Cited by 117Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsCholesterol and Lipid Metabolism

Apolipoproteins as markers and managers of coronary risk

Chan, D.C.·2006·QJM

Abstract

Coronary artery disease (CAD) is a major cause of morbidity and mortality in Western communities. Reliable indices of coronary risk assessment and targets for drug treatment are important to the management of patients. Although plasma LDL cholesterol is well established as a predictor of CAD, it may not be the best circulatory marker. Results from recent epidemiological studies and statin trials suggest that apolipoprotein B-100 (apoB), with or without apoA-I, is superior to LDL cholesterol in predicting coronary events. Measurements of apolipoproteins are internationally standardized, automated, cost-effective and more convenient and precise than those for LDL cholesterol. ApoB may also be preferable to the measurement of non-HDL cholesterol. Measurement of apolipoproteins (apoB and possibly apoA-I) should be routinely added to the routine lipid profile (cholesterol, triglycerides and high-density lipoprotein cholesterol) to assess the atherogenic potential of lipid disorders. This is particularly relevant to dyslipidaemias characterized by an elevation in plasma triglycerides. Apolipoproteins, especially apoB, could also replace the standard "lipid profile" as a target for therapy in at-risk patients.

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Crossref · 10.1093/qjmed/hcl027

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Authors
Chan, D. C.
Affiliations
The University of Western Australia (AU)
Corresponding author
Chan, D.C.
Venue
QJM
Published
2006-02-27
Volume
99
Issue
5
Pages
277-287
ISSN
  • 0033-5622 (ISSN-L)
  • 1460-2725
  • 1460-2393
OpenAlex
W2161147110
Cited by
117
References
55
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 2 · 2014: 9 · 2013: 3 · 2012: 4
FWCI
1.57
Type
journal article
Language
en
Open access
closed
Locations
  • QJM (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
Funders
National Heart Foundation of Australia
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords
apolipoprotein B-100, apolipoprotein A-I, coronary artery disease, coronary risk assessment, LDL cholesterol, non-HDL cholesterol, dyslipidemia, triglyceride elevation, lipid profile, atherogenic lipoproteins
MeSH terms
Anticholesteremic Agents, Apolipoproteins, Apolipoproteins B, Cholesterol, Coronary Artery Disease, Female, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Biomarkers, Apolipoprotein A-I, Risk Assessment, Apolipoprotein B-100

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