Li, J., Dou, K., Zhou, Z., Zhao, D. H., Ye, P., Zhao, J., & Guo, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1069992 · Cited by 34 · see citing works
Oishi, K., Konishi, T., Hashimoto, C., Yamamoto, S., Takahashi, Y., & Shiina, Y. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.09.024 · Cited by 32 · see citing works
On, S., Kim, H. Y., Kim, H. S., Park, J., & Kang, K. W. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112625 · Cited by 29 · see citing works
Zhu, S., Zhang, J., Jiang, X. J., Wang, W., & Chen, Y. Q. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104060 · Cited by 29 · see citing works
Current Research Landscape of Marine-Derived Anti-Atherosclerotic Substances
Cao, Q., Zhao, J., Xing, M., Han, X., Zhang, Q., Liang, H., Ji, A., & Song, S. (2020) · Marine Drugs · doi:10.3390/md18090440 · Cited by 29 · see citing works
Hypertriglyceridemia in Diabetes Mellitus: Implications for Pediatric Care
Hartz, J. C., de Ferranti, S. D., & Gidding, S. S. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2018-00079 · Cited by 27 · see citing works
Quindry, J. C., & Franklin, B. A. (2017) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000134 · Cited by 27 · see citing works
Protective Effects of ω-3 PUFA in Anthracycline-Induced Cardiotoxicity: A Critical Review
Serini, S., Vasconcelos, R. O., Gomes, R. N., & Calviello, G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122689 · Cited by 26 · see citing works
Li, Q., Hou, C., Peng, Y., Zhu, X., Shi, C., Zhang, K., Tu, M., Guo, F., Huang, D., & Miao, Y. (2019) · BioMed Research International · doi:10.1155/2019/2620750 · Cited by 26 · see citing works
Brook, M. S., Din, U. S. U., Tarum, J., Selby, A., Quinlan, J. I., Bass, J. J., Gharahdaghi, N., Boereboom, C., Abdulla, H., Franchi, M. V., et al. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2021.09.729 · Cited by 26 · see citing works
Liu, W., Gao, M., Yang, S., Sun, C., Bi, Y., Li, Y., Wang, J., & Yuan, X. (2023) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2023.108451 · Cited by 26 · see citing works
López-Toledano, M. A., Thorsteinsson, T., Daak, A. A., Maki, K. C., Johns, C., Rabinowicz, A. L., & Sancilio, F. D. (2017) · Journal of clinical lipidology · doi:10.1016/j.jacl.2017.01.017 · Cited by 26 · see citing works
Lozano‐Muñoz, I., Muñoz, S., Díaz, N. F., Medina, A., Bazaes, J., & Riquelme, C. E. (2020) · Molecules · doi:10.3390/molecules25204615 · Cited by 25 · see citing works
Yang, B., Tseng, P., Hu, X., Zeng, B., Chang, J. P., Liu, Y., Chu, W.-J., Zhang, S., Zhou, Z.-L., Chu, C., et al. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101196 · Cited by 22 · see citing works
Maki, K. C., Palacios, O. M., Buggia, M., Trivedi, R., Dicklin, M. R., & Maki, C. E. (2018) · Clinical Therapeutics · doi:10.1016/j.clinthera.2018.10.014 · Cited by 22 · see citing works
Dietary and serum <i>n</i> -3 PUFA and polycystic ovary syndrome: a matched case–control study
Lu, L., Li, X., Lv, L., Xu, Y., Wu, B., & Huang, C. (2022) · British Journal of Nutrition · doi:10.1017/s0007114521003007 · Cited by 20 · see citing works
Omega-3 Fatty Acid Therapy: The Tide Turns for a Fish Story
O’Keefe, J. H., Jacob, D., & Lavie, C. J. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.11.008 · Cited by 20 · see citing works
Masuda, D., Miyata, Y., Matsui, S., & Yamashita, S. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.11.014 · Cited by 19 · see citing works
Habitual Fish Oil Supplementation and Incident Chronic Kidney Disease in the UK Biobank
Liu, M., Ye, Z., Yang, S., Zhang, Y., Wu, Q., Zhou, C., He, P., Zhang, Y., Hou, F. F., & Qin, X. (2022) · Nutrients · doi:10.3390/nu15010022 · Cited by 19 · see citing works
Gou, N., Ji, H., Chang, Z., Zhong, M., & Deng, W. W. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2020.735590 · Cited by 19 · see citing works
Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies
Musa, M., Zeppieri, M., Atuanya, G. N., Enaholo, E. S., Topah, E. K., Ojo, O. M., & Salati, C. (2023) · Life · doi:10.3390/life13051120 · Cited by 20 · see citing works
Lamonaca, P., Prinzi, G., Kisialiou, A., Cardaci, V., Fini, M., & Russo, P. (2017) · Marine Drugs · doi:10.3390/md15030081 · Cited by 18 · see citing works
da Silva, P. S., Mediano, M. F. F., da Silva, G. M. S., de Brito, P. D., Cardoso, C. S. D. A., de Almeida, C. F., Sangenis, L. H. C., Pinheiro, R. O., Hasslocher‐Moreno, A. M., do Brasil, P. E. A. A., et al. (2017) · Nutrition Journal · doi:10.1186/s12937-017-0259-0 · Cited by 17 · see citing works
Poznyak, A. V., Zhang, D., Orekhova, V. A., Grechko, A. V., Wetzker, R., & Orekhov, A. N. (2020) · PubMed Central · Cited by 17 · see citing works
Abdi, A. D., Olvera-Hernández, S., Reyes‐Castro, L. A., Mezo‐González, C. E., Croyal, M., García‐Santillán, J. A., Ouguerram, K., Zambrano, E., & Bolaños, F. J. (2021) · Nutrients · doi:10.3390/nu13093075 · Cited by 16 · see citing works
Cardiometabolic risks and omega‐3 index in recent‐onset bipolar I disorder
Wulsin, L., Blom, T., Durling, M., Welge, J., Delbello, M., Adler, C., McNamara, R., & Strakowski, S. (2018) · Bipolar Disorders · doi:10.1111/bdi.12633 · Cited by 16 · see citing works
Scanlon, G., Loughman, J., Farrell, D., & McCartney, D. M. A. (2019) · Nutrition Research Reviews · doi:10.1017/s095442241900012x · Cited by 16 · see citing works
Pasta, A., Formisano, E., Cremonini, A. L., Maganza, E., Parodi, E., Piras, S., & Pisciotta, L. (2020) · Nutrients · doi:10.3390/nu12072056 · Cited by 16 · see citing works
Hong, J., Bledsoe, J. W., Overturf, K., Lee, S., Iassonova, D. R., & Small, B. C. (2022) · Frontiers in Sustainable Food Systems · doi:10.3389/fsufs.2022.837628 · Cited by 15 · see citing works
Takeda, Y., Sakuma, I., Hiramitsu, S., Okada, M., Ueda, S., & Sakurai, M. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1094100 · Cited by 15 · see citing works
Ding, D., Li, Y., Xiao, M., Dong, H., Lin, J.-S., Chen, G., Chen, Z.-Y., Tang, X., & Chen, Y. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa039 · Cited by 15 · see citing works
Laumann, R. D., Iversen, T., Mogensen, P. R., Lauritzen, L., Mølgaard, C., & Frandsen, T. L. (2020) · Nutrition and Cancer · doi:10.1080/01635581.2020.1803934 · Cited by 15 · see citing works
Lin, W. (2021) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-021-00436-2 · Cited by 15 · see citing works
An update on renal tubular injury as related to glycolipid metabolism in diabetic kidney disease
Feng, A., Yin, R., Xu, R., Zhang, B., & Yang, L. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1559026 · Cited by 16 · see citing works
Davis, D. W., Crew, J., Planinić, P., Alexander, J. M., & Basu, A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17207528 · Cited by 14 · see citing works
Tognocchi, M., Conte, M., Testai, L., Martucci, M., Serra, A., Salvioli, S., Calderone, V., Mele, M. L., & Conte, G. (2022) · Foods · doi:10.3390/foods11030398 · Cited by 12 · see citing works
Brum, I. D. S. D. C., Mafra, D., Moreira, L. D. S. G., Teixeira, K. T. R., Stockler‐Pinto, M. B., Cardozo, L., & Borges, N. A. (2022) · Nutrition Research · doi:10.1016/j.nutres.2022.06.004 · Cited by 12 · see citing works
Maki, K., Johns, C., Harris, W., Puder, M., Freedman, S., Thorsteinsson, T., Daak, A. A., Rabinowicz, A. L., & Sancilio, F. (2017) · Clinical Therapeutics · doi:10.1016/j.clinthera.2017.01.019 · Cited by 11 · see citing works
The Future of Lipid-Lowering Therapy
Zwol, W. H.-V., Rimbert, A., & Kuivenhoven, J. A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8071085 · Cited by 12 · see citing works
Zhou, J., Cai, L., Ni, S., Zhong, Z., Yang, M., Yu, H., Zhao, Y., Xun, P., & Bai, J. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521002300 · Cited by 12 · see citing works
Lipid-Lowering Medications for Managing Dyslipidemia: A Narrative Review
Alqahtani, M. S., Alzibali, K. F., Mahdi, A. M. M., Alharbi, O. M. A., Harbi, R. H. A., Alkhaldi, H. S. M., Alsayafi, Z. A. A., Bisher, F. H. A., Buqurayn, M. H., & Alharbi, M. M. (2024) · Cureus · doi:10.7759/cureus.65202 · Cited by 11 · see citing works
Metabolic alterations in spinal and bulbar muscular atrophy
Francini‐Pesenti, F., Vitturi, N., Tresso, S., & Sorarú, G. (2020) · Revue Neurologique · doi:10.1016/j.neurol.2020.03.020 · Cited by 11 · see citing works
The Role of VEGF Family in Lipid Metabolism
Zhou, Y., Zhu, X., Wang, H., Duan, C., Cui, H., Shi, J., Shi, S., Yuan, G., & Hu, Y. (2022) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201023666220506105026 · Cited by 12 · see citing works
Jiao, Y., Watts, T., Xue, J., Hannafon, B. N., & Ding, W. (2018) · BMC Cancer · doi:10.1186/s12885-018-4946-9 · Cited by 11 · see citing works
Liu, Y., Sun, Y., Xue, B.-H., Wang, X.-D., & Yu, W. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06331-1 · Cited by 11 · see citing works
Miller, M. R., Kruger, M. C., Wynne, C., Waaka, D., Li, W., Frampton, C., Wolber, F. M., & Eason, C. (2020) · Marine Drugs · doi:10.3390/md18110524 · Cited by 11 · see citing works
Strikić, D., Vujević, A., Perica, D., Leskovar, D., Paponja, K., Pećin, I., & Merćep, I. (2023) · Diabetology · doi:10.3390/diabetology4040048 · Cited by 9 · see citing works
Nutraceuticals in the management of autonomic function and related disorders: A comprehensive review
da Costa, P. C. T., Freire, M. O. D. L., Coutinho, D. D. O., Godet, M., Magnani, M., Antunes, V. R., de Souza, E. L., Vidal, H., & Alves, J. L. D. B. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107368 · Cited by 11 · see citing works
Effects of Vine Tea Extract on Meat Quality, Gut Microbiota and Metabolome of Wenchang Broiler
Zhou, L., Li, H., Hou, G., Wang, J., Zhou, H., & Wang, D. (2022) · Animals · doi:10.3390/ani12131661 · Cited by 10 · see citing works
Elkin, R. G., El-Zenary, A. S. A., Bomberger, R., Haile, A. B., Weaver, E. A., Ramachandran, R., & Harvatine, K. J. (2022) · Poultry Science · doi:10.1016/j.psj.2022.102318 · Cited by 10 · see citing works
Ramirez, J. L., Zahner, G. J., Spaulding, K. A., Khetani, S. A., Hills, N. K., Gasper, W. J., Harris, W. S., Cohen, B. E., & Grenon, S. M. (2019) · Lipids · doi:10.1002/lipd.12140 · Cited by 10 · see citing works
Estefes-Duarte, J. A., Espinosa‐Sánchez, A., Pérez‐Hernández, N., Ortiz, M. I., & Fernández‐Martínez, E. (2024) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010340506241014112341 · Cited by 9 · see citing works
Elevated high-density lipoprotein triglycerides increase atherosclerotic risk
Liu, W., Chen, S., Yang, C., Lei, F., Huang, X., Zhang, X., Sun, T., Lin, L., Wang, C., Cao, Y., et al. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2025.100791 · Cited by 8 · see citing works
Jarullah, H. H., & Saleh, E. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094015 · Cited by 8 · see citing works
RSSDI consensus recommendations for dyslipidemia management in diabetes mellitus
Saboo, B., Agarwal, S., Makkar, B. M., Chawla, R., Ghosh, S. K., Viswanathan, V., Gupta, S., Kumar, C. V., Maheshwari, A., Sreenivasamurthy, L., et al. (2022) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-022-01063-6 · Cited by 8 · see citing works
Velidakis, N., Stachteas, P., Gkougkoudi, E., Papadopoulos, C. E., & Kadoglou, N. P. E. (2024) · Pharmaceuticals · doi:10.3390/ph17050568 · Cited by 8 · see citing works
Nutritional adjuvants with antioxidant properties in the treatment of canine leishmaniasis
Gonçalves, R. D. S., de Pinho, F. A., Dinis‐Oliveira, R. J., Mendes, M. O., de Andrade, T. S., Solcà, M. D. S., Larangeira, D. F., Silvestre, R., & Barrouin‐Melo, S. M. (2021) · Veterinary Parasitology · doi:10.1016/j.vetpar.2021.109526 · Cited by 8 · see citing works
Obara, K., Kawaguchi, A., Inaba, R., Kawakita, M., Yamaguchi, R., Yamashita, H., Xu, K., Ou, G., Yamaki, F., Yoshioka, K., et al. (2021) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b21-00362 · Cited by 8 · see citing works
Zhang, C., Xie, Y., Zhou, J., Zhang, C., Xiang, Q., Zhong, Y., Xiao, J., Feng, J., Liao, B., Chen, X., et al. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70372 · Cited by 8 · see citing works
Ahmad, M. F., Alsayegh, A. A., Khanam, A., Ahmed, A., Raposo, A., Bantun, F., Zeyaullah, M., Babalghith, A. O., Aldairi, A. F., Mozaffar, B., et al. (2025) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.70346 · Cited by 9 · see citing works
Chao, T., Sun, J., Ge, Y., & Wang, C. (2023) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2023.10.035 · Cited by 7 · see citing works
- Authors
- Backes, J., Anzalone, D., Hilleman, D., & Catini, J.
- Affiliations
- University of Kansas (US)
- AstraZeneca (United States) (US)
- Creighton University (US)
- Corresponding author
- Backes, James
- Venue
- Lipids in Health and Disease
- Published
- 2016-07-22
- Volume
- 15
- Issue
- 1
- Pages
- 118-118
- ISSN
- 1476-511X (ISSN-L)
- PMC
- PMC4957330
- OpenAlex
- W2487890137
- Cited by
- 195
- References
- 97
- Citations by year
- 2026: 8 · 2025: 20 · 2024: 20 · 2023: 20 · 2022: 26 · 2021: 29 · 2020: 25 · 2019: 15 · 2018: 9 · 2017: 20 · 2016: 1 · 2015: 2
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Lipids in Health and Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Creighton Digital Repository (CDR) (submittedVersion)
- KU ScholarWorks (The University of Kansas) (submittedVersion, cc-by)
- Funders
- AstraZeneca
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- omega-3 fatty acids, severe hypertriglyceridemia, triglyceride-lowering therapy, icosapent ethyl, eicosapentaenoic acid, docosahexaenoic acid, docosapentaenoic acid, VLDL, non-HDL cholesterol, lipoprotein lipase, hepatic lipogenesis, fatty acid beta-oxidation, bioavailability, drug-drug interactions, cardiovascular risk, pancreatitis
- MeSH terms
- Adult, Hypolipidemic Agents, Biological Availability, Docosahexaenoic Acids, Drug Combinations, Esters, Humans, Lipoprotein Lipase, Cholesterol, LDL, Lipoproteins, VLDL, Liver, Oxidation-Reduction, Triglycerides, Eicosapentaenoic Acid, Hypertriglyceridemia, Fatty Acids, Omega-3, Lipogenesis, Diacylglycerol O-Acyltransferase
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