Continuous positive airway pressure reduces blood pressure in patients with obstructive sleep apnea; a systematic review and meta-analysis with 1000 patients
Abstract
BACKGROUND: Obstructive sleep apnea (OSA) may lead to the development of hypertension and therapy with continuous positive airway pressure (CPAP) can promote reduction in blood pressure. OBJECTIVE: The objective of this study is to review systematically the effects of CPAP on blood pressure in patients with OSA. METHODS: The search was conducted in the following databases, from their beginning until February 2013: MEDLINE, Embase, Cochrane CENTRAL, Lilacs and PEDro. In addition, a manual search was performed on references of published studies. Randomized clinical trials (RCTs) that used CPAP compared with placebo CPAP or subtherapeutic CPAP for treatment of patients with OSA and that evaluated office SBP and DBP and 24-h ambulatory blood pressure were selected. RESULTS: Sixteen RCTs were included among 3409 publications, totaling 1166 patients. The use of CPAP resulted in reductions in office SBP [-3.20 mmHg; 95% confidence interval (CI) -4.67 to -1.72] and DBP (-2.87 mmHg; 95% CI -5.18 to -0.55); in night-time SBP (-4.92 mmHg; 95% CI -8.70 to -1.14); in mean 24-h blood pressure (-3.56 mmHg; 95% CI -6.79 to -0.33), mean night-time blood pressure (-2.56 mmHg; 95% CI -4.43 to -0.68) and 24-h DBP (-3.46 mmHg; 95% CI -6.75 to -0.17). However, no significant change was observed in daytime SBP (-0.74 mmHg; 95% CI -3.90 to 2.41) and daytime DBP (-1.86 mmHg; 95% CI -4.55 to 0.83). CONCLUSION: Treatment with CPAP promoted significantly but small reductions in blood pressure in individuals with OSA. Further studies should be performed to evaluate the effects of long-term CPAP and the impact on cardiovascular risk.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Better oxygenation through night-time continuous positive air pressure reduces nocturnal hypertension and reduces catecholamines and aldosterone secretion.
“Further, better oxygenation through night‐time continuous positive air pressure reduces nocturnal hypertension 65 and reduces catecholamines and aldosterone secretion 66.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [65]
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2009.06.005 · Cited by 19,575 · see citing works
Chobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izzo, J. L., Jones, D. W., Materson, B. J., Oparil, S., Wright, J. T., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000107251.49515.c2 · Cited by 13,271 · see citing works
Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2010) · International Journal of Surgery · doi:10.1016/j.ijsu.2010.02.007 · Cited by 12,156 · see citing works
The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults
Young, T., Palta, M., Dempsey, J., Skatrud, J., Weber, S., & Badr, S. (1993) · New England Journal of Medicine · doi:10.1056/nejm199304293281704 · Cited by 10,183 · cited 1× · see citing works
“Its prevalence is higher than 10% [1,2], and it is associated with increased cardiovascular mortality and with all causes of mortality [3–6].”
BackgroundJames, P. A., Oparil, S., Carter, B. L., Cushman, W. C., Dennison-Himmelfarb, C., Handler, J., Lackland, D. T., LeFevre, M. L., MacKenzie, T. D., Ogedegbe, O., et al. (2014) · JAMA · doi:10.1001/jama.2013.284427 · Cited by 7,950 · see citing works
Marin, J. M., Carrizo, S. J., Vicente, E., & Agusti, A. G. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71141-7 · Cited by 4,678 · see citing works
Epidemiology of Obstructive Sleep Apnea: A Population Health Perspective
Young, T., Peppard, P. E., & Gottlieb, D. J. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2109080 · Cited by 4,244 · see citing works
Goff, D. C., Lloyd-Jones, D. M., Bennett, G., Coady, S., D’Agostino, R. B., Gibbons, R., Greenland, P., Lackland, D. T., Levy, D., O’Donnell, C. J., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437741.48606.98 · Cited by 3,697 · see citing works
Sympathetic neural mechanisms in obstructive sleep apnea.
Somers, V. K., Dyken, M. E., Clary, M. P., & Abboud, F. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118235 · Cited by 2,527 · see citing works
Sleep Disordered Breathing and Mortality: Eighteen-Year Follow-up of the Wisconsin Sleep Cohort
(2008) · Sleep · doi:10.5665/sleep/31.8.1071 · Cited by 1,853 · see citing works
Pepperell, J., Ramdassingh-Dow, S., Crosthwaite, N., Mullins, R., Jenkinson, C., Stradling, J. R., & Davies, R. J. O. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07445-7 · Cited by 1,055 · see citing works
Sleep Disordered Breathing and Mortality: Eighteen-Year Follow-up of the Wisconsin Sleep Cohort
Jones, S. (2009) · Yearbook of Pulmonary Disease · doi:10.1016/s8756-3452(08)79181-3 · Cited by 958 · see citing works
Becker, H. F., Jerrentrup, A., Ploch, T., Grote, L., Penzel, T., Sullivan, C. E., & Peter, J. H. (2003) · Circulation · doi:10.1161/01.cir.0000042706.47107.7a · Cited by 931 · see citing works
Sleep Apnea as an Independent Risk Factor for All-Cause Mortality: The Busselton Health Study
(2008) · Sleep · doi:10.5665/sleep/31.8.1079 · Cited by 889 · see citing works
Robinson, K. A., & Dickersin, K. (2002) · International Journal of Epidemiology · doi:10.1093/ije/31.1.150 · Cited by 833 · see citing works
Augmented Resting Sympathetic Activity in Awake Patients With Obstructive Sleep Apnea
Carlson, J. T., Hedner, J. A., Elam, M., Ejnell, H., Sellgren, J., & Wallin, B. G. (1993) · CHEST Journal · doi:10.1378/chest.103.6.1763 · Cited by 681 · see citing works
Prognostic value of 24-hour blood pressure variability
Frattola, A., Parati, G., Cuspidi, C., Albini, F., & Mancia, G. (1993) · Journal of Hypertension · doi:10.1097/00004872-199310000-00019 · Cited by 659 · see citing works
Efficacy of Positive Airway Pressure and Oral Appliance in Mild to Moderate Obstructive Sleep Apnea
Barnes, M., McEvoy, R. D., Banks, S., Tarquinio, N., Murray, C. G., Vowles, N., & Pierce, R. J. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200311-1571oc · Cited by 597 · see citing works
Predictive Role of the Nighttime Blood Pressure
Hansen, T. W., Li, Y., Boggia, J., Thijs, L., Richart, T., & Staessen, J. A. (2011) · Hypertension · doi:10.1161/hypertensionaha.109.133900 · Cited by 597 · see citing works
Haentjens, P. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.8.757 · Cited by 569 · see citing works
Barbé, F., Mayoralas, L. R., Duran, J., Masa, J. F., Maimó, A., Montserrat, J. M., Monasterio, C., Bosch, M., Ladaria, A., Rubio, M., et al. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-11-200106050-00007 · Cited by 534 · see citing works
Narkiewicz, K., Kato, M., Phillips, B. G., Pesek, C. A., Davison, D. E., & Somers, V. K. (1999) · Circulation · doi:10.1161/01.cir.100.23.2332 · Cited by 485 · see citing works
Campos-Rodriguez, F., Martinez-Garcia, M. A., de la Cruz-Moron, I., Almeida-Gonzalez, C., Catalan-Serra, P., & Montserrat, J. M. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-156-2-201201170-00006 · Cited by 379 · see citing works
He, J., & Whelton, P. K. (1999) · American Heart Journal · doi:10.1016/s0002-8703(99)70312-1 · Cited by 325 · see citing works
Montesi, S. B., Edwards, B. A., Malhotra, A., & Bakker, J. P. (2012) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.2170 · Cited by 316 · see citing works
Robinson, G. V., Smith, D. M., Langford, B. A., Davies, R. J. O., & Stradling, J. R. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00062805 · Cited by 314 · see citing works
Effect of CPAP on Blood Pressure in Patients With OSA/Hypopnea
Fava, C., Dorigoni, S., Dalle Vedove, F., Danese, E., Montagnana, M., Guidi, G. C., Narkiewicz, K., & Minuz, P. (2014) · Chest · doi:10.1378/chest.13-1115 · Cited by 305 · see citing works
Martínez-García, M.-A., Campos-Rodríguez, F., Catalán-Serra, P., Soler-Cataluña, J.-J., Almeida-Gonzalez, C., De la Cruz Morón, I., Durán-Cantolla, J., & Montserrat, J.-M. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201203-0448oc · Cited by 298 · see citing works
Kohler, M., Stoewhas, A., Ayers, L., Senn, O., Bloch, K. E., Russi, E. W., & Stradling, J. R. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201106-0964oc · Cited by 288 · see citing works
Effect of Continuous Positive Airway Pressure on Blood Pressure
Dimsdale, J. E., Loredo, J. S., & Profant, J. (2000) · Hypertension · doi:10.1161/01.hyp.35.1.144 · Cited by 288 · see citing works
White, W. B., Dey, H. M., & Schulman, P. M. (1989) · American Heart Journal · doi:10.1016/0002-8703(89)90593-0 · Cited by 277 · see citing works
Durán-Cantolla, J., Aizpuru, F., Montserrat, J. M., Ballester, E., Téran‐Santos, J., Aguirregomoscorta, J. I., González, M., Lloberes, P., Masa, J. F., de la Peña, M., et al. (2010) · BMJ · doi:10.1136/bmj.c5991 · Cited by 256 · see citing works
Daytime sleepiness and polysomnographic variables in sleep apnoea patients
Mediano, O., Barceló, A., de la Peña, M., Gozal, D., Agustí, A. G. N., & Barbé, F. (2007) · European Respiratory Journal · doi:10.1183/09031936.00009506 · Cited by 221 · see citing works
CPAP and measures of cardiovascular risk in males with OSAS
Kohler, M., Pepperell, J. C. T., Casadei, B., Craig, S., Crosthwaite, N., Stradling, J. R., & Davies, R. J. O. (2008) · European Respiratory Journal · doi:10.1183/09031936.00026608 · Cited by 197 · see citing works
Norman, D., Loredo, J. S., Nelesen, R. A., Ancoli‐Israel, S., Mills, P. J., Ziegler, M. G., & Dimsdale, J. E. (2006) · Hypertension · doi:10.1161/01.hyp.0000217128.41284.78 · Cited by 187 · see citing works
Campos‐Rodríguez, F., Grilo, A., Pérez‐Ronchel, J., Merino-Sanchez, M., Gonzalez-Benitez, M. A., Beltrán-Robles, M., & Almeida, C. (2006) · CHEST Journal · doi:10.1378/chest.129.6.1459 · Cited by 185 · see citing works
Effects of CPAP on oxidative stress and nitrate efficiency in sleep apnoea: a randomised trial
Alonso‐Fernández, A., Rio, F. G., Arias, M. A., Hernánz, Á., de la Peña, M., Piérola, J., Barceló, A., López‐Collazo, E., & Agustí, A. G. N. (2008) · Thorax · doi:10.1136/thx.2008.100537 · Cited by 184 · see citing works
Lam, J. C. M., Lam, B., Yao, T. J., Lai, A. Y. K., Ooi, C. G., Tam, S., Lam, K. S. L., & Ip, M. S. M. (2010) · European Respiratory Journal · doi:10.1183/09031936.00047709 · Cited by 170 · see citing works
Stanchina, M. L., Welicky, L. M., Donat, W. E., Lee, D. J., Corrao, W. M., & Malhotra, A. (2013) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.2916 · Cited by 155 · see citing works
Mills, P. J., Kennedy, B. P., Loredo, J. S., Dimsdale, J. E., & Ziegler, M. G. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00494.2005 · Cited by 146 · see citing works
Engleman, H. M., Gough, K., Martin, S. E., Kingshott, R. N., Padfield, P. L., & Douglas, N. J. (1996) · SLEEP · doi:10.1093/sleep/19.5.378 · Cited by 133 · see citing works
Drager, L. F., Pedrosa, R. P., Diniz, P. M., Diegues‐Silva, L., Marcondes, B. F., Couto, R. B., Giorgi, D., Krieger, E. M., & Lorenzi‐Filho, G. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.165969 · Cited by 126 · see citing works
Hypertension and obstructive sleep apnea
Phillips, C. L., & O’Driscoll, D. M. (2013) · Nature and Science of Sleep · doi:10.2147/nss.s34841 · Cited by 108 · see citing works
Hui, D. S. C., To, K. W., Ko, F. W. S., Fok, J. P. C., Chan, M. C., Ngai, J. C. L., Tung, A., Ho, C. W., Tong, M. W., Szeto, C., et al. (2006) · Thorax · doi:10.1136/thx.2006.064063 · Cited by 108 · see citing works
Cross, M. D., Mills, N. L., Al-Abri, M., Riha, R. L., Vennelle, M., Mackay, T. W., Newby, D. E., & Douglas, N. J. (2008) · Thorax · doi:10.1136/thx.2007.081877 · Cited by 108 · see citing works
Sleep Apnea and Hypertension: Interactions and Implications for Management
Kapa, S., Kuniyoshi, F. H. S., & Somers, V. K. (2008) · Hypertension · doi:10.1161/hypertensionaha.106.076190 · Cited by 92 · see citing works
Nguyen, P. K. P., Katikireddy, C. K., McConnell, M. V., Kushida, C. A., & Yang, P. C.-M. (2010) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/1532-429x-12-50 · Cited by 69 · see citing works
Treatment of obstructive sleep apnea reduces arterial stiffness
Buchner, N. J., Quack, I., Stegbauer, J., Woznowski, M., Kaufmann, A., & Rump, L. C. (2011) · Sleep And Breathing · doi:10.1007/s11325-010-0465-x · Cited by 60 · see citing works
(2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.03.006 · Cited by 48 · see citing works
Sleep and blood pressure: spontaneous baroreflex sensitivity in dippers and non-dippers
VAILE, J. C., Stallard, T. J., Al-Ani, M., Jordan, P. J., Townend, J., & Littler, W. A. (1996) · Journal of Hypertension · doi:10.1097/00004872-199612000-00007 · Cited by 43 · see citing works
Cardiovascular regulation in different sleep stages in the obstructive sleep apnea syndrome
Gapelyuk, A., Riedl, M., Suhrbier, A., Kraemer, J. F., Bretthauer, G., Malberg, H., Kurths, J., Penzel, T., & Wessel, N. (2011) · Biomedizinische Technik/Biomedical Engineering · doi:10.1515/bmt.2011.018 · Cited by 21 · see citing works
Toraldo, D. M., Nuccio, F. D., & Nicolardi, G. (2011) · Expert Review of Respiratory Medicine · doi:10.1586/ers.10.86 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Circadian Syndrome: is the Metabolic Syndrome and much more!
Zimmet, P., Alberti, K. G. M. M., Stern, N., Bilu, C., El‐Osta, A., Einat, H., & Kronfeld‐Schor, N. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12924 · Cited by 387 · see citing works
Bratton, D. J., Gaisl, T., Wons, A. M., & Kohler, M. (2015) · JAMA · doi:10.1001/jama.2015.16303 · Cited by 362 · see citing works
Clinical consequences and economic costs of untreated obstructive sleep apnea syndrome
Knauert, M. P., Naik, S., Gillespie, M. B., & Kryger, M. H. (2015) · World Journal of Otorhinolaryngology - Head and Neck Surgery · doi:10.1016/j.wjorl.2015.08.001 · Cited by 297 · see citing works
Inflammation in sleep apnea: An update
Unnikrishnan, D. C., Jun, J. C., & Polotsky, V. Y. (2014) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-014-9304-x · Cited by 225 · see citing works
Pamidi, S., Wroblewski, K., Stepien, M., Sharif-Sidi, K., Kilkus, J., Whitmore, H., & Tasali, E. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201408-1564oc · Cited by 185 · see citing works
The hypertension of Cushing's syndrome
Isidori, A. M., Graziadio, C., Paragliola, R. M., Cozzolino, A., Ambrogio, A. G., Colao, A., Corsello, S. M., & Pivonello, R. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000415 · Cited by 220 · see citing works
Pengo, M. F., Soranna, D., Giontella, A., Perger, E., Mattaliano, P., Schwarz, E. I., Lombardi, C., Bilo, G., Zambon, A., Steier, J., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.01945-2019 · Cited by 178 · see citing works
Sleep: important considerations for the prevention of cardiovascular disease
Grandner, M. A., Alfonso-Miller, P., Fernandez-Mendoza, J., Shetty, S., Shenoy, S., & Combs, D. (2016) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000324 · Cited by 166 · see citing works
Hu, X., Fan, J., Chen, S., Yin, Y., & Zrenner, B. (2015) · Journal of Clinical Hypertension · doi:10.1111/jch.12472 · Cited by 156 · see citing works
Kuna, S. T., Reboussin, D. M., Strotmeyer, E. S., Millman, R. P., Zammit, G., Walkup, M. P., Wadden, T. A., Wing, R. R., Pi-Sunyer, F. X., Spira, A. P., et al. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201912-2511oc · Cited by 151 · see citing works
Quality Measures for the Care of Adult Patients with Obstructive Sleep Apnea
Aurora, R. N., Collop, N. A., Jacobowitz, O., Thomas, S. M., Quan, S. F., & Aronsky, A. J. (2015) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.4556 · Cited by 135 · see citing works
Chronotherapy for Hypertension
Bowles, N. P., Thosar, S. S., Herzig, M. X., & Shea, S. A. (2018) · Current Hypertension Reports · doi:10.1007/s11906-018-0897-4 · Cited by 131 · see citing works
Intermittent hypoxia: a low-risk research tool with therapeutic value in humans
Mateika, J. H., El‐Chami, M., Shaheen, D., & Ivers, B. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00564.2014 · Cited by 118 · see citing works
Floras, J. S. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.05.003 · Cited by 107 · see citing works
Boyd, S. B., Walters, A. S., Waite, P. D., Harding, S. M., & Song, Y. (2015) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.4838 · Cited by 99 · see citing works
Aardoom, J. J., Loheide‐Niesmann, L., Ossebaard, H. C., & Riper, H. M. (2020) · Journal of Medical Internet Research · doi:10.2196/16972 · Cited by 96 · see citing works
Shiina, K. (2024) · Hypertension Research · doi:10.1038/s41440-024-01852-y · Cited by 99 · see citing works
Eskandari, D., Zou, D., Grote, L., Hoff, E., & Hedner, J. A. (2018) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.6968 · Cited by 89 · see citing works
Blood-pressure variability in patients with obstructive sleep apnea: current perspectives
Marrone, O., & Bonsignore, M. R. (2018) · Nature and Science of Sleep · doi:10.2147/nss.s148543 · Cited by 81 · see citing works
Sleep Apnea Research in Animals. Past, Present, and Future
Chopra, S., Polotsky, V. Y., & Jun, J. C. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2015-0218tr · Cited by 74 · see citing works
Ryan, S., Cummins, E. P., Farré, R., Gileles‐Hillel, A., Jun, J. C., Oster, H., Pépin, J., Ray, D. W., Reutrakul, S., Sánchez‐de‐la‐Torre, M., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.02295-2019 · Cited by 70 · see citing works
Maternal Sleep-Disordered Breathing
Pamidi, S., & Kimoff, R. J. (2018) · Chest · doi:10.1016/j.chest.2017.10.011 · Cited by 61 · see citing works
From CPAP to tailored therapy for obstructive sleep Apnoea
Sutherland, K., Kairaitis, K., Yee, B. J., & Cistulli, P. A. (2018) · Multidisciplinary Respiratory Medicine · doi:10.1186/s40248-018-0157-0 · Cited by 62 · see citing works
The why, when and how to test for obstructive sleep apnea in patients with atrial fibrillation
Desteghe, L., Hendriks, J., McEvoy, R. D., Chai‐Coetzer, C. L., Dendale, P., Sanders, P., Heidbüchel, H., & Linz, D. (2018) · Clinical Research in Cardiology · doi:10.1007/s00392-018-1248-9 · Cited by 58 · see citing works
Mateika, J. H., & Komnenov, D. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.05.011 · Cited by 59 · see citing works
Xia, W., Huang, Y., Peng, B., Zhang, X., Wu, Q., Sang, Y., Luo, Y., Liu, X., Chen, Q., & Tian, K. (2018) · Sleep Medicine · doi:10.1016/j.sleep.2018.03.016 · Cited by 57 · see citing works
Systemic hypertension in obstructive sleep apnea
Lombardi, C., Pengo, M. F., & Parati, G. (2018) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.12.57 · Cited by 56 · see citing works
Boyd, S. B., Chigurupati, R., Cillo, J. E., Eskes, G. A., Goodday, R. H. B., Meisami, T., Viozzi, C. F., Waite, P. D., & Wilson, J. (2018) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2018.06.173 · Cited by 48 · see citing works
Obstructive Sleep Apnea and Cardiovascular Disease: Where Do We Stand?
Peker, Y. (2023) · The Anatolian Journal of Cardiology · doi:10.14744/anatoljcardiol.2023.3307 · Cited by 39 · see citing works
Jun, J. C., Chopra, S., & Schwartz, A. R. (2016) · European Respiratory Review · doi:10.1183/16000617.0077-2015 · Cited by 38 · see citing works
Patil, S. P., Billings, M. E., Bourjeily, G. R., Collop, N. A., Gottlieb, D. J., Johnson, K. G., Kimoff, R. J., & Pack, A. I. (2023) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.10832 · Cited by 39 · see citing works
Shim, C. Y., Kim, D., Park, S., Lee, C. J., Cho, H., Ha, J., Cho, Y., & Hong, G. (2018) · European Respiratory Journal · doi:10.1183/13993003.01774-2017 · Cited by 33 · see citing works
Linz, D., Mancia, G., Mahfoud, F., Narkiewicz, K., Ruilope, L. M., Schlaich, M. P., Kindermann, I., Schmieder, R. E., Ewen, S., Williams, B., et al. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001142 · Cited by 33 · see citing works
the Italian Society of Hypertension (SIIA), Pinto, R. D., SIIA Young Researchers Study Group, President of, S. I. I. A., Past President of, S. I. I. A., Italian Society of Hypertension (SIIA), Grassi, G. M., Ferri, C., Pengo, M. F., Lombardi, C., et al. (2021) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-021-00436-y · Cited by 32 · see citing works
Lui, M. M., Tse, H., Lam, D. C.-L., Lau, K. K., Chan, C. W., & Ip, M. (2021) · European Respiratory Journal · doi:10.1183/13993003.03687-2020 · Cited by 32 · see citing works
Obstructive sleep apnea and hormones – a novel insight
Ruchała, M., Bromińska, B., Cyrańska-Chyrek, E., Kuźnar-Kamińska, B., Kostrzewska, M., & Batura‐Gabryel, H. (2016) · Archives of Medical Science · doi:10.5114/aoms.2016.61499 · Cited by 35 · see citing works
Serinel, Y., Yee, B. J., Grunstein, R. R., WONG, K. K. H., Cistulli, P. A., Arima, H., & Phillips, C. L. (2016) · Thorax · doi:10.1136/thoraxjnl-2016-209504 · Cited by 31 · see citing works
Kang, K., Chiu, S., Lee, C., Lin, M., & Hsu, W. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.06.017 · Cited by 30 · see citing works
Bock, J. M., Needham, K., Gregory, D. A., Ekono, M. M., Wickwire, E. M., Somers, V. K., & Lerman, A. (2022) · Mayo Clinic Proceedings Innovations Quality & Outcomes · doi:10.1016/j.mayocpiqo.2022.01.002 · Cited by 30 · see citing works
Sapiña-Beltrán, E., Santamaria-Martos, F., Benítez, I., Torres, G., Masa, J. F., Sánchez-de-la-Torre, M., Barbé, F., & Dalmases, M. (2019) · Journal of Hypertension · doi:10.1097/hjh.0000000000001934 · Cited by 28 · see citing works
Kang, K., Yeh, T., Ko, J., Lee, C., Lin, M., & Hsu, W. (2022) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2022.101590 · Cited by 27 · see citing works
Walia, H. K., Griffith, S. D., Foldvary‐Schaefer, N., Thomas, G., Bravo, E. L., Moul, D. E., & Mehra, R. (2015) · CHEST Journal · doi:10.1378/chest.15-0697 · Cited by 26 · see citing works
Adeva‐Andany, M. M., Domínguez-Montero, A., Castro-Quintela, E., Funcasta-Calderón, R., & Fernández‐Fernández, C. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2506231 · Cited by 24 · see citing works
The relationship between obstructive sleep apnoea and coronary heart disease
Pafili, K., Steiropoulos, P., & Παπάνας, Ν. (2015) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000172 · Cited by 24 · see citing works
Bradicich, M., Pengo, M. F., Steier, J. S., & Schwarz, E. I. (2024) · ERJ Open Research · doi:10.1183/23120541.00718-2024 · Cited by 21 · see citing works
Geng, Y., Smolensky, M. H., Sum‐Ping, O., Hermida, R. C., & Castriotta, R. J. (2022) · Chronobiology International · doi:10.1080/07420528.2022.2080557 · Cited by 21 · see citing works
Effect of CPAP, Weight Loss, or CPAP Plus Weight Loss on Central Hemodynamics and Arterial Stiffness
Jain, S., Gurubhagavatula, I., Townsend, R. R., Kuna, S. T., Teff, K. L., Wadden, T. A., Chittams, J. L., Hanlon, A. L., Maislin, G., Saif, H., et al. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09392 · Cited by 21 · see citing works
Khoshkish, S., Hohl, M., Linz, B. M., Arzt, M. E., Mahfoud, F., Baumert, M., Schöpe, J., Böhm, M., & Linz, D. (2018) · Journal of Clinical Hypertension · doi:10.1111/jch.13202 · Cited by 21 · see citing works
Zhang, D., Luo, J., Qiao, Y., & Xiao, Y. (2016) · Journal of Thoracic Disease · doi:10.21037/jtd.2016.09.40 · Cited by 20 · see citing works
Carter, J. R., Fonkoue, I. T., Grimaldi, D., Emami, L., Gozal, D., Sullivan, C. E., & Mokhlesi, B. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00516.2015 · Cited by 20 · see citing works
Obstructive sleep apnea syndrome, continuous positive airway pressure and treatment of hypertension
Floras, J. S. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.06.024 · Cited by 20 · see citing works
Maiolino, G., Bisogni, V., Silvani, A., Pengo, M. F., Lombardi, C., & Parati, G. (2020) · Journal of Thoracic Disease · doi:10.21037/jtd-cus-2020-014 · Cited by 20 · see citing works
Crinion, S. J., Kleinerova, J., Kent, B., Nolan, G., Taylor, C. T., Ryan, S., & McNicholas, W. T. (2021) · ERJ Open Research · doi:10.1183/23120541.00338-2021 · Cited by 18 · see citing works
Song, Y., Sun, F., Redline, S. S., & Wang, R. (2020) · Research Synthesis Methods · doi:10.1002/jrsm.1406 · Cited by 16 · see citing works
Upper airway surgery for obstructive sleep apnea reduces blood pressure
Pang, K. P., Pang, E. B., Pang, K. A., Vicini, C., Chan, Y. H., & Rotenberg, B. W. (2017) · The Laryngoscope · doi:10.1002/lary.26759 · Cited by 16 · see citing works
Dieu, H. D. T., Vo-Thi-Kim, A., Tran-Van, H., & Duong‐Quy, S. (2020) · Multidisciplinary Respiratory Medicine · doi:10.4081/mrm.2020.468 · Cited by 16 · see citing works
Wons, A. M., & Kohler, M. (2015) · Europe PMC (PubMed Central) · doi:10.5167/uzh-117346 · Cited by 14 · see citing works
Multimodal Telemonitoring for Weight Reduction in Patients With Sleep Apnea
Murase, K., Minami, T., Hamada, S., Gozal, D., Takahashi, N., Nakatsuka, Y., Takeyama, H., Tanizawa, K., Endo, D., Akahoshi, T., et al. (2022) · CHEST Journal · doi:10.1016/j.chest.2022.07.032 · Cited by 14 · see citing works
McEvoy, R. D., & Michael, M. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.07.014 · Cited by 13 · see citing works
Huang, Z., Liu, Z., Luo, Q., Zhao, Q., Zhao, Z., Ma, X., Xi, Q., & Yang, D. (2014) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.09.015 · Cited by 12 · see citing works
Chen, Q., Cheng, Y., Shen, M., Yin, B., Yi, H., Feng, J., Li, M., Li, Q. Y., Li, Y., & Wang, J. (2019) · Blood Pressure · doi:10.1080/08037051.2019.1686343 · Cited by 12 · see citing works
Altay, S., Fırat, S., Peker, Y., & Collaborators, T. T. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12124144 · Cited by 11 · see citing works
Lv, M., Mao, J., Wang, S., Zhang, C., Qian, C., Zhu, R., Xiong, S., Zhang, Y., & Guo, L. (2024) · Respiratory Medicine · doi:10.1016/j.rmed.2024.107852 · Cited by 11 · see citing works
Freedman, N. S. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.06.033 · Cited by 11 · see citing works
Impact of Continuous Positive Airway Pressure on Cardiovascular Risk Factors in High-Risk Patients
Zhao, Y. Y., & Redline, S. S. (2015) · Current Atherosclerosis Reports · doi:10.1007/s11883-015-0540-7 · Cited by 9 · see citing works
The influence of sleep apnea syndrome and intermittent hypoxia in carotid adventitial vasa vasorum
López‐Cano, C., Rius, F., Sánchez, E., Gaeta, A. M., Betriu, À., Fernández, E., Yeramian, A., Hernández, M., Bueno, M., Gutiérrez-Carrasquilla, L., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211742 · Cited by 9 · see citing works
Blood pressure response to treatment of obese vs non‐obese adults with sleep apnea
Kuna, S. T., Townsend, R. R., Keenan, B. T., Maislin, D. G., Gíslason, Þ., Benediktsdóttir, B., Gudmundsdóttir, S., Arnardóttir, E. S., Sifferman, A., Staley, B. A., et al. (2019) · Journal of Clinical Hypertension · doi:10.1111/jch.13689 · Cited by 9 · see citing works
Giordano, N. A., Houser, M. C., Pelkmans, J. L., Pasquel, F. J., Pak, V., Rogers, A. E., Yeager, K. A., Mucha, S., Schmitt, M. G., & Miller, A. H. (2024) · Nursing Research · doi:10.1097/nnr.0000000000000779 · Cited by 7 · see citing works
Altered Resting Cerebral Blood Flow in Obstructive Sleep Apnea: A Helpful Change or Not?
Macey, P. M. (2015) · SLEEP · doi:10.5665/sleep.4962 · Cited by 7 · see citing works
Efficacy of Orthognathic Surgery in OSAS Patients: A Systematic Review and Meta‐Analysis
Ali, S. A., Marrapodi, M. M., Shivakumar, G. C., Shivakumar, S., Hurkadle, J., Cicciù, M., & Minervini, G. (2025) · Journal of Oral Rehabilitation · doi:10.1111/joor.13936 · Cited by 6 · see citing works
Heeley, E. L., Billot, L., Anderson, C. S., Antic, N. A., Neal, B. C., McEvoy, R. D., & for the SAVE investigators (2015) · International Journal of Stroke · doi:10.1177/1747493015607504 · Cited by 6 · see citing works
Seixas, A. A., Ravenell, J. E., Williams, N. J., Williams, S. K., Zizi, F., Ogedegbe, G. G., & Jean‐Louis, G. (2015) · Journal of Human Hypertension · doi:10.1038/jhh.2015.78 · Cited by 5 · see citing works
Zhao, Y. Y., Wang, R., Gleason, K. J., Lewis, E. F., Quan, S. F., Toth, C. M., Song, Y., Morrical, M. G., Rueschman, M., Mittleman, M. A., et al. (2022) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.10012 · Cited by 5 · see citing works
Sleep Disturbances in General Medical Disorders
Chokroverty, S. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6578-6_47 · Cited by 5 · see citing works
Alternations of Blood Pressure Before and After OSA Surgery
Tsai, M., Lin, P., Lin, H., Friedman, M., Salapatas, A. M., Lu, Y., Su, M., & Lin, M. (2020) · Otolaryngology · doi:10.1177/0194599820926137 · Cited by 5 · see citing works
Shi, J. C., Yuan, Y., Deng, X., Pan, Y., He, M., Liu, G., Sun, D., Wang, J., Wang, W., & Li, Y. (2018) · Sleep And Breathing · doi:10.1007/s11325-018-1688-5 · Cited by 4 · see citing works
Serinel, Y., Hoyos, C. M., Qasem, A., Yee, B. J., Grunstein, R. R., WONG, K. K. H., & Phillips, C. L. (2019) · International Journal of Cardiology Hypertension · doi:10.1016/j.ijchy.2019.100002 · Cited by 4 · see citing works
The USPSTF and screening for obstructive sleep apnea: Dispelling misconceptions
Mehra, R., & Foldvary‐Schaefer, N. (2017) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.84a.17023 · Cited by 3 · see citing works
Punjabi, N. M., & Gottlieb, D. J. (2022) · CHEST Journal · doi:10.1016/j.chest.2021.12.031 · Cited by 3 · see citing works
Obstructive Sleep Apnea and Hypertension
Yao, X., Li, M., Yao, L., & Shao, L. (2019) · Springer eBooks · doi:10.1007/978-981-15-0591-1_13 · Cited by 3 · see citing works
Kasiakogias, A., Tsioufis, C. P., Thomopoulos, C., & Tousoulis, D. M. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000377 · Cited by 3 · see citing works
The role of the tongue base in obstructive sleep apnoea
Hendricks, R., Patel, Z., Suleman, L., Khalfey, H., Engela, E., & Adams, S. (2024) · Transactions of the Royal Society of South Africa · doi:10.1080/0035919x.2024.2355464 · Cited by 2 · see citing works
Wang, L., Zou, J., Li, S., Tian, C., Ran, J., Yang, X., Liu, Y., Nie, G., Jiang, L., & Peng, W. (2024) · Scientific Reports · doi:10.1038/s41598-024-76378-x · Cited by 2 · see citing works
Advancements of CPAP Therapy for Obstructive Sleep Apnea
Chen, N. (2017) · Advances in oto-rhino-laryngology · doi:10.1159/000470895 · Cited by 2 · see citing works
Mehra, R., Moul, D. E., & Strohl, K. P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-24288-2.00108-2 · Cited by 2 · see citing works
Huang, Z., & Liu, Z. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000374 · Cited by 2 · see citing works
Fuchs, F. D. (2017) · Springer eBooks · doi:10.1007/978-3-319-63272-8_4 · Cited by 1 · see citing works
Holistic Treatment Outcomes in OSA: Clinical Evidence for the SLEEP GOAL
Pang, K. P., Pang, E. B., & Rotenberg, B. W. (2021) · Current Otorhinolaryngology Reports · doi:10.1007/s40136-021-00365-3 · Cited by 1 · see citing works
Valenzuela‐Pascual, F., Verdejo-Amengual, F. J., Martínez-Navarro, O., Blanco‐Blanco, J., Arab, R. A. E., Rubinat, E., Masbernat, M. A., Rubí‐Carnacea, F., Martí, B. M., Barbé, F., et al. (2024) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2023-001889 · Cited by 2 · see citing works
Current Concepts in Assessing Outcomes for OSA Surgery
Pang, K. P., Pang, E. B., Pang, E. B., & Rotenberg, B. W. (2016) · Current Otorhinolaryngology Reports · doi:10.1007/s40136-016-0105-5 · Cited by 1 · see citing works
From CPAP to tailored therapy for obstructive sleep apnoea
Cistulli, P. A., Sutherland, K., Kairaitis, K., & Yee, B. J. (2018) · Multidisciplinary Respiratory Medicine · doi:10.4081/mrm.2018.212 · Cited by 1 · see citing works
Mokhlesi, B., & Carter, J. R. (2016) · Thorax · doi:10.1136/thoraxjnl-2016-208718 · Cited by 1 · see citing works
Marrone, O., & Bonsignore, M. R. (2019) · European Respiratory Journal · doi:10.1183/13993003.01219-2019 · Cited by 1 · see citing works
Sleep surgery improves blood pressure: How can it be?
Weaver, E. M. (2022) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2022.101619 · Cited by 1 · see citing works
Beneficial effect of continuous positive airway pressure therapy in obstructive sleep apnea syndrome
Magyar, M. T. (2014) · Orvosi Hetilap · doi:10.1556/oh.2014.30040
A Case of Hypertensive Intracerebral Hemorrhage Accompanying Sleep Apnea
Yoon, D. W., Lee, S. K., Kim, J., Yun, C., Lee, S. H., & Shin, C. (2013) · Sleep Medicine Research · doi:10.17241/smr.2013.4.2.56
Carbonic anhydrase activity in sleep apnea - a potential therapeutic mechanism for intervention
Eskandari, D. (2016) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Bonsignore, M. R., Marrone, O., & McNicholas, W. T. (2017) · Barcelona Respiratory Network · doi:10.23866/brnrev:2017-m0037
Özkök, A., Kanbay, A., & Köktürk, O. (2017) · Springer eBooks · doi:10.1007/978-3-319-56827-0_20
Al-Khatib, K. (2017) · DalSpace (Dalhousie University)
- Authors
- Schein, A. S. O., Kerkhoff, A. C., Coronel, C. C., Plentz, R. D. M., & Sbruzzi, G.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- Fundação Universitária de Cardiologia (BR)
- Universidade Federal de Ciências da Saúde de Porto Alegre (BR)
- Corresponding author
- Sbruzzi, Graciele
- Venue
- Journal of Hypertension
- Published
- 2014-09
- Volume
- 32
- Issue
- 9
- Pages
- 1762-1773
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W2079463895
- Cited by
- 109
- References
- 55
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 8 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 8 · 2019: 8 · 2018: 14 · 2017: 11 · 2016: 12 · 2015: 18 · 2014: 7 · 2013: 1
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- obstructive sleep apnea, continuous positive airway pressure, blood pressure reduction, hypertension, ambulatory blood pressure, office blood pressure, nocturnal blood pressure, cardiovascular risk
- MeSH terms
- Blood Pressure, Blood Pressure Determination, Circadian Rhythm, Humans, Hypertension, Risk Factors, Randomized Controlled Trials as Topic, Blood Pressure Monitoring, Ambulatory, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
