The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Defective Cardiac Ryanodine Receptor Regulation During Atrial Fibrillation
Open accessAbstract
Background— Ca 2+ leak from the sarcoplasmic reticulum (SR) may play an important role in triggering and/or maintaining atrial arrhythmias, including atrial fibrillation (AF). Protein kinase A (PKA) hyperphosphorylation of the cardiac ryanodine receptor (RyR2) resulting in dissociation of the channel-stabilizing subunit calstabin2 (FK506-binding protein or FKBP12.6) causes SR Ca 2+ leak in failing hearts and can trigger fatal ventricular arrhythmias. Little is known about the role of RyR2 dysfunction in AF, however. Methods and Results— Left and right atrial tissue was obtained from dogs with AF induced by rapid right atrial pacing (n=6 for left atrial, n=4 for right atrial) and sham instrumented controls (n=6 for left atrial, n=4 for right atrial). Right atrial tissue was also collected from humans with AF (n=10) and sinus rhythm (n=10) and normal cardiac function. PKA phosphorylation of immunoprecipitated RyR2 was determined by back-phosphorylation and by immunoblotting with a phosphospecific antibody. The amount of calstabin2 bound to RyR2 was determined by coimmunoprecipitation. RyR2 channel currents were measured in planar lipid bilayers. Atrial tissue from both the AF dogs and humans with chronic AF showed a significant increase in PKA phosphorylation of RyR2, with a corresponding decrease in calstabin2 binding to the channel. Channels isolated from dogs with AF exhibited increased open probability under conditions simulating diastole compared with channels from control hearts, suggesting that these AF channels could predispose to a diastolic SR Ca 2+ leak. Conclusions— SR Ca 2+ leak due to RyR2 PKA hyperphosphorylation may play a role in initiation and/or maintenance of AF.
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Cites
Atrial Fibrillation Begets Atrial Fibrillation: A Study in Awake Chronically Instrumented Goats
Wijffels, M. C. E. F., Kirchhof, C. J. H. J., Dorland, R., & Allessie, M. A. (1995) · Circulation · doi:10.1161/01.cir.92.7.1954 · Cited by 3,494
PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor)
Marx, S. O., Reiken, S., Hisamatsu, Y., Jayaraman, T., Burkhoff, D., Rosemblit, N., & Marks, A. R. (2000) · Cell · doi:10.1016/s0092-8674(00)80847-8 · Cited by 1,978
Self-citationNew ideas about atrial fibrillation 50 years on
Nattel, S. (2002) · Nature · doi:10.1038/415219a · Cited by 1,481
Morillo, C. A., Klein, G. J., Jones, D. L., & Guiraudon, C. M. (1995) · Circulation · doi:10.1161/01.cir.91.5.1588 · Cited by 1,037
Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein
Brillantes, A.-M. B., Ondrias, K., Scott, A., Kobrinsky, E., Ondriašová, E., Moschella, M. C., Jayaraman, T., Landers, M., Ehrlich, B. E., & Marks, A. R. (1994) · Cell · doi:10.1016/0092-8674(94)90214-3 · Cited by 827
Self-citationIonic Remodeling Underlying Action Potential Changes in a Canine Model of Atrial Fibrillation
Yue, L., Feng, J., Gaspo, R., Li, G.-R., Wang, Z., & Nattel, S. (1997) · Circulation Research · doi:10.1161/01.res.81.4.512 · Cited by 813
Epidemiology and natural history of atrial fibrillation: clinical implications
Chugh, S. S., Blackshear, J. L., Shen, W.-K., Hammill, S. C., & Gersh, B. J. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)01107-4 · Cited by 768
Wehrens, X. H. T., Lehnart, S. E., Huang, F., Vest, J. A., Reiken, S. R., Mohler, P. J., Sun, J., Guatimosim, S., Song, L.-S., Rosemblit, N., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00434-3 · Cited by 764
Self-citationRensma, P. L., Allessie, M. A., Lammers, W. J., Bonke, F. I., & Schalij, M. J. (1988) · Circulation Research · doi:10.1161/01.res.62.2.395 · Cited by 640
Electrical Remodeling in Atrial Fibrillation: Time Course and Mechanisms
Goette, A., Honeycutt, C., & Langberg, J. J. (1996) · Circulation · doi:10.1161/01.cir.94.11.2968 · Cited by 602
Cited by
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H., Cigarroa, J. E., Cleveland, J. C., Conti, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.03.022 · Cited by 2,955
Pathophysiological mechanisms of atrial fibrillation: a translational appraisal
Schotten, U., Verheule, S., Kirchhof, P., & Goette, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2009 · Cited by 1,273
Atrial Fibrillation: Epidemiology, Pathophysiology, and Clinical Outcomes
Staerk, L., Sherer, J. A., Ko, D., Benjamin, E. J., & Helm, R. H. (2017) · Circulation Research · doi:10.1161/circresaha.117.309732 · Cited by 1,201
Atrial Remodeling and Atrial Fibrillation: Mechanisms and Implications
Nattel, S., Burstein, B., & Dobrev, D. (2008) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.107.754564 · Cited by 1,124
Self-citationHeijman, J., Voigt, N., Nattel, S., & Dobrev, D. (2014) · Circulation Research · doi:10.1161/circresaha.114.302226 · Cited by 677
Self-citation
Metadata
- Authors
- Vest, J. A., Wehrens, X. H. T., Reiken, S. R., Lehnart, S. E., Dobrev, D., Chandra, P., Danilo, P., Ravens, U., Rosen, M. R., & Marks, A. R.
- Venue
- Circulation
- Published
- 2005-04-26
- Volume
- 111
- Issue
- 16
- Pages
- 2025-2032
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2087974663
- Cited by
- 356
- References
- 36
- FWCI
- 13.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vest, J. A., Wehrens, X. H. T., Reiken, S. R., Lehnart, S. E., Dobrev, D., Chandra, P., Danilo, P., Ravens, U., Rosen, M. R., & Marks, A. R. (2005). Defective Cardiac Ryanodine Receptor Regulation During Atrial Fibrillation. Circulation. https://doi.org/10.1161/01.cir.0000162461.67140.4c
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