Effect of Nasal Continuous Positive Airway Pressure Treatment on Blood Pressure in Patients With Obstructive Sleep Apnea

Becker, Heinrich F.; Jerrentrup, Andreas; Ploch, Thomas; Grote, Ludger; Penzel, Thomas; Sullivan, Colin E.; Peter, J. Hermann

doi:10.1161/01.cir.0000042706.47107.7a

Cited by 931Obstructive Sleep Apnea ResearchSleep and related disordersBlood Pressure and Hypertension Studies

Effect of Nasal Continuous Positive Airway Pressure Treatment on Blood Pressure in Patients With Obstructive Sleep Apnea

Becker, Heinrich F., Jerrentrup, Andreas, Ploch, Thomas, Grote, Ludger, Penzel, Thomas, Sullivan, Colin E., Peter, J. Hermann·2003·Circulation

DOI 10.1161/01.cir.0000042706.47107.7a

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Abstract

Background— There is increasing evidence that obstructive sleep apnea (OSA) is an independent risk factor for arterial hypertension. Because there are no controlled studies showing a substantial effect of nasal continuous positive airway pressure (nCPAP) therapy on hypertension in OSA, the impact of treatment on cardiovascular sequelae has been questioned altogether. Therefore, we studied the effect of nCPAP on arterial hypertension in patients with OSA. Methods and Results— Sixty consecutive patients with moderate to severe OSA were randomly assigned to either effective or subtherapeutic nCPAP for 9 weeks on average. Nocturnal polysomnography and continuous noninvasive blood pressure recording for 19 hours was performed before and with treatment. Thirty two patients, 16 in each group, completed the study. Apneas and hypopneas were reduced by ≈95% and 50% in the therapeutic and subtherapeutic groups, respectively. Mean arterial blood pressure decreased by 9.9±11.4 mm Hg with effective nCPAP treatment, whereas no relevant change occurred with subtherapeutic nCPAP ( P =0.01). Mean, diastolic, and systolic blood pressures all decreased significantly by ≈10 mm Hg, both at night and during the day. Conclusions— Effective nCPAP treatment in patients with moderate to severe OSA leads to a substantial reduction in both day and night arterial blood pressure. The fact that a 50% reduction in the apnea-hypopnea index did not result in a decrease in blood pressure emphasizes the importance of highly effective treatment. The drop in mean blood pressure by 10 mm Hg would be predicted to reduce coronary heart disease event risk by 37% and stroke risk by 56%.

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[30]30. Jerrentrup A, Becker HF, Heitmann J, et al. Does continuous non- invasive blood pressure recording affect sleep quality in patients with nCPAP-therapy? Eur Respir J. 1999;14:85s. Abstract.

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Authors: Becker, H. F., Jerrentrup, A., Ploch, T., Grote, L., Penzel, T., Sullivan, C. E., & Peter, J. H.
Affiliations: The University of Sydney (AU)
ORCID: Jerrentrup, Andreas
Grote, Ludger
Penzel, Thomas
Sullivan, Colin E.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2003-01-07
Volume: 107
Issue: 1
Pages: 68-73
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.0000042706.47107.7a
OpenAlex: W2045561532
Cited by: 931
References: 34
Citations by year: 2026: 3 · 2025: 9 · 2024: 10 · 2023: 14 · 2022: 18 · 2021: 16 · 2020: 21 · 2019: 16 · 2018: 31 · 2017: 24 · 2016: 34 · 2015: 52 · 2014: 49 · 2013: 46 · 2012: 45
FWCI: 37.98
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: ResMed
Topics: Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords: obstructive sleep apnea, nasal continuous positive airway pressure, hypertension, blood pressure reduction, apnea-hypopnea index, cardiovascular risk, stroke risk, coronary artery disease
MeSH terms: Blood Pressure, Female, Humans, Hypertension, Kinetics, Male, Middle Aged, Nose, Pressure, Polysomnography, Sleep Apnea, Obstructive

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Effect of Nasal Continuous Positive Airway Pressure Treatment on Blood Pressure in Patients With Obstructive Sleep Apnea

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