The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Characterization of Complicated Carotid Plaque With Magnetic Resonance Direct Thrombus Imaging in Patients With Cerebral Ischemia
Open accessAbstract
Background— Thromboembolic disease secondary to complicated carotid atherosclerotic plaque is a major cause of cerebral ischemia. Clinical management relies on the detection of significant (>70%) carotid stenosis. A large proportion of patients suffer irreversible cerebral ischemia as a result of lesser degrees of stenosis. Diagnostic techniques that can identify nonstenotic high-risk plaque would therefore be beneficial. High-risk plaque is defined histologically if it contains hemorrhage/thrombus. Magnetic resonance direct thrombus imaging (MRDTI) is capable of detecting methemoglobin within intraplaque hemorrhage. We assessed this as a marker of complicated plaque and compared its accuracy with histological examination of surgical endarterectomy specimens. Methods and Results— Sixty-three patients underwent successful MRDTI and endarterectomy with histological examination. Of these, 44 were histologically defined as complicated (type VI plaque). MRDTI demonstrated 3 false-positive and 7 false-negative results, giving a sensitivity and specificity of 84%, negative predictive value of 70%, and positive predictive value of 93%. The interobserver (κ=0.75) and intraobserver (κ=0.9) agreement for reading MRDTI scans was good. Conclusions— MRDTI of the carotid vessels in patients with cerebral ischemia is an accurate means of identifying histologically confirmed complicated plaque. The high contrast generated by short T 1 species within the plaque allows for ease of interpretation, making this technique highly applicable in the research and clinical setting for the investigation of carotid atherosclerotic disease.
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Writing Committee Members, Greenland, P., Alpert, J. S., Beller, G. A., Benjamin, E. J., Budoff, M. J., Fayad, Z. A., Foster, E., Hlatky, M. A., Hodgson, J. M., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3182051b4c · Cited by 1,873
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Decreasing incidence of lacunar vs other types of cerebral infarction in a Japanese population
Kubo, M., Kiyohara, Y., Ninomiya, T., Tanizaki, Y., Yonemoto, K., Doi, Y., Hata, J., Oishi, Y., Shikata, K., & Iida, M. (2006) · Neurology · doi:10.1212/01.wnl.0000216132.95207.b4 · Cited by 90
Metadata
- Authors
- Moody, A. R., Murphy, R. E., Morgan, P. S., Martel, A. L., Delay, G. S., Allder, S., MacSweeney, S. T., Tennant, W. G., Gladman, J., Lowe, J., & Hunt, B. J.
- Venue
- Circulation
- Published
- 2003-06-24
- Volume
- 107
- Issue
- 24
- Pages
- 3047-3052
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2112271940
- Cited by
- 454
- References
- 19
- FWCI
- 13.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Moody, A. R., Murphy, R. E., Morgan, P. S., Martel, A. L., Delay, G. S., Allder, S., MacSweeney, S. T., Tennant, W. G., Gladman, J., Lowe, J., & Hunt, B. J. (2003). Characterization of Complicated Carotid Plaque With Magnetic Resonance Direct Thrombus Imaging in Patients With Cerebral Ischemia. Circulation. https://doi.org/10.1161/01.cir.0000074222.61572.44
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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